AqueK658

Species: A.queenslandica
Alias: AqueK658
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK

Sequence

Name Sequence Type Origin Length Description Download
AqueK658.AA Protein None 699 None Fasta, JSON
AqueK658.kin_dom Protein Kinase Domain None 214 None Fasta, JSON

Protein domain

Protein domains of AqueK658.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK658.AA TKL 26-284 14 7e-19 64.62 In-house 1-364 (364) Show / Hide
Range on Protein: 26-284
Range on HMM: 1-364/364
Sequence Identity: 14% (52 aa)

IEKGAYSSTVRVRWQG----------TEYRGNKLHDVHLRLEKKKGGEE------------------LLGRLRRHCELVFSLNHPNLVQHIGVALSTQDG
| .|...   . .|.|          ..    |..  .  .. |.  |.                  .  ....   .  .|.|||.|| .|.... ..|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PAPILITPSLPTNLANIISANTRLPPAVSHSILRDVSQGLAYLHN-RP----KAPVPHGSLSANNVLLTRGLE--------------A
            .. .    .  . | ...       . . ... .|...|..|||. .|    | |. |  |  .|.|. . ..              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KLSNLGVAAILESGSGGGSKGAAII-----------AHTKT-------PEQTCYAPPPEEQ----------PLTMAGDVFSFGVLVLHILSGKYPIPTGE
|.. .| .  ..  ..    . ..             .|.        ||    ... .|           . . . ||.|||..   ||... |     
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

GKKEI---------ERRGMYISQIPEK------------NN----LLPLVKECLQNDPAQRPLALTLVERL
   .|         . ..    . | .            ..    .  | ..| . || .|| ......||
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase AqueK658.AA S_TKc 20-288 16 8.2e-13 10.99 SMART 1-231 (231) Show / Hide
Range on Protein: 20-288
Range on HMM: 1-231/231
Sequence Identity: 16% (47 aa)

VEIGEAIEKGAYSSTVRVRWQG--TEYRGNKLHDVHLRLEKKKGGEELLGRLRRHCELVFSLNHPNLVQHIGVALSTQDGPAPILITPSLPT---NLANI
 ||.. | |||...  ..|. .   ..   ...                 ..||  ..  . .|||.|. ..|  .        ...  ...   .|  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------EHIRREIQILKK-HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDY

ISANTR------LPPAVSHSILRDVSQGLAYLHNRPKAPVPHGSLSANNVLLTRGLEAKLSNLGVAAILESGSGGGSKGAAIIAHTKTPEQTCYAPPPEE
|  . |      .|. .  .... . ..|.|.|..      |  |   |.||..  . |..  |.|..|        .      .   ||          
IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGII---HRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL--------

QPLTM-AGDVFSFGVLVLHILSGKYPIPTGEGKKEIERRGMYISQIPEKNNLLPLVKECLQNDPAQRPLALTLVE-----RLTRFS
 . .  . |. |.|...   |.|. | |     ... .. .          .. ... ||| ||..|| |  . .     ..  . 
-GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase AqueK658.AA TK 20-172 9 2.2e-08 23.44 In-house 1-296 (486) Show / Hide
Range on Protein: 20-172
Range on HMM: 1-296/486
Sequence Identity: 9% (27 aa)

VEIGEAIEKGAYS---STVRVRWQGT-EYRGNKL------------------HDVHLRLEKKKGGEELLGRLR---------------RHCELVFS---L
...|. . .|..       . .|.|   ..|..                   ..|     |.. ...   ..                 . . ...   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

NHPNLVQHIGVALSTQD---------GPAPILITPSLP-TN----LANIISANTR---------------------------------------------
.|||.|. .|| .  .          .. .....   |  .    | .   .. .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------LPPAVSHS-------------------ILRDVSQGLAYLHNRP---KAPVPHGSLSANNVLLTRGLE-----------AKLSNLG
           |. .  ..                   . .....|..||| ..      . |. | | |.|.....            .|..  |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG

Kinase AqueK658.AA TyrKc 20-284 17 2.4e-08 -87.82 SMART 1-280 (280) Show / Hide
Range on Protein: 20-284
Range on HMM: 1-280/280
Sequence Identity: 17% (53 aa)

VEIGEAIEKGAYSSTVRVRWQGTEYRGNKLHDV---HLRLEKKKGGEELLGRLRRHCELVFSL--NHPNLVQHIGVALSTQDG----PAPILITPSLPT-
.. |. .  ||.   .. .|           .|    |. ..       .  ..|  ..  .|  .|||.|. .||... .      . . ...   |  
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

NLANIISANTR-LPPAVSHSILRDVSQGLAYLHNRPKAPVPHGSLSANNVLLTRGLEAKLSNLGVAAILESG-SGGGSKGAAIIA----HTK--------
.| . . .. . |...  .|.  ....| .||| .   .. |  | | |.|..... .| |  | .  .... . |   .  . .    ..|        
DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWM

---TPEQTCYAPPPEEQPLTMAGDVFSFGVLVLHILSG---KYPI-----PTGEGKKEIERRGMYISQIPE---------KNNLLPLVKECLQNDPAQRP
   .    ..         | . ||.||||.   |..     ||       . .   |  ..|..  | |.            .  . |.| . ||..||
APECINYGKF---------TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

LALTLVERL
   ...|..
TFSEIHECF

Kinase AqueK658.AA Src-Echino1 132-284 25 1.8e-07 21.43 In-house 104-252 (252) Show / Hide
Range on Protein: 132-284
Range on HMM: 104-252/252
Sequence Identity: 25% (41 aa)

DVSQGLAYLHNRPKAPVPHGSLSANNVLLTRGLEAKLSNLGVAAILESGSGGGSKGAAIIAHTKTPEQTCYAPPPEEQPLTMAGDVFSFGVLVLHILS-G
..  |. ||  .    | |  |.| |||. .|   |. ..| | ...     | .|| .  .  .||   |         |.  ||.|||.|.  ..  |
HIASGMDYLGSK---NVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYG------RFTIKSDVWSFGILMTEMVTFG

KYPIPTGEGKKEIER--RGMYISQIPEKNNLLPLV--KECLQNDPAQRPLALTLVERL
.|| |    .  ...  ||  . .. .  . |  .    |   || |||    | . .
RYPYPGMMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF

Kinase AqueK658.AA TK 212-284 23 3.9e-07 19.15 In-house 372-486 (486) Show / Hide
Range on Protein: 212-284
Range on HMM: 372-486/486
Sequence Identity: 23% (27 aa)

TMAGDVFSFGVLVLHILS-GKYPIPTGEGK------------KEIERRG--------------MYISQIPEKN--------------NLLPL-VKECLQN
| . ||.|||||.  |.. |. | . |                |  |||              |   | |                  .. .  ..| . 
TTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHY

DPAQRPLALTLVERL
||..||   .|.|.|
DPEDRPTFSQLHEQL

Kinase AqueK658.AA MLK 20-169 16 4e-07 20.9 In-house 1-175 (291) Show / Hide
Range on Protein: 20-169
Range on HMM: 1-175/291
Sequence Identity: 16% (29 aa)

VEIGEAIEKGAYSSTVRVRWQGTE--YRGNKLHDVHLRLEKKKGG-EELLGRLRRHCELVFSLNHPN----LVQHIGVALSTQDGPAPILITPSLPT-NL
 .. | | .|.. .  . ||....   .  ..  |. | .  |.  ..    ... |...  |.|||     .|  || |...  .   ...  ..   |
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP--CHFCIVMEYCEGGSL

ANIISANT--------------RLPPAVSHSILRDVSQGLAYLHNRPKAPVPHGSLSANNVLLTR------GLEAKLS
.|.. ...              . ....  ..  ....|..|||.  . |..|  |   |.|...      .. .| .
YNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKIC

Kinase AqueK658.AA MLK 20-165 23 6.1e-07 18.73 In-house 1-141 (280) Show / Hide
Range on Protein: 20-165
Range on HMM: 1-141/280
Sequence Identity: 23% (35 aa)

