Gene AqueK623 (A.queenslandica)
AqueK623
Species: A.queenslandica
Alias: AqueK623
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| AqueK623.AA | Protein | None | 455 | None | Fasta, JSON |
| AqueK623.kin_dom | Protein Kinase Domain | None | 199 | None | Fasta, JSON |
Protein domains of AqueK623.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | AqueK623.AA | TKL | 21-266 | 18 | 9e-43 | 148.41 | In-house | 1-355 (364) | Show / Hide |
Range on Protein: 21-266
Range on HMM: 1-355/364
Sequence Identity: 18% (71 aa)
LGRGAYGVVTEVIVSG----------TTCAAKKLHPAIIQGYTL-------------------------KRFCDEVLLHSQQRHPNIVLLIG-VYYPRR-
.|.|..|.| . | .. | ||.. . |. ... |....|. ||||||...| . .|.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
---------SKLPMLVMEYLPL-S-LTQCLEREELPLQMKYSILLDVAKGLCYLHGKR------PPIVHRDLTANNVLLTSSYS--------------AK
.. ...|||| | | | . . .. . .. ||.|.|..||| .. |||.||||. .|.|. . . .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK
ISDLGVSRLAD---TFKMHE---------------LTTAPGNAMVMPPEALKDNP---------------VYDHKLDVFSYGCLILHVLTGQFPQPTNQF
|.|.| || . .. . . | |. |.||.|.... |. | ||.|.| .. .||..
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-------
VQEPGKEPFKRVP--------------EWDRRSSYIKNIP--------------KVNELLPLAKHCLSDAPSSRP
|.. | ... .. || .. |...| . |..||
-------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRP
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| Kinase | AqueK623.AA | TK | 18-204 | 17 | 8.1e-33 | 106.77 | In-house | 4-384 (486) | Show / Hide |
Range on Protein: 18-204
Range on HMM: 4-384/486
Sequence Identity: 17% (65 aa)
GKELGRGAYG---VVTEVIVSG---------------------------TTCAAKKLHPAIIQGYTLKR---------------FCDEVLLHSQ--QRHP
||.||.|..| .| . .. | |..| | |.. . . .. .. | . .. .||
GKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHP
NIVLLIGVYYPRRS----------KLPMLVMEYLPL-----SLTQCLE--REE-----------------------------------------------
||| |.|| .. . .|.|||| |. || . | |..
NIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDD
----------------------------LPLQMKYSILLDVAKGLCYLHGKRP----PIVHRDLTANNVLLTSSYS-----------AKISDLGVSR---
|... . . ...|.|. ||| |. .||||| | |.|..... .||.| | ||
LIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGS
--LADTFKMHELTTAPG------------------------NAMV----MPPEALKDNP--------VYDHKLDVFSYGCLI
|| .. .. . .... |.||.|.|. .. .| ||.|.|.|.
GVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM
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| S_TKc | AqueK623.AA | S_TKc | 15-275 | 22 | 4.9e-32 | 113.67 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 15-275
Range on HMM: 1-231/231
Sequence Identity: 22% (64 aa)
KETGKELGRGAYGVVTEVIV--SGTTCAAKKLHPAIIQGYTLKRFCDEVLLHSQQRHPNIVLLIGVYYPRRSKLPMLVMEYLPL---SLTQCLEREE---
| ....|.||.|.| .. .| .| |... .... |. .... .||||| |..|.. . .||||.. .| . ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG
----LPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLGVSRLADTFKMHELTTAPGNAMVMPPEALKDNPVYDH-KLDVFSYG
.| . ... ....| |.| . |.|||| |.||.. ||.| |..|. || | |.|| | |.. | |. | |
LRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSCG
CLILHVLTGQFPQPTNQFVQEPGKEPFKRVPEWDRRSSYIKNIPKVNELLPLAKHCLSDAPSSRPEIVDSYH---------FV
|.. |.|. | | .. ||.. |.. . ..|| |. || . . . ..
CILYEMLCGYPPFP-------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | AqueK623.AA | TKL-Unique | 17-201 | 29 | 2.4e-31 | 107.88 | In-house | 1-215 (290) | Show / Hide |
Range on Protein: 17-201
Range on HMM: 1-215/290
Sequence Identity: 29% (64 aa)
TGKELGRGAYGVVTEVIVSGTTCAAKKLHP-AIIQGYTLKRFCDEVLLHSQQR-HPNIVLLIGVYYPRRSKLP--MLVMEYLPL-SLTQCLE--------
.. .|.|.||.| .. |. | |..|| . . .. | .|| . . . |||||...|. . | .||||.|. || |
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN
---REELPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSS-----YSAKISDLGVSRLADTF---KMHEL-----TTAPGNAMVMPPEALKD
.|..|..... .|.|.|..||| . ||| ||||. |.|... ...||.| | |..... . |. .| |.. |.|| |..
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM
N-PVYDHKLDVFSYG
| |. | ||.|.|
NFCQYSEKSDVYSFG
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| Kinase | AqueK623.AA | Pkinase_Tyr | 16-204 | 28 | 3.3e-27 | 92.79 | Pfam | 2-204 (270) | Show / Hide |
Range on Protein: 16-204
Range on HMM: 2-204/270
Sequence Identity: 28% (59 aa)
ETGKELGRGAYGVVTEVIVS------GTTCAAKKLHPAIIQGY-TLKRFCDEVLLHSQQ-RHPNIVLLIGVYY-PRRSKLPMLVMEYLPL-SLTQCLERE
. ||.||.||.|.| . . ....| |.| . . .. | |. . .| .||||| |.|| . .... ...|||| |. .| | .
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH
-----ELPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLGVSRLADTFKMHELT-TAPGNAMV----MPPEALKDNPVYDHKL
|..... .. ...|||. ||. |. ..|||| | |.|.|.. .||.| | .|. . .. |.... |.||..... . .|
REDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKS
DVFSYGCLI
|| |.| |.
DVWSFGVLM
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| Kinase | AqueK623.AA | LRRK | 15-213 | 25 | 1.3e-26 | 91.2 | In-house | 1-282 (351) | Show / Hide |
Range on Protein: 15-213 Range on HMM: 1-282/351 Sequence Identity: 25% (73 aa) KETGKELGRGAYG-VVTEVIVSG----------------------------TTCAAKKLHPA-----------------------------IIQGYTLKR . ....|||..| .| .. | .. |.||.. .. ... LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA FCD---EVLLHSQQRHPNIVLLIGV-YYPRRSKLPMLVMEYLPL-SLTQCLE---REE-------LPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTAN |. || . | .||||| |.|. |. ..||||.|. .| . |. . . .. ..|. | |..|||. ||| ..|||.||||. FREFRHEVWIMSHLNHPNIVSLKGFCIHPL-----CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSP NVLLTSS------------YSAKISDLGVSR-LADTFKMHELTTAPGNAMVMPPEALKDN--PVYDHKLDVFSYGCLILHVLTGQ-FP |.|| || . |||.| | || .|.| . . || | || ...| .|. | |..|.| .. . ||.| .| NILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP |
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| Kinase | AqueK623.AA | HH498 | 109-213 | 38 | 4.5e-26 | 79.31 | In-house | 120-225 (284) | Show / Hide |
Range on Protein: 109-213 Range on HMM: 120-225/284 Sequence Identity: 38% (41 aa) LQMKYSILLDVAKGLCYLHG-KRPPIVHRDLTANNVLLTSSYSAKISDLGVSRLADTFKMHELTTAPGNAMVMPPEALKDNPVYDHKLDVFSYGCLILHV || | | .|||.| ||| .||.||||. |.|. |.. | | || .| ||| | || . . |. | |||||. | LQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEM LTGQFP .|. | HTREVP |
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| Kinase | AqueK623.AA | STE | 15-213 | 22 | 3.1e-25 | 86.12 | In-house | 1-267 (359) | Show / Hide |
Range on Protein: 15-213
Range on HMM: 1-267/359
Sequence Identity: 22% (61 aa)
KETGKELGRGAYGVVTEVIVS-----------------GTTCAAKKLH---------------PAIIQGYTLKRFCDEVLLHSQQR--HPNIVLLIGVYY
| ...|.||.|.| . |. .| |... . ... .... |. .... . ||||| .| |.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
PR------RSKLPMLVMEYLP-LSLTQCLER-----EELP----------LQMKYSILLDVAKG-LCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLG
...| ..|||.. ||.. ... ..|. . |. .. || | ||| .. |.|||. . |.|| .|..| |
KEGHNHKNDDEL-WICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDFG
VSR-LADTFK-------------MH-ELTTAPGNAMVMPPEALKD-----NPVYDHKLDVFSYGCLILHVLTGQFP
|. |.|. | . .| | | || .. .. || | |. | ||.|.. .||. |
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP
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| Kinase | AqueK623.AA | Dicty4 | 16-201 | 29 | 9.8e-24 | 76.18 | In-house | 2-204 (277) | Show / Hide |
Range on Protein: 16-201 Range on HMM: 2-204/277 Sequence Identity: 29% (61 aa) ETGKELGRGAYGVVTEVIVSGTTCAAKKL--HPAIIQGYTLKRFCDEVLLHSQQRHPNIVLLIGVYY-PRRSK-LPMLVMEYLPL-SLTQCLER------ .....|.|..| | .. |. | ||| | ..|. | || . .. |||||.|. | || . .. |.||.| .| | NIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQ EELPLQ--MKYS---ILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLGVSRLADTFKMHEL--TTAPGNAMVMPPEALKDNPVYDHKLDV .. .|. . . .|.|.|. .||. | |.|||| . | | .. .|..|.| |.. . ..| .|| | . | || . .| |. | || QSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQP-YNEKADV FSYG .|.| YSFG |
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| Kinase | AqueK623.AA | Pkinase | 15-213 | 23 | 2.1e-23 | 83.86 | Pfam | 1-211 (293) | Show / Hide |
Range on Protein: 15-213 Range on HMM: 1-211/293 Sequence Identity: 23% (52 aa) KETGKELGRGAYGVVTEVIVSGTT--CAAKKLHPAIIQGYTLKRFCD--EVLLHSQQRHPNIVLLIGVYYPRRSKLPMLVMEYLPL-----SLTQCLE-R ..|. .|.|..|.| . . || | |.. . ... |. .. .||||| |..... .. . .||||.. .| .. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW EELPL--QMKY--SILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSA----KISDLGVSRLADTFKMHELTTAPGNAMVMPPEALKDNPVYDHKLD .. .. ... .... ...|| |.| . |.|||| |.|. . . ||.| |.....|. . . .|| | |.|| ..... |..| | RHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD VFSYGCLILHVLTGQFP ..|.||.. .|.|..| MWSCGCILYEMLCGRPP |
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| Kinase | AqueK623.AA | Ciliate-E2-Unclassified | 16-221 | 19 | 2.8e-23 | 77.6 | In-house | 2-277 (352) | Show / Hide |
Range on Protein: 16-221
Range on HMM: 2-277/352
Sequence Identity: 19% (53 aa)
ETGKELGRGAYGVVTEVIVSGTT--CAAKKLHPAIIQGYTLKRFCD---EVLLHSQQR------------------HPNIVLLIGVYYPRRSKLPMLVME
. .| .|.|..|.| ... . . | | .. ..|. .... | ... ... ||..... .|. . . . .|||
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVME
YLP-LSLTQCLE------------------REELPLQMKY-----SILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSY---SAKISDLGVSRLADTF
|.. ..| |... |.... | .. . .||.||| | |.|||.. .|.|.... ||.|.| |. ...
YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN
--------------KMHELTTAPGNAMVM----PPEALKDNPVYD---HKLDVFSYGCLILHVLTGQFPQPTNQFVQ
| ....| |. . | .|| |. . .. .| |..| |... |.|..| . |. |
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQ
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| Kinase | AqueK623.AA | TK-Unique | 15-204 | 26 | 8.3e-23 | 75.56 | In-house | 1-229 (294) | Show / Hide |
Range on Protein: 15-204
Range on HMM: 1-229/294
Sequence Identity: 26% (62 aa)
KETGKELGRGAYGVVTEVIVSG-------TTCAAKKLHPAIIQGYTLKRFCDEVLLHSQQR-HPNIVLLIGVYYPRRSKLPMLVMEYLPLS-----LTQC
| |...|.||.| | |.| ..|.| |.. . .. . . | .| .... ||||| ..|. .|..|||.| . | .|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTC
L-----------------------EREELPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLGVSR-LADTFKMHELTT-APGN
..|.. .. |... ..|.|. ||.. | |||||| | |||||. . .||.|.| .| . .. . .. .
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP
AMVMPPEALK--DNPVYDHKLDVFSYGCLI
. |.||.|| ... . | || |.|.|.
IRWMAPESLKCYHGMYHTTKSDVWSFGVLM
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| Kinase | AqueK623.AA | RIPK | 21-213 | 25 | 2.1e-22 | 73.12 | In-house | 1-227 (290) | Show / Hide |
Range on Protein: 21-213 Range on HMM: 1-227/290 Sequence Identity: 25% (57 aa) LGRGAYGVVTEVI-VSGTTCAAKKLHP-----AIIQGYTLKRFCDEVLLHSQQRHPNIVLLIGVYYPR----RSKLPMLVMEYLPL-SLTQCLEREE--- .|.|. | | . .. . .||| | . .. . |. . |. .|| . |. .||. .|||| . || | .. VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ ---LPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLGVSRLADTFKMHE----------LTTAP--GNAMVMPPEALK---DN .|. . .. .. | ||||.. ||| |||| |.|. . . .||.|.|.. . . | . .. | ||||.. . HHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKK P--VYDHKLDVFSYGCLILHVLTGQFP | | . | || |.. .. |||. | PIKVVTPKYDVYSFAIVMWEVLTQKHP |
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| Kinase | AqueK623.AA | TyrKc | 15-275 | 24 | 1.1e-17 | 62.94 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 15-275 Range on HMM: 1-280/280 Sequence Identity: 24% (72 aa) KETGKELGRGAYGVVTEVIVSGTTCAAKKLHPAIIQGYTLKRFCDEVLLHSQQ--RHPNIVLLIGVYYPR-----RSKLPMLVMEYLPL-SLTQCLEREE . ||.||.||.|.| . . . ...| |.|.. .. |..| . .. .||||| |.|| .. .|.|||| |. .| . | . . ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR --LPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLGVSRLADTF----KMHELTTA----PGNAMV----MPPEALKDNPVYD |... . |. ...|.| ||| | ...|||| | |.|... . .|||| | || . .. .. |..|. |.||..... .. PKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG-KFT HKLDVFSYGCLILHVLTGQFPQPTNQFVQEPGKEPFKRVPEWDRRSSYIKNIPK---------VNELLPLAKHCLSDAPSSRPEIVDSYHFV .| ||.|.| .. ..| . . .. | . . ..| |. .. . . | |. . | | |..|| . ... TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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