Gene AqueK675 (A.queenslandica)
AqueK675
Species: A.queenslandica
Alias: AqueK675
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| AqueK675.AA | Protein | None | 435 | None | Fasta, JSON |
| AqueK675.kin_dom | Protein Kinase Domain | None | 222 | None | Fasta, JSON |
Protein domains of AqueK675.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | AqueK675.AA | RAF | 170-282 | 41 | 8.3e-32 | 106.14 | In-house | 14-129 (275) | Show / Hide |
Range on Protein: 170-282 Range on HMM: 14-129/275 Sequence Identity: 41% (48 aa) TVQKGYWHGNVWVHQRTIKR---QEDVRSFANEVNTLCCIRHENIQLFMGVCLDLPAGDTFGIIMSEVKGDTLYNHIHKLGH-NFTTPSKLKILRQISEG || .| |||.| | ...| ... |.||| . .||||| |||| | . . ...|... || ||| ||| | . ....| .|| | TVYRGHWHGDVAVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGYCMKP-DNPHYAIVTQWCKGSTLYHHIHVQKTEKFDMNWTIQIAQQICQG MEYLHAKGIQHGGLSSK | |||||.| |. |.|| MDYLHAKNIIHRDLKSK |
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| Kinase | AqueK675.AA | KSR | 170-282 | 40 | 1.6e-29 | 97.8 | In-house | 14-128 (272) | Show / Hide |
Range on Protein: 170-282 Range on HMM: 14-128/272 Sequence Identity: 40% (48 aa) TVQKGYWHGNVWVHQRTIK----RQEDVRSFANEVNTLCCIRHENIQLFMGVCLDLPAGDTFGIIMSEVKG-DTLYNHIHKLGHNFTTPSKLKILRQISE .| .| ||| | . .... |. | || . .||||| |||| | | ..|.|| || ||| ||| . . ....| .|| KVHRGHWHGEVAIKLYYMDHIHDEHHDLEDFKDEVMMYKNTRHENIVLFMGACMNPPH---LAIVMSLCKGSQTLYHHIHVRREKLDMNRTMQIAQQICQ GMEYLHAKGIQHGGLSSK || ||||||| |. |.|| GMGYLHAKGIIHKDLKSK |
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| Kinase | AqueK675.AA | RAF | 170-282 | 36 | 2.2e-24 | 75.7 | In-house | 14-132 (282) | Show / Hide |
Range on Protein: 170-282 Range on HMM: 14-132/282 Sequence Identity: 36% (44 aa) TVQKGYWHGNVWVHQRTIKR--QEDVRS---FANEVNTLCCIRHENIQLFMGVCLDLPAGDTFGIIMSEVKGDTLYNHIHKLGH--NFTTPSKLKILRQI || .| |||.| | .. .|... | ||| . || || |||| . | .|. |. . .|| ||| .| . |.||. TVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMG-YMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKFDMHWLIDISRQV SEGMEYLHAKGIQHGGLSSK . ||.||||| | | | |. CQGMDYLHAKNIIHRDLKSN |
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| Kinase | AqueK675.AA | TKL-Unique | 196-282 | 28 | 8.9e-15 | 48.69 | In-house | 42-141 (290) | Show / Hide |
Range on Protein: 196-282 Range on HMM: 42-141/290 Sequence Identity: 28% (29 aa) FANEVNTLCCIR-HENIQLFMGVCLD-LPAGDTFGIIMSEVKGDTLYNHIH---------KLGHNFTTPSKLKILRQISEGMEYLHAKG--IQHGGLSSK | ||||.. ... |.|| ..||.| | .. . |.|. . | .||...| . .... ..|. ..|. ||.||| .. | |. | |. FENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSS |
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| Kinase | AqueK675.AA | TKL | 170-282 | 21 | 3.6e-14 | 47.43 | In-house | 8-169 (364) | Show / Hide |
Range on Protein: 170-282
Range on HMM: 8-169/364
Sequence Identity: 21% (36 aa)
TVQKGYWHG---------NVWVHQRTIKRQE-DVRS--------------------------FANEVNTLCCIR--HENIQLFMGVCLDLPAGD------
