Gene AqueK677 (A.queenslandica)

AqueK677

Species: A.queenslandica
Alias: AqueK677
External Links:
Annotation:

Classification

Group: TKL
Family: RAF
Subfamily: RAF

Sequence

Name Sequence Type Origin Length Description Download
AqueK677.AA Protein None 894 None Fasta, JSON
AqueK677.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of AqueK677.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RBD AqueK677.AA RBD 138-208 36 4.3e-19 68.95 Pfam 1-77 (77) Show / Hide 
Range on Protein: 138-208
Range on HMM: 1-77/77
Sequence Identity: 36% (28 aa)

ALIRAHLPEGQRTIVPIRQGVTIQDALMKAMKTRNLTPNTCIVY-----AESPRLLIEWDTDTTQLSG-KEVFVEYQ
 ....||| .||. |. | |.|..|.|||. |...|.|  | ||      |. .  . |.|| . | |  |..||  
KFCCVHLPNNQRCVVEVRPGMTVRDMLMKICKRHGLNPMCCHVYRVGDPHEGEKKPLDWHTDISWLPGPQELWVENL
RBD AqueK677.AA RBD 138-208 34 1.4e-18 69.02 SMART 1-76 (76) Show / Hide 
Range on Protein: 138-208
Range on HMM: 1-76/76
Sequence Identity: 34% (26 aa)

ALIRAHLPEGQRTIVPIRQGVTIQDALMKAMKTRNLTPNTCIVYAES-----PRLLIEWDTDTTQLSGKEVFVEYQ
 ... ||| .|||.| .| |.|..|.|||. |.|.|.| .|.|.. .      .  ..|... . | |.|..||  
KFCCVHLPDNQRTVVKVRPGMTVHDMLMKICKKRGLNPECCHVFRRHHPHEGEKKPLDWHQPISYLPGQELWVENR
C1_1 AqueK677.AA C1_1 219-267 30 1.4e-18 71.81 Pfam 1-55 (55) Show / Hide 
Range on Protein: 219-267
Range on HMM: 1-55/55
Sequence Identity: 30% (17 aa)

HNFVRK-TFIALAFCDVCKKLL-----FQGFRCETCGFRYHQRCSPRVPIQCGGV
|..|.. .|   .||..|....     .||..|..|....|.||...||. ||. 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 AqueK677.AA C1 219-264 22 2.6e-15 58.12 SMART 1-61 (61) Show / Hide 
Range on Protein: 219-264
Range on HMM: 1-61/61
Sequence Identity: 22% (14 aa)

HNFVRKTFIALAFCDVCKKLLFQ---------GFRCETCGFRYHQRCSPRVPI-------QC
|......|   ..|..|.|....         |.||. |....|..|...||         |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 AqueK677.AA C1_3 230-257 23 2.9e-05 14.89 Pfam 1-30 (30) Show / Hide 
Range on Protein: 230-257
Range on HMM: 1-30/30
Sequence Identity: 23% (7 aa)

AFCDVCKKLLF--QGFRCETCGFRYHQRCS
 .|..|.. .    ...| .| |  |..| 
FTCNCCGLPIYRDPFYHCMQCDFMLHEDCA
Kinase AqueK677.AA RAF 581-840 59 2.2e-168 550.4 In-house 1-282 (282) Show / Hide 
Range on Protein: 581-840
Range on HMM: 1-282/282
Sequence Identity: 59% (169 aa)

IEVGERIGSGSFGTVYKGKWHGPVAVKKLNVSNPTEQQMQA---FKNEVAVLMKTRHANILLFMGWTSKPR---LTIVTQWCDGSTLFSHIHVLED--RF
..|..|||||||||||.|.|||.||||.|||..|| .||||   |||||||. ||||.|||||||..|||    . ||||||..|.|. |||| |   .|
VMVMTRIGSGSFGTVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKF

EMYKIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDMTVKIGDFGLATVKTRWD--GNEKVRQPTGSILWMAPEVIR-----------MEEPDPYTF
.| ..||| ||..|| ||||||.||||||||||||||.|||||||||||.||||||   ||... |||..||||||||||           | .  ||.|
DMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSF

YCDVYSFGVVVYELISGQLPY-PHVQDRDQILFMVGRGFLRPDPSSARKDTPKSFKQLCIKCCQFEKDDRPLFHQILADLES
  ||||||.| |||.....||  |...||||.||.|||.|||| |  |.|.||. ..|   | .|....|||| |||. .. 
QSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase AqueK677.AA RAF 581-838 52 6.4e-154 517.65 In-house 1-275 (275) Show / Hide 
Range on Protein: 581-838
Range on HMM: 1-275/275
Sequence Identity: 52% (145 aa)

IEVGERIGSGSFGTVYKGKWHGPVAVKKLNVSNPTE-QQMQAFKNEVAVLMKTRHANILLFMGWTSKP---RLTIVTQWCDGSTLFSHIHVLED-RFEMY
...|||||.|.|||||.|.|||.|||| ||.  ||  .|.|||||||... |||| ||.||||...||    . |||||| ||||..|||| .. .|.| 
VQIGERIGQGRFGTVYRGHWHGDVAVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGYCMKPDNPHYAIVTQWCKGSTLYHHIHVQKTEKFDMN

KIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDMTVKIGDFGLATVK-TRWD--GNEKVRQPTGSILWMAPEVIRME---------EPDPYTFYCDV
..|.| .|..||.|||||| ||||||||.|||||....|.|.||||.||| .||   .. ...||.|.|.|||||||||          .  |..|. ||
WTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDV

YSFGVVVYELISGQLPYPHVQDRDQILFMVGRGFLRPDPSSARKDTPKSFKQLCIKCCQFEKDDRPLFHQILADL
|.||.| |||..|..|| | | ..||..||.|| ||.|.| ||...||. | |   |  .....||.| ||.. .
YAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI
Kinase AqueK677.AA TKL 587-838 25 1.9e-89 303.47 In-house 1-364 (364) Show / Hide 
Range on Protein: 587-838
Range on HMM: 1-364/364
Sequence Identity: 25% (95 aa)

IGSGSFGTVYKGKWHG-----------PVAVKKLNVS------------------------NPTEQQMQAFKNEVAVLMK-TRHANILLFMG--------
||||.||.||||||.|           .|||||...                         .|. .... |..|....|. .|| ||..|||        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-WTSKP-----RLTIVTQWCDGSTLFSHIHVLEDRFEMYKIIDICRQTAQGVDYLHA--------KQIIHRDLKSNNIFLHDDMT--------------V
 .  .|      | ||...|.| .|....|       . .........|.|..|||.        ..||||||||.||......|              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDFGLATVKT------------------RWDGNEKVRQPTGSILWMAPEVIRMEEPDP-------------YTFYCDVYSFGVVVYELISGQLPYPHV
||.||||.....                  . .....   . |.. ||||||.|......             |.  |||||||.| .|......|| . 
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

QDRDQI------LFMVGRG--FLRPDPS---------SARKDTPKSFKQLCIKCCQFEKDDRPLFHQILADL
  ...|      .......  .||| .          .  .|.|.|.|.|. .|.. . ..|| | .||  |
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK677.AA Pkinase 581-838 26 9.1e-74 256.17 Pfam 1-293 (293) Show / Hide 
Range on Protein: 581-838
Range on HMM: 1-293/293
Sequence Identity: 26% (78 aa)

IEVGERIGSGSFGTVYKGKWHGP---VAVKKLNVSNPTEQQMQAFKN--EVAVLMKTRHANILLFMGWT-SKPRLTIVTQWCDGS----TLFSHIH-VLE
...|..|||||||.|||....|    ||||......  ... |.  .  |.... . .| ||. . .|  .|... .|. .|.|      ||..|.   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DRF--EMYKIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDMTV----KIGDFGLATVKTRWDGNEKVRQPTGSILWMAPEVIRMEEPDPYTFYCDV
 .|  ..  ......|...|..|.|.. |||||||. ||........    ||.||||| ..  .  |.    ..|.. .|||||||  .  .|.  .|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR--GGQYYGPKVDM

YSFGVVVYELISGQLPYPHV---QDRDQILFMVGRGFLRPDPSSARKDTP-------------------KSFKQLCIKCCQFEKDDRPLFHQILAD--L
.|.|...||...|..|.|.     . .  ..|. |   .| ...  .. .                   ...|... .|...   .|| ..||| .  .
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK677.AA S_TKc 581-841 25 3.1e-64 220.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 581-841
Range on HMM: 1-231/231
Sequence Identity: 25% (71 aa)

