Gene AqueK628 (A.queenslandica)
AqueK628
Species: A.queenslandica
Alias: AqueK628
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| AqueK628.AA | Protein | None | 169 | None | Fasta, JSON |
| AqueK628.kin_dom | Protein Kinase Domain | None | 127 | None | Fasta, JSON |
Protein domains of AqueK628.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | AqueK628.AA | TKL | 19-165 | 19 | 2.6e-25 | 88.12 | In-house | 134-364 (364) | Show / Hide |
Range on Protein: 19-165
Range on HMM: 134-364/364
Sequence Identity: 19% (46 aa)
ILSISLDVACALNYLHLFKP-----HPILHRDVSSANVLLQPMGG--------GLGGWKAKVSDYGSANLQHLI---------------------IRSVN
.....||.|...|||| .| ||.||| |.|.|. . |..|..|.| . . ..
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQ
PGGPLYAAPEA--GNP--------------REHSPSMDVFSYGVLLLEMITRRIPLPEER--------------VGLIDGIRR-----------------
| | . |||. |.. .| |...||.|.|..| |..||..| .. .. .| .|
CGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCP
---ASFRYLVERCLIVEYRHRPTMNDIITEL
|.. | ..| . . ||....|. .|
DCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
|
|||||||||
| Kinase | AqueK628.AA | MLK | 19-123 | 31 | 1.3e-16 | 54.25 | In-house | 126-235 (291) | Show / Hide |
Range on Protein: 19-123 Range on HMM: 126-235/291 Sequence Identity: 31% (35 aa) ILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQP-MGGGLGGWKAKVSDYGSANLQHLI-I-RSVNPGGPLYAAPEA---GNPREHSPSMDVFSYGV .....|..| ...||| .|.|| ||| | |.|. . ... ..|..| | . | . . |.| . . |||. | . ||.|.|| AMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGV LLLEMITRRIP .| ||.||..| VLWEMLTREVP |
|||||||||
| Kinase | AqueK628.AA | Dicty5 | 14-123 | 30 | 6.4e-14 | 44.29 | In-house | 101-202 (260) | Show / Hide |
Range on Protein: 14-123 Range on HMM: 101-202/260 Sequence Identity: 30% (34 aa) LAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGLGGWKAKVSDYG-SANLQHLIIRSVNPGGPLYAAPEAGNPREHSPSMDVFSYGV .||. .|.. .|.| .. .|| | |||. | |.|. ||.|. |.| | . .. | . . |.| | . ||.|.|. IAYFQQLHMAIDIAQSMRHLHSMN---IIHRDLKSMNFLITEN------WKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGI LLLEMITRRIP | ||.|| | VLWEMFTRKEP |
|||||||||
| Kinase | AqueK628.AA | LRRK | 22-123 | 29 | 1.3e-12 | 40.96 | In-house | 169-282 (351) | Show / Hide |
Range on Protein: 22-123 Range on HMM: 169-282/351 Sequence Identity: 29% (34 aa) ISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGL------GGWKAKVSDYGSAN----LQH-LIIRSVNPGGPLYAAPEAGNPR---EHSPSMDV |.|..| ...||| ..| ||.||| | |.||. . . .||..|.| ... .. ..| . |.. ||| . | . |. IALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGN--PGWMAPEIMRYNGEEEYTEKVDC FSYGVLLLEMITRR-IP .|.|..| | .||. .| YSFGMILWELLTRQHHP |
|||||||||
| Pkinase | AqueK628.AA | Pkinase | 10-169 | 17 | 2.4e-12 | 44.74 | Pfam | 99-293 (293) | Show / Hide |
Range on Protein: 10-169
Range on HMM: 99-293/293
Sequence Identity: 17% (37 aa)
ESVGL--AYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGLGGWKAKVSDYGSAN---LQHLIIRSVNPGGPLYAAPEAGN-PREHSP
.. .. . . .. . ....|.|.| |.|||. ..|.|. | .. . |..| |.| . . .. | | |.||| . ....|
RHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILID-NNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP
SMDVFSYGVLLLEMITRRIPLPEE-------RVGLIDGIRR-------------------------------ASFRYLVERCLIVEYRHRPTMNDIITEL
. |..|.|..| ||...| | |.. .|. |.. ... ....|| . ||| ....
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT----AEQI
NDT--I
.
LQHPWF
|
|||||||||
| Kinase | AqueK628.AA | STE | 29-160 | 17 | 3.3e-12 | 39.54 | In-house | 163-350 (359) | Show / Hide |
Range on Protein: 29-160 Range on HMM: 163-350/359 Sequence Identity: 17% (36 aa) A-LNYLHLFKPHPILHRDVSSANVLLQPMGGGLGGWKAKVSDYGSAN-LQHLII-----------------RSVNPGGPLYAAPEAGNP------REHSP . |.||| . | |||. .||.|| .| .| | . |.. . | | | . ||| .. ... GLLYYLHSHH---IIHRDIKPANILL-----------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDT SMDVFSYGVLLLEMITRRIPL---PEERVGLIDGIRR-------------------------------------------ASFRYLVERCLIVEYRHRPT . |. | | ...||.| . |. . |. . . .|. ...||. ....||| KCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPT MND .. ASQ |
|||||||||
| Kinase | AqueK628.AA | CZAK | 20-53 | 54 | 2.8e-11 | 37.38 | In-house | 108-142 (279) | Show / Hide |
Range on Protein: 20-53 Range on HMM: 108-142/279 Sequence Identity: 54% (19 aa) LSISLDVACALNYLHL-FKPHPILHRDVSSANVLL ... .|.| |||| .|| |||||| || |.|| WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILL |
|||||||||
| Kinase | AqueK628.AA | TKL-Unique | 19-123 | 26 | 5.7e-11 | 35.1 | In-house | 112-233 (290) | Show / Hide |
Range on Protein: 19-123 Range on HMM: 112-233/290 Sequence Identity: 26% (34 aa) ILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGLGG-----WKAKVSDYGSANLQHLIIRSVNP-----------GGPLYAAPEAGNP--RE .... .|.| ...||| .| |.||| | |.|. . |..|..| | . .. |... | | ....||| . RVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVD------NNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQ HSPSMDVFSYGVLLLEMITRRI------P | . ||.|.|. | |..|| | | YSEKSDVYSFGIVLWEIATRKITKTYKKP |
|||||||||
| Kinase | AqueK628.AA | HH498 | 17-71 | 41 | 2.4e-10 | 28.58 | In-house | 121-169 (284) | Show / Hide |
Range on Protein: 17-71 Range on HMM: 121-169/284 Sequence Identity: 41% (23 aa) PAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGLGGWKAKVSDYG . .. ||.||| |||| .||| ||| | |.|. | .|.| |.| QSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDG------HAVVADFG |
|||||||||
| Kinase | AqueK628.AA | IRAK | 20-53 | 45 | 1.7e-08 | 26.37 | In-house | 112-146 (317) | Show / Hide |
Range on Protein: 20-53 Range on HMM: 112-146/317 Sequence Identity: 45% (16 aa) LSISLDVACALNYLHLFKPH-PILHRDVSSANVLL .||.. ||....|| . | || |.|..|||.|| CSICWGTACGIQFLHQNHPCTPIIHGDIKSANILL |
|||||||||
| S_TKc | AqueK628.AA | S_TKc | 1-169 | 15 | 2.4e-08 | -54.64 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1-169
Range on HMM: 1-231/231
Sequence Identity: 15% (38 aa)
M--------------------------------------------------------------------PT---SLRKELESVG-------LAYPAILSI
.. .|.. ... | . . ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY
SLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGLGGWKAKVSDYGSANLQHLIIRSVNPGGPLYAAPEAGNPREHSP-SMDVFSYGVLLLEMITRR
..|||.|.| . |.|||. .|.|| |..| |.| . . | | | ||| ... . |. | |..| ||....
MYQICCALEYCHSHG---IIHRDLKPENILLDE--------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY
IPLPEERVGLIDGIRRASFRYLVERCLIVEYRHRPTMNDIIT-----ELNDTI
| | . ... |. ... ....|| .. ..||| .. . . .
PPFP-QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| Kinase | AqueK628.AA | LISK-DD1 | 104-123 | 65 | 6.9e-08 | 24.84 | In-house | 211-230 (290) | Show / Hide |
Range on Protein: 104-123 Range on HMM: 211-230/290 Sequence Identity: 65% (13 aa) SMDVFSYGVLLLEMITRRIP | ||||.|..|||.|||..| SCDVFSFGMVLLELITRKKP |
|||||||||
| TyrKc | AqueK628.AA | TyrKc | 3-165 | 14 | 5.2e-05 | -141.61 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 3-165 Range on HMM: 1-280/280 Sequence Identity: 14% (42 aa) TSLRKELES-------------------------------------VG------------------------------------------------LAYP .| |.| . .| | . ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK AILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGLGGWKAKVSDYG-SANLQHL--------IIRS----VNPG-GPL-YAAPEAGNPREHS ||.....|| .||| ... ||| |.|. . .|.|| | | .. . .|. . |. |||. | .. . DLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT PSMDVFSYGVLLLEMITRRIPLPEE-----------RVGLIDGIRRASFRY---------------LVERCLIVEYRHRPTMNDIITEL . ||.|.||.. |. |. . ... . . .| |. . . ..| . |||...|. .. TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||
| Kinase | AqueK628.AA | HH498 | 106-123 | 55 | 6.6e-05 | 11.06 | In-house | 208-225 (284) | Show / Hide |
Range on Protein: 106-123 Range on HMM: 208-225/284 Sequence Identity: 55% (10 aa) DVFSYGVLLLEMITRRIP |||||. . || ||..| DVFSYAMCIWEMHTREVP |
|||||||||
| Kinase | AqueK628.AA | LISK-DD1 | 20-71 | 42 | 0.000196 | 12.22 | In-house | 126-172 (290) | Show / Hide |
Range on Protein: 20-71 Range on HMM: 126-172/290 Sequence Identity: 42% (22 aa) LSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGLGGWKAKVSDYG ..|.||.||| ||| . |.||| | | |. | .. |..|| | | VKIALDIACAMAYLHSKN---IIHRDLKSKNILVDENGDSQ--WRIKVCDFG |
|||||||||
| Kinase | AqueK628.AA | IRAK | 90-119 | 34 | 0.000883 | 9.47 | In-house | 188-219 (317) | Show / Hide |
Range on Protein: 90-119 Range on HMM: 188-219/317 Sequence Identity: 34% (11 aa) YAAPEAGN--PREHSPSMDVFSYGVLLLEMIT | .||. . .. .. ||.| |. ||| .| YMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLT |
|||||||||
| Pkinase_Tyr | AqueK628.AA | Pkinase_Tyr | 5-53 | 26 | 0.004415 | 11.06 | Pfam | 98-144 (270) | Show / Hide |
Range on Protein: 5-53 Range on HMM: 98-144/270 Sequence Identity: 26% (13 aa) LRKE-LESVGLAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLL ||| . | . .|......|....||. . . |||. |.|. LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLV |
|||||||||
| Kinase | AqueK628.AA | CZAK | 90-123 | 32 | 0.016853 | 5.08 | In-house | 188-221 (279) | Show / Hide |
Range on Protein: 90-123 Range on HMM: 188-221/279 Sequence Identity: 32% (11 aa) YAAPEAGNPREHSPSMDVFSYGVLLLEMITRRIP . ||| .. ||.|.| .| ..|| . | WMAPECFKGENYTEKVDVYSFGMILWCIITCDQP |
|||||||||
| Kinase | AqueK628.AA | TKL-Unique | 155-165 | 45 | 0.031064 | 3.9 | In-house | 280-290 (290) | Show / Hide |
Range on Protein: 155-165 Range on HMM: 280-290/290 Sequence Identity: 45% (5 aa) RPTMNDIITEL ||. ..||..| RPSFDEIIHRL |
|||||||||
| Kinase | AqueK628.AA | LRRK | 155-167 | 30 | 0.200746 | 0.78 | In-house | 339-351 (351) | Show / Hide |
Range on Protein: 155-167 Range on HMM: 339-351/351 Sequence Identity: 30% (4 aa) RPTMNDIITELND ||....|. | . RPHFSQIVKRLSQ |
|||||||||
| Kinase | AqueK628.AA | MLK | 155-165 | 36 | 0.313517 | 0.18 | In-house | 281-291 (291) | Show / Hide |
Range on Protein: 155-165 Range on HMM: 281-291/291 Sequence Identity: 36% (4 aa) RPTMNDIITEL ||.. |...| RPSFRQIVQHL |
|||||||||
| Kinase | AqueK628.AA | Pkinase_Tyr | 106-120 | 53 | 0.602102 | 3.83 | Pfam | 196-210 (270) | Show / Hide |
Range on Protein: 106-120 Range on HMM: 196-210/270 Sequence Identity: 53% (8 aa) DVFSYGVLLLEMITR || |.|||. |..|. DVWSFGVLMWEIFTY |
|||||||||
| Kinase | AqueK628.AA | Pkinase_Tyr | 154-165 | 41 | 3.408398 | 1.28 | Pfam | 259-270 (270) | Show / Hide |
Range on Protein: 154-165 Range on HMM: 259-270/270 Sequence Identity: 41% (5 aa) HRPTMNDIITEL .|||. .|. .| DRPTFSEIHEQL |
|||||||||