.| ||.|.| . .| ..|... | .. | |. .....| |.|| .|||.|.. | |
EVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPV
----TFGIIMSEVKGDTLYNHIHKLGHNFTTPSKLKILRQISEGMEYLHA--------KGIQHGGLSSK
..|.| ..| .|....| . .... ..|. ||.|||. ..| | | ||
GPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSK
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| Kinase | AqueK675.AA | TKL | 333-408 | 17 | 8.1e-11 | 35.2 | In-house | 265-364 (364) | Show / Hide |
Range on Protein: 333-408 Range on HMM: 265-364/364 Sequence Identity: 17% (17 aa) KPTPSTDIFAFGTIAYELTTLKLPFLNQSLLDLI---------WSVGNNGHQ-SLK---------LLPRSC---FRSVIHRCWSH--TRRTTFKDILSSI . ....|...|| . .|. | ..|. .. . | . |...|.. .. . .| ... . .||.| . | .|..||. . EYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| S_TKc | AqueK675.AA | S_TKc | 154-414 | 16 | 8.9e-11 | -18.85 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 154-414
Range on HMM: 1-231/231
Sequence Identity: 16% (49 aa)
SEEIQLYGEAASSCKETVQKGYWHGNVWVHQRTIKRQEDVRSFANEVNTLCCIRHENIQLFMGVCLDLPAGDTFGIIMSEVKG--DTLYNHIHKLGHN--
| ... |. | .. ... .. ||. ... .|.. | .|.|| . .|. | | . ..| . | .|. .|.| |..
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL
---FTTPSKLKILRQISEGMEYLHAKGIQHG------------------GLSSKLVTINHRVCISLSFHNTNNRQLEGCDLPYLTPEEIRSITQLSNGYL
|. ....|| ...||.| .|| | ||. .| . |. || .
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL-------------------TTFCGTPWYMAPEVL-----------
FLPTKPTP-STDIFAFGTIAYELTTLKLPFLNQSLLDLIWSVGNNGHQSLKLLPRSCFRSVIHRCWSH--TRRTTFKDILS---SIQDNTSF
. .. . |. ..| | ||. . . || . .. .| . ... | .|. ..| | ..| | |
----GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | AqueK675.AA | Pkinase_Tyr | 190-274 | 25 | 2.4e-09 | 32.27 | Pfam | 42-132 (270) | Show / Hide |
Range on Protein: 190-274 Range on HMM: 42-132/270 Sequence Identity: 25% (24 aa) QED--VRSFANEVNTLCCI-RHENIQLFMGVCLDLPAGDT--FGIIMSEVKGDTLYNHIHKL---GHNFTTPSKLKILRQISEGMEYLHAKGI .|. ..| .|..... . .|.|| ..|||. . |. |.| ... |... .| ....|.. .|.. .||..|||||..|.. HEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT--DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNC |
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| Kinase | AqueK675.AA | TyrKc | 157-408 | 20 | 5.7e-08 | -93.77 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 157-408 Range on HMM: 1-280/280 Sequence Identity: 20% (63 aa) IQLYGEAASSCKETVQKGYWHGNVWVHQR----TIKRQEDVRSFANEVNTLCCI--RHENIQLFMGVCLD-----LPAGDTFGIIMSEVKGDTLYNHIHK |.| . . . .| || | . ..| .. | .| . .| . .|.|| . |||.. . .. . . .|| . ....| ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK-DYLRK LGHNFTTPSKLKILRQISEGMEYLHAKGIQHGGLSSK-----------LVTINHRVCIS------LSFHN-------TNNRQLE--GCD--LPY--LTPE ....... .|.. ||..|||||| | . ||. ||.| || . |. | |.. ||. . || HRPKLCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE EIRSITQLSNGYLFLPTKPTPSTDIFAFGTIAYELTTL-KLPFLN-----QSLLDLIWSVGNNGHQSLKLL---------PRSCFRSVIHRCWSH--TRR | | . | |. .|...|| .|. |. . | . | ..| | . . | .. .. .|| . | CI-------NYGKF-----TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDR TTFKDILSSI ||..| . . PTFSEIHECF |
