Gene SMG1 (S.moellendorffii)

SMG1

Species: S.moellendorffii
Alias: SMG1
External Links:
Annotation:

Classification

Group: Atypical
Family: PIKK
Subfamily: SMG1

Sequence

Name Sequence Type Origin Length Description Download
SMG1.AA Protein None 2943 None Fasta, JSON
SMG1.NA RNA None 8189 None Fasta, JSON

Protein domain

Protein domains of SMG1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HEAT SMG1.AA HEAT 270-300 25 0.002142 15.62 Pfam 1-31 (31) Show / Hide 
Range on Protein: 270-300
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

LFVALVAAASDEEHTVRLQASKTFGALLRHK
.. .|. . .|..  ||..| ...|.|..| 
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT SMG1.AA HEAT 1251-1282 28 3.392096 4.54 Pfam 1-31 (31) Show / Hide 
Range on Protein: 1251-1282
Range on HMM: 1-31/31
Sequence Identity: 28% (9 aa)

ITPQLFACVSSHPEAKVRKQLEGLLMSLANVY
| | |. | . .|...||..    | .|. ..
ILPHLLKCLN-DPDWEVREAACWCLGQLCEHC
Kinase SMG1.AA PIKK 1494-1787 35 3.8e-100 339.03 In-house 1-290 (290) Show / Hide 
Range on Protein: 1494-1787
Range on HMM: 1-290/290
Sequence Identity: 35% (107 aa)

TVANFNDQITILATKTKPKKVSVTGSDGQVYNYLLKGREDLRLDARIMQLLRASNKMLRASSATRREGLAVKCYSVTPISGRAGLIQWVDNVTSLYSVYK
 .. . . .|..|.|.|||| .  |.||  | ||.||.||||.|.|.|||..  |..|.  .....  |    |||.| | | |||.|||| ..|   ||
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

AWQLRQQAAQLSSNAVSGAPPP------LPRPSDMFYGKIIPALKEKGLRKVISRRDWPQDVKRKVLLDLMKETPRQLLYRELWCASDGLKGLNKKIKRF
  |..|... .  . ..   ..      |...|         ..| ..... .....||...| .|. ..|  ||. .. ...|  .        . ...
--QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMS---------YYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENY

SGSVAVMSVIGHVLGLGDRHLDNILIDFSSGDVVHIDYNICFE-KGRRLKVPEIVPFRLTQTIQNALGPTGVEGFFRASCEAVLSVLQKNKEVILMLLEA
  |.|||.. | .|||||||..||.|| ..|..||||.. ||| ...||.|||.||||||. . ||.||.|||| ||..||.|. .. ...| .. ..|.
TRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEV

F
|
F
Kinase SMG1.AA SMG1 1502-1739 50 6.6e-88 291.33 In-house 1-242 (242) Show / Hide 
Range on Protein: 1502-1739
Range on HMM: 1-242/242
Sequence Identity: 50% (122 aa)

ITILATKTKPKKVSVTGSDGQVYNYLLKGREDLRLDARIMQLLRASNKMLRASSATRREGLAVKCYSVTPISGRAGLIQWVDNVTSLYSVYKAWQLRQQA
|||| |||||||.   ||||. | || || ||| || |||| |   | |              . |||||.  |.|||||||  | |. .|| || |  |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAA

AQLS----SNAVSGAPPPLPRPSDMFYGKIIPALKEKGLRKVISRRDWPQDVKRKVLLDLMKETPRQLLYRELWCASDGLKGLNKKIKRFSGSVAVMSVI
 |      |      |   ||||...| || ||||  ||   .||||||  | . || .||  ||  || .||| .        .  . .  | ||||..
LQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMV

GHVLGLGDRHLDNILIDFSSGDVVHIDYNICFEKGRRLKVPE
| ..|||||||||.|||   |.||||||.||||||. |.|||
GYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE
Kinase SMG1.AA PI3Kc 1525-1855 21 5.1e-48 166.76 SMART 1-336 (336) Show / Hide 
Range on Protein: 1525-1855
Range on HMM: 1-336/336
Sequence Identity: 21% (76 aa)

NYLLKGREDLRLDARIMQLLRASNKMLRASSATRREGLAVKCYSVTPISGRAGLIQWVDNVTSLYSVYK--------------AWQLRQQAAQLSSNAVS
  ..|...||| |.|.||..|  ||...  ...||  | .. |.. |.. . |.|.|| |...| .. |              . ...   . ...    
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQ-K--

GAPPPLPRPSDMFYGKIIPALKEKGLRKVISRRDWPQDVKRKVLLDLMKETPRQLLYRELWCASDGLKGLNKKIKRFSGSVAVMSVIGHVLGLGDRHLDN
. . .... ..    .....  .. ...... .     .|  ||.| ..|.  .                .. ...|  |.|........||.||||.||
NMY-MMIW-HQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN-----------EDWWEARDNFTRSCAGYCMVTYILGIGDRHNDN

ILIDFSSGDVVHIDYNICFEKGRRLKVP-----EIVPFRLTQTIQNALG----PTGVEGFFRASCEAVLSVLQKNKEVILMLLEAFVWDPL-VEWMRGDG
|..|  .| ..|||.. .|..|... ..     | ||||||. .... |    |.|..| ||  |. .. .. |....|. |.|..|.||.  .|  .  
IMLDMKTGHCFHIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM--

HDEATIGGEERKGMELAVSLSLFASHV--QENRVALQEHH-DQLLRTLPTIPSTLQSW
  | .|  .. . .. ..|  . | ..  . ....| ||. . .. .. ..  ...  
--EKDIKYLRQRFRLDHLSDEEAAQYFMQT-MCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase SMG1.AA PI3_PI4_kinase 1684-1797 32 3.5e-44 157.88 Pfam 164-300 (300) Show / Hide 
Range on Protein: 1684-1797
Range on HMM: 164-300/300
Sequence Identity: 32% (44 aa)

IKRFSGSVAVMSVIGHVLGLGDRHLDNILI--DFSSGDVVHIDYNICFE--KGRRLKVPEIVPFRLTQ------TIQNAL------GPTGVEGFFRASCE
...|  |.|.|.|....||.||||.|||..  | ..| ..|||...||.  |. ....|| ||||.|.       ...|.      .|.| .|.|| .|.
RDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCW

AVLSVLQKNKEVILMLL-------EAFVWDPLVEWMR
 .. .| ........||       |..|.|.|..| .
HAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
Kinase SMG1.AA ATR 1690-1787 43 5e-40 133.82 In-house 170-267 (267) Show / Hide 
Range on Protein: 1690-1787
Range on HMM: 170-267/267
Sequence Identity: 43% (43 aa)

SVAVMSVIGHVLGLGDRHLDNILIDFSSGDVVHIDYNICFEKGRRLKVPEIVPFRLTQTIQNALGPTGVEGFFRASCEAVLSVLQKNKEVILMLLEAF
| ||....| ..|||||| ||||||   |..||.|||. | .|....||||||||||. .....|| . .| ||  || .. ....... |. ....|
SYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase SMG1.AA FRAP 1690-1797 48 1.9e-39 137.34 In-house 143-251 (251) Show / Hide 
Range on Protein: 1690-1797
Range on HMM: 143-251/251
Sequence Identity: 48% (53 aa)

SVAVMSVIGHVLGLGDRHLDNILIDFSSGDVVHIDYNICFEKG-RRLKVPEIVPFRLTQTIQNALGPTGVEGFFRASCEAVLSVLQKNKEVILMLLEAFV
| |.||..| .|||||||. ||...  .| .||||.  |||   || | || .|||||  . ||.  .|.|| .|  || |. |.  .|| ..  |||||
SLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFV

WDPLVEWMR
.|||  |  
YDPLFYWRL
Kinase SMG1.AA ATM 1690-1795 49 6.5e-38 118.45 In-house 143-248 (304) Show / Hide 
Range on Protein: 1690-1795
Range on HMM: 143-248/304
Sequence Identity: 49% (52 aa)

SVAVMSVIGHVLGLGDRHLDNILIDFSSGDVVHIDYNICFEKGRRLKVPEIVPFRLTQTIQNALGPTGVEGFFRASCEAVLSVLQKNKEVILMLLEAFVW
|||  |..| .|||||||  ||||   | ..||||  . ||.|. |  || ||||||  |   .| ||||| ||  ||  . |.   .| .| . |  ..
SVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLY

DPLVEW
||| .|
DPLFDW
Kinase SMG1.AA DNAPK 1686-1797 29 6e-25 87.62 In-house 189-301 (301) Show / Hide 
Range on Protein: 1686-1797
Range on HMM: 189-301/301
Sequence Identity: 29% (33 aa)

RFSGSVAVMSVIGHVLGLGDRHLDNILIDFSSGDVVHIDYNICFE-KGRRLKVPEIVPFRLTQTIQNALGPTGVEGFFRASCEAVLSVLQKNKEVILMLL
.|  . ||  . . .|| |||||.| .. .. ||.. ||.   |   .  | |||  |||||    | . | .. | .. .    .  ..| . . .   
HFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFC

EAFVWDPLVEWMR
. |. ||.. | .
DVFINDPSFDWKN
Kinase SMG1.AA ATR 1493-1588 36 1.1e-21 70.25 In-house 1-96 (267) Show / Hide 
Range on Protein: 1493-1588
Range on HMM: 1-96/267
Sequence Identity: 36% (35 aa)

VTVANFNDQITILATKTKPKKVSVTGSDGQVYNYLLKGREDLRLDARIMQLLRASNKMLRASSATRREGLAVKCYSVTPISGRAGLIQWVDNVTSL
  .| |.| . |||.  ||||.|. ||||. |  . | ..||| | | |.     |...|     ||  . .. |.| |.  ....| ||.|  .|
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATL
Kinase SMG1.AA DNAPK 1493-1584 34 4.2e-18 62.33 In-house 2-93 (301) Show / Hide 
Range on Protein: 1493-1584
Range on HMM: 2-93/301
Sequence Identity: 34% (32 aa)

VTVANFNDQITILATKTKPKKVSVTGSDGQVYNYLLKGREDLRLDARIMQLLRASNKMLRASSATRREGLAVKCYSVTPISGRAGLIQWVDN
| .| | . .|..|   .||.. . | |     .. || ||||.| || ||    |  .   ..     |  . |.. |   | ||| ||||
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDN
Kinase SMG1.AA FRAP 1524-1584 42 8.5e-18 62.06 In-house 2-62 (251) Show / Hide 
Range on Protein: 1524-1584
Range on HMM: 2-62/251
Sequence Identity: 42% (26 aa)

YNYLLKGREDLRLDARIMQLLRASNKMLRASSATRREGLAVKCYSVTPISGRAGLIQWVDN
| .||||.||.| | |.|||    |..|.    |.. .| .. ||. |.| ..||| || .
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHH
Kinase SMG1.AA PI3_PI4_kinase 1523-1595 23 2.4e-14 54.74 Pfam 1-98 (300) Show / Hide 
Range on Protein: 1523-1595
Range on HMM: 1-98/300
Sequence Identity: 23% (23 aa)

VYNYLLKGREDLR--LDARIMQLL-----------------------RASNKMLRASSATRREGLAVKCYSVTPISGRAGLIQWVDNVTSLYSVYKAW
 | ...|| .|||   |.|.||..                       |  ||...  ...||  . .  |.. | . . |.|.||.|.|..  . . .
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTY
Kinase SMG1.AA ATM 1526-1581 39 7.9e-12 33.67 In-house 2-57 (304) Show / Hide 
Range on Protein: 1526-1581
Range on HMM: 2-57/304
Sequence Identity: 39% (22 aa)

YLLKGREDLRLDARIMQLLRASNKMLRASSATRREGLAVKCYSVTPISGRAGLIQW
 | |||.||| || . |     | .|     ||.  | .  | | |.| |.| . |
QLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW