Gene AqueK629 (A.queenslandica)

AqueK629

Species: A.queenslandica
Alias: AqueK629
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH498

Sequence

Name Sequence Type Origin Length Description Download
AqueK629.AA Protein None 572 None Fasta, JSON
AqueK629.kin_dom Protein Kinase Domain None 144 None Fasta, JSON

Protein domain

Protein domains of AqueK629.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK629.AA TKL 1-211 21 4.7e-32 112.71 In-house 81-364 (364) Show / Hide 
Range on Protein: 1-211
Range on HMM: 81-364/364
Sequence Identity: 21% (62 aa)

MQHHPNIVNFLG---------VYYAP--HSTLPTLVMEYLPR-T-LTSCLESNSLKIQMKYAILLDVAKGLIYLHQKN------PCVIHRDLTANNVLLT
. .||||| |.|         | . |  ... . .|||| |. . |   .      .. .  . ||.|.|. |||..|      | .|||||. .|.|. 
RLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVD

HNL-------------LQAKISDLGVSRKW----ADTMLTKAPG------------NTMV-----MPPEALKDNP---------------VYDHKLDVFS
 |.               .||.|.| || .     ...  .. .            .| .     |.||.|....                |. | ||.|
ENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYS

YGCLILHVLTGQFPRPTNQFK--PKPSRKSA----DDYIKVPECNRRSYYI---------EKLPQV-SDLTSLVKQCLSDDPTKRPEMKIASSII
.| ..  .||..       ..  | .... .    .. ..| . ..|              . |..  .. .| ..| . ||.||| ..   ...
FGIVLWEILTRCR-----PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK629.AA TK 1-137 17 1e-24 79.17 In-house 95-384 (486) Show / Hide 
Range on Protein: 1-137
Range on HMM: 95-384/486
Sequence Identity: 17% (52 aa)

MQH----HPNIVNFLG------------VYYAPHSTLPTLVMEYLPRT-----LTSCLESNS--------------------------------------
|.|    |||||...|            | .  |.  . .|||| |       | . | ...                                      
MCHSLGHHPNIVRLYGVCTQGEPKPCFEV-V-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNS

---------------------------------------LKIQMKYAILLDVAKGLIYLHQKNP----CVIHRDLTANNVLLTHNLL----------QAK
                                       |  . .  . ...|.|. |||.||      ..|||| | |.|...|.           ..|
PCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCK

ISDLGVSR-------KWAD---TMLTKAPGNTMV--------------------------MPPEALKDNP--------VYDHKLDVFSYGCLI
|.| | ||       .  .      .| .. |..                          |.||.|.|.         .. .| ||.|.|.|.
IADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM
Kinase AqueK629.AA HH498 45-146 39 5.2e-23 69.43 In-house 121-225 (284) Show / Hide 
Range on Protein: 45-146
Range on HMM: 121-225/284
Sequence Identity: 39% (42 aa)

QMKYAILLDVAKGLIYLHQ-KNPCVIHRDLTANNVLLTHNLLQAKISDLGVSR---KWADTMLTKAPGNTMVMPPEALKDNPVYDHKLDVFSYGCLILHV
| |  | .|||.|  |||    . .|||||.  |.|. |    |.. | | ||      |  .|| |||   | ||  . .  |. | |||||.  |   
QSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILI-HEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEM

LTGQFP
.|.  |
HTREVP
Kinase AqueK629.AA MLK 4-146 27 7.2e-23 76.25 In-house 64-235 (291) Show / Hide 
Range on Protein: 4-146
Range on HMM: 64-235/291
Sequence Identity: 27% (48 aa)

HPN----IVNFLGVYYAPHSTLPTLVMEYLPR-TLTSCLESNS---------------LKIQMKYAILLDVAKGLIYLHQKNP-CVIHRDLTANNVLLTH
|||    |. |.||   | . .  .||||..   | . | ...                . . .  . |..|.|. |||.. |  .|||||   |.|...
HPNNHPCIIQFYGVCLQPPCHF-CIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE

-----NLLQAKISDLGVSRKWADT-M-LTKAPGNTMVMPPEAL--KDNPVYDHKLDVFSYGCLILHVLTGQFP
     . ...||.| |.||.| ..    ....|.   | ||..  . .  |. | ||.|.| ..  .||.. |
ICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase AqueK629.AA Ciliate-E2 4-202 18 2.6e-22 73.39 In-house 91-353 (365) Show / Hide 
Range on Protein: 4-202
Range on HMM: 91-353/365
Sequence Identity: 18% (55 aa)

HPNIVNFLGVYYAPHSTLPTLVMEYLPR-TLTSCLESNSLK----------IQMKYA--ILLDVAK---------------GLIYLHQKNPCVIHRDLTA
||||...  ...    .   |||||.   .| .....|..|          . .| .  |   ...               .| |||.||. .||||.  
HPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKP

NNVLLTHNLLQAKISDLGVSRKWAD-----------TMLTKAP-----------------------GNTMVMPPEALKDNPV--------YDHKLDVFSY
.|.|.       ||.|.| |.|  |            ...                          |. . |.|| |.  .         ||.| |..| 
ENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL

GCLILHVLTGQFPRPTNQFKPKPSRKSADDYIKVPECNRRSYYIEKLPQVSDLT--------------------------SLVKQ----CLSDDPTKRP
|...   |.|..|                             ..... .  |.                            | |.    .|  || ||.
GVILYEMLFGKPPF----------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRI
Kinase AqueK629.AA TKL-Unique 3-134 30 3.5e-22 75.12 In-house 53-215 (290) Show / Hide 
Range on Protein: 3-134
Range on HMM: 53-215/290
Sequence Identity: 30% (49 aa)

H-HPNIVNFLGVYY--APHSTLPTLVMEYLPR-TLTSCLE---------SNSLKI--QMKYAILLDVAKGLIYLHQKNPCVIHRDLTANNVLLTHNL---
| ||||| . |.     ..     .||||.|. .| . |          .|..|.  |... . .|.|.|..||| ..| .|||||.  |.|.. |.   
HYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIA

-LQAKISDLGVSRKWADTMLTKAP-----------GNTMVMPPEALKDN-PVYDHKLDVFSYG
 ...||.| | |.  .  . ...            |..  |.|| |..|   |. | ||.|.|
EWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFG
Kinase AqueK629.AA STE 3-202 22 5.5e-22 74.5 In-house 87-346 (359) Show / Hide 
Range on Protein: 3-202
Range on HMM: 87-346/359
Sequence Identity: 22% (62 aa)

H-HPNIVNFLGVYYAP------HSTLPTLVMEYLP-RTLTSCLESN-SLKIQMK--------------YAILLDVAKG-LIYLHQKNPCVIHRDLTANNV
| |||||...| |.        ...|  ..|||..  .|.. .... . . ...               .|. .. || | |||...  .||||. . |.
HMHPNIVKYYGCYFKEGHNHKNDDEL-WICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANI

LLTHNLLQAKISDLGVSRKWADTML------------TKA-PGNTMV----MPPEALKD-----NPVYDHKLDVFSYGCLILHVLTGQFP----RPT--N
||      .|..| ||. . .|.|             | .   ||.|    | || ..      .. || | |. | ||.|.. .||. |     |.   
LL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTPWMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAM

QFKPKPSRKSA---------DDYIKVPE-----CNRRSYYIEKLPQV------------SDLTSLVKQCLSDDPTKRP
  .|. .....         ..  . |.     .  .|        .            ...   ...||  || |||
FMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEM-IS--------YGGSGTTYPHKWSPEFKDFINKCLQKDPNKRP
Kinase AqueK629.AA LRRK 3-146 31 6.7e-22 74.24 In-house 115-282 (351) Show / Hide 
Range on Protein: 3-146
Range on HMM: 115-282/351
Sequence Identity: 31% (54 aa)

HHPNIVNFLGVYYAPHSTLPTLVMEYLPR-TLTSCLESNS----------LKIQMKYAILLDVAKGLIYLHQKNPCVIHRDLTANNVLL-TH--------
.|||||. .|.   |    ...||||.|  .| . |....          .. ..|. | |..|||. ||| .|| .|||||.  |.|| ..        
NHPNIVSLKGFCIHP----LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNY

--NLLQAKISDLGVSR--KWADTMLTKAPGNTMV-MPPEALKDN--PVYDHKLDVFSYGCLILHVLTGQ-FP
  .   |||.| | ||  .   . ..|  . . . | || ...|   .|. | |..|.| .. . ||.| .|
PNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP
Kinase AqueK629.AA Pkinase_Tyr 3-137 32 2.5e-21 72.84 Pfam 62-204 (270) Show / Hide 
Range on Protein: 3-137
Range on HMM: 62-204/270
Sequence Identity: 32% (49 aa)

HHPNIVNFLGVYY--APHSTLPTLVMEYLPR-TLTSCLESN-----SLKIQMKYAILLDVAKGLIYLHQKNPCVIHRDLTANNVLLTHNLLQAKISDLGV
||||||...|| .    ..  . .|||| |   | . | ..     .|.....  . ...|||. ||..||   ||||| | |.|.|.|. ..||.| | 
HHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENN-VVKICDFGL

SRKW--ADTMLTKAPGNTMV----MPPEALKDNPVYDHKLDVFSYGCLI
.|     |.  ... |....    |.||.....  . .| || |.| |.
ARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGK-FTTKSDVWSFGVLM
Kinase AqueK629.AA Pkinase 3-202 20 2.2e-20 73.18 Pfam 58-282 (293) Show / Hide 
Range on Protein: 3-202
Range on HMM: 58-282/293
Sequence Identity: 20% (48 aa)

HHPNIVNFLGVYYAPHSTLPTLVMEYLPRTLTSCLESN-------SLKI--QMKYA--ILLDVAKGLIYLHQKNPCVIHRDLTANNVLLTHNLLQA----
.||||| ......  .. .  .||||.. .|. ...         . ..  ... .  ... ...|| |.|..   .|||||   |.|.  |  .     
NHPNIVRLYDWFED-KDHIY-MVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNGHIDACV

KISDLGVSRKWADTMLTKAPGNTMV------MPPEALKDNPVYDHKLDVFSYGCLILHVLTGQFPRPTNQFKPKPSRKSADDYIKVPECNRRSYYIEKLP
||.| |....     . . . .| .      |.|| ..... |..| |..|.||..  .|.|..| |     ... .     . .. ..  .. . .. .
KICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCS

QV-----------------SDLTSLVKQCLSDDPTKRP
                   ... ...| ||  ||.|||
ISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP
Kinase AqueK629.AA TK-Unique 4-137 26 2.7e-20 66.8 In-house 63-229 (294) Show / Hide 
Range on Protein: 4-137
Range on HMM: 63-229/294
Sequence Identity: 26% (46 aa)

HPNIVNFLGVYYAPHSTLPTLVMEYLPRT-LTSCLESNS---------------------------LKIQMKYAILLDVAKGLIYLHQ--KNPCVIHRDL
|||||..||.   .    . ..|||.|.  | ..| ..                            .. .  | .. ..|.|. ||..  |.  ..||||
HPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKK--IVHRDL

TANNVLLTHNLLQAKISDLGVSR-----KWADTMLTKAPGNTMVMPPEALK--DNPVYDHKLDVFSYGCLI
 | |||||.. ...||.|.| .|     .  ..| .. .   . |.||.||  ... .  | || |.|.|.
CARNVLLTED-KVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLM
Kinase AqueK629.AA DRK 4-134 34 7.4e-19 60.53 In-house 56-189 (258) Show / Hide 
Range on Protein: 4-134
Range on HMM: 56-189/258
Sequence Identity: 34% (48 aa)

HPNIVNFLGVYYAPHSTLPTLVMEYLPR-TLTSCLESNSLKIQ--MKYAILLDVAKGLIYLHQKNPCVIHRDLTANNVLLTHNLLQAKISDLGVSR---K
||||. |.|    | . .   .|||.||  | . |   |....      . .|.|||.||||  || .|||||   | ||     | |..| | |    |
HPNICQFMGTCNNPPDIC--ICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHN-LLVDEHWQVKVADFGLSTRFKK

WADTMLTKAP-GNTMVMPPEALKDNPVYDHKLDVFSYG
  .   .. . | .    || | . . |  | ||.|..
HKQHKFAMTMCGTPCWTAPEVLRNQR-YTEKADVYSFA
Kinase AqueK629.AA S_TKc 1-215 18 2.8e-13 17.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-215
Range on HMM: 1-231/231
Sequence Identity: 18% (52 aa)

MQ-------------------------------------------HHPNIVNFLGVYYAPHSTLPTLVMEYLPR---TLTSCLESNS-------LKIQMK
 .                                           ||||||....|..    .   .||||..    .| . ....        .   . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HA

YAILLDVAKGLIYLHQKNPCVIHRDLTANNVLLTHNLLQAKISDLGVSRKWADTMLTKAPGNTMV-----MPPEALKDNPVYDH-KLDVFSYGCLILHVL
  ..  ....| |.|..   .|||||   |.||..   . ||.| |..|.           .|..     |.|| |     |.. | |. | ||..   |
RFYMYQICCALEYCHSH--GIIHRDLKPENILLDE---HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

TGQFPRPTNQFKPKPSRKSADDYIKVPECNRRSYYIEKLPQVSDLTSLVKQCLSDDPTKRPEMKIASS-----IIEGFI
.|. | |             .  .|.                ... .....||  ||.|||    |        .  ..
CGYPPFP-----------QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK629.AA TyrKc 1-211 23 1e-12 -17.2 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-211
Range on HMM: 1-280/280
Sequence Identity: 23% (67 aa)

MQ-----------------------------------------------HHPNIVNFLGVYYAP-----HSTLPTLVMEYLPR-TLTSCLESNS--LKIQ
 .                                               ||||||...||   .      .  . .|||| |   | . | ..   |. .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

MKYAILLDVAKGLIYLHQKNPCVIHRDLTANNVLLTHNLLQAKISDLGVSRKWADT--------MLTKA---PGNTMV----MPPEALKDNPVYDHKLDV
 .  . ...|.|  |||.|  ..||||| | |.|...|. ..|||| | ||.. |         . .|.    |.||.    |.||..... .. .| ||
DLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG-KFTTKSDV

FSYGCLILHVLT-GQFPRPTNQFKPKPSRKSADDYIKVPECNRRSYYIEKLPQ---------VSDLTSLVKQCLSDDPTKRPEMKIASSII
.|.| ..  ..| || | |   ..         . . | |. .. |. .. |           ... .. |||   || .|| ..   ...
WSFGVCMWEIFTYGQQPYPGMIQQ-------MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK629.AA DRK 187-213 29 0.000305 10.31 In-house 232-258 (258) Show / Hide 
Range on Protein: 187-213
Range on HMM: 232-258/258
Sequence Identity: 29% (8 aa)

TSLVKQCLSDDPTKRPEMKIASSIIEG
. | . |.. ||. || |     ..| 
IQLMNDCWNEDPQHRPSMQECLERLEA
Kinase AqueK629.AA MLK 188-211 37 0.000803 9.29 In-house 268-291 (291) Show / Hide 
Range on Protein: 188-211
Range on HMM: 268-291/291
Sequence Identity: 37% (9 aa)

SLVKQCLSDDPTKRPEMKIASSII
.| ||| ..|| ||| ..   .. 
KLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK629.AA LRRK 185-213 24 0.011183 5.28 In-house 323-351 (351) Show / Hide 
Range on Protein: 185-213
Range on HMM: 323-351/351
Sequence Identity: 24% (7 aa)

DLTSLVKQCLSDDPTKRPEMKIASSIIEG
.. .| ..| . ||.||| .    .... 
MYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK629.AA TK 189-211 30 0.077732 1.07 In-house 464-486 (486) Show / Hide 
Range on Protein: 189-211
Range on HMM: 464-486/486
Sequence Identity: 30% (7 aa)

LVKQCLSDDPTKRPEMKIASSII
| .|| . || .|| ..   . .
LMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK629.AA TK-Unique 185-211 22 0.095984 1.94 In-house 268-294 (294) Show / Hide 
Range on Protein: 185-211
Range on HMM: 268-294/294
Sequence Identity: 22% (6 aa)

DLTSLVKQCLSDDPTKRPEMKIASSII
....| |.|....|..||      ...
EMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK629.AA TKL-Unique 185-202 38 0.371631 0.05 In-house 264-281 (290) Show / Hide 
Range on Protein: 185-202
Range on HMM: 264-281/290
Sequence Identity: 38% (7 aa)

DLTSLVKQCLSDDPTKRP
... | .||  .||..||
EYRDLIQQCWHHDPSQRP
IBR AqueK629.AA IBR 426-476 27 3.975482 2.55 Pfam 1-44 (44) Show / Hide 
Range on Protein: 426-476
Range on HMM: 1-44/44
Sequence Identity: 27% (15 aa)

ECPL--CRTFAERIDANNPCAKCHACSTRKGYEYTFCWYCLEEWKEAPSSK-KC
 ||   |  . |. | .|. ..|. | ..      ||| |.|.| .    . .|
WCPNPDCQYWIEHEDGCNH-MTCPKCGHE------FCWNCKEPWHP---PCYTC
IBR AqueK629.AA IBR 507-540 27 8e-06 19.85 Pfam 1-35 (44) Show / Hide 
Range on Protein: 507-540
Range on HMM: 1-35/44
Sequence Identity: 27% (10 aa)

ACPT--CGKIVEIIPVGCKFVLCPRCKNEYCFLCLK
 ||.  |....|  . . . . ||.|. |.|..|..
WCPNPDCQYWIEHEDGCNH-MTCPKCGHEFCWNCKE
IBR AqueK629.AA IBR 485-545 19 0.000799 6.93 SMART 1-78 (78) Show / Hide 
Range on Protein: 485-545
Range on HMM: 1-78/78
Sequence Identity: 19% (16 aa)

DLLSLRDAPDVILCGKSVPNRRACP--TCGKIVEII--------------PVGCKFVLCP-RCKNEYCFLCLK---SKNNC
.    .   ..| |    |.|. ||   |. ...                ...|. | ||  |. |.|. |..   .  .|
EKYERYMLRSYIECN---PDRKWCPYPDCSMAMRVQEWSCSQCHISQNSDCEDCNRVTCPRKCHHEFCWRCKHPWHPPVSC