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| Kinase | AqueK675.AA | NZAK | 155-276 | 27 | 7.8e-08 | 21.86 | In-house | 2-128 (329) | Show / Hide |
Range on Protein: 155-276 Range on HMM: 2-128/329 Sequence Identity: 27% (35 aa) EEIQLYGEAA--SSCKETVQKGYWHGNVWVHQRTIKRQEDVRSFANEVNTLCCIRHENIQLFMGVCLDLPAGDTFGIIMSE-VKGDTLYNHI---HKLGH ||| |.. | | | | | .| | .|. | ||| || .. |. |.. | .| . |. | . . .| . EEISFIGGCQFFSRVKKCRKKNTEIANEQVDKVHCKIITKCDFFYHETDILEKIRHFNIPRYYSACIKHAEDDNYHCIYMEWMEGGNLTQFLMNDKKQLR NFTTPSKLKILRQISEGMEYLHAKGIQH | |.. | |.| ||| ..| | -FKEHRIIKMIADIAETMSYLHKHHIIH |
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| Kinase | AqueK675.AA | RAF | 335-408 | 26 | 1.4e-07 | 22.07 | In-house | 195-275 (275) | Show / Hide |
Range on Protein: 335-408 Range on HMM: 195-275/275 Sequence Identity: 26% (22 aa) TPSTDIFAFGTIAYELTTLKLPFL-NQSLLDLIWSVGNNGHQSLKLL--PRSCFRSV---IHRCWSHTR--RTTFKDILSSI ....| .||||. ||| . .|. .|. .|| |. | ..... .| ... . ||| .. | .| .|...| SFQSDVYAFGTVWYELMAGEWPYQHIQWHEQIIWMVC-RGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI |
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| Kinase | AqueK675.AA | TK | 248-277 | 36 | 1e-06 | 17.57 | In-house | 230-264 (486) | Show / Hide |
Range on Protein: 248-277 Range on HMM: 230-264/486 Sequence Identity: 36% (13 aa) HNFTTPSKLKILRQISEGMEYLHAK------GIQHG |..|.. .| . .||..||||||.| .. |. HQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHR |
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| Kinase | AqueK675.AA | KSR | 335-370 | 36 | 2e-06 | 17.7 | In-house | 194-229 (272) | Show / Hide |
Range on Protein: 335-370 Range on HMM: 194-229/272 Sequence Identity: 36% (13 aa) TPSTDIFAFGTIAYELTTLKLPFLNQSLLDLIWSVG ....| .||||| ||. . .|| .| .|| .. SHHSDVYAFGTIWYEMICGEWPFKYQCAESIIWQMC |
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| Kinase | AqueK675.AA | Ciliate-E6 | 238-282 | 22 | 3e-06 | 16.28 | In-house | 35-82 (154) | Show / Hide |
Range on Protein: 238-282 Range on HMM: 35-82/154 Sequence Identity: 22% (11 aa) TLYNHIHKLGHNFTTPSK---LKILRQISEGMEYLHAKGIQHGGLSSK .|...||.. . .. .|.. |.....||||.|.. .. .. | NLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLK |
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| Kinase | AqueK675.AA | Ciliate-B1 | 239-276 | 42 | 3e-06 | 18.04 | In-house | 104-141 (290) | Show / Hide |
Range on Protein: 239-276 Range on HMM: 104-141/290 Sequence Identity: 42% (16 aa) LYNHIHKLGHNFTTPSKLKILRQISEGMEYLHAKGIQH |||.| . . |||. ..| .. || .| .|||. .| | LYNYIYNCHQNFTHDIVLDFCIQIAKGIQYLHKHKICH |
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| Kinase | AqueK675.AA | Pkinase | 182-276 | 22 | 3.6e-05 | 19.37 | Pfam | 32-131 (293) | Show / Hide |
Range on Protein: 182-276 Range on HMM: 32-131/293 Sequence Identity: 22% (23 aa) VHQRTIKRQEDVRSFA-NEVNTLCCIRHENIQLFMGVCLDLPAGDTFGIIMSEVKGD----TLYNHIH-KLGHNF--TTPSKLKILRQISEGMEYLHAKG . |..| ..|.. . .|. . ..|.|| . ... | .| ..| . |. |. .|. . . .| . ....|| .|.||.|..| IKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMG IQH | | IIH |
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| Kinase | AqueK675.AA | LZK | 339-408 | 34 | 0.000119 | 11.51 | In-house | 169-241 (241) | Show / Hide |
Range on Protein: 339-408 Range on HMM: 169-241/241 Sequence Identity: 34% (26 aa) DIFAFGTIAYELTTLKLPFLNQSLLDLIWSVGNNGHQSLKLL-PRSC---FRSVIHRCWSH-TR-RTTFKDILSSI ||. || . |. | .|. . || ||.| ||.|. | .| |. . ||| .| | |. ||. . DIWSFGVVLWEMLTCEIPYKDVDSMAIIWGVGSN---SLHLPMPSTCPEGFKLLMKQCWSQKPRNRPSFRQILMHW |
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| Kinase | AqueK675.AA | RAF | 311-366 | 27 | 0.000784 | 7.97 | In-house | 173-231 (282) | Show / Hide |
Range on Protein: 311-366 Range on HMM: 173-231/282 Sequence Identity: 27% (16 aa) YLTPEEIR-SITQLSNGYLFLPTKP-TPSTDIFAFGTIAYELTTLKLPF-LNQSLLDLI .. || || . . |. . | .. |...||.. ||| | ..|. . . |.| WMAPEVIRNLMIDWRGDVLMQDENPYSFQSDVYSFGIVMYELMTRHMPYGCHIWNRDQI |
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| Kinase | AqueK675.AA | TKL-Unique | 339-408 | 21 | 0.003381 | 7.34 | In-house | 210-290 (290) | Show / Hide |
Range on Protein: 339-408 Range on HMM: 210-290/290 Sequence Identity: 21% (18 aa) DIFAFGTIAYELTTLKL------PFLNQSLLDLIWSVGNNGHQSLKL-LPRSC---FRSVIHRCWSH--TRRTTFKDILSSI |...||.. .|. | |. |. . . .. | .. . .| .| .| | .|| | . | .| .|.... DVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYM-EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
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| Kinase | AqueK675.AA | LZK | 207-281 | 33 | 0.010195 | 4.9 | In-house | 45-115 (241) | Show / Hide |
Range on Protein: 207-281 Range on HMM: 45-115/241 Sequence Identity: 33% (25 aa) RHENIQLFMGVCLDLPAGDTFGIIMSEVKGDTLYNHIHKLGHNFTTPSKLKILRQISEGMEYLHAKGIQHGGLSS .|.|| | ||| | . ||| ||. . . . . | .|| .||.||| | | | | KHPNIIEFKGVCTQSPC---YCIIMEYCPHGQLYE-VLRERRTITPQLMVDWSKQIAQGMHYLHQHKIIHRDLKS |
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| Kinase | AqueK675.AA | Pkinase | 335-408 | 15 | 0.012494 | 10.38 | Pfam | 190-293 (293) | Show / Hide |
Range on Protein: 335-408 Range on HMM: 190-293/293 Sequence Identity: 15% (16 aa) TPSTDIFAFGTIAYELTTLKLPFLNQ----SLLDLIWSVGNNGHQSLKLLPR-----------------------SCFRSVIHRCWS--HTRRTTFKDIL .|. |....| | ||. . ..|| .. . .| .. . .... |. . ....| .|. ..| |...|| GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL SS--I . . QHPWF |
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| Kinase | AqueK675.AA | TK | 388-408 | 21 | 0.052554 | 1.65 | In-house | 464-486 (486) | Show / Hide |
Range on Protein: 388-408 Range on HMM: 464-486/486 Sequence Identity: 21% (5 aa) VIHRCWSH--TRRTTFKDILSSI .. .||.. .| ||..... . LMQQCWHYDPEDRPTFSQLHEQL |
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