Gene HisK_h (S.moellendorffii)

HisK_h

Species: S.moellendorffii
Alias: HisK_h
External Links:
Annotation:

Classification

Group: Atypical
Family: HisK

Sequence

Name Sequence Type Origin Length Description Download
HisK_h.AA Protein None 1067 None Fasta, JSON
HisK_h.NA RNA None 3204 None Fasta, JSON

Protein domain

Protein domains of HisK_h.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PAS_3 HisK_h.AA PAS_3 22-88 29 4.4e-18 63.35 Pfam 1-75 (94) Show / Hide 
Range on Protein: 22-88
Range on HMM: 1-75/94
Sequence Identity: 29% (22 aa)

NTFTNAAYQNMTGCSQEELLGLR----WVEHVHPEDLQEVWDQAI---TLREG-GLNVEFRLIHKNGSWRWVNCQ
 .. . ..  |.| . ||..|.     | .|.||.|.. |...      |..|   ..|.|..||.|.|||| ..
IIYWSPRWEEMFGYTPEEFHGKSTYEDWYHHIHPDDRERVRQAHQEHWKLKKGQPYECEYRIRHKDGEWRWVRDR
PAS HisK_h.AA PAS 1-66 30 3e-06 27.95 SMART 2-68 (68) Show / Hide 
Range on Protein: 1-66
Range on HMM: 2-68/68
Sequence Identity: 30% (21 aa)

MARGPKTNVPRGVFICSTDAHNTFTNAAYQNMTGCSQEELLGLRWVEHVHPEDL--QEVWDQAITLRE
. |    | | |..... |   |. |.|...|.| |.|||.|  | . .||||.  ... .  ..|..
RYRAILENMPDGIWVWDHDGRITYWNPAACQMFGYSPEELIGQSWWDLIHPEDRNLERFQE-HQRLQQ
PAS_4 HisK_h.AA PAS_4 6-113 20 0.001127 16.35 Pfam 1-123 (123) Show / Hide 
Range on Protein: 6-113
Range on HMM: 1-123/123
Sequence Identity: 20% (26 aa)

KTNVPRGVFIC-STDAHNTFTNAA----YQN-MTGCSQEELLGLRWV-E---HV----HPEDLQEVWDQAITLREGGLNVEFRLIHKNGSWRWVNCQSVD
 ...| ....| ..| . .. |.|    |.  . |.. ||..| .|  |   ..    | ..... | ...  .|    .....   ||..||. ..   
FDHSPDCIAVCKDPDGRYRYANPACSNWYREWWFGWPPEEWIGRTWWGEMWPPELEDPHQQRFHRQWRRVLEGEEPIFFHHHHHH-PNGEERWWEWRYQ-

MPGC-FENE--SHVGIIEDITWRKE
.| .  . |   ...|..||| |..
HPLRDPDGEVIGVIWICRDITERRR
PAC HisK_h.AA PAC 70-111 27 0.009455 15.93 SMART 1-43 (43) Show / Hide 
Range on Protein: 70-111
Range on HMM: 1-43/43
Sequence Identity: 27% (12 aa)

NVEFRLIHKNGSWRWVNCQSVDMPGCFENESHVGI-IEDITWR
..|.|...|.|||.||  . . .    ..  ..   . ||| |
TWEYRFYRKDGSWIWVQVSWTPIRDWQGQPQYWICVHRDITER
PAS_3 HisK_h.AA PAS_3 145-238 27 2.2e-11 40.75 Pfam 1-94 (94) Show / Hide 
Range on Protein: 145-238
Range on HMM: 1-94/94
Sequence Identity: 27% (27 aa)

KVFYSARCKNMLGIEQSCES--ADTLDVLINRLHSSYRDCVQTALKDYLAAHKTVGSPFHIETPIRTSQDKYCWFRLRGQALW-DEQGNPLRMAGSL
... | |.. |.| .   |    .| . .....|   |. |. |..... . |  |.|...|  ||. . ...|.| ||...  || |.|.|| | .
IIYWSPRWEEMFGYTP-EEFHGKSTYEDWYHHIHPDDRERVRQAHQEHW-KLK-KGQPYECEYRIRHKDGEWRWVRDRGRVIRWDENGQPVRMIGVH
PAC HisK_h.AA PAC 202-244 25 0.001236 19.32 SMART 1-43 (43) Show / Hide 
Range on Protein: 202-244
Range on HMM: 1-43/43
Sequence Identity: 25% (11 aa)

HIETPIRTSQDKYCWFRLRGQALWDEQGNPLRMAGSLSDITER
..|  ...    . | ....... |.||.|... .. .|||||
TWEYRFYRKDGSWIWVQVSWTPIRDWQGQPQYWICVHRDITER
PAS HisK_h.AA PAS 123-192 19 0.005827 15.86 SMART 1-68 (68) Show / Hide 
Range on Protein: 123-192
Range on HMM: 1-68/68
Sequence Identity: 19% (14 aa)

ERFALAVRGSNDGLWDWDIRTNKVFYSARCKNMLGIEQSCESADTLDVLINRLHSSYR--DCVQTALKDYLA
||.. ..  ..||.| || . . .. .... .|.|  .| |       . . .|  .|  . .|  ... ..
ERYRAILENMPDGIWVWDHDGRITYWNPAACQMFG--YSPEELIGQ-SWWDLIHPEDRNLERFQE-HQRLQQ
PAS_4 HisK_h.AA PAS_4 226-246 38 2.023601 4.37 Pfam 103-123 (123) Show / Hide 
Range on Protein: 226-246
Range on HMM: 103-123/123
Sequence Identity: 38% (8 aa)

DEQGNPLRMAGSLSDITERIR
|..| ..   . . ||||| |
DPDGEVIGVIWICRDITERRR
HisKA HisK_h.AA HisKA 271-336 38 1.9e-27 98.45 SMART 1-89 (89) Show / Hide 
Range on Protein: 271-336
Range on HMM: 1-89/89
Sequence Identity: 38% (34 aa)

ARSEFLAVMSHEIRTPLNGVIGMASVLLD----------TDPTPDQ-------------EECLETIRTSGECLLSIINDILDFSKIDAG
|...||| ||||.||||....|.|..|.|          || .|.|             .| ||||. ... ....|||.||.|.|.||
AKRQFLANMSHELRTPLTAIRGYAELLQDWYYKQRYHHWTDLDPEQRLPMLRREFNCEYREYLETIQREADRMQRLINDLLDLSRIEAG
HisKA HisK_h.AA HisKA 271-336 50 3.7e-27 97.62 Pfam 1-69 (69) Show / Hide 
Range on Protein: 271-336
Range on HMM: 1-69/69
Sequence Identity: 50% (35 aa)

ARSEFLAVMSHEIRTPLNGVIGMASVLLD-TDPTPDQ--EECLETIRTSGECLLSIINDILDFSKIDAG
|...||| ||||.||||....|.|..|.| || .|.|  .| ||||. ... ....|||.||||.|.||
AKRQFLANMSHELRTPLTAIRGYAELLQDYTDLDPEQMRREYLETIQREAQRMQRLINDLLDFSRIEAG
HATPase_c HisK_h.AA HATPase_c 382-533 25 4.5e-35 123.77 SMART 1-130 (130) Show / Hide 
Range on Protein: 382-533
Range on HMM: 1-130/130
Sequence Identity: 25% (46 aa)

VDTIRLRQVLINLIGNSCKFTHA--------------GHILVNVSLLCKSCQKQLKATDFWECRSCSKDVNSFKGRELDSDAKHVKPVEYFKFSISDSGI
 | .||||||.||..|. |.|..              |.| | |.                                               ....|.|.
GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH----------------------------------------------RITVEDNGP

GIAE------DKLGLLFEKFSQCDQ--------LTSSMYGG--TGLGLAVSKSLVDLMGGEIVVESREGVGSTFSFSIPLEI
||..      ...  .||.| . |.         .|. |||  |||||...|..|...||.| ||      .||.|..|||.
GIPPEMHKSIEDIPRIFEPFYRTDDSPSRMCPDSRSRKYGGGLTGLGLSICKRIVEQHGGTIWVE------TTFTFTLPLER
HATPase_c HisK_h.AA HATPase_c 382-532 28 5.8e-35 123.92 Pfam 1-120 (120) Show / Hide 
Range on Protein: 382-532
Range on HMM: 1-120/120
Sequence Identity: 28% (46 aa)

VDTIRLRQVLINLIGNSCKFTHA-GHILVNVSLLCKSCQKQLKATDFWECRSCSKDVNSFKGRELDSDAKHVKPVEYFKFSISDSGIGIAE------DKL
 | .||.||. ||..|. |.|.. ||| | |.                                           ..  ....|.|.||..      ...
GDPDRLHQVVWNLVDNAIKHTPEGGHITVRVHRDD----------------------------------------DHVRITVEDNGPGIPPEMHSIAEDI

GLLFEKFSQCDQ-LTSSMYGG--TGLGLAVSKSLVDLMGGEIVVESREGVGSTFSFSIPLE
  .||.| . |.  . ..|||  |||||.... .|...||.| |||..| |.||.| .|||
PRIFEPFYRTDPDSR-RKYGGGLTGLGLYICRRIVEQHGGTIWVESEPGGGTTFTFTLPLE
Kinase HisK_h.AA HisK 383-532 23 9.7e-31 107.5 In-house 2-164 (164) Show / Hide 
Range on Protein: 383-532
Range on HMM: 2-164/164
Sequence Identity: 23% (46 aa)

DTIRLRQVLINLIGNSCKFTHAG------HILVNVS-------LLCKSCQKQLKATDFWECRSCSKDVNSFKGRELDSDAKHVKPVE-----------YF
|  |..|.|||||.|. |||  |      .| ..|.       .                     |. ||         .  .|  |           ..
DPNRIKQILINLISNALKFTQKGGIPFQGYIKIKVEQINTQNNI---------------------KY-NS---------IFIQKIQENMVQEQLQQKNLI

KFSISDSGIGIAEDKLGLLFEKFSQCDQ---------LTSSM---YGGTGLGLAVSKSLVDLMG--------GEIVVESREGVGSTFSFSIPLE
..|..|.|.|. |...  .|..|.. |.          ....     | ||||.....|. ..|        ..| |.| .|.|||||| |   
QISVQDTGCGMPEEQQKKIFKMFGNIDDQHQMIKKTFNHQNKKNNQHGCGLGLTICNNLAKGLGPEHNQNGNRGIQVQSEVGKGSTFSFYIYNN
REC HisK_h.AA REC 556-665 13 0.000116 9.98 SMART 1-150 (150) Show / Hide 
Range on Protein: 556-665
Range on HMM: 1-150/150
Sequence Identity: 13% (22 aa)

PRILVIDNH----KITRQVMC------EQIESWGIE--------CQCSGDVA-------SALKLLANR--------------FHVAVVDNVLVE------
.|||..| .     . |...       .  |..|.|        . .  | .        ||.||..               ... ..|  . .      
MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG

-----TFQKKLQIKRIAEEFPGTKFILL---KPVGHRVNAQEAYGFSCTLSRPLRQSTLKDAL
     .. ....           . |.|     . .|| |  . |    .. | ..  | ...
GMDGIELCRRIR-----------PIIMLTAHDDEEDRVRAL-EAGADDYITKPFDPEELLARI
Response_reg HisK_h.AA Response_reg 558-605 19 0.008518 12.58 Pfam 1-51 (115) Show / Hide 
Range on Protein: 558-605
Range on HMM: 1-51/115
Sequence Identity: 19% (10 aa)

ILVIDNHKITRQVMCEQIE-SWGI-ECQCSGDVASALKLLANR-FHVAVVD
.|..| | . |... . .| ..|. ..    | ..||... .. ... . |
VLIVDDHPLMREGLRQILEQKEGYEVVAEADDGEEALEWWQEHHPDLIIMD
REC HisK_h.AA REC 703-815 26 6.1e-38 133.29 SMART 1-150 (150) Show / Hide 
Range on Protein: 703-815
Range on HMM: 1-150/150
Sequence Identity: 26% (42 aa)

PKVLVVEDN----KVNQMVAI------RLLNNLGCT--------VDVACNGQ-------EAVSIVDKP------------VEYDLIFMDCHMP-------
...|.|.|.     |....        |||  .|..        ||.| .|.       ||. ....              ..|||.||. ||       
MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG

VLDGFQASRLIRSKQKLTPIVALTAATMESELEKCLECGMDDYVRKPCTKQELQRVL
 .||... | ||      ||..||| ..|.  ...|| |.|||. ||.. .||. ..
GMDGIELCRRIR------PIIMLTAHDDEEDRVRALEAGADDYITKPFDPEELLARI
Response_reg HisK_h.AA Response_reg 705-816 31 5.9e-31 113.45 Pfam 1-115 (115) Show / Hide 
Range on Protein: 705-816
Range on HMM: 1-115/115
Sequence Identity: 31% (37 aa)

VLVVEDNKVNQMVAIRLLN-NLGC-TVDVACNGQEAVSIVDKPVEYDLIFMDCHMPVLDGFQASRLI-RSKQ-KLTPIVALTAATMESELEKCLECGMDD
||.|.|. .....  ..|.   |.  |..| .|.||. ....   .|||.||. || .||... | | | ..   |||...||  .|.  ...|. |..|
VLIVDDHPLMREGLRQILEQKEGYEVVAEADDGEEALEWWQEHH-PDLIIMDINMPGMDGLELCRRIRRQHPHPQTPIIMCTAHGDEDDAVEALQAGAND

YVRKPCTKQELQRVLH
|. ||. ..||   . 
YITKPFDPDELHAAIR
CSD HisK_h.AA CSD 897-964 46 9.8e-28 103.26 Pfam 1-71 (71) Show / Hide 
Range on Protein: 897-964
Range on HMM: 1-71/71
Sequence Identity: 46% (33 aa)

LMFGKVKWFSPTRGFGFITPDDGSPDIFVHQTSIHAEG---FRSLREGEIVEYVVELGQDGRMRAGNVTGP
 | |.||||.  .|||||||.||. |.|||...|  .|   ||.| ||. ||. .. . ...  | |||.|
MMTGTVKWFNDEKGFGFITPEDGDKDVFVHFSAIQMDGPKYFRTLQEGQKVEFDIVQQGQKGPQAANVTKP
CSP HisK_h.AA CSP 899-964 41 1.2e-25 92.4 SMART 1-70 (70) Show / Hide 
Range on Protein: 899-964
Range on HMM: 1-70/70
Sequence Identity: 41% (29 aa)

FGKVKWFSPTRGFGFITPDDG--SPDIFVHQTSIHAEGFRSLREGEIVEYVVEL--GQDGRMRAGNVTGP
 |.||||. |.|||||.||||  . |.|||. .| ..|...|..|..||..|.   .....  | ||. .
TGTVKWFNATKGFGFIRPDDGNGGKDVFVHPSQIQMNGMKTLQHGDKVEFDVRSYPRGNKKPQAENVRKL
Zf-CCHC HisK_h.AA zf-CCHC 1028-1045 55 1.5e-07 32.23 Pfam 1-18 (18) Show / Hide 
Range on Protein: 1028-1045
Range on HMM: 1-18/18
Sequence Identity: 55% (10 aa)

GRCFNCNEPGHLARDCSV
..|.||..|||.||||  
RKCYNCGKPGHWARDCPQ
ZnF_C2HC HisK_h.AA ZnF_C2HC 1029-1045 58 4e-07 30.91 SMART 1-17 (17) Show / Hide 
Range on Protein: 1029-1045
Range on HMM: 1-17/17
Sequence Identity: 58% (10 aa)

RCFNCNEPGHLARDCSV
.|.||..|||.||||  
KCYNCGKPGHWARDCPN
ZnF_C2HC HisK_h.AA ZnF_C2HC 1049-1065 76 3.7e-08 34.33 SMART 1-17 (17) Show / Hide 
Range on Protein: 1049-1065
Range on HMM: 1-17/17
Sequence Identity: 76% (13 aa)

GCYSCGKQGHFARDCPN
.|| ||| ||.||||||
KCYNCGKPGHWARDCPN
Zf-CCHC HisK_h.AA zf-CCHC 1048-1065 66 9.4e-08 32.98 Pfam 1-18 (18) Show / Hide 
Range on Protein: 1048-1065
Range on HMM: 1-18/18
Sequence Identity: 66% (12 aa)

AGCYSCGKQGHFARDCPN
 .|| ||| ||.|||||.
RKCYNCGKPGHWARDCPQ