Gene RSK-p3_e-2 (S.moellendorffii)

RSK-p3_e-2

Species: S.moellendorffii
Alias: RSK-p3_e-2
External Links:
Annotation:

Classification

Group: AGC
Family: RSK
Subfamily: RSK-p3

Sequence

Name Sequence Type Origin Length Description Download
RSK-p3_e-2.AA Protein None 556 None Fasta, JSON
RSK-p3_e-2.NA RNA None 1671 None Fasta, JSON
RSK-p3_e-2.kin_dom Protein Kinase Domain None 319 None Fasta, JSON

Protein domain

Protein domains of RSK-p3_e-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RSK-p3_e-2.AA AGC 47-365 26 1.2e-131 342.35 In-house 1-395 (395) Show / Hide 
Range on Protein: 47-365
Range on HMM: 1-395/395
Sequence Identity: 26% (114 aa)

FRIIKSIGHGDMGTVFLVALR------GDNSPYAMKVMKKEV-LAARE--NFHRAQTE------------KEILKALD----------HPFLPR-LLAHF
|...| || |  |.|.||  .      . .  |||||.||..    ..    ....||            ..||. ..          |||. . |   |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETDKH--TFLVTDYCC--------GGDLNVLRQKQ---PDKRFSESATRFYAAE-------VLLALEYLHE-HGIIYRD-LKPENILIKENGHVMLTDFD
....|   ..| .|..        ||..  . ..|     .||.|...||||||       ..|||||||. .|||.|| |||||||. |.||..|||| 
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSLNLAT------------KKKTSSSPLFTDKKKKPSKPRPLSCGLHFELPRIITQRRKNTSKSCKKAVARIFPRSCGSSSDCRSN--------------
|.  . .            | .. ... .   |.             .. .                       . |. ..  | |              
LCKEGMNDGEKGQQSQSNMKFHW-HNKKY-Q-KS------------NMD-T-N---------------------K-CNPNNWQRNNMSQEDDTTRKKRDR

--SFVG--TEEYVAPEVVWGSGHGLPVDWWT--FGVFLYELVYAKTPFKGSR----------RKDTFYNIL------CKEVELPGP-----------PTP
  .|.|  | ||.|||..    .| ..|||.  .|...||... ..|| |            ....| .|.       ..|..| |              
TWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPE

LKDLIAGLLVKDPEQRLGSRQ------GALEVRNHAFF
.|||| .||.||||.|||...      || |..|| .|
AKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase RSK-p3_e-2.AA AktR 47-365 34 1.3e-97 330.57 In-house 1-268 (268) Show / Hide 
Range on Protein: 47-365
Range on HMM: 1-268/268
Sequence Identity: 34% (115 aa)

FRIIKSIGHGDMGTVFLVALR-GDNSPYAMKVMKKEVLAARENFHRAQTEKEILK-ALDHPFLPRLLAHFETDKHTFLVTDYCCGGDL-NVLRQKQPDKR
|...| .| |  |.|.||  .  ..  ||||. ||. .  |. .|...||. |..   .|||. .|   |.|... |.. .||.||.| ..|..|   |.
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKK---KK

FSESATRFYAAEVLLALEYLHEH-GIIYRDLKPENILIKENGHVMLTDFDLSLNLATKKKTSSSPLFTDKKKKPSKPRPLSCGLHFELPRIITQRRKNTS
|||. .|||.|..||||||||.|  ||||||||||||. |.||| .||| ||                                                
FSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK-----------------------------------------------

KSCKKAVARIFPRSCGSSSDCRSNSFVGTEEYVAPEVVWG-SGHGLPVDWWTFGVFLYELVYAKTPFKGSRRKDTFYNILCKE-VELPGPPTP---LKDL
                 . | . .||.|| ||.|||..    ||. .||||.||.|.||.|.  .||  . ... | .|. |. .. | |. .   .|||
------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDL

IA-GLLVKDPEQRLG-SRQGALEVRNHAFF
|  .|| |.|..||| .. |. |...| .|
IQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase RSK-p3_e-2.AA RSK 50-365 30 1.4e-85 290.67 In-house 1-278 (278) Show / Hide 
Range on Protein: 50-365
Range on HMM: 1-278/278
Sequence Identity: 30% (103 aa)

IKSIGHGDMGTVFLVALR---GDNSPYAMKVMKKEVLAAREN-FHRAQTEKEILKALD-HPFLPRLLAHFETDKHTFLVTDYCCGGDLNVLRQKQPDK-R
.|  | |. | |||.        .  ||||| || ....|.    .. || .||..   |||. .|   |.|.....|...|| ||.|    ||.  .  
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSESATRFYAAEVLLALEYLHEHGIIYRDLKPENILIKE---NGHVMLTDFDLSLN-LAT-KKKTSSSPLFTDKKKKPSKPRPLSCGLHFELPRIITQRR
|||.  .||.||. ||.|.||..|||.|||||||||  .   .||..||||...    .  ...| .                                 
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMT---------------------------------

KNTSKSCKKAVARIFPRSCGSSSDCRSNSFVGTEEYVAPEVVW----GSGHGLPVDWWTFGVFLYELVYAKTPFKG---SRRKDTFYNILCKEVELPGP-
                             |..| ||.|||..     ..||.  .|||..|| .||.   ..||.|   . ||... .|. ..  |..| 
-----------------------------FCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPN

----PTPLKDLIAGLLVKDPEQRLGS-RQGALEVRNHAFF
     .. |||| ..| .||..|||. .|.| |...|..|
WQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase RSK-p3_e-2.AA S_TKc 47-365 25 1.9e-85 291.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 47-365
Range on HMM: 1-231/231
Sequence Identity: 25% (85 aa)

FRIIKSIGHGDMGTVFLVALRGDNSPYAMKVMKKEVLAARENFHRAQTEKEILKALDHPFLPRLLAHFETDKHTFLVTDYCCG--GDLNVLRQKQPDKR-
..|.. ||.| .|.|...  ....  .|.|..|           ... | .|||  .||.. .|. .|.. .| ..|..|| |  |||  . .|.. .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSESATRFYAAEVLLALEYLHEHGIIYRDLKPENILIKENGHVMLTDFDLSLNLATKKKTSSSPLFTDKKKKPSKPRPLSCGLHFELPRIITQRRKN
   |.|  .|||......||||.|.||||.|||||||||. |  |....|| |.  |                                           
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

TSKSCKKAVARIFPRSCGSSSDCRSNSFVGTEEYVAPEVVWGSGHGL-PVDWWTFGVFLYELVYAKTPFKGSRRKDTFYNILCKEVELPGPPTPLKDLIA
                         ..|.|| .|.||||.   |.|  ..||| .|. |||... ..||      .. .....        . ..||.| 
-------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG--------SPEAKDFIR

GLLVKDPEQRLGSRQGAL---EVRNHAFF
..|.||||.|..  .      ....| .|
KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RSK-p3_e-2.AA Ciliate-E2-Unclassified 47-365 20 5e-66 225.68 In-house 1-352 (352) Show / Hide 
Range on Protein: 47-365
Range on HMM: 1-352/352
Sequence Identity: 20% (84 aa)

FRIIKSIGHGDMGTVFLVALRGDNSPY-----AMKVMKKEVLAARENFHRAQTEKEILKA-------------------LDHPFLPRLLAHFETDKHTFL
..||| ||.|  |.|...  . ..  |     ..|.... ..  ...  .   |.....                    ..|||. ... .|..... ..
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VTDYCCGGDLNVLRQKQPD---------------KRFSESATR-----FYAAEVLLALEYLHEHG-IIYRDLKPENILIKENG---HVMLTDFDLSLNLA
|..|| ||||    .|..                |.|.| ...     ||.|..|..|||||. . ||.||.||||||...||   .. ..|| .| .. 
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

TK---KKTSSSPLFTDKKKKPSKPRPLSCGLHFELPRIITQRRKNTSKSCKKAVARIFPRSCGSSSDCRSNSFVGTEEYV----APEVVWGSGHGLP---
.    . |..                                         .          .  .......|.|| .|     ||||  | ... .   
QNNNCD-TNQ-----------------------------------------Q-------QKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAY

-VDWWTFGVFLYELVYAKTPFKGSRRKD----------------TFYNILCKEVELPGPPT---------PLKDLIAGLLVKDPEQRLGSRQGALEVRNH
 .|.|..|| |||... . ||..  ...                 . ||. |... |  |            ||.|  || |... ....| .. .. ||
KCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNH

AFF
 .|
PWF
Kinase RSK-p3_e-2.AA RSK-Unclassified 47-194 44 1.2e-62 195.4 In-house 1-148 (283) Show / Hide 
Range on Protein: 47-194
Range on HMM: 1-148/283
Sequence Identity: 44% (66 aa)

