Gene ATR (S.moellendorffii)
ATR
Species: S.moellendorffii
Alias: ATR
External Links:
Annotation:
Sequence
Protein domains of ATR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| UME | ATR.AA | UME | 399-502 | 24 | 3.7e-27 | 93.95 | Pfam | 1-112 (112) | Show / Hide |
Range on Protein: 399-502 Range on HMM: 1-112/112 Sequence Identity: 24% (28 aa) LPSFLRQHFVRLLNNIDRKLLR---SEDVQMQKQALRCIERLLE-MIGSHLSAFIPKIMALLS---QPQ--DLQYESLSVWLSFVKRLAQVSPANLKTVA .. ||..||. ... .. ... . ... .|...| ||.... |.| |.|.. |.|||.| . . .|.|.....| |...|. | |. |.... MADFLQDHFLGIITRFSMVMHDFQGRQPYFEKKRCIRSIEEMIKYMCGKHISSARPQIMACLQSALEIPEEELRYHCFRCWHVFIQTLDEV-PEHLGPLI SQIVVALMPCLES .|..|.. | ... DQTFVIIIPYWDT |
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| UME | ATR.AA | UME | 399-502 | 26 | 1.7e-25 | 91.95 | SMART | 1-115 (115) | Show / Hide |
Range on Protein: 399-502 Range on HMM: 1-115/115 Sequence Identity: 26% (31 aa) LPSFLRQHFVRLLNNIDRKLLRSE---DVQMQKQALRCIERLLE-MIGSHLSAFIPK---IMALLSQ---PQDLQYESLSVWLSFVKRLAQVSPAN-LKT .. || .||. .......... |. ... .|.||| ||.... |.| |.|.| |. |||.| .|.......| .|.|.|. ||.. ... FADFLQDHFLGIMQWFNMIMHDSHGKKPYYEKKRALRSIEFMIKYMMGKHISSFRPQIIQIMACLQTALEIPELRHHCCRCWHCFIKHLNEVSCEHYIGP VASQIVVALMPCLES . .||.... | ... LIDQIFAIILPYWPT |
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| TPR_1 | ATR.AA | TPR_1 | 1012-1031 | 45 | 0.001915 | 16.01 | Pfam | 15-34 (34) | Show / Hide |
Range on Protein: 1012-1031 Range on HMM: 15-34/34 Sequence Identity: 45% (9 aa) GNWAEALTFCEQALELEPKS ||. ||. ....||||.|. GNYDEAIECYQKALELNPNN |
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| TPR_2 | ATR.AA | TPR_2 | 1012-1031 | 40 | 0.003655 | 15.28 | Pfam | 15-34 (34) | Show / Hide |
Range on Protein: 1012-1031 Range on HMM: 15-34/34 Sequence Identity: 40% (8 aa) GNWAEALTFCEQALELEPKS |...||. ..|.||.|.|. GDYDEAIEYYEKALKLDPNN |
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| FAT | ATR.AA | FAT | 1070-1432 | 18 | 3.6e-54 | 181.59 | Pfam | 1-408 (408) | Show / Hide |
Range on Protein: 1070-1432 Range on HMM: 1-408/408 Sequence Identity: 18% (79 aa) YMRGVQAAWRLGQWDL--INEYVHGSE-LEAGSTE------SDSA----FDLSLAKVLQTL--RSKDQV--KFQEQLTHARLALLAPLAA-ASMESYVRA ...|||||||||. . ||. |. | . .|| .| |. . .. | . ... .... || |. ..| ..||| |. APLAAEAAWRLGQWDETYMDEYISVMKKLL-GE-DQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRH YPVIVKLHMLRELEDFF---SLADKG--------GDNKDQLFENWNGRLKMT-LPSLSTREPILALRRLLFS----------VCDLQSEMGGCWLQYAKL |||.|...|| |||.. | .. . .. ......|. ||... . .. ..||..|.. || ... .| .|...|.| YPVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKFANL CRTSGHYETANRAILQAQAAG----------APNAHRERAKLFWDMKKTHRAIDELQQVLVNVPLSVLGTASGAALSGLVLNTSQTESALELTV-EEQVC || .|... . ...... .|. . ...|..|. .. . |. .|.. . . . ||... . .. . . . . | |.. CRKHGRMQLCEKTLKMLYTYDPSEEDWHPRAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEIN-GLTY---NLEVINNTNLEYFYT NDAA-KTLLLLGRWAHCT--------GQKQKEDVISIYTRVKDLQPMWEK-GYFYMARYYDDLLVDARKRQEENKEHRSNTTKRGSNADDKP---WWTYL | . ...|.| . .|.||.... | .. . |.|.| ....|.|.. .. ..... .. . .... KLLAMRCYHKQGMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQN--------------YTHMIIQHV PDTVLCYAKTLHRSHH-HLFQALPRLLT | |. . .. |. . .| ..|||. VPAVKCFFHSIALSQGSNSRQDTLRLLW |
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| TPR_2 | ATR.AA | TPR_2 | 1252-1285 | 14 | 0.393404 | 8.09 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 1252-1285 Range on HMM: 1-34/34 Sequence Identity: 14% (5 aa) PNAHRERAKLFWDMKKTHRAIDELQQVLVNVPLS . |.. .... . ... .||. ....| | AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR_1 | ATR.AA | TPR_1 | 1252-1279 | 21 | 9.499493 | 3.11 | Pfam | 1-28 (34) | Show / Hide |
Range on Protein: 1252-1279 Range on HMM: 1-28/34 Sequence Identity: 21% (6 aa) PNAHRERAKLFWDMKKTHRAIDELQQVL ..|. .. .. |.. ||. .|..| AEAWYNLGNCYYKMGNYDEAIECYQKAL |
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| FATC | ATR.AA | FATC | 1309-1317 | 55 | 15.636119 | 1.5 | Pfam | 1-9 (33) | Show / Hide |
Range on Protein: 1309-1317 Range on HMM: 1-9/33 Sequence Identity: 55% (5 aa) LELTVEEQV ..|.||.|| EPLSVEQQV |
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| Kinase | ATR.AA | ATR | 1626-1894 | 44 | 4.8e-104 | 351.96 | In-house | 1-267 (267) | Show / Hide |
Range on Protein: 1626-1894 Range on HMM: 1-267/267 Sequence Identity: 44% (121 aa) STIFAIRDDVEILVSLQRPKKVVLVASDGTEHPFLCKPKDDLRKDARMMEFTGMINRLLSKDPSSRRRKLYIRTFAVIPLTEDCGMVEWVSHTRGLRHIL . | . | |||| |||.|||. | ||| . .|||||||||| | |.| .||... || .||| . .||.||||| ..|...||| | .|| || AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL QDLYVSAGMFTKETNPTIKRIYEDNKDKKISATELMRDKILPMFPPVFHKWFLNTFPEPTAWFQSRLAYAHTTAVWSMVGHIVGLGDRHGENILYDSTTG . |. .. . . ... . .. .|. .|| ||.|| ||. .||.|. |. || .| ..|||.||| |.||||||..||| |. .| DKLWKEKKQ--YMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKING DCVHVDFSCLFDKGLQLEKPELVPFRLTQNMVDGLGITGYEGVFLRTCEITLSVLRANRETLMSVLETF .|||||. |.| .| |.| ||.||||||.||| |.| . .|.| | || .. ..| .|. .|||...| ECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | ATR.AA | PI3Kc | 1658-1979 | 24 | 6.9e-84 | 285.91 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 1658-1979
Range on HMM: 1-336/336
Sequence Identity: 24% (88 aa)
PFLCKPKDDLRKDARMMEFTGMINRLLSKDPSSRRRKLYIRTFAVIPLTEDCGMVEWVSHTRGLRHILQDLYVSAG---------MFTKET------NPT
....|..||||.|.|||.. ...|....|| .|||.|..|....||. ..|||.|||... |. |. .. .. || ... .
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMY-
IKRIYEDNKDKKISAT--------ELMRDKILPMFPPVFHKWFLNTFPEP-TAWFQSRLAYAHTTAVWSMVGHIVGLGDRHGENILYDSTTGDCVHVDFS
. .. ........ .... .. | .|||...||...||.| .|...| ... .|...||..| |.||||..||. | .|| |.|.||
MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG
CLFDKGLQLEKP-----ELVPFRLTQNMVDGLG----ITGYEGVFLRTCEITLSVLRANRETLMSVLETFIHDPL-VEWTKSHKSSATEVQNPHAQVTGP
..|..| .... |.||||||..||.. | ..||.| | ..|. .. ..| .....|...|....||. .|...
HIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM------------------
FGLCIGTDWAFQRALANIEARLRGV-VVGVAAAPS---------LPLSVEGQAHRLIQEAVSHENL
. .......|.| . ||. .. |.|.. .|..... ..
-----------EKDIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| Kinase | ATR.AA | PI3_PI4_kinase | 1656-1904 | 26 | 1.6e-77 | 268.69 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 1656-1904 Range on HMM: 1-300/300 Sequence Identity: 26% (80 aa) EHPFLCKPKDDLR--KDARMMEFT-----------------------GMINRLLSKDPSSRRRKLYIRTFAVIPLTEDCGMVEWVSHTRGLRHILQDLYV ..||..| .|||| .|.|||.. ...|....|| .|||.. .... .||. ..|||.||| .. ....|. .| WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV SAGMFT--KETNPTIKRIYEDNKDKKISATELMRDKILPMFPPVFHKWFLNTFPEP-TAWFQSRLAYAHTTAVWSMVGHIVGLGDRHGENILY--DSTTG . .. || . .|. .. .... .|. . .| . ..|....||. ..|.. ..|...| .. |....|..| |.||||..||. | ||| KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG DCVHVDFSCLFD--KGLQLEKPELVPFRLTQ------NMVDGL------GITGYEGVFLRTCEITLSVLRANRETLMSVL-------ETFIHDPLVEWTK ..|.|| . |. |. ..|||.||||.|. .||... . .|..| | ..|. .. .|| . . .|..| |...||.|..|.. HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
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| Kinase | ATR.AA | PIKK | 1759-1894 | 48 | 2.2e-64 | 220.18 | In-house | 154-290 (290) | Show / Hide |
Range on Protein: 1759-1894 Range on HMM: 154-290/290 Sequence Identity: 48% (67 aa) ELMRDKILPMFPPVFHKWFLNTFPEPTAWFQSRLAYAHTTAVWSMVGHIVGLGDRHGENILYDSTTGDCVHVDFSCLFD-KGLQLEKPELVPFRLTQNMV |. |. . .|..|.|||. .|| |..|. .| .|. ..||..||| | ||||||.|||. |..||..||.|| |.| .. |. ||.||||||.||| EVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMV DGLGITGYEGVFLRTCEITLSVLRANRETLMSVLETF ...|..| |||| |.|| .. ..| .|||||.|.|.| NAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
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| Kinase | ATR.AA | ATM | 1769-1903 | 48 | 6.1e-49 | 154.31 | In-house | 115-249 (304) | Show / Hide |
Range on Protein: 1769-1903 Range on HMM: 115-249/304 Sequence Identity: 48% (66 aa) FPPVFHKWFLNTFPEPTAWFQSRLAYAHTTAVWSMVGHIVGLGDRHGENILYDSTTGDCVHVDFSCLFDKGLQLEKPELVPFRLTQNMVDGLGITGYEGV | ||| . . | .| || |||| | |.|| |.|||||| ||| . ||.| |..| | || |||||| .|||.|||| ||| FQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGV FLRTCEITLSVLRANRETLMSVLETFIHDPLVEWT | | || |. |.| |||. . | . ||| .|| FRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWT |
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| Kinase | ATR.AA | PIKK | 1627-1729 | 37 | 9.6e-41 | 141.68 | In-house | 1-103 (290) | Show / Hide |
Range on Protein: 1627-1729 Range on HMM: 1-103/290 Sequence Identity: 37% (39 aa) TIFAIRDDVEILVSLQRPKKVVLVASDGTEHPFLCKPKDDLRKDARMMEFTGMINRLLSKDPSSRRRKLYIRTFAVIPLTEDCGMVEWVSHTRGLRHILQ | . . |... ..|.||| .. .|| |.|.|||...|||.|.|.|.. ...|..| ||| ...|.| |||..|||.. || .||| .. .|. |. RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK DLY ... QWC |
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| Kinase | ATR.AA | FRAP | 1787-1904 | 43 | 2.5e-34 | 120.39 | In-house | 133-251 (251) | Show / Hide |
Range on Protein: 1787-1904 Range on HMM: 133-251/251 Sequence Identity: 43% (52 aa) WFQSRLAYAHTTAVWSMVGHIVGLGDRHGENILYDSTTGDCVHVDFSCLFDKGLQLEK-PELVPFRLTQNMVDGLGITGYEGVFLRTCEITLSVLRANRE ||. | | |. ||.| | |||||| ||. . || ||.|| |. .. || ||..||||| .| . ..| || . |||. . |.| ..| WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKE TLMSVLETFIHDPLVEWTK .| ||| |. ||| | SVMAVLEAFVYDPLFYWRL |
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| Kinase | ATR.AA | SMG1 | 1784-1846 | 52 | 2.1e-21 | 67.54 | In-house | 180-242 (242) | Show / Hide |
Range on Protein: 1784-1846 Range on HMM: 180-242/242 Sequence Identity: 52% (33 aa) PTAWFQSRLAYAHTTAVWSMVGHIVGLGDRHGENILYDSTTGDCVHVDFSCLFDKGLQLEKPE | |. .|| ||| |||| |.|||||| .|.| | |||. ||.|. |.|| | || PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE |
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| Kinase | ATR.AA | FATC | 1958-1990 | 60 | 7.4e-20 | 66.65 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 1958-1990 Range on HMM: 1-33/33 Sequence Identity: 60% (20 aa) LPLSVEGQAHRLIQEAVSHENLGHMYVWWMPWF .|||||.|. ||||||...||| .||..|.||. EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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| Kinase | ATR.AA | DNAPK | 1627-1725 | 36 | 1.3e-18 | 64.18 | In-house | 3-101 (301) | Show / Hide |
Range on Protein: 1627-1725 Range on HMM: 3-101/301 Sequence Identity: 36% (36 aa) TIFAIRDDVEILVSLQRPKKVVLVASDGTEHPFLCKPKDDLRKDARMMEFTGMINRLLSKDPSSRRRKLYIRTFAVIPLTEDCGMVEWVSHTRGLRHIL | . | .. || |||.... | ||||. | ||| | | | . || | | ||. .||.| |..||| | |. || RIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDIL |
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| Kinase | ATR.AA | FRAP | 1656-1717 | 40 | 4.3e-17 | 59.45 | In-house | 1-62 (251) | Show / Hide |
Range on Protein: 1656-1717 Range on HMM: 1-62/251 Sequence Identity: 40% (25 aa) EHPFLCKPKDDLRKDARMMEFTGMINRLLSKDPSSRRRKLYIRTFAVIPLTEDCGMVEWVSH |. || | ..|.| | | | |.||||| .| .... | |. ...||| . |.. || | EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHH |
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| Kinase | ATR.AA | DNAPK | 1805-1904 | 29 | 1.4e-16 | 56.66 | In-house | 201-301 (301) | Show / Hide |
Range on Protein: 1805-1904 Range on HMM: 201-301/301 Sequence Identity: 29% (30 aa) GHIVGLGDRHGENILYDSTTGDCVHVDFSCLFD-KGLQLEKPELVPFRLTQNMVDGLGITGYEGVFLRTCEITLSVLRANRETLMSVLETFIHDPLVEWT . | | |||| .| . .|| . .|| | .. | ||| ||||| . . . |.. . .| | |. . || ||.. | HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWK K . N |
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| Kinase | ATR.AA | ATM | 1660-1714 | 45 | 7.7e-14 | 40.2 | In-house | 3-57 (304) | Show / Hide |
Range on Protein: 1660-1714 Range on HMM: 3-57/304 Sequence Identity: 45% (25 aa) LCKPKDDLRKDARMMEFTGMINRLLSKDPSSRRRKLYIRTFAVIPLTEDCGMVEW | | .||||.|| | | | || . |.||| | |. |.|| |..|| LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW |
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| Kinase | ATR.AA | SMG1 | 1635-1715 | 30 | 4.8e-11 | 32.67 | In-house | 1-81 (242) | Show / Hide |
Range on Protein: 1635-1715 Range on HMM: 1-81/242 Sequence Identity: 30% (25 aa) VEILVSLQRPKKVVLVASDGTEHPFLCKPKDDLRKDARMMEFTGMINRLLSKDPSSRRRKLYIRTFAVIPLTEDCGMVEWV . || .|||.. . ||| |.| | .|| | |.| | ..| . . | ..| || |.. || ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWV |
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