Gene AqueK694 (A.queenslandica)

AqueK694

Species: A.queenslandica
Alias: AqueK694
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Unique

Sequence

Name Sequence Type Origin Length Description Download
AqueK694.AA Protein None 1315 None Fasta, JSON
AqueK694.kin_dom Protein Kinase Domain None 193 None Fasta, JSON

Protein domain

Protein domains of AqueK694.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK694.AA TKL 657-846 21 1.2e-43 151.38 In-house 1-288 (364) Show / Hide 
Range on Protein: 657-846
Range on HMM: 1-288/364
Sequence Identity: 21% (63 aa)

LGRGAYGVVMVGVFHG----------LKVAVKYLHP-------------------------AIASYYNQERFIREMKMASLLRHPNLVQFIGATFGDR--
.|.|..|.|  |...|            |||| ..                          .  .  .......|..| | |||||.|||.|. .  .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PLILTECM-TTSLYHENKKGQLARPSILSIAIQVALGLNYLHLQKP-----NALIHRDVSSPNILLDN----------MGAAKYRAKV
            . | .| .   ||.|         . ....|...|.|.|||| ..|      ..||||  |.|||.|.          . .| ...|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

SDYGSFARAVDS----------------------QTKQPGNTAYSAPEAFNPN----------------EHTPAMDVYSFSVLLMEMIINKAP
.|.|   .   |                        .| |.... |||... .                | ....||||| ..| |..  . |
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP
Kinase AqueK694.AA MLK 651-841 24 2.9e-32 109.29 In-house 1-230 (291) Show / Hide 
Range on Protein: 651-841
Range on HMM: 1-230/291
Sequence Identity: 24% (57 aa)

KLTDKELGRGAYGVVMVGVFHGLK-----VAVKYLHPAI----ASYYNQERFIREMKMASLLRHPN----LVQFIGATFGD-R-PLILTE-----CMTTS
 .. . .| |..|.|  |....       ||||  .  |     .|  |. | .| . .. |.|||     .|| |.   .    .|..|     .. . 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LYHENKKGQ-----------LARPSILSIAIQVALGLNYLHLQKPNALIHRDVSSPNILLD---NMGAAKYRAKVSDYGSFARAVDS---QTKQPGNTAY
|. ...|.                .....| |.| |..||| ..| ..||||  |.|||.|   .   ..  .|..| | .    ..    ....|. |.
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW

SAPEAF---NPNEHTPAMDVYSFSVLLMEMI
 |||..     .  . . ||.|. |.| ||.
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEML
Kinase AqueK694.AA TKL-Unique 655-846 27 8e-32 109.58 In-house 3-233 (290) Show / Hide 
Range on Protein: 655-846
Range on HMM: 3-233/290
Sequence Identity: 27% (64 aa)

KELGRGAYGVVMVGVFHGLKVAVKYLHPAIASYYNQ--ERFIREMKMASLLR-HPNLVQFIGATFG---DRP--LILTECMTT-SLY---HE--------
. .|.|.||.|  |...| .||.| .||  ..  |.  . |..| .  . |. |||.|...|...    . |   | .|..   |||   |         
NKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

NKKGQLARPSILSIAIQVALGLNYLHLQKPNALIHRDVSSPNILLDNM-GAAKYRAKVSDYGSFARAVD--SQTKQP-----------GNTAYSAPEAFN
|..  |    ....||..|.|..|||  .|   ||||  |.|.|.||    |....|..| | ...  .  ....             |.. ..||| ..
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFG-LSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

P--NEHTPAMDVYSFSVLLMEMIINKA------P
   .  .   |||||.. | |.. .|       |
MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase AqueK694.AA TK 650-840 15 4.2e-31 100.91 In-house 1-387 (486) Show / Hide 
Range on Protein: 650-840
Range on HMM: 1-387/486
Sequence Identity: 15% (62 aa)

VKLTDKELGRGAYG---VVMVGVFHGL---------------------------KVAVKYLHPAIASYYNQER---------------FIREMKMAS--L
..|  |.||.|..|   .|. |  .|.                           .|||| |..  |.  ....               . .|||| .  |
ITL-GKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSL

LRHPNLVQFIGATFGDR-------------PLILTECMTT--------SLYHENK---------------------------------------------
..|||.|...|. . ..             ..|..|.|          .  ....                                             
GHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

-----------------------------KGQLARPSILSIAIQVALGLNYLHLQKPNAL----IHRDVSSPNILLDNMGAAK-------YRAKVSDYG-
                             |.||  .  | .. |.| |. ||| ..   .    .|||.   |.|... .  |       . .|..|.| 
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGL

S------FARAVD---SQTKQPGNTA---------------------------YSAPEAFN---------PNEHTPAMDVYSFSVLLMEM
|       ||...     ... . ..                           . |||..|          . .|.. ||.|| ||. |.
SRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
Kinase AqueK694.AA Pkinase_Tyr 650-841 27 3.1e-23 79.31 Pfam 1-208 (270) Show / Hide 
Range on Protein: 650-841
Range on HMM: 1-208/270
Sequence Identity: 27% (61 aa)

VKLTDKELGRGAYGVVMVGVFH------GLKVAVKYLHPAIASYYN--QERFIREMKMASLL-RHPNLVQFIGATF-GDRP---LILTECMTT-SLYH--
...  |.||.||.|.|. |. .      ...|||| | .  |.  .  .| |.||.|. . | .|||.|...|.    ..|   .| .| |   .|..  
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

ENK---KGQLARPSILSIAIQVALGLNYLHLQKPNALIHRDVSSPNILLDNMGAAKYRAKVSDYGSFARAV-------DSQTKQPGNTAYSAPEAFNPNE
 ..   |..|  . .|....|.| |..||. ..   .||||.   |.|...    .  .|..| |  ||..        .... .      |||..| ..
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE----NNVVKICDFG-LARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK

HTPAMDVYSFSVLLMEMI
 | . ||.|| ||. |..
FTTKSDVWSFGVLMWEIF
Kinase AqueK694.AA HH498 653-840 30 8.1e-23 68.82 In-house 3-219 (284) Show / Hide 
Range on Protein: 653-840
Range on HMM: 3-219/284
Sequence Identity: 30% (67 aa)

TDKELGRGAYGVVMVGVFHGLKVAVK-YLHPAIASYYN-----QERFIREMKMASLLRHPNLVQFIGATFGDRP--LILTE-CMTTSLY-----------
. .  | |..| |  | . .  |||| |   |. .          .|.||  . . | ||. |||..|.  |    .| |. |   ||.           
FHEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIPIGGA

------HENK--KGQLARPSILSIAIQVALGLNYLHLQKPNALIHRDVSSPNILLDNMGAAKYRAKVSDYGS--FARAVDSQ--TKQPGNTAYSAPEAFN
      |..|     .  .|.. |.. || | ||||   .   ||||  | |||..  |    .|.| |.|   | . ..    ||||||  . ||| | 
GANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDG----HAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFS

-PNEHTPAMDVYSFSVLLMEM
     .   ||.|.   . ||
QCQKYSIKVDVFSYAMCIWEM
Kinase AqueK694.AA Dicty4 653-840 28 9.6e-21 66.06 In-house 3-210 (277) Show / Hide 
Range on Protein: 653-840
Range on HMM: 3-210/277
Sequence Identity: 28% (62 aa)

TDKELGRGAYGVVMVGVFHGLKVAVKYL--HPAIASYYNQERFIREMKMASLLRHPNLVQFIGATF-----GDRPLILTECM-TTSLY---HE-----NK
.....|.|..| |  |   | .|||| |  |   .. .  . | .| .  . .||||...| ||         ...| || |  ..||   |       .
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

KGQLARPSILS---IAIQVALGLNYLHLQKPNALIHRDVSSPNILLDNMGAAKYRAKVSDYGSFAR---AVDSQTK----QPGNTAYSAPEAFNPNEHTP
. .|  | |..   .|. .|.|.|.||   |.  ||||  | |.| |    . .|.||.| | ...    . ...     . | ... |||    .. . 
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVD----KNWRVKVCDFG-LSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNE

AMDVYSFSVLLMEM
. |||||. .| |.
KADVYSFGIVLWEI
Kinase AqueK694.AA STE 652-841 18 2.7e-20 68.45 In-house 1-262 (359) Show / Hide 
Range on Protein: 652-841
Range on HMM: 1-262/359
Sequence Identity: 18% (51 aa)