FRIIKSIGHGDMGTVFLVALRGDNSPYAMKVMKKEVLAARENFHRAQTEKEILKALDHPFLPRLLAHFETDKHTFLVTDYCCGGDLNVLRQKQPDKRFSE
|  .. || ||.| |.||  .. .  |||||..|. .  .    .. ||..|.   .|||  .|   | |    .|. .|| |||.    |   .|.|.|
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

SATRFYAAEVLLALEYLHEHGIIYRDLKPENILIKENGHVMLTDFDLS
   ||||.|| .||||||  ..|||||||.||.    |||||||||||
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLS
Kinase RSK-p3_e-2.AA Akt 47-191 44 7.3e-52 164.03 In-house 1-145 (264) Show / Hide 
Range on Protein: 47-191
Range on HMM: 1-145/264
Sequence Identity: 44% (66 aa)

FRIIKSIGHGDMGTVFLVALRGDNSPY-AMKVMKKEVLAARENFHRAQTEKEILKALDHPFLPRLLAHFETDKHTFLVTDYCCGGDLNVLRQKQPDKRFS
|...| .| |  | ||||    ..  | |||| ||... ..  .  ..||. ||.  .|||.  |   | | .. ..|.||| ||.|  . |.  ..|||
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQR--KRRFS

ESATRFYAAEVLLALEYLHEHGIIYRD-LKPENILIKENGHVMLTDF
|. .|||.||. ||.|.||...||||| |||||||. ..||. ||||
EDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDF
Kinase RSK-p3_e-2.AA SGK 47-205 36 1.3e-51 157.43 In-house 1-184 (283) Show / Hide 
Range on Protein: 47-205
Range on HMM: 1-184/283
Sequence Identity: 36% (67 aa)

FRIIKSIGHGDMGTVFLVALRGD------------------NSPYAMKVMKKEVLA-------ARENFHRAQTEK-EILKALDHPFLPRLLAHFETDKHT
|...| || |  | |..|   .|                     ||||| .|.          ...     ..|.  ||| . |||.  |   | |..  
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FLVTDYCCGGDLNVLRQKQPDKRFSESATRFYAAEVLLALEYLHEHGIIYRDLKPENILIKENGHVMLTDFDLSL-NLATKKKTSS
..| ||  ||..    |.   |.|.|.  ||||||. .||||||.  ||||||||||||    ||. |||| |.  . .|...|..
YFVMDYVNGGEMFYHLQRE--KHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFT
Kinase RSK-p3_e-2.AA PKA 47-191 41 2.5e-49 170.18 In-house 1-145 (263) Show / Hide 
Range on Protein: 47-191
Range on HMM: 1-145/263
Sequence Identity: 41% (61 aa)

FRIIKSIGHGDMGTVFLVALRGDNSPYAMKVMKKEVLAARENFHRAQTEKEILKALDHPFLPR-LLAHFETDKHTFLVTDYCCGGDLNVLRQKQPDKRFS
| ||...| |  |.| |.  ...   ||||..||.    .   ..  .|| ||....|||. . . ..| .|.. ..| .|..||..    .|   .|||
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKS--GRFS

ESATRFYAA-EVLLALEYLHEHGIIYRDLKPENILIKENGHVMLTDF
.. ..|||| .. ||||||| . ||||||||||||| .|||. .|||
NPHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDF
Kinase RSK-p3_e-2.AA PKC 47-191 43 1.7e-47 151.92 In-house 1-144 (262) Show / Hide 
Range on Protein: 47-191
Range on HMM: 1-144/262
Sequence Identity: 43% (63 aa)

FRIIKSIGHGDMGTVFLVALRGDNSPYAMKVMKKEVLAARENFHRAQTEKEILK-ALDHPFLPRLLAHFETDKHTFLVTDYCCGGDLNVLRQKQPDKRFS
|. .| .| |  | |.|. ..| .  ||.||.||.|    .    ..||| .|  |  ||||  |   | |  . | |  |. ||||    . |  .||.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDL--MFHIQQQRRFK

ESATRFYAAEVLLALEYLHEHGIIYRDLKPENILIKENGHVMLTDF
|. .||||||...|| .|||.|||||||| .|.|. . ||. ..||
EEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADF
Kinase RSK-p3_e-2.AA Pkinase 47-211 32 7.4e-43 152.61 Pfam 1-170 (293) Show / Hide 
Range on Protein: 47-211
Range on HMM: 1-170/293
Sequence Identity: 32% (59 aa)

FRIIKSIGHGDMGTVFLVALRGDNSPYAMKVMKKEVLAARENFHRAQT---EKEILKALDHPFLPRLLAHFETDKHTFLVTDYCCGG----DLN----VL
..|.. || | .|.|..   .|..  .|.|..||.   ........ .   | .|.| |.||.  ||.  ||...|  .|..|| ||    ||     . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-

RQKQPDKRF--SESATRFYAAEVLLALEYLHEHGIIYRDLKPENILIKENGHV----MLTDFDLSLNLATKKKTSSSPLFTD
   . ...|  ||   .||. ..| .|||.|..|||.||||||||||..|||.     ..|| |.  .     . ... .|.
---WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTT
Kinase RSK-p3_e-2.AA RSK-Unclassified 264-365 42 4.8e-42 129.53 In-house 178-283 (283) Show / Hide 
Range on Protein: 264-365
Range on HMM: 178-283/283
Sequence Identity: 42% (45 aa)

RSNSFVGTEEYVAPEVVWGSGHGLPVDWWTFGVFLYELVYAKTPFKGSRRKDTFYNILCKEVELP---GPPTPLKDLIAGLLVKDPEQRLGSRQG-ALEV
| |||.|||||.|||.. . ||.  ||||| |. .||.    .|..|  .  |||||. ..| .|         .|||  || . |  |||. .| | ..
RTNSFCGTEEYLAPEMIRRCGHTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDI

RNHAFF
. | ||
KRHPFF
Kinase RSK-p3_e-2.AA MAST 47-194 41 3.7e-40 126.93 In-house 1-146 (334) Show / Hide 
Range on Protein: 47-194
Range on HMM: 1-146/334
Sequence Identity: 41% (61 aa)

FRIIKSIGHGDMGTVFLVALRGDNSPYAMKVMKKEVLAARENFHRAQTEKEILKALDHPFLPRLLAHFETDKHTFLVTDYCCGGDLNVLRQKQPDKRFSE
| .|| |. |  | |.||  .  |  .||||.||  .. .   .  |.|. ||. .. ||   .   |.|... ..| .|  |||.. | .     .| |
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYG--YFDE

SATRFYAAEVLLALEYLHEHGIIYRDLKPENILIKENGHVMLTDFDLS
. ...| ||. |.|||||.|||. |||||.|.||  |||. |||| ||
WMAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLS
Kinase RSK-p3_e-2.AA SGK 267-365 44 8.7e-32 95.08 In-house 184-283 (283) Show / Hide 
Range on Protein: 267-365
Range on HMM: 184-283/283
Sequence Identity: 44% (45 aa)

SFVGTEEYVAPEVVWGSGHGLPVDWWTFGVFLYELVYAKTPFKGSRRKDTFY-NILCKEVELPGPPTPL-KDLIAGLLVKDPEQRLGSRQGALEVRNHAF
.| || || ||||  . .|.  ||||  | .|||. | . ||  || | . | ||. ..  .|   ..  .||| ||| |||..|||......|..|| |
TFCGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFY-SRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPF

F
|
F
Kinase RSK-p3_e-2.AA MAST 269-365 40 7.8e-31 96.37 In-house 225-334 (334) Show / Hide 
Range on Protein: 269-365
Range on HMM: 225-334/334
Sequence Identity: 40% (45 aa)

VGTEEYVAPEVVWGSG-HGLPVDWWTFGVFLYELVYAKTPFKGSRRKDTFYNILCKE---VELP-G--------PPTPLKDLIAGLLVKDPEQRLGSRQG
.|| .| ||||  | | || |||||  |. .||.    .|| .. .  .| ||| ..   .|.| |        .. . .|||  ||  ||..|||.. |
CGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGANNG

ALEVRNHAFF
| || .| ||
ADEVKQHPFF
Kinase RSK-p3_e-2.AA Akt 266-365 39 7.4e-30 92.56 In-house 160-264 (264) Show / Hide 
Range on Protein: 266-365
Range on HMM: 160-264/264
Sequence Identity: 39% (41 aa)

NSFVGTEEYVAPEVVWGSGHGLPVDWWT-FGVFLYELVYAKTPFKGSRRKDTFYNILCKEVELPGP---PTPLKDLIAGLLVKDPEQRLG-SRQGALEVR
..| || || |||.  | ||. .||||. .|...||. .   ||    ..  | .|. ..|. |         |||| ||| |||..|||   ..| |..
KTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIK

NHAFF
.| .|
RHPWF
Kinase RSK-p3_e-2.AA Pkinase 266-365 25 1.1e-26 95.49 Pfam 169-293 (293) Show / Hide 
Range on Protein: 266-365
Range on HMM: 169-293/293
Sequence Identity: 25% (33 aa)

NSFVGTEEYVAPEVVW-GSGHGLPVDWWTFGVFLYELVYAKTPFKGS------RRKDTFYNILCKEVELPGP----------------------PTPLKD
..|.|| .|.||||.  |...| .||.| .|. |||..  ..||.|.      . .  ...|...... . |                      . ..||
TTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKD

LIAGLLVKDPEQRLGSRQGALEVRNHAFF
.| ..| |||..|..    | .. .| .|
FIKWCLCKDPKKRPT----AEQILQHPWF
Kinase RSK-p3_e-2.AA PKC 264-365 32 3.1e-23 72.03 In-house 156-262 (262) Show / Hide 
Range on Protein: 264-365
Range on HMM: 156-262/262
Sequence Identity: 32% (35 aa)

RSNSFVGTEEYVAPEVVWGSGHGLPVDWWTFGVFLYELVYAKTPFKGSRRKDTFYNILCKEVELPGP-PTPLKDLIAGLLVKDPEQRLGS----RQGALE
. ..| || .|.|||.. .   |  |||| ||| .||.   . || |    . | .|. ...  |       .... |.. |.||.|||.    ..|. .
TTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPFHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQD

VRNHAFF
.| |.||
IREHPFF
Kinase RSK-p3_e-2.AA PKA 270-365 32 5.9e-22 79.26 In-house 160-263 (263) Show / Hide 
Range on Protein: 270-365
Range on HMM: 160-263/263
Sequence Identity: 32% (34 aa)

GTEEYVAPEVVWGS-GHGLPVDWWTFGVFLYELVYAKTPFKGS--RRKDTFYNILCKEVELPGPPTP-L---KDLIAGLLVKDPEQRLGSRQ-GALEVRN
|| || |||.. .. ||| .||||..|.  ||..  ..||  .     ...  |.  ... |   .. .   ||||  ||..|...|.|. . |.  ..|
GTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKN

HAFF
| .|
HKWF
Kinase RSK-p3_e-2.AA TyrKc 47-274 18 2e-09 -70.21 SMART 1-280 (280) Show / Hide 
Range on Protein: 47-274
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

FRIIKSIGHGDMGTVFLVALRGDNSPYAMKVMKKEVLAARENFHRAQTEKEILKAL--DHPFLPRLLAHFETD-------KHTFLVTDYCCGGDLNVLRQ
 . .| .|.|  |.|..  ..    . | |..|..    || |.|   | .|.. |  .|| . ||..   ..       .  ..|. |...|||.   .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMR---EARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KQPDKRFSESATRFYAAEVLLALEYLHEHGIIYRDLKPENILIKENGHVMLTDFDLSLNLATK-KKTSSSPLFTDKKKKPSK------------------
|  .| .. .    ..  .    ||||....| |||   |.|..||..|  .|| || ..  . ..  |.   . |..| .|                  
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

-------------------PRPLSCG------LHFELPRIITQR-RKNTSKS--------CKKAVARIFPRSCGSSSDCRSNSFVGTEEY
                     .   |        .|. . . |. |    ..        | ... .|  . .    ..| .     |. 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase RSK-p3_e-2.AA Pkinase_Tyr 47-191 26 2e-06 22.43 Pfam 1-155 (270) Show / Hide 
Range on Protein: 47-191
Range on HMM: 1-155/270
Sequence Identity: 26% (42 aa)

FRIIKSIGHGDMGTVFLVALR----GDNSPYAMKVMKKEVLAA---RENFHRAQTEKEILKAL-DHPFLPRLLAHFE-TDKH--TFLVTDYCCGGDL-NV
 ...| .|.|  |.|..  ..    ... | | |..|         || | |   | .|.| | .|| . ||..     ...   ..|. |...||| . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR---EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LRQK-QPDKRFSESATRFYAAEVLLALEYLHEHGIIYRDLKPENILIKENGHVMLTDF
||..  ...... .    .....  ..|||.....| |||   |.|..||..|  .||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDF
Kinase RSK-p3_e-2.AA Pkinase_Tyr 292-310 33 5.090112 0.69 Pfam 198-218 (270) Show / Hide 
Range on Protein: 292-310
Range on HMM: 198-218/270
Sequence Identity: 33% (7 aa)

WTFGVFLYELVY-AKTP-FKG
| ||| ..|..   ..| ..|
WSFGVLMWEIFTYGEQPTYPG