Gene ABR (Human)
ABR
Species: Human
Alias: ABR
External Links:
Annotation:
Sequence
Protein domains of ABR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| RhoGEF | ABR.AA | RhoGEF | 354-542 | 29 | 9.4e-59 | 202.42 | SMART | 1-211 (211) | Show / Hide |
Range on Protein: 354-542 Range on HMM: 1-211/211 Sequence Identity: 29% (63 aa) VLSGFLASEEIYINQLEALLL-PMKPLKATATTSQ-PVLTIQQIETIFY-KIQDIYEIHKEFYDNLCPKVQQW---------------DSQVTMGHLFQK |. ....|. |...|. .. |||.. ...... |.|. .....||. |..|||.|..|.| | ...| |.. ..|..|.| VIQELMQTERNYVRDLHIIVQHYMKPMQKEEKCHKLPFLSPDEVNHIFGPNIEEIYEFHRRFLDELEERIEEWDCSMDWKSFRNFQIRDICDRIGDCFMK L---ASQLGVYKAFVDNYKVALETAEK--CSQSNNQFQKISEELKVKGPKDSKDS-HTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDA . .... .|.....|.. ||.. .| |...|..||| .|. . . .|. | | . |.| .| ||. |.|. | |...||||| ||||| ||.| WFHAEEMFKMYSEYCNNHPYALKHLKKWMCCKKNPRFQKFCKECESHPNCRSN-SEH-RLTLEDFLIKPMQRITKYPLLLKEILKHTPPDHPDYEDLQKA LRISQNFLSSINE |..........|| LDCMKDVAQHCNE |
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| RhoGEF | ABR.AA | RhoGEF | 354-542 | 29 | 1.2e-50 | 175.77 | Pfam | 1-196 (196) | Show / Hide |
Range on Protein: 354-542 Range on HMM: 1-196/196 Sequence Identity: 29% (60 aa) VLSGFLASEEIYINQLEALLLPM-KPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCP--KVQQW--DSQVT--MGHLF--QK-LASQLGVY |. .. .|. |...|. .. |||. | ..|.|. ..|.||| |..|||.|..|.. | ....| ..... .|..| | ... . .| VIQEIIQTERSYVRDLNIIIEHYMKPLRNCA--NPPILSPDEIHTIFSNIEEIYEFHQRFLEDLEERDRMECWNPPDYQCQTIGDCFMFLKHMFPFFKMY KAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVT-MEALLYKPIDRVTRSTLVLHDLLKHTPV-DHP-DYPLLQDALRISQNFLSSI .. || |... .||...| .||.. .... . .. . . . . .| ||. |..| | | .|||||| ||| ||. || || ....|.| SEYCNNYPKAMKLLKKCRKKNPKFQQFLKWCEKE----NDPCCRRLDLLQSFLIKPVQRIPRYPLLLKELLKHTPPCDHPKDYEDLQKALEAMKEVASHI NE || NE |
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| PH | ABR.AA | PH | 561-720 | 18 | 1.8e-13 | 51.97 | SMART | 1-82 (82) | Show / Hide |
Range on Protein: 561-720
Range on HMM: 1-82/82
Sequence Identity: 18% (30 aa)
LVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQS
..| |.| | ..| |...||.|.|.. | | ..| ||| |. .. .
VIKEGWLYKKSK-RWKKRWFVLFNDCLYYYKDK----------KPKGSIPLSDC-TVRE-P---------------------------------------
RAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKD
|.||. .. .|.| .|. |. || .||||....
------------------------CFEIHH-DR-TYYFQCESEEEMQEWMQAIQKAIHNN
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| PH | ABR.AA | PH | 561-718 | 15 | 8.9e-11 | 41.51 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 561-718
Range on HMM: 1-92/92
Sequence Identity: 15% (25 aa)
LVKDGFLVEVS-ESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQ
..| |.| . .|.| |...||...|.. | .| .. |..|. . .. | . |
VIKEGWLHKKGKRKSWKKRWFVLFNNCLYYYKDDK------------------------------------------YRPKGSIPLSDCQVTKVPDN---
SRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQK
|.|.. ....|.| .|. |. .| .|||....
---------------------KRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQSACR
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| C2 | ABR.AA | C2 | 765-854 | 19 | 7.2e-14 | 49.77 | Pfam | 1-90 (90) | Show / Hide |
Range on Protein: 765-854 Range on HMM: 1-90/90 Sequence Identity: 19% (19 aa) LHVIVHSAKGFKQ-------SANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIE--LEGSQS-LRILCYEKCYDKTKVNKDNNEIVDKIMGKGQ |.| |..|.. . ... |...... . ..| ||.| ..| |.|.|.|... .. |. ||. .. .. .. |...|. . LRVHVIEARNLPPMDWDKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNTLNPVWNETFTFDVPPPDLQHTLRFTVWDWDRFGR----------DDFIGQCC |
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| C2 | ABR.AA | C2 | 764-871 | 14 | 1e-13 | 52.83 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 764-871 Range on HMM: 1-92/92 Sequence Identity: 14% (18 aa) FLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTA---EPKWDE---EFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQL |.| ...|.. . . |.... ||.| ..| |.|.| .|.... | ||. .... ...|. .| TLTVHIIEARNLP---DPYVKVY-----------KTKVVKNTLSGFNPVWNEWMETFYFDVHP-Q-LRFEVWDH----------------DFIGHCCIPP D------------PQTVETKNWHTDV . .... ..| NNPHWHQWDGCIHLSDIL-GYRH-WW |
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| RhoGAP | ABR.AA | RhoGAP | 917-1096 | 32 | 3.8e-69 | 236.95 | SMART | 1-193 (193) | Show / Hide |
Range on Protein: 917-1096 Range on HMM: 1-193/193 Sequence Identity: 32% (66 aa) SKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDI-----------LLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIA | .| |||.|.|..||.|....||||..|... ||.|.. || ... ...... |....|| ||.|||||||||.|..||. |.| . SHIPIIVRKCIEYIEKHGMDTEGIYRKCGNQSRIQELRNAFDRGPD-DLCSTDNYITHEFNDWEEWDVHDVAGVLKQYFRELPEPLITFELYEEFIEAMK L--------------SDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQ . .|. .. ... |...||.... |. .|. ||.||||... |||..||||..|||||..|. ..|. .... ... CYQIEQTSRKQWNHSEDEEERIHALHQLISQLPPCHRNTLRYLM-HLNRVAEHSDVNKMNAHNLAICFGPTLFWPP----------MMDMRHQNKCVEFL VLLYY . |. IEHYD |
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| RhoGAP | ABR.AA | RhoGAP | 920-1073 | 41 | 6.4e-69 | 235.83 | Pfam | 1-156 (156) | Show / Hide |
Range on Protein: 920-1073 Range on HMM: 1-156/156 Sequence Identity: 41% (65 aa) PYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFME--GIALSDPAAKENCMM | |||.|.|..|..|....||||.|| .. |..|.. || . . |. ... |....|. ||.|||||||||.|..||..|.| . |. . ..| PMIVRKCIEYIEQHGLDTEGIYRVSGNKSRIKELREAFDRGPDVDLNDWEWHDVHDVASVLKQYFRELPEPLFTFELYEEFIEAMAAKIEDEEERIEAMR HLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKA |.|.||.||. |. .|..||.|||. . .|||. ||||..|||.|..|.. .|. ELIRKLPPPNYDTLRYLMRHLHRVAQHSDVNKMNAHNLAICFGPNLFWPPDDDSMD |
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