LTD-KELGRGAYGVVMVGVFH-----------------GLKVAVKYLH---------------PAIASYYNQERFIREMKMASLLR--HPNLVQFIGATF
... ...|.||.|.|  .. |                 |  .|.| ..               . .    .......|.|. . ..  ||| |...|. |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

--------GDRPLILTECMT----TSLYHEN-KKGQLAR-----------PSILSIAIQVALG-LNYLHLQKPNALIHRDVSSPNILLDNMGAAKYRAKV
        .|   |  | |     ....... ..|.              . |  |. |.  | |.||| ..    ||||. . ||||         .| 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL---------VKL

SDYGSFARAVDS------------------QT-KQPGNTAYSAPEAFNP------NEHTPAMDVYSFSVLLMEMI
.| |  .. .||                  ..    |   . |||  ..      ....   |..|.  ...||.
CDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA
Kinase AqueK694.AA UTK 650-840 24 5e-20 65.21 In-house 1-233 (296) Show / Hide 
Range on Protein: 650-840
Range on HMM: 1-233/296
Sequence Identity: 24% (59 aa)

VKLTDKELGRGAYGVVMVGVFHG-------LKVAVKYLHPAIASYYNQE---RFIREMK---MASLLR-HPNLVQFIGATFGDRPL-ILTECMT-TSLYH
|.| . .||.||.|.| .. |         ..|||| . .  ..  ..|   .|..| .   | . .. |||.....|  . . |. |.||.|   .| .
VQLGR-QLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRS

---ENKKGQLARPSILS------IAIQVALGLNYLHLQKPNALIHRDVSSPNILLDN---MGAAKYRAKVSDYG--SFARAVDS---------------Q
    ... . |.| .|.       | ..| |..||| ..   ..|||.   |.|..    |.   . .|..|.|   ..|.| .               |
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCG---FVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQ

TKQPGNTAYSAPEAFNPN-EHTPAMDVYSFSVLLMEM
  ..   .  ||||.. .  .| . ||.|| |...|.
HQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEI
Kinase AqueK694.AA Dicty5 652-846 29 3.5e-19 62.69 In-house 2-202 (260) Show / Hide 
Range on Protein: 652-846
Range on HMM: 2-202/260
Sequence Identity: 29% (62 aa)

LTDKELGRGAYGVVMVGVFHGLKVAVKYLHPAIASYYNQERFIREMKMASLLR--HPNLVQFIGATFGDRPL--ILTE-CMTTSLY---HENKK--GQ-L
   .    || | |  |.. |  ||.| . .     .. . | ||  . |.    |||.. . ||   .     ..|| |   ||     . .|  || .
SFHDWIASGASGRVYNGIYKGMDVAIKVYSQENCMCFDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPI

ARPSILSIAIQVALGLNYLHLQKPNALIHRDVSSPNILLDNMGAAKYRAKVSDYGSFARAVDSQ---TKQPGNTAYSAPEAFNPNEHTPAMDVYSFSVLL
| . .|..|| .| .. .||       ||||. | |.|.       . .|. |.|   | || .   |   |  .. |.| || .  .   ||||| . |
AYFQQLHMAIDIAQSMRHLHSM---NIIHRDLKSMNFLI----TENWKIKIIDFG-TSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVL

MEMIINKAP
 ||.  | |
WEMFTRKEP
Kinase AqueK694.AA Pkinase 651-846 22 3.9e-17 61.66 Pfam 1-211 (293) Show / Hide 
Range on Protein: 651-846
Range on HMM: 1-211/293
Sequence Identity: 22% (50 aa)

KLTDKELGRGAYGVVMVGVFHGLK--VAVKYLHPAIASYYNQERFIR--EMKMASLLRHPNLVQFIGATF-GDRPLILTECMTT-----SLY----HENK
  . . .|.|..|.|  .. .|    |||| .    ..   ... .|  | ..   |.||| |.....   .|.. . .|..       .|.       .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WR

KGQL--ARPSILSIAIQVALGLNYLHLQKPNALIHRDVSSPNILLDNMGAAKYRAKVSDYGSFARA--VDSQTKQPGNTA---YSAPEAFN-PNEHTPAM
.| .      . ... |.. ||.|.| .     ||||. . |||.|| |  . . |..| | .|.     ...   . .    | |||  .  ....|. 
HGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFG-LAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVYSFSVLLMEMIINKAP
|..|. ..| ||.  . |
DMWSCGCILYEMLCGRPP
Kinase AqueK694.AA S_TKc 651-968 16 1.3e-16 62.45 SMART 1-231 (231) Show / Hide 
Range on Protein: 651-968
Range on HMM: 1-231/231
Sequence Identity: 16% (56 aa)

KLTDKELGRGAYGVVMVGVFHG--LKVAVKYLHPAIASYYNQERFIREMKMASLLRHPNLVQFIGATFGDRPLILTECMTT---SLYHENKKGQ------
    ...|.||.|.|. .. ..   .||.| ..         |...||... .  .|||.|.....   |.  . .|.. .   .|..  || .      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LARPSILSIAIQVALGLNYLHLQKPNALIHRDVSSPNILLDNMGAAKYRAKVSDYGSFARAVDSQTKQPGNTAYSAPEAFNPNEHTP-AMDVYSFSVLL
 .    . ... |....|.|.| ..    ||||.   |||||.      . |..| | .|| .   | . |   | ||| .    ... . |..|. ..|
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE------HIKICDFG-LARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

MEMIINKAPDMTVNERRDQASKIAGWTGPLPLSRAETIQEATPVLKESNCIAAIDFGTSSLSVAYTIPLSRTTRGDIKVLPLHSTLERIPNAILIMKDKL
 ||.  . |        ..  |. |                                                                           
YEMLCGYPPFP----QMQMMFKKIG---------------------------------------------------------------------------

GQKYSTIAIGPKAQSLYSSSLNRTTQ--------V-------HSFT
          | | .. .  |..  .                | . 
---------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase AqueK694.AA CZAK 746-841 35 2.5e-16 55.95 In-house 108-216 (279) Show / Hide 
Range on Protein: 746-841
Range on HMM: 108-216/279
Sequence Identity: 35% (39 aa)

LSIAIQVALGLNYLHL-QKPNALIHRDVSSPNILLDNMGA---------AKYRAKVSDYG-S-FARAVDSQ-TKQPGNTAYSAPEAFNPNEHTPAMDVYS
...|| .| | ||||   |||  .||| || |||||                 .|..|.| |   .   .. |   |  .. ||| |     |.  ||||
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYTEKVDVYS

FSVLLMEMI
|  .| ..|
FGMILWCII
Kinase AqueK694.AA TyrKc 650-891 23 3.5e-14 6.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 650-891
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

VKLTDKELGRGAYGVVMVGVFHGLKVAVKYLHPAIASYYNQERFIREMKMASLL--RHPNLVQFIGATFG--------DRPLILTECMT---TSLYHENK
..| .|.||.||.|.|. |.   ..|||| |..       .| |.||... . |  .|||.|...|.           . ..|..| |       |  ..
ITL-GKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

KGQLARPSILSIAIQVALGLNYLHLQKPNALIHRDVSSPNILLDNMGAAKYRAKVSDYGSFARAVDSQ-----------------TKQPGNTAYSAPEAF
...|  .  ||...|.| | .||| .    .||||    |.|... .    ..|.|| |  .|....                  .| .      |||..
RPKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH----TVKISDFG-LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

NPNEHTPAMDVYSFSVLLMEMI---INKAPD-----MTVNERRDQASKIAGWTGPLPL-------SRAETIQEATPVLKE--------SNCIAAI
| .. |.. ||.|| |.. |.        |.     |.  | . .  .      |            .|  |  .   .|        |...  .
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK694.AA CZAK 654-714 32 1e-06 20.55 In-house 4-68 (279) Show / Hide 
Range on Protein: 654-714
Range on HMM: 4-68/279
Sequence Identity: 32% (22 aa)

DKELGRGAYGVVMVGVFHGLKVAVKYLHPAIASYYNQER------FIREMKMASLLRHPNLVQFIGA
 .. |.| .| |  ..  |  ||.| .|    .. |         | .|    | |.||| |||.||
GQTIGQGFFGEVYKAYWRGKDVAIKIIH--RNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGA