Gene AqueK600 (A.queenslandica)
AqueK600
Species: A.queenslandica
Alias: AqueK600
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| AqueK600.AA | Protein | None | 799 | None | Fasta, JSON |
| AqueK600.kin_dom | Protein Kinase Domain | None | 199 | None | Fasta, JSON |
Protein domains of AqueK600.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | AqueK600.AA | TKL | 554-790 | 18 | 5e-47 | 162.55 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 554-790
Range on HMM: 1-364/364
Sequence Identity: 18% (68 aa)
LGRGSYAVVTVGIFRD----------LRVAVKSLHNIIISDYNL-------------------------ALFSREMSIASRVRHPNLVQFIGATKVDN--
.|.|....| |..| |||| .. . .. . .|. . || ||||.|||.|. . .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------PLILTELM-STSLNQELRRNRLTNQQILSIAQDVALGLNYLHLFKP-----QPIIHRDVSSPNVLLKPCTG---------AAGFEAKV
. | .|.. || | .|....|.|.|.|.|||| .| |||||| |.|.|.. .| .|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI
ADYGTAKLVQVDS--------------------TGTVMPGNVAYAAPEARDPD----------------QHSPAMDVYSYSVLLMEMTLGSPPEMTMAER
.|.|... .. .. | