Gene ABR (Mouse)

ABR

Species: Mouse
Alias: ABR
External Links:
Annotation:

Classification

Group: Atypical
Family: BCR

Sequence

Name Sequence Type Origin Length Description Download
ABR.AA Protein None 1185 None Fasta, JSON
ABR.NA RNA None 3555 None Fasta, JSON

Protein domain

Protein domains of ABR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Bcr-Abl_Oligo ABR.AA Bcr-Abl_Oligo 1-64 41 4.2e-11 42.61 Pfam 1-74 (89) Show / Hide 
Range on Protein: 1-64
Range on HMM: 1-74/89
Sequence Identity: 41% (31 aa)

MWDPQEFERHWQAEFPG--EETPVMKLESVPD--------MERELERCKLNLKRLQQVLAEEKFKVWYLQAALA
| ||  |   |.| ||    | | | . |. |        || ||||||    || | .  | |   |||  ||
MVDPVGFAEWWRAQFPDWFQEPPYMECRSMGDRWVSLRSPMEQELERCKASIRRLEQEVNKERFRMIYLQTLLA
RhoGEF ABR.AA RhoGEF 421-609 29 9.4e-59 202.42 SMART 1-211 (211) Show / Hide 
Range on Protein: 421-609
Range on HMM: 1-211/211
Sequence Identity: 29% (63 aa)

VLSGFLASEEIYINQLEALLL-PMKPLKATATTSQ-PVLTIQQIETIFY-KIQDIYEIHKEFYDNLCPKVQQW---------------DSQVTMGHLFQK
|.  ....|. |...|. ..   |||.. ...... |.|. .....||.  |..|||.|..|.| |   ...|               |.. ..|..|.|
VIQELMQTERNYVRDLHIIVQHYMKPMQKEEKCHKLPFLSPDEVNHIFGPNIEEIYEFHRRFLDELEERIEEWDCSMDWKSFRNFQIRDICDRIGDCFMK

L---ASQLGVYKAFVDNYKVALETAEK--CSQSNNQFQKISEELKVKGPKDSKDS-HTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDA
.   .... .|.....|.. ||.. .|  |...|..|||  .|.  . . .|. | | . |.| .| ||. |.|.  | |...||||| |||||  ||.|
WFHAEEMFKMYSEYCNNHPYALKHLKKWMCCKKNPRFQKFCKECESHPNCRSN-SEH-RLTLEDFLIKPMQRITKYPLLLKEILKHTPPDHPDYEDLQKA

LRISQNFLSSINE
|..........||
LDCMKDVAQHCNE
RhoGEF ABR.AA RhoGEF 421-609 29 1.2e-50 175.77 Pfam 1-196 (196) Show / Hide 
Range on Protein: 421-609
Range on HMM: 1-196/196
Sequence Identity: 29% (60 aa)

VLSGFLASEEIYINQLEALLLPM-KPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCP--KVQQW--DSQVT--MGHLF--QK-LASQLGVY
|.  .. .|. |...|. ..    |||.  |  ..|.|. ..|.|||  |..|||.|..|.. |    ....|  .....  .|..|   | ... . .|
VIQEIIQTERSYVRDLNIIIEHYMKPLRNCA--NPPILSPDEIHTIFSNIEEIYEFHQRFLEDLEERDRMECWNPPDYQCQTIGDCFMFLKHMFPFFKMY

KAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVT-MEALLYKPIDRVTRSTLVLHDLLKHTPV-DHP-DYPLLQDALRISQNFLSSI
  .. ||  |... .||...| .||.. .... .    ..  . . .  . .| ||. |..|  | | .||||||  ||| ||. || ||   ....|.|
SEYCNNYPKAMKLLKKCRKKNPKFQQFLKWCEKE----NDPCCRRLDLLQSFLIKPVQRIPRYPLLLKELLKHTPPCDHPKDYEDLQKALEAMKEVASHI

NE
||
NE
PH ABR.AA PH 628-787 18 4.6e-14 53.98 SMART 1-82 (82) Show / Hide 
Range on Protein: 628-787
Range on HMM: 1-82/82
Sequence Identity: 18% (30 aa)

LVKDGFLVEMSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKTKISALKSEIQKEKANKGQS
..| |.|  .|  ..| |...||.|.|.. | |          ..|  ||| |.   .. .                                       
VIKEGWLYKKSK-RWKKRWFVLFNDCLYYYKDK----------KPKGSIPLSDC-TVRE-P---------------------------------------

RAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKD
                         |.||. .. .|.|  .|. |. || .||||.... 
------------------------CFEIHH-DR-TYYFQCESEEEMQEWMQAIQKAIHNN
PH ABR.AA PH 628-785 16 5.9e-11 42.14 Pfam 1-92 (92) Show / Hide 
Range on Protein: 628-785
Range on HMM: 1-92/92
Sequence Identity: 16% (27 aa)

LVKDGFLVEMS-ESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKTKISALKSEIQKEKANKGQ
..| |.|  ..  .|.| |...||...|.. | .|        |..| .||| |. .  ....                                     
VIKEGWLHKKGKRKSWKKRWFVLFNNCLYYYKDDK--------YRPKGSIPLSDCQVTKVPDN-------------------------------------

SRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQK
                          |.|.. ....|.|  .|. |. .| .|||....
---------------------KRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQSACR
C2 ABR.AA C2 832-921 19 2.7e-14 51.2 Pfam 1-90 (90) Show / Hide 
Range on Protein: 832-921
Range on HMM: 1-90/90
Sequence Identity: 19% (19 aa)

LHVIVHSAKGFKQ-------SANLYCTLEVDSFGYFVSKAKTRVFRDTTEPKWDEEFEIE--LEGSQS-LRILCYEKCYDKTKVNKDNNEIVDKIMGKGQ
|.| |..|.. .        ... |......  .  ..| ||.| ..|. |.|.|.|...  ..  |. ||. .. .. ..           |...|. .
LRVHVIEARNLPPMDWDKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNTLNPVWNETFTFDVPPPDLQHTLRFTVWDWDRFGR----------DDFIGQCC
C2 ABR.AA C2 831-938 14 7.8e-14 53.21 SMART 1-92 (92) Show / Hide 
Range on Protein: 831-938
Range on HMM: 1-92/92
Sequence Identity: 14% (18 aa)

FLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTT---EPKWDE---EFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQL
 |.| ...|.. .   . |....           ||.| ..|     |.|.|   .|....   | ||. ....                ...|. .|  
TLTVHIIEARNLP---DPYVKVY-----------KTKVVKNTLSGFNPVWNEWMETFYFDVHP-Q-LRFEVWDH----------------DFIGHCCIPP

D------------PQTVESKNWHTDV
.             ....  ..|   
NNPHWHQWDGCIHLSDIL-GYRH-WW
RhoGAP ABR.AA RhoGAP 984-1163 32 2.6e-69 237.5 SMART 1-193 (193) Show / Hide 
Range on Protein: 984-1163
Range on HMM: 1-193/193
Sequence Identity: 32% (67 aa)

SKVPYIVRQCIEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDI-----------LLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIA
| .| |||.|||..||.|....||||..|... ||.|.. || ...             ...... |....|| ||.|||||||||.|..||. |.| . 
SHIPIIVRKCIEYIEKHGMDTEGIYRKCGNQSRIQELRNAFDRGPD-DLCSTDNYITHEFNDWEEWDVHDVAGVLKQYFRELPEPLITFELYEEFIEAMK

L--------------SDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQ
.              .|. ..  ... |...||.... |. .|. ||.||||... |||..||||..|||||..|.          ..|.  .... ...
CYQIEQTSRKQWNHSEDEEERIHALHQLISQLPPCHRNTLRYLM-HLNRVAEHSDVNKMNAHNLAICFGPTLFWPP----------MMDMRHQNKCVEFL

VLLYY
.  |.
IEHYD
RhoGAP ABR.AA RhoGAP 987-1140 42 5.6e-69 236.04 Pfam 1-156 (156) Show / Hide 
Range on Protein: 987-1140
Range on HMM: 1-156/156
Sequence Identity: 42% (66 aa)

PYIVRQCIEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFME--GIALSDPAAKENCMM
| |||.|||..|..|....||||.|| .. |..|.. || .  . |. ... |....|. ||.|||||||||.|..||..|.|     . |.  . ..| 
PMIVRKCIEYIEQHGLDTEGIYRVSGNKSRIKELREAFDRGPDVDLNDWEWHDVHDVASVLKQYFRELPEPLFTFELYEEFIEAMAAKIEDEEERIEAMR

HLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKA
 |.|.||.||. |. .|..||.|||. . .|||. ||||..|||.|..|.. .|. 
ELIRKLPPPNYDTLRYLMRHLHRVAQHSDVNKMNAHNLAICFGPNLFWPPDDDSMD