Gene AqueK691 (A.queenslandica)

AqueK691

Species: A.queenslandica
Alias: AqueK691
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Unique

Sequence

Name Sequence Type Origin Length Description Download
AqueK691.AA Protein None 408 None Fasta, JSON
AqueK691.kin_dom Protein Kinase Domain None 128 None Fasta, JSON

Protein domain

Protein domains of AqueK691.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK691.AA TKL 6-147 22 4.9e-28 98.04 In-house 1-200 (364) Show / Hide 
Range on Protein: 6-147
Range on HMM: 1-200/364
Sequence Identity: 22% (46 aa)

LGKGGWGEVKVAGFRG----------LKVAAKCLYEIIISPHNI-------------------------TKFSREMNIASKLRHPNLLQFIGATTEGN--
.|.|| |||  . .||            || | . .   . ...                          .. .|... |.|||||..||.|. ....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PIILTELM-PTSLRKELETGGLAYHAVLNISLDVACALNYLHLFKP-----HPILHRDVSSANVLLQTTGGVH--------GGLRAKV
            . | .|..   ||.  |       |  ....||.|...||||  .|      ||.|||  |.|.|.   . ..           ..|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

SDYGT
.|.|.
CDFGL
Kinase AqueK691.AA CZAK 3-146 35 1.8e-24 85.9 In-house 4-167 (279) Show / Hide 
Range on Protein: 3-146
Range on HMM: 4-167/279
Sequence Identity: 35% (59 aa)

EVVLGKGGWGEVKVAGFRGLKVAAKCLYEIIISPHNITK------FSREMNIASKLRHPNLLQFIGATTEGN---PIILTELMP-TSLRKELETGGLAYH
. . |.|  |||. |  ||  || | ..   ..  | .       | .|  | |||.||| .||.|| .|..     | .| |   |||. | |    ||
GQTIGQGFFGEVYKAYWRGKDVAIKIIH--RNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLL-TDHYFYH

AV-----LNISLDVACALNYLHL-FKPHPILHRDVSSANVLLQTTGG-------VHGGLRAKVSDYG
       .|. .|.|   ||||  .|| |||||| || |.||                . .|..|.|
KQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFG
Kinase AqueK691.AA MLK 2-148 23 2.6e-17 56.73 In-house 3-180 (291) Show / Hide 
Range on Protein: 2-148
Range on HMM: 3-180/291
Sequence Identity: 23% (42 aa)

TEVVLGKGGWGEVKVAGFRGLK-----VAAKCLY-EIIISPHN----ITKFSREMNIASKLRHPN----LLQFIGATTE-GN-PIILTELMPT-SLRKEL
.. ..|.|. |.|  . .|.       || |    .|. .       . .| .| .....|.|||      || |. .. ..   |..| ..  ||   |
FHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVL

ETG---------------GLAYHAVLNISLDVACALNYLHLFKPHPILHRDVSSANVLLQT-TGGVHGGLRAKVSDYGTV
 ..                   . ..|..|..| ...|||  .|.|| |||  | |.|.    .   ... .|..| ||.
HGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHGTLKICDFGTS
Kinase AqueK691.AA TKL-Unique 5-151 26 1.7e-15 51.23 In-house 4-167 (290) Show / Hide 
Range on Protein: 5-151
Range on HMM: 4-167/290
Sequence Identity: 26% (45 aa)

VLGKGGWGEVKVAGFRGLKVAAKCLY-EIIISPHNITKFSREMNIASKLR-HPNLLQFIGATT-----EGNPIILTELMPT-SLRKELE-----------
..| || |.|. . .|| .|| | .  .  .|.  . .|..| |. .||. |||.....|...     ..| .| .| .|  ||.. |            
KIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNN

TGGLAYHAVLNISLDVACALNYLHLFKPHPILHRDVSSANVLLQTTGGVHGG-----LRAKVSDYGTVSLQ
   | .  .... .|.| ...|||  .|  |.|||  | |.|      |  .     ...|..| |.. ..
NCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFL------VDNNSNIAEWNIKICDFGLSKFN
Kinase AqueK691.AA Pkinase_Tyr 5-146 25 1.9e-15 52.91 Pfam 6-156 (270) Show / Hide 
Range on Protein: 5-146
Range on HMM: 6-156/270
Sequence Identity: 25% (41 aa)

VLGKGGWGEVKVAGFR------GLKVAAKCLYEIIISPHN--ITKFSREMNIASKL-RHPNLLQFIGATT-EGNP---IILTELMPT-SLRKELETG---
.||.|  |||. .  .      ...|| |.|     ....  . .| ||..| ..| .|||.....|. | .| |   .| .|.||  .|.. | .    
KLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHRED

--GLAYHAVLNISLDVACALNYLHLFKPHPILHRDVSSANVLLQTTGGVHGGLRAKVSDYG
   |  .  |......|....||.  .   . |||.   |.|.        .. .|..| |
KQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE------NNVVKICDFG
Kinase AqueK691.AA TK 41-146 14 2.3e-14 43.82 In-house 84-296 (486) Show / Hide 
Range on Protein: 41-146
Range on HMM: 84-296/486
Sequence Identity: 14% (32 aa)

KFSREMNIASKLR-----HPNLLQFIGATTEGN-------------PIILTELMP-TS----LRKELETGG-----------------------------
.| .|........     |||.....|. |.|              ..|..|.||  .    ||. | .                               
DFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGD

------------------------------------------------LAYHAVLNISLDVACALNYLHLFKPHPI----LHRDVSSANVLLQTTGGVHG
                                                |  |  | .....||.. |||  .         |||.   |.|.   . ...
ITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKW

-----GLRAKVSDYG
     |. .|..|.|
HFDGCGPVCKIADFG
Kinase AqueK691.AA DRK 1-146 33 3.4e-14 44.51 In-house 2-145 (258) Show / Hide 
Range on Protein: 1-146
Range on HMM: 2-145/258
Sequence Identity: 33% (50 aa)

MTEVVLGKGGWGEVKVAGFRGLKVAAKCLYEIIIS-PHNITKFSREMNIASKLRHPNLLQFIGATTE-GNPIILTELMPT-SLRKEL--ETGGLAYHAVL
   .  |.|..|||     || .|| | |    |     .  | || |. ..|||||  ||.|. ..   . | .| ||  || . |  |   .    ..
KIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMK

NISLDVACALNYLHLFKPHPILHRDVSSANVLLQTTGGVHGGLRAKVSDYG
 . .|.|  ..|||   |  |.|||  | | |      |    . ||.|.|
QMMFDCAKGMIYLHCCNPI-IIHRDLKSHNLL------VDEHWQVKVADFG
Kinase AqueK691.AA Dicty4 2-77 37 3e-13 40.73 In-house 3-85 (277) Show / Hide 
Range on Protein: 2-77
Range on HMM: 3-85/277
Sequence Identity: 37% (31 aa)

TEVVLGKGGWGEVKVAGFRGLKVAAKCL--YEIIISPHNITKFSREMNIASKLRHPNLLQFIGATT-----EGNPIILTELMP
.|. .|||. |||  .  || .|| | |    .  .   .. | .| .| .|.||||...| || |      | . | ||.||
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMP
Kinase AqueK691.AA TK-Unique 3-146 20 4e-13 41.72 In-house 4-178 (294) Show / Hide 
Range on Protein: 3-146
Range on HMM: 4-178/294
Sequence Identity: 20% (37 aa)

EVVLGKGGWGEVKVAGFRGLK-------VAAKCLYEIIISPHNITKFSREMNIASKLR-HPNLLQFIGATT-EG-NPIILTELMPTS-LRKELETGG---
. |.|.|  |.|  ....|..       ..|  . ..  ...   .| .| .. ..|  |||..|..|..|  . .. |. | .| . |.. | | .   
GDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAM

------------------------LAYHAVLNISLDVACALNYLHLFKPHPILHRDVSSANVLLQTTGGVHGGLRAKVSDYG
                        . .. ....  ..||...||.   .. | |||... ||||.       ....|..|.|
RQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQ-RKKIVHRDLCARNVLLTE------DKVCKICDFG
Kinase AqueK691.AA Pkinase 38-134 18 1.3e-10 38.6 Pfam 42-147 (293) Show / Hide 
Range on Protein: 38-134
Range on HMM: 42-147/293
Sequence Identity: 18% (20 aa)

NITKFS-REMNIASKLRHPNLLQFIGAT-TEGNPIILTELMPT-----SLRKELE---TGGL--AYHAVLNISLDVACALNYLHLFKPHPILHRDVSSAN
..|..  .|  |  .|.||| ......  ..... . .|...      .|   ..    |..   .. . .. . ....|.|.|      |.|||. ..|
DQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPEN

VLLQTTGGV
.|.  .| .
ILIDNNGHI
Kinase AqueK691.AA HH498 95-146 44 2.4e-10 28.59 In-house 124-169 (284) Show / Hide 
Range on Protein: 95-146
Range on HMM: 124-169/284
Sequence Identity: 44% (23 aa)

LNISLDVACALNYLHLFKPHPILHRDVSSANVLLQTTGGVHGGLRAKVSDYG
. ||.|||   ||||   .||| |||  | |.|.   |      .|.| |.|
MTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDG------HAVVADFG
Kinase AqueK691.AA LISK 5-63 31 1.1e-09 27.48 In-house 1-64 (296) Show / Hide 
Range on Protein: 5-63
Range on HMM: 1-64/296
Sequence Identity: 31% (20 aa)

VLGKGGWGEVKVAGFR--GLKVAAKCLY---EIIISPHNITKFSREMNIASKLRHPNLLQFIGA
..|||. |.|     |  |  .| | .    .  . | .. .. ||. .  .||||| .||.|.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGV
Kinase AqueK691.AA S_TKc 1-251 13 3.6e-09 -42.36 SMART 2-231 (231) Show / Hide 
Range on Protein: 1-251
Range on HMM: 2-231/231
Sequence Identity: 13% (40 aa)

MTEVVLGKGGWGEVKVAGFRG--LKVAAKCLYEIIISPHNITKFSREMNIASKLRHPNLLQFIGATTEGNPIILTELMPT---SLRKELETGG-------
    ..|||. |.|. .  ..   .|| |..           .. ||..| .| .|||. .....  ...  . .|....   .|.. ..  |       
EILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LAYHAVLNISLDVACALNYLHLFKPHPILHRDVSSANVLLQTTGGVHGGLRAKVSDYGTVSLQPLARTCNPVKIRNFYHVVEVYVRTWTNGLVTVYGDAS
.    .  .   ..|||.|.|  .   |.|||.  .|.|| .        . |..| |   .                                      
FPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--------HIKICDFGLARQL-------------------------------------

LASCSAVSAVWW-----ALPHSY------------VCLCC----FMMMAVRVAAAAKGDAKGARK-------DYQPAKRWEHSTVQV-------GDYL
    . .   |.       ....              ..|    |     ..    .       |       .. |.||.    .           ..
---TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK691.AA TyrKc 5-212 18 1e-08 -81.59 SMART 6-280 (280) Show / Hide 
Range on Protein: 5-212
Range on HMM: 6-280/280
Sequence Identity: 18% (53 aa)

VLGKGGWGEVKVAGFRGLKVAAKCLYEIIISPHNITKFSREMNIASKL--RHPNLLQFIGATTE--------GNPIILTELMPT-SLRKELETGG--LAY
.|| |  |||  .  . ..|| |.| |       .  | ||..| .||  .|||.....|. |.        . . |..|.||  .|.. |   .  |  
KLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCM

HAVLNISLDVACALNYLHLFKPHPILHRDVSSANVLLQTTGGVHGGLRAKVSD-------YGT-------VSLQP----LARTCNPVK------IRNF--
   |......||  .|||    ... |||    |.|.   .      ..|.||       |             .     ..|  |..      |.    
KDLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

------------------------YHVVE--VYVRTWTNGLVTVYGDASLAS--------CSAVSAVW----WAL-----PHSYVCLCCF
                        . ...  .  .   . . . |     ..        |..         |.      |    .  ||
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK691.AA LISK 95-146 38 3.9e-05 12.4 In-house 104-150 (296) Show / Hide 
Range on Protein: 95-146
Range on HMM: 104-150/296
Sequence Identity: 38% (20 aa)

LNISLDVACALNYLHLFKPHPILHRDVSSANVLLQTTGGVHGGLRAKVSDYG
..|.||.||.. |||  .   |.|||  | |.|. . .   .. |.|| | |
VKIALDIACGMSYLHSMN---IIHRDLKSKNCLVREND--NNQWRIKVCDFG
Kinase AqueK691.AA HH498 41-64 41 0.001478 6.7 In-house 48-71 (284) Show / Hide 
Range on Protein: 41-64
Range on HMM: 48-71/284
Sequence Identity: 41% (10 aa)

KFSREMNIASKLRHPNLLQFIGAT
.| ||  | ..| ||.  ||..|.
MFCREVSIMCRLNHPCVVQFVYAC
Kinase AqueK691.AA Kelch_1 238-297 15 6.203093 3.53 Pfam 1-45 (45) Show / Hide 
Range on Protein: 238-297
Range on HMM: 1-45/45
Sequence Identity: 15% (9 aa)

KRWEHSTVQVGDYLYMWGGNRDQPADLPYVHNNERKKSMCSVMEVCHLSTGKWEQKPTTG
.|  |. . .....|  ||  .               .  .  |. ...|..|.. |. .
PRCGHGVCVHNGKIYVIGGCDG---------------QYLNSVECYDPETNQWTRCPPMP
Kelch_1 AqueK691.AA Kelch_1 302-349 18 4e-06 25.78 Pfam 1-45 (45) Show / Hide 
Range on Protein: 302-349
Range on HMM: 1-45/45
Sequence Identity: 18% (9 aa)

GVVGYAAAAIGNEIFYFGGWCHHEDCHHNSLYSFNVDTFNWKELSPTT
  .|.........|. .||..       || ......|  |....| .
PRCGHGVCVHNGKIYVIGGCDG---QYLNSVECYDPETNQWTRCPPMP