Gene AMPK_e (S.moellendorffii)

AMPK_e

Species: S.moellendorffii
Alias: AMPK_e
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: AMPK

Sequence

Name Sequence Type Origin Length Description Download
AMPK_e.AA Protein None 435 None Fasta, JSON
AMPK_e.NA RNA None 1308 None Fasta, JSON
AMPK_e.kin_dom Protein Kinase Domain None 132 None Fasta, JSON

Protein domain

Protein domains of AMPK_e.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AMPK_e.AA AMPK 61-192 75 1.2e-112 335.69 In-house 123-254 (254) Show / Hide 
Range on Protein: 61-192
Range on HMM: 123-254/254
Sequence Identity: 75% (99 aa)

HRDLKPENLLLDSRCNVKIADFGLSNIMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGSLPFDDENIPNLFKKIKTGLYTLPSH
||||||||||||   |.||.||||||.| || ||||.||||.|||||.||||||.|||||.|||||||||.||| |||||||.|.|.|||| | |..|..
HRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKF

LSPGAKDLIPRMLLVEPMKRMTIPEIRQHPWF
||| ||||| .|| | ||||.|| .||.||||
LSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase AMPK_e.AA CAMKL 61-192 52 2.8e-85 272.08 In-house 150-297 (297) Show / Hide 
Range on Protein: 61-192
Range on HMM: 150-297/297
Sequence Identity: 52% (79 aa)

HRDLKPENLLLDSRC--NVKIADFGLSNIMRD-----GHFLKTSCGSPNYAAPEVISG--KLYAGPEVDVWSCGVILYALLCGSLPFDDE--------NI
|||.||||.|||..   |.||.|||.||..|.     |..|||.||||.|.|||...|  | | ||.||.|||||||||..|| |||||.        ||
HRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI

PNLFKKIKTGLYTLP--SHLSPGAKDLIPRMLLVEPMKRMTIPEIRQHPWF
 .|..||..| |  |  .|.|  ..||| .|| | |.||.|| .|..|||.
-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase AMPK_e.AA CAMK 61-192 33 1.2e-77 249.57 In-house 202-425 (425) Show / Hide 
Range on Protein: 61-192
Range on HMM: 202-425/425
Sequence Identity: 33% (74 aa)

HRDLKPENLLLDSR-----------------CNVKIADFGLSNIMRD------------------------GHFLKTSCGSPNYAA-PEVISG-------
||||||||.|||..                 .|.||.|||..|....                        |. .||.||.| |.| |||..|       
HRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQ

------KLYAGPEVDVWSCGVILYALLCGSLPFDDE-------------NIPNLFKKIKTGLYT-LPSHLSP-----------------------GAKDL
      | | ||..|.||||||||..||| .||...             |...||.||..| |.  |...||                        .|||
NATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDL

IPRMLLVEPMKRMTIPEIRQHPWF
| .|| |.| ||||| .. .|||.
IRKMLQVDPEKRMTIEQCLNHPWM
Kinase AMPK_e.AA NuaK 61-192 53 1.1e-73 192.88 In-house 122-252 (252) Show / Hide 
Range on Protein: 61-192
Range on HMM: 122-252/252
Sequence Identity: 53% (70 aa)

HRDLKPENLLLDSRCNVKIADFGLSNIMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGSLPFDDENIPNLFKKIKTGLYTLPSH
||||| || |||  ||.|||||||||.  |..||.| |||| || ||.. |. | ||||| || ||.||..  |..||| ..  .| | |. | |  | .
HRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMPFDGHDFKHLVKQISQGAYYEPCK

LSPGAKDLIPRMLLVEPMKRMTIPEIRQHPWF
 |  |  ||  || |.| .| || .| .|.| 
PS-DACMLIRWMLMVNPRRRATIYDICHHWWV
Kinase AMPK_e.AA MARK 61-192 48 1.1e-71 233.66 In-house 127-262 (262) Show / Hide 
Range on Protein: 61-192
Range on HMM: 127-262/262
Sequence Identity: 48% (66 aa)

HRDLKPENLLLDSRC--NVKIADFGLSNIMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGSLPFDDEN--IPNLFKKIKTGLYT
|||.||||.|.|..   |.||.|||.|..   |  |.| ||.| |.|||....| | ||.||.||.||.||...||..|||. .  . .|.||| .| |.
HRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYD

LPSHLSPGAKDLIPRMLLVEPMKRMTIPEIRQHPWF
 |.|.|.....|| |.| | |..|.|| || .|||.
IPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase AMPK_e.AA BRSK 61-192 55 3.9e-69 234.68 In-house 123-254 (254) Show / Hide 
Range on Protein: 61-192
Range on HMM: 123-254/254
Sequence Identity: 55% (73 aa)

HRDLKPENLLLDSRCNVKIADFGLSNIMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGSLPFDDENIPNLFKKIKTGLYTLPSH
|||||||||||| . |.||||||.  . ...  | |||||| || ||||.|  | |   ||||||||||||| | |||||.|. .|  |.| | . .|  
HRDLKPENLLLDEKNNIKIADFGMASLQVKDMMLHTSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHMPHF

LSPGAKDLIPRMLLVEPMKRMTIPEIRQHPWF
  | . ||   |. |.| ||... ||..|||.
IHPDCQDLLRGMIEVDPDKRISLKEIQKHPWY
Kinase AMPK_e.AA QIK 61-192 52 2e-64 220.36 In-house 141-272 (272) Show / Hide 
Range on Protein: 61-192
Range on HMM: 141-272/272
Sequence Identity: 52% (69 aa)

HRDLKPENLLLDSRCNVKIADFGLSNIMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGSLPFDDENIPNLFKKIKTGLYTLPSH
||||| ||.|||.  |.||||||.||    |. |.| |||| |||||.  || | ||.||.|| ||.||.| ||.|||| ....|| ...  |.. .|  
HRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFF

LSPGAKDLIPRMLLVEPMKRMTIPEIRQHPWF
.| .  .|| .|| |.| .|.||  |.||.| 
MSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase AMPK_e.AA GIN4 61-192 54 3.5e-62 197.26 In-house 157-293 (293) Show / Hide 
Range on Protein: 61-192
Range on HMM: 157-293/293
Sequence Identity: 54% (74 aa)

HRDLKPENLLLDSRCN-VKIADFGLSNIMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGSLPFDDE--NIPNLFKKIKTGLYTL
||||||||||||.. | .||||||.  .  |.. |.|||||| |||||...|  | |   |||||||||.||| | ||||.|  || .|  |.. | | .
HRDLKPENLLLDHKYNRIKIADFGMAALETDNKLLETSCGSPHYAAPEIVMGIPYHGFASDVWSCGVILFALLTGHLPFDEEDGNIRKLLLKVQKGKYEM

PSH--LSPGAKDLIPRMLLVEPMKRMTIPEIRQHPWF
||   .|  |.||| ..| |.| ||... .| .||  
PSDDEISREAQDLIRKILVVDPEKRIKTRDILKHPLI
Kinase AMPK_e.AA CAMK1 61-192 47 2.9e-59 170.91 In-house 131-276 (276) Show / Hide 
Range on Protein: 61-192
Range on HMM: 131-276/276
Sequence Identity: 47% (70 aa)

HRDLKPENLLLDSR---CNVK--IADFGLSNIMRDGH-FLKTSCGSPNYAAPEVISG---KLYAGPEVDVWSCGVILYALLCGSLPFDDEN-IPNLFKKI
||||||||||. .      .|  ||||||| |  ..  ..|| ||.| | ||||. .   | | . ..|.||.|||.| ||||  || ||| ...||.||
HRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPY-DKACDMWSIGVITYILLCGYPPFYDENVDNELFEKI

KTGLYTLPSH----LSPG-AKDLIPRMLLVEPMKRMTIPEIRQHPWF
| . |. ||      | . |||.|  || |.| || |. .. .|||.
KKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase AMPK_e.AA MELK 55-192 52 3.5e-54 183.44 In-house 115-254 (254) Show / Hide 
Range on Protein: 55-192
Range on HMM: 115-254/254
Sequence Identity: 52% (74 aa)

SQKYGGHRDLKPENLLLDSRCNVKIADFGLSNIMR---DGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGSLPFDDENIPNLFKKIK
|| |  ||||||||||.|   ..|. ||||    .   | | |.| |||| |||||.|.|| | | | |||| |..||.|.|| |||||.|.  ..||| 
SQGY-AHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIM

TGLYTLPSHLSPGAKDLIPRMLLVEPMKRMTIPEIRQHPWF
 | |  | .||| .|.|. .|| |.| ||. . .. .||| 
SGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV
Kinase AMPK_e.AA Pkinase 61-192 35 1.5e-51 182.34 Pfam 131-293 (293) Show / Hide 
Range on Protein: 61-192
Range on HMM: 131-293/293
Sequence Identity: 35% (59 aa)

HRDLKPENLLLDSRCNV----KIADFGLSNI--MRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGSLPFDDE------NIPNLFK
||||||||.|.|.....    ||.||||.       .. ..| ||.|.|.||||| |  | ||.||.||||.||| .||| .||...      .   ...
HRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMIC

KIKTGLYTLPSHLS---------------------PGAKDLIPRMLLVEPMKRMTIPEIRQHPWF
.|. . .  ..  .                     . .||.| ..| . | || |...| |||||
RIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
S_TKc AMPK_e.AA S_TKc 29-192 26 1.9e-19 71.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 29-192
Range on HMM: 1-231/231
Sequence Identity: 26% (67 aa)

FVLLR-----------LVKKTE-------------------------------YNSHTSPDHFW------SG-------ILSQKYGG-------------
. .||           ......                               | .  . ||..      .|       .. .. ..             
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFY

-----------------HRDLKPENLLLDSRCNVKIADFGLSNIMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGSLPFDDENI
                 ||||||||.|||.  ..||.||||. ..      .| ||.|.| ||||.    | ....|.||||.||| .|||  ||.  ..
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QM

PNLFKKIKTGLYTLPSHLSPGAKDLIPRMLLVEPMKRMTIPEIRQ-------HPWF
  .||||.          || |||.| ..| ..| ||.|. |. |       ||||
QMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
UBA_CAMKL AMPK_e.AA UBA_CAMKL 215-252 46 8.9e-14 47.53 In-house 1-41 (41) Show / Hide 
Range on Protein: 215-252
Range on HMM: 1-41/41
Sequence Identity: 46% (19 aa)

DEDILREVTKL--GFDRNLLVDSLRTRVA-NTATVTYYLML
||.|..|. |.  ||||. ...||| . . |..|.||||.|
DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL
KA1 AMPK_e.AA KA1 392-434 31 1.3e-11 42.14 Pfam 1-48 (48) Show / Hide 
Range on Protein: 392-434
Range on HMM: 1-48/48
Sequence Identity: 31% (15 aa)

GSSLVKFELQV-----REEKYLLDLQKLEGPFFIFLDFCGSFLAELRV
... ||||.||     |...|..|.....|. . ..|.|  .| |.|.
EPEVVKFEIQVCKVPGRLGLYGVDFKRVSGNQWQYKDLCTKILKEMRL