VEIGEAIEKGAYSSTVRVRWQGTEYRGNKLHDVHLRLEKKKGGE-ELLGRLRRHCELVFSLNHPNLVQHIGVALSTQDGPAPILITPSLPTNLANIISAN
..| | |  | .   .|  |.| | .   .   .   |.      | .  .|.   |.  |.||| ..  || |  .|    ...       | ..... 
LKIKEIIGNGGFGKVYRAQWKGEEVA---VKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCL--EDPHLCLVMEYCRGGSLNRVCAGK

TRLPPAVSHSILRDVSQGLAYLHNRPKAPVPHGSLSANNVLLTRGLE
 | || |       . .|. ||||    |. |  | ..|.|.    .
-RIPPHVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKIC

Kinase AqueK658.AA TK-Unique 128-174 31 2e-06 18.68 In-house 135-180 (294) Show / Hide
Range on Protein: 128-174
Range on HMM: 135-180/294
Sequence Identity: 31% (15 aa)

SILRDVSQGLAYLHNRPKAPVPHGSLSANNVLLTRGLEAKLSNLGVA
... .. .|..||.  .|  . |. |.| |||||.....|....| |
HFAWQIACGMEYLASQRKK-IVHRDLCARNVLLTEDKVCKICDFGMA

Kinase AqueK658.AA Ciliate-B1 237-285 24 8e-06 16.51 In-house 233-290 (290) Show / Hide
Range on Protein: 237-285
Range on HMM: 233-290/290
Sequence Identity: 24% (14 aa)

GEGKKEIER--RGMYIS--QIPEKNNLLPLVKE-----CLQNDPAQRPLALTLVERLT
| . .|...  |..     | .. ||.. ....     ||| ||..|. .  ...|| 
GNTQQEVANQIRNFQCCDYQCHFQNNIYQEIQQLIQKYCLQPDPENRITIDQIIDRLM

Kinase AqueK658.AA NZAK 216-285 23 2.5e-05 13.29 In-house 254-329 (329) Show / Hide
Range on Protein: 216-285
Range on HMM: 254-329/329
Sequence Identity: 23% (18 aa)

DVFSFGVLVLHILSGKYP----IPTGEGKKEIERRGMYISQIPEK--NNLLPLVKECLQNDPAQRPLALTLVERLT
||.|||..|. . ..  |     |        ...  || |||.   . .  ... |.  || .||     .. . 
DVWSFGCTVWQMFGYNPPNTIYSPKEMASMVSDQKFNYIPQIPFHVPDKMKDFITQCWDIDPKKRPKDFSHMIEKL

Kinase AqueK658.AA Pkinase 216-284 18 6.1e-05 18.56 Pfam 194-293 (293) Show / Hide
Range on Protein: 216-284
Range on HMM: 194-293/293
Sequence Identity: 18% (18 aa)

DVFSFGVLVLHILSGKYPIPTG------EGKKEIERRGM--YISQIPEK---------------------NNLLPLVKECLQNDPAQRPLALTLVER--L
|..|.|...   |.|. | |        . .. |.|...  . ...|..                      ... ..| ||. ||..|| |  ...   .
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF





Kinase AqueK658.AA Pkinase 78-143 17 0.000102 17.76 Pfam 56-127 (293) Show / Hide
Range on Protein: 78-143
Range on HMM: 56-127/293
Sequence Identity: 17% (13 aa)

SLNHPNLVQHIGVALSTQDGPAPILITPSLPT-----NLANIIS--ANTRL--PPAVSHSILRDVSQGLAYLHNR
.||||| |. ...  .   .. . .... ..       |. .||  .....  .. .  .... . .||.|.|..
RLNHPNIVRLYDWFED---KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM

Kinase AqueK658.AA CTKA 259-284 38 0.000301 10.02 In-house 265-290 (290) Show / Hide
Range on Protein: 259-284
Range on HMM: 265-290/290
Sequence Identity: 38% (10 aa)

LLPLVKECLQNDPAQRPLALTLVERL
|. . .||..  |.|||   || . |
LYHCMQECWKFEPNQRPTFETLQRML

Kinase AqueK658.AA TKL-ciliate1 262-284 26 0.000397 10.02 In-house 257-279 (279) Show / Hide
Range on Protein: 262-284
Range on HMM: 257-279/279
Sequence Identity: 26% (6 aa)

LVKECLQNDPAQRPLALTLVERL
| . |.  .|..|| .  . ..|
LMMRCWCQNPNKRPNFNEIIQIL

Kinase AqueK658.AA TK-Unique 264-284 38 0.000973 8.91 In-house 274-294 (294) Show / Hide
Range on Protein: 264-284
Range on HMM: 274-294/294
Sequence Identity: 38% (8 aa)

KECLQNDPAQRPLALTLVERL
|.|.| .| .||   ... ||
KSCWQWEPEERPSFRQIKHRL

Kinase AqueK658.AA MLK 262-284 30 0.004389 5.78 In-house 258-280 (280) Show / Hide
Range on Protein: 262-284
Range on HMM: 258-280/280
Sequence Identity: 30% (7 aa)

LVKECLQNDPAQRPLALTLVERL
| ..| . || .||   .....|
LMQDCWNQDPHKRPKFSEILQQL

Kinase AqueK658.AA TKL-ciliate1 129-160 37 0.011082 5.0 In-house 108-138 (279) Show / Hide
Range on Protein: 129-160
Range on HMM: 108-138/279
Sequence Identity: 37% (12 aa)

ILRDVSQGLAYLHNRPKAPVPHGSLSANNVLL
...|. ||. ||| | . |  |  |   | |.
WCKDIAQGMQYLHMR-QNPLIHRDLKMQNILY

Kinase AqueK658.AA NZAK 110-176 24 0.015212 3.79 In-house 88-154 (329) Show / Hide
Range on Protein: 110-176
Range on HMM: 88-154/329
Sequence Identity: 24% (17 aa)

NLANIISAN---TRLPPAVSHSILRDVSQGLAYLHNRPKAPVPHGSLSANNVLLTRGLEAKLSNLGVAAI
||..... .    |  .    ... |. ... |||   |  . |  .  |||.|    . || . |   |
NLTQFLMNDKKQLRFKEHRIIKMIADIAETMSYLH---KHHIIHRDIKSNNVILDFNKNLKLIDFGSSII

Kinase AqueK658.AA CTKA 212-230 47 0.026902 3.36 In-house 212-230 (290) Show / Hide
Range on Protein: 212-230
Range on HMM: 212-230/290
Sequence Identity: 47% (9 aa)

TMAGDVFSFGVLVLHILSG
. | ||..||||.  |.|.
SCASDVWAFGVLLWEIMSM

Kinase AqueK658.AA CTKA 153-181 27 0.076566 1.81 In-house 157-185 (290) Show / Hide
Range on Protein: 153-181
Range on HMM: 157-185/290
Sequence Identity: 27% (8 aa)

LSANNVLLTRGLEAKLSNLGVAAILESGS
| . |.|| ..   |....| .  |...|
LACRNCLLGQYCHIKIADFGHGRTLRTES

Kinase AqueK658.AA MLK 207-223 29 0.079772 2.27 In-house 209-225 (291) Show / Hide
Range on Protein: 207-223
Range on HMM: 209-225/291
Sequence Identity: 29% (5 aa)

EEQPLTMAGDVFSFGVL
.... ... ||.|.||.
RCEKYSEKCDVWSWGVV

Kinase AqueK658.AA MLK 262-284 39 0.284188 0.33 In-house 269-291 (291) Show / Hide
Range on Protein: 262-284
Range on HMM: 269-291/291
Sequence Identity: 39% (9 aa)

LVKECLQNDPAQRPLALTLVERL
| |.| . ||..||     |. |
LMKQCWNQDPHKRPSFRQIVQHL

Kelch_1 AqueK658.AA Kelch_1 416-464 26 0.000161 19.97 Pfam 1-45 (45) Show / Hide
Range on Protein: 416-464
Range on HMM: 1-45/45
Sequence Identity: 26% (13 aa)

GMHSASAIVLEGKLYIGGGMTKDLQSDRILYEYDISGMVHKWTALPTCP
  ..... |..||.|. ||..   |. .  . || .   ..|| .|. |
PRCGHGVCVHNGKIYVIGGCDG--QYLNSVECYDPE--TNQWTRCPPMP

Kelch_1 AqueK658.AA Kelch_1 514-559 36 3.6e-08 33.08 Pfam 1-45 (45) Show / Hide
Range on Protein: 514-559
Range on HMM: 1-45/45
Sequence Identity: 36% (17 aa)

SRQNPCVASHNLSLIVAGGYRNKQVLADVEVFDQATFQWISFPPLL
 | . .|..||  . |.||. . | | .||..|  | ||   ||. 
PRCGHGVCVHNGKIYVIGGCDG-QYLNSVECYDPETNQWTRCPPMP

Kelch AqueK658.AA Kelch 526-572 27 1.9e-07 32.02 SMART 1-55 (55) Show / Hide
Range on Protein: 526-572
Range on HMM: 1-55/55
Sequence Identity: 27% (15 aa)

SLIVAGGYRN--------KQVLADVEVFDQATFQWISFPPLLVPTSCASCCVVRD
 ..|.||. .        .|.|. ||..|  | .| . ||. .| . ...||. .
CIYVIGGWNGNHCCEPGEMQCLNSVECYDPETNKWRMCPPMPYPRCYHGVCVHNG

Kelch AqueK658.AA Kelch 476-525 21 0.007097 7.41 SMART 1-55 (55) Show / Hide
Range on Protein: 476-525
Range on HMM: 1-55/55
Sequence Identity: 21% (12 aa)

TLVLVGGLEIMTR------KTSNKLFMWDKERQEWCNTLPSMNVSRQNPCVASHNL
 .  .||    ..       ..|. ...| |...| . .|.|.. | . .|..|| 
CIYVIGGWNGNHCCEPGEMQCLNSVECYDPETNKWRM-CPPMPYPRCYHGVCVHNG

Kelch_1 AqueK658.AA Kelch_1 561-580 30 0.027813 11.95 Pfam 1-20 (45) Show / Hide
Range on Protein: 561-580
Range on HMM: 1-20/45
Sequence Identity: 30% (6 aa)

PTSCASCCVVRDILYILGGS
| .....||. . .|. ||.
PRCGHGVCVHNGKIYVIGGC

Kelch_1 AqueK658.AA Kelch_1 466-512 21 0.031625 11.75 Pfam 3-45 (45) Show / Hide
Range on Protein: 466-512
Range on HMM: 3-45/45
Sequence Identity: 21% (10 aa)

AYFSMGVVNKTLVLVGGLEIMTRKTSNKLFMWDKERQEWCNTLPSMN
..... |.|  .  .||        .|. ...| | ..|.  .|.|.
CGHGVCVHNGKIYVIGGCDG---QYLNSVECYDPETNQWT-RCPPMP

Kelch_1 AqueK658.AA Kelch_1 618-659 23 0.000748 17.58 Pfam 7-45 (45) Show / Hide
Range on Protein: 618-659
Range on HMM: 7-45/45
Sequence Identity: 23% (10 aa)

AVPSSNFLLAVGGAMAGSNTPTRSVYVYFPEMSRWSFLCEMP
..   . . ..||      ....||..| ||  .|... .||
VCVHNGKIYVIGGCDG---QYLNSVECYDPETNQWTRCPPMP

Kelch AqueK658.AA Kelch 624-672 21 0.001369 13.68 SMART 1-55 (55) Show / Hide
Range on Protein: 624-672
Range on HMM: 1-55/55
Sequence Identity: 21% (12 aa)

FLLAVGGAMA------GSNTPTRSVYVYFPEMSRWSFLCEMPTAHAKCIAAVLSA
 . ..|| .       |... ..|| .| ||   |. .  ||.... . ..|.  
CIYVIGGWNGNHCCEPGEMQCLNSVECYDPETNKWRMCPPMPYPRCYHGVCVHNG

Kelch_1 AqueK658.AA Kelch_1 662-680 26 48.038179 0.34 Pfam 1-19 (45) Show / Hide
Range on Protein: 662-680
Range on HMM: 1-19/45
Sequence Identity: 26% (5 aa)

HAKCIAAVLSAGRMIVIGG
.  . ...   |.. ||||
PRCGHGVCVHNGKIYVIGG