IEVGERIGSGSFGTVYKGKWHG---PVAVKKLNVSNPTEQQMQAFKNEVAVLMKTRHANILLFMGWTSKPRLTIVTQWCDG--STLFSHIHVLEDR----
 |... ||.|.||.|||.....    ||.|...         . ...|...|.| .| ||  . ..    .| .|.  |||   .||..|.    .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FEMYKIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDMTVKIGDFGLATVKTRWDGNEKVRQPTGSILWMAPEVIRMEEPDPYTF-YCDVYSFGVV
 |    .  ...|......|.| ..|||||||  ||.| .  ..||.|||||..          .   |.  .|||||.      .|..  ||..|.|..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCI

VYELISGQLPYPHVQDRDQILFMVGRGFLRPDPSSARKDTPKSFKQLCIKCCQFEKDDRPLFHQILA-D-----LESL
.||...|. |.|   . .... ..|               ....|..  ||.|.. ..||   ..|. .      . .
LYEMLCGYPPFP---QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK677.AA TKL-Unique 583-838 31 3.6e-64 219.49 In-house 1-290 (290) Show / Hide 
Range on Protein: 583-838
Range on HMM: 1-290/290
Sequence Identity: 31% (92 aa)

VGERIGSGSFGTVYKGKWHG-PVAVKKLNV-SNPTEQQMQAFKNEVAVLMKTR-HANILLFMGWTSK-----PRLTIVTQWCDGSTLFSHIH--------
... ||.|..|.||||||.| |||.|.... . .  . || |.||| .. | . |.||...||.. .     |.. ||.  |.|..| ...|        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-VLEDRFEMYKIIDICRQTAQGVDYLHAKQ--IIHRDLKSNNIFLHDD-----MTVKIGDFGLATVKTRWDGNEKVRQ-------PTGSILWMAPEVIRM
   .  . | ..... .. ||| .||| ..  |||||||| |. .  .     . .|| ||||...... . . . .        . ||..||||||.||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

EEPDPYTFYCDVYSFGVVVYELISGQL------PYPHVQDRDQILFMVGR--GFLRPDPSSARKDTPKSFKQLCIKCCQFEKDDRPLFHQILADL
.. . |.  .||||||.|..|......      || .. |..|.. ||      .||  ..   . ||... |  .|.  . ..|| | .|.  |
NF-CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM-DQEQWCEMVHYMEENYRPPIPN---HCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK677.AA KSR 581-838 35 2e-62 211.6 In-house 1-272 (272) Show / Hide 
Range on Protein: 581-838
Range on HMM: 1-272/272
Sequence Identity: 35% (98 aa)

IEVGERIGSGSFGTVYKGKWHGPVAVKKLNVS-NPTEQQ-MQAFKNEVAVLMKTRHANILLFMG-WTSKPRLTIVTQWCDG-STLFSHIHVLEDRFEMYK
.. ||.|| | ||.|..| ||| ||.| ..      | . . .|| ||. . .||| || ||||   . | | ||.  | |  ||..||||  ... | .
LKYGECIGQGRFGKVHRGHWHGEVAIKLYYMDHIHDEHHDLEDFKDEVMMYKNTRHENIVLFMGACMNPPHLAIVMSLCKGSQTLYHHIHVRREKLDMNR

IIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDMTVKIGDFGLATVK---TRWDGNEKVRQPTGSILWMAPEVIRM-----EEPD----PYTFYCDVY
 ..| .| .||. ||||| ||| |||| |||.     | | ||||  ..       .  . . | |    .||| ||      .|.     |.. . |||
TMQIAQQICQGMGYLHAKGIIHKDLKSKNIFYENKGKVVITDFGLFSITRLLHCCQREDHLCIPHGWLCYLAPELIRAMRPNYDEYQCMCLPFSHHSDVY

SFGVVVYELISGQLPYPHVQDRDQILFMVGRG-FLRPDPSSARKDTPKSFKQLCIKCCQFEKDDRPLFHQILADL
.|| . ||.| | .|. . |   .|.. ...|  .|.. ..      .  | .   |  .|...|| | .|.  |
AFGTIWYEMICGEWPF-KYQCAESIIWQMCQGEGMRQVLRNVQ--CGREMKEILMMCWSYEPQERPTFQDIMKML
Kinase AqueK677.AA Dicty4 581-840 35 1.1e-61 204.54 In-house 1-277 (277) Show / Hide 
Range on Protein: 581-840
Range on HMM: 1-277/277
Sequence Identity: 35% (101 aa)

IEVGERIGSGSFGTVYKGKWHG-PVAVKKLNVSNPT--EQQMQAFKNEVAVLMKTRHANILLFMGWTS----KP-RLTIVTQWCDGSTLFSHIHV-----
| ...|||.||||.||||.| |  |||||||  | .  |  ...|..||. . | || ||.||||       .| .. |||  .   .|.| .|      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-LEDRFEMYKIID---ICRQTAQGVDYLHA--KQIIHRDLKSNNIFLHDDMTVKIGDFGLAT-VKTRWDGNEKVRQPTGSILWMAPEVIRMEEPDPYTFY
  ..  .   |.    ... .|.|. .||.    |||||||| |.   ....||..||||..  |.  | . .   . |. .|||||| . .   ||.  
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQ---PYNEK

CDVYSFGVVVYELISGQLPYP-HVQDRDQILFMVGRGFLRPDPSSARKDTPKSFKQLCIKCCQFEKDDRPLFHQILAD--LES
 |||||| | .|.  .| ||. | .. .|. . |..  |||  ..   ..|.|.|.|  .|   .   || | .|.    ||.
ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPD---WCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK677.AA Pkinase_Tyr 581-838 29 1e-56 192.74 Pfam 1-270 (270) Show / Hide 
Range on Protein: 581-838
Range on HMM: 1-270/270
Sequence Identity: 29% (82 aa)

IEVGERIGSGSFGTVYKGKWH-------GPVAVKKLNVSNPTEQQ--MQAFKNEVAVLMKT-RHANILLFMGWTS---KP-RLTIVTQWCDGSTLFSHIH
|. |. .|.|.||.||||.|.        |||||.|.  . ...|  ...| .|......  .| ||. ..|  .   .| .. ||.  . .  | .. .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

VL---EDRFEMYKIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDMTVKIGDFGLATVKTRWDGNEKVRQPTGSIL---WMAPEVIRMEEPDPYTFY
     .... |  ....|.| |.| .||..|..|||||   |. ......|||.|||||      |..  .|. .|. |   |||||.|.  .   .|  
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGK---FTTK

CDVYSFGVVVYELIS-GQLP-YPHVQDRDQILFMV-GRGFLRPDPSSARKDTPKSFKQLCIKCCQFEKDDRPLFHQILADL
 ||.||||. .|... |. | || . .  ... ..  .|        . ...|.   .|  .| ... .||| | .|. .|
SDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYR----MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK677.AA TK 581-838 16 3.9e-56 186.32 In-house 1-486 (486) Show / Hide 
Range on Protein: 581-838
Range on HMM: 1-486/486
Sequence Identity: 16% (80 aa)

IEVGERIGSGSFG---TVYKGKWHG----------------------------PVAVKKLNVSNPTEQQ-MQA--------------FKNEVAVLM--KT
|..|. .|.| ||   .||||.|.|                            ||||| |   ....|. ...              . .| ....  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHANILLFMGWTSKPR-------------LTIVTQWCDGST----LFSHIHV-LEDRFEMYKIID-----------------------------------
.| ||. . |  ....             . ||. ....      | .. .   ......   .|                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------------------------------------ICRQTAQGVDYLHAK------QIIHRDLKSNNIFLHDDMT-----------VKIGDFGLATV
                                      .|.| |.|  |||.|      ...||||   |. ......           .||.||||. .
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

KT----RWDGNEKVRQPTGS----------------------------ILWMAPEVIRMEE------PDPYTFYCDVYSFGVVVYELIS-GQLPYPHVQD
..    | .....    ..|                            | |||||...  .         .|   ||.||||...|. . || ||.   .
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

R---------DQILFMVGRG--------------FLRPDPSSAR----------KDTPKSFKQLCIKCCQFEKDDRPLFHQILADL
          .... .. ||              . .| |  .              |. . .|. .|.... .||| | |..  |
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK677.AA MLK 581-838 29 7.2e-54 185.22 In-house 1-291 (291) Show / Hide 
Range on Protein: 581-838
Range on HMM: 1-291/291
Sequence Identity: 29% (88 aa)

IEVGERIGSGSFGTVYKGKWHGPV------AVKKLNVSN----PTEQQMQAFKNEVAVLMKTRHAN----ILLFMGWTSKP-R-LTIVTQWCDGSTLFSH
|.. | ||||||| |.||.|..        |||. . .      |. . ..|. |.  | . .| |    |  |.|  ..|   . ||...|.|. |.. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

