Gene PDK1-2 (S.moellendorffii)

PDK1-2

Species: S.moellendorffii
Alias: PDK1-2
External Links:
Annotation:

Classification

Group: AGC
Family: PDK1

Sequence

Name Sequence Type Origin Length Description Download
PDK1-2.AA Protein None 489 None Fasta, JSON
PDK1-2.NA RNA None 1470 None Fasta, JSON
PDK1-2.kin_dom Protein Kinase Domain None 267 None Fasta, JSON

Protein domain

Protein domains of PDK1-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PDK1-2.AA PDK1 36-302 41 3.3e-146 451.18 In-house 1-307 (307) Show / Hide 
Range on Protein: 36-302
Range on HMM: 1-307/307
Sequence Identity: 41% (126 aa)

FAYGRLLGMGSYSKVVRAKKKDS----GAEFALKIMDKKHITKENKVAYVKMERLILDHLD-----HPGVVRLFFTFQDTHNLYMGLECCHGGELFDQIR
|  |. .| ||||.|..|. |..    ....|.||  |..| .|.|| ||. |. |..||.     |||.|.|.|||||  .|| .|| | .|.|  ...
FIFGKNIGEGSYSTVYLAREKETKNDENKMYAIKICEKRYIIREKKVKYVHREKEIMCHLNNECNGHPGIVKLYFTFQDEQCLYFVLEYCPNGDLLHYMK

R--KGRLSLEEARFYAAEIVDVLEYIHGQGLIHRDLKPENLLLTADGHIKVADFGSA---KVTTP---------------LQNGLS--DAQADDKSCTFV
.   | ..   .|||||||.| ||..|. | |||||||||.||. |.||. .|||.|   |. ..                 .| .  . .   .. .||
KQPFGSFDMDCCRFYAAEIIDALEHLHSNGIIHRDLKPENILLDKDMHIMITDFGTAGFDKILPEYQSQQQNQFQQQFQQHNKGMDKPEEDKQTRCKSFV

GTAEYVSPEVLNGHPVTIGADLWALGCIIYQMLEGRPPFKGG-----SEYLTFQKVLAKDLVIPSH--FPSAAKELINKLLNLEPDKRPGA--GPAGYTA
|||||||||.|.. ..| ..|.||||||||||. |.|||.|      .||.||||... ....|    ||  ||.|. ||| ..|..|...  .. || .
GTAEYVSPELLTDKECTPSCDIWALGCIIYQMVAGQPPFRGMNDATNNEYHTFQKIMKCQYDFPDNFRFPPCAKDLVKKLLVRDPNDRLTSCDECGGYQQ

LKSHAFF
.| | ||
IKAHPFF
Kinase PDK1-2.AA AGC 36-302 29 1.2e-144 376.73 In-house 1-395 (395) Show / Hide 
Range on Protein: 36-302
Range on HMM: 1-395/395
Sequence Identity: 29% (119 aa)

FAYGRLLGMGSYSKVVRAKKK------DSGAEFALKIMDKKH---ITKENKVAYVKME------------RLILDHLD----------HPGVVR-LFFTF
|   ...| ||..||  ..||      |.|  .|.|...|||   |.|.|.|.... |            | || ...          || .|. |...|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDTHN--LYMGLECCH---------GG-ELFDQIR---RKGRLSLEEARFYAAE-------IVDVLEYIHG-QGLIHRD-LKPENLLLTADGHIKVADFG
||  .  ||. .| .          || ||| ...   ..||.. |.|||||||       ||  |||.|  .| |||| |||||.||..||||| .|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

SAKVTTPLQNGLSDAQA------------------------------------------DDKSCTFVG--TAEYVSPEVLNGHPVTIGADLWA--LGCII
..|.    ..  .  ..                                          .|.  ||.|  |.||..||.|     .  .| |.  |||..
LCKEGMNDGEKGQQ-SQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLM

YQMLEGRPPFKGGS----------EYLTFQKVL------AKDLVIP----------SHFPSAAKELINKLLNLEPDKRPGAGPA-----GYTALKSHAFF
|.|| |.||| | .          .. .|||..       ... .|          ..| . || ||.|||. .|.||.|.|.      |.  .|.| .|
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PDK1-2.AA S_TKc 36-302 35 1.9e-98 334.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 36-302
Range on HMM: 1-231/231
Sequence Identity: 35% (98 aa)

FAYGRLLGMGSYSKVVRAKKKDSGAEFALKIMDKKHITKENKVAYVKMERLILDHLDHPGVVRLFFTFQDTHNLYMGLECCHG--GELFDQIRRKGR---
.  .|..| |...|| ....|..| ..|.||..            .. |. || . .|| .|.|. .||| ..||| .|.| |  |.||| |...||   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LSLEEARFYAAEIVDVLEYIHGQGLIHRDLKPENLLLTADGHIKVADFGSAKVTTPLQNGLSDAQADDKSCTFVGTAEYVSPEVLNGHPVTI-GADL
   ..  .||||...|.. |||.| .| |||||||||.||.   |||..|||.|..                  ||.|| .|..||||   . .   .| 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCGTPWYMAPEVL---GYGKCKCDW

WALGCIIYQMLEGRPPFKGGSEYLTFQKVLAKDLVIPSHFPSAAKELINKLLNLEPDKRPGAGPAGY--TALKSHAFF
|..|||.| || |.|||    ....|.|..          .. ||..|.|.|. .|.|||.|  |     . |.| .|
WSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PDK1-2.AA RSK 38-302 33 2e-86 293.42 In-house 1-278 (278) Show / Hide 
Range on Protein: 38-302
Range on HMM: 1-278/278
Sequence Identity: 33% (97 aa)

YGRL--LGMGSYSKVVRAKKKDSGAEFALKIMDKKHITKENK-VAYVKMERLILDHLD-HPGVVRLFFTFQDTHNLYMGLECCHGGELFDQIRRKGR---
   |  .| |... . .   .|.| ..| |. .|. | . .| ..... || || .   || .|.|. .||.   ||. .|.|.|||||. ......   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LSLEEARFYAAEIVDVLEYIHGQGLIHRDLKPENLLLTA---DGHIKVADFGSAKVTTPLQNGLSDAQADDKSCTFVGTAEYVSPEVLNG--HPV--TIG
.| .||.||.||||  .|..| || ||||||||| |..    .||||. ||| .| .        ...   .  ||..|.||. ||.|.   ...  .  
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF--------RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKA

ADLWALGCIIYQMLEGRPPFKG---GSEYLTFQKVLAKD--LVIP--SHFPSAAKELINKLLNLEPDKRPGAGPAGYTALKSHAFF
.|.| ||...| || |.|||.|    .   ...... ..  | .|  .    .||.||.|.|  .| ||.|.|| .   .|.|..|
CDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PDK1-2.AA Akt 36-302 40 6.5e-85 271.36 In-house 1-264 (264) Show / Hide 
Range on Protein: 36-302
Range on HMM: 1-264/264
Sequence Identity: 40% (111 aa)

FAYGRLLGMGSYSKVVRAKKKDSGAEF-ALKIMDKKHITKENKVAYVKMERLILDHLDHPGVVRLFFTFQDTHNLYMGLECCHGGELFDQIRRKGRLSLE
| . ..|| ||. ||. .||||..  . |.|.  |..| . |.|...| || || | .|| .| | . ||. ..||. .. | |||||  ..||.| | .
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

EARFYAAEIVDVLEYIHGQGLIHRD-LKPENLLLTADGHIKVADFGSAKVTTPLQNGLSD-AQADDKSCTFVGTAEYVSPEVLNGHPVTIGADLWA-LGC
.||||.|||.  .|. | .. | || |||||.|. .||||...||| .|          .  . .||  || ||.|| .||.|||.  |  .| |. |||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCK---------ENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGC

IIYQMLEGRPPF-KGGSEYLTFQKVLAKDLVIP--SHFPSAAKELINKLLNLEPDKRPGAGPAGYTALKSHAFF
..| |. ||||| .   . . |.| . ... .|  . .  ..| ||..|||  |.||.|.|| .   .|.| .|
VMYEMMCGRPPFYNQDHHQM-FKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PDK1-2.AA CAMK 41-286 23 2.4e-82 265.04 In-house 1-414 (425) Show / Hide 
Range on Protein: 41-286
Range on HMM: 1-414/425
Sequence Identity: 23% (99 aa)

LLGMGSYSKVVRAKKKDSG------------AEFALKIMDKKHITK-------------------------ENKVAYVKMERLILDH-------LDHPGV
 || ||..|| ... | ..             ..| ||.||| ...                         ... . |. |  |. .       |||| .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRLFFTFQDTHN-------------------LYMGL---ECCHGGEL----FDQIRRK---------------GRLSLEEARFYAAEIVDVLEYIHGQGL
..|. ...|.|.                   .|| .   | | ||||    || |...               ||.. .|||.|   |.. ..|.| .. 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKPENLLLTAD-----------------GHIKVADFGSAKVTTPLQNGL--------------SDAQADDKSCTFVGTAEYVS-PEVLNG------
.||||||||.||. .                 . ||..||| |.. .| .| .              ..   ..|  ||.|| ||.. ||||||      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------HPVTIGADLWALGCIIYQMLEGRPPFKGG-------------SEYLTFQKVLAKDLV-IPSHFPS-----------------------AAKE
         ...  .| |..|.| | || |.||| |              ..| .|.|... .   .|..|.                         .| 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LINKLLNLEPDKRP
||.|.|. .|.||.
LIRKMLQVDPEKRM
Kinase PDK1-2.AA Pkinase 36-302 31 5.1e-82 283.59 Pfam 1-293 (293) Show / Hide 
Range on Protein: 36-302
Range on HMM: 1-293/293
Sequence Identity: 31% (97 aa)

FAYGRLLGMGSYSKVVRAKKKDSGAEFALKIMDKKHITKENKVAYVK-MERLILDHLDHPGVVRLFFTFQDTHNLYMGLECCHGG----ELFDQIR--RK
.  || .| ||...| ....|..| ..|.||..|.|. .. ... .. .|  |. .|.|| .|||. .|.|  ..|| .|.| ||    .||| |.  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRL--SLEEARFYAAEIVDVLEYIHGQGLIHRDLKPENLLLTADGHI----KVADFGSAKVTTPLQNGLSDAQADDKSCTFVGTAEYVSPEVLN-GHPVT
|..  | .|..||. .|.  |||.| .| |||||||||.|.  .|||    |..|||.||.             .    ||.|| .|..|||.. | . .
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

IGADLWALGCIIYQMLEGRPPFKGG------SEYLTFQKVLAKDLVIPSHFP---------------------SAAKELINKLLNLEPDKRPGAGPAGYT
  .| |..|||.|.|| |||||.|       ...  ..... ..|  ..  .                     ...|..|...|.. | |||.      .
PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AE

ALKSHAFF
 .. | .|
QILQHPWF
Kinase PDK1-2.AA PKA 36-302 39 3.5e-79 269.37 In-house 1-263 (263) Show / Hide 
Range on Protein: 36-302
Range on HMM: 1-263/263
Sequence Identity: 39% (108 aa)

FAYGRLLGMGSYSKVVRAKKKDSGAEFALKIMDKKHITKENKVAYVKMERLILDHLDHPGVVR-LFFTFQDTHNLYMGLECCHGGELFDQIRRKGRLSLE
|   ..||.||. .|  ...|.||  .|.|...|  | ... |  |. |. ||  ..|| .|. . .||||  .||| .| . |||.|. .|..||.|  
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

EARFYAA-EIVDVLEYIHGQGLIHRDLKPENLLLTADGHIKVADFGSAKVTTPLQNGLSDAQADDKSCTFVGTAEYVSPEVLNGH-PVTIGADLWALGCI
.|.|||| .||  |||.| | .|.|||||||.|.  .||||..||| || .            || . |  || ||  ||..... .   . | ||||..
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKV------------DDRTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGIL

IYQMLEGRPPFKGG--SEYLTFQKVLAKDLVIPSHFPSAA---KELINKLLNLEPDKRPGAGPAGYTALKSHAFF
|| || | |||     .   ...| .. ..  |.|| |.|   | ||.|||.  . || |   .|    | | .|
IYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase PDK1-2.AA SGK 36-302 34 2.7e-78 241.29 In-house 1-283 (283) Show / Hide 
Range on Protein: 36-302
Range on HMM: 1-283/283
Sequence Identity: 34% (101 aa)

FAYGRLLGMGSYSKVVRAKKKDS------------------GAEFALKIMDKKHIT-------KENKVAYVKMER-LILDHLDHPGVVRLFFTFQDTHNL
| .  ..| ||. ||  .|.||                   .. .|.|.  |.||        | ... ... ||  ||  . ||  | | . || .  |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YMGLECCHGGELFDQIRRKGRLSLEEARFYAAEIVDVLEYIHGQGLIHRDLKPENLLLTADGHIKVADFGSAKVTTPLQNGLSDAQADDKSCTFVGTAEY
|. ..   |||.|  ..| ....  .|||||||||  ||| | |  |.|||||||.|| ..||..  ||| .|          . .. |.  || || ||
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCK---------EGIKTNDTTFTFCGTPEY

VSPEVLNGHPVTIGADLWALGCIIYQMLEGRPPFKGGSEYLTFQKVLAKDLVIPSHFPSAAKELINKLLNLEPDKRPGAGPAGYTALKSHAFF
  ||||...|     | | |||. | |. | |||      . ... . ..| ||  . ..|..||. ||. .|.|| |.  ..    |.| ||
LAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF
Kinase PDK1-2.AA AktR 36-302 38 2.7e-77 263.08 In-house 1-268 (268) Show / Hide 
Range on Protein: 36-302
Range on HMM: 1-268/268
Sequence Identity: 38% (107 aa)

FAYGRLLGMGSYSKVVRAKKK-DSGAEFALKIMDKKHITKENKVAYVKMERLILD-HLDHPGVVRLFFTFQDTHNLYMGLECCHGGELFDQIRRKGRLSL
| . ..||.| ..||. ..|| |..  .|.|. .||.| ..|.  .. .|| |.  . .||. |.|...||.  .|.  .| | |||||. ...|...| 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

EEARFYAAEIVDVLEYIHGQ-GLIHRDLKPENLLLTADGHIKVADFGSAKVTTPLQNGLSDAQADDKSCTFVGTAEYVSPEVLNG-HPVTIGADLWALGC
|.||||.|.|.  ||| | .   | |||||||.||  |||.| .||| .|    ||.  ..   |.|  .|.|| ||..||...   . .  .|.||.|.
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK----LQFMMHY---DEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGI

IIYQMLEGRPPFKGGSEYLTFQKVLAKD-LVIPSH--FPSAAKELIN-KLLNLEPDKRPGAGPAGYTALKSHAFF
 || |. | |||  ..    ||| . |. . .| .  | |..|.||. |||.  | ||.| . .| . .||| .|
FIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PDK1-2.AA RSK 36-302 33 4.6e-74 252.37 In-house 1-271 (271) Show / Hide 
Range on Protein: 36-302
Range on HMM: 1-271/271
Sequence Identity: 33% (94 aa)

FAYGRLLGMGSYSKVVRAKKK---DSGAEFALKIMDKKHITKENKVAYVKMERLILDHLDHPGVVRLFFTFQDTHNLYMGLECCHGGELFDQIRRKGRLS
.   . .| ||.|||   ||.   |.. ..| || .|. .    .  . ..|| || . .|| .|.|.  |||  ..|| .. . ||.||| . ... .|
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

LEEARFYAAEIVDVLEYIHGQGLIHRDLKPENLLLTAD----GHIKVADFGSAKVTTPLQNGLSDAQADDK-SCTFVGTAEYVSPEVLNGHPVTIGADLW
 .|..||.|||   .|| | || .|||||||| |. ..    ||||..||| ||           . ....   || .||.|. ||||.    .  .| |
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAK----------QLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWW

ALGCIIYQMLEGRPPFKGGSEYLTFQKVLAKDLVI-------PSHFPSAAKELINKLLNLEPDKRPGAGPAGYTALKSHAFF
 .| . | || |..|| ..    .... .  .|..       ..     ||.|. ..|   | .|.|||| |    |.|..|
SFGVLMYEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase PDK1-2.AA Ciliate-E2 36-302 22 1.4e-72 247.44 In-house 1-365 (365) Show / Hide 
Range on Protein: 36-302
Range on HMM: 1-365/365
Sequence Identity: 22% (88 aa)

FAYGRLLGMGSYSKVVRAKK-----------------------KDSGAEFALKIMDKKHITKENKVAYVK----------MERLILDHLDHPGVVRLFFT
.   ...| |....| ..|.                       |. . ..|.||| |. |   ... ..           .|. || .|.|| ..... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--DTHNLYMGLECCHGGELFDQIR------------RKGRLSLEEAR---------------FYAAEIVDVLEYIHGQG-LIHRDLKPENLLLTADGH
||  |..|.|. .| | ||.||| |.              ......|..               ||.|.|.. |||.| ..  ||||.||||.|.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

IKVADFGSAK-VTTP--------LQNGLSDAQ--------------ADDKSCTFVGTAEYVSPEVLNGHP---------VTIGADLWALGCIIYQMLEGR
||..||| .| ....        ... . . .               ..   |..||..|..||.||| .          .  .|.|.||.|.|.|| |.
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

PPFKGGSEYLTFQKVLAKDLVIP------------------SHFPSAAKELINK----LLNLEPDKRPGAGPAGYTALKSHAFF
|||        .|. . ... .|                   . .  .| ||.|    .|. .|.||..    |.  .. | .|
PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase PDK1-2.AA TyrKc 36-296 19 1.9e-12 -21.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 36-296
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

FAYGRLLGMGSYSKVVRAKKKDSGAEFALKIMDKKHITKENKVAYVKMERLILDHL--DHPGVVRLFFTFQDT-------HNLYMGLECCHGGELFDQIR
   |. || | . .|.... |    . | | . . .      ..    |  |. .|  .|| .|||.    .        . |.. .| . .| | | .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RKGR-LSLEEARFYAAEIVDVLEYIHGQGLIHRDLKPENLLLTADGHIKVADFGSAKVTTPL-QNGLSDAQADDKS------CTFVGTAEYVSPEVLNGH
.... |....   ..  | .  ||.| ...|||||   | |.......|..||| ..  .   |.|   .  | ..      . ..      .||..| .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLPIRWMAPECINYG

PVTIGADLWALGCIIYQMLE-GRPPFKG-----GSEYLTFQKVLAK-DLVIPSH--------FPSAAKELINKLLNLEPDKRPGAGPAGYTAL
  |.  | |. |  .. ..  | .|  |      | .  ...| .   . .| .         |..  ... .  . .|..||      .  .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase PDK1-2.AA Pkinase_Tyr 147-179 42 0.000329 14.88 Pfam 124-156 (270) Show / Hide 
Range on Protein: 147-179
Range on HMM: 124-156/270
Sequence Identity: 42% (14 aa)

LEYIHGQGLIHRDLKPENLLLTADGHIKVADFG
.|| . ...|||||   | |.| ....|..|||
MEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase PDK1-2.AA Pkinase_Tyr 36-99 25 0.763854 3.48 Pfam 1-69 (270) Show / Hide 
Range on Protein: 36-99
Range on HMM: 1-69/270
Sequence Identity: 25% (18 aa)

FAYGRLLGMGSYSKVVRAKKK----DSGAEFALKIMDKKHITKEN--KVAYVKMERLILDHL-DHPGVVRL
   |. || |.. .|.... |    . . . | |.. | . ..|.  . .  . |  |. .| .|| .|||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRL
PDK1_PH PDK1-2.AA PDK1_PH 388-488 49 9e-60 204.89 In-house 1-112 (112) Show / Hide 
Range on Protein: 388-488
Range on HMM: 1-112/112
Sequence Identity: 49% (55 aa)

EPWQKFLF-EGETILASSRVRKFRKLSV----KKRQLILTDRPRLFYVHPIKLVFKGEVPWS-RDIYVRVE-----NDLKFCICTPKRTYNLEDTKGQAR
.||..||. |||.||. ..|.|...|..    |.|||||||.||||||.|...|.|||.||| .|.||...     |. .|.|.||.|||..||.||.|.
TPWHQFLMPEGEHILKCGWVYKRKGLFAKPKKKRRQLILTDGPRLFYVDPMTMVIKGEIPWSSKDLYVEYKPDRKNNFKHFFIHTPNRTYYFEDPKGCAN

VWKESIEKLVNA
.|.| |||... 
KWCEAIEKVCKR