IHVLED-------------RFEMYKIIDICRQTAQGVDYLHAKQ---IIHRDLKSNNIFLHD------DMTVKIGDFGLATVKTRWDGNEKVRQPTGSIL
.|  ..             .  .  ..... | |.|..|||...   |||||||| || ...      ..|.|| |||... ... .   .  .. |.  
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNA-GTYA

WMAPEVIRMEEPDPYTFYCDVYSFGVVVYELISGQLPYP-HVQDRDQILFMVGRGFLRPDPSSARKDTPKSFKQLCIKCCQFEKDDRPLFHQILADL
|||||||   . ..|.  |||.|.||| .|......||  |.     .  ..  |  .| ||.     |...|.|  .| . .  .|| | ||.  |
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPST----CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK677.AA STE 581-835 24 2.9e-49 169.96 In-house 1-352 (359) Show / Hide 
Range on Protein: 581-835
Range on HMM: 1-352/359
Sequence Identity: 24% (87 aa)

IEVGERIGSGSFGTVYKGKWHGP------------------VAVKKLNVSNPT---------------EQQMQAFKNEVAVLMKTR--HANILLFMGWTS
 |  |.||.|.||||||.. | .                  .|.|..|..| .               ...|| ...|. ...| .  | ||  . |   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KP--------RLTIVTQWCDGSTLFSHIH-VLEDRF-------------EMYKIIDICRQTAQG-VDYLHAKQIIHRDLKSNNIFLHDDMTVKIGDFGLA
|          | |.  ..|| .| . |. . .  .             |   |. ||||. .|  .||| ..|||||.|. ||.|     ||. |||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQ-IAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

TVKTR--------------WDGNEKVRQPTGSILWMAPEVIRMEE---PDPYTFYCDVYSFGVVVYELISGQLPY---PHVQDRDQILFM--VGR-----
.  |                .. .|    .|.  |||||||. ..    ..|.. ||..|.| .. |.. |. |.   .. .   .|.|.  ...     
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----GFLRPDPSSAR---------------KDTPKSFKQLCIKCCQFEKDDRPLFHQIL
    |   | |.                  .   ..||.   ||.| . ..||  .| |
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLL
Kinase AqueK677.AA CAMK 586-780 18 1.5e-48 154.17 In-house 1-334 (425) Show / Hide 
Range on Protein: 586-780
Range on HMM: 1-334/425
Sequence Identity: 18% (62 aa)

RIGSGSFGTVYKGKWH-GP--------------VAVKKLN-----------------VSNP---------TEQQMQAFKNEVAVLMK-------TRHANI
 .|.||||.|....    .              ||.| ..                 ...          ... .. ...|.....|        .| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LLFMGWTSKPR--------------------LTIVT---QWCDGS----TLFSHIHVLED--------------RFEMYKIIDICRQTAQGVDYLHAKQI
. .  .   |.                    . .|.     |.|      ||..|   ..              ||.      . || ...|.|.| . |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKSNNIFLHDDM-----------------TVKIGDFGLATVKTRWDG---------------------NEKVRQPTGSILWMA-PEVIRM------
.|||||  || | |..                 ..|| |||.|..... ..                     ..| . . |.   || |||..       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-----EEPDPYTFYCDVYSFGVVVYELISGQLPY
     || ..|.. ||. | ||. | . .| .|.
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPF
Kinase AqueK677.AA TyrKc 581-838 28 2.2e-40 141.38 SMART 1-280 (280) Show / Hide 
Range on Protein: 581-838
Range on HMM: 1-280/280
Sequence Identity: 28% (83 aa)

IEVGERIGSGSFGTVYKGKWHGPVAVKKLNVSNPTEQQMQAFKNEVAVLMKT--RHANILLFMGWTSK--------PRLTIVTQWCDGSTLFSHIHVLED
|. |. .|.| ||.||||.|  .||||.|. .      ...| .|  ...|   .| ||. . |  ..        . | ||.  ...  | ....  ..
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

RFEMYKIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDMTVKIGDFGLATVKTRWD-----GNEKVR----QPT--GSILWMAPEVIRMEEPDPYTF
.. | . ...| | |.| .||| |..|||||   |. .... ||||.||||.   .  |     .  ..     .      | |||||.|       .|.
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFTT

YCDVYSFGVVVYELIS-GQLPYPHV----QDRDQILFMVGRGFLRPDPSSARKD-----TPKSFKQLCIKCCQFEKDDRPLFHQILADL
  ||.||||. .|. . || ||| .     . ....  | .|. .| | ..         |.   |.  .|.... .||| | .|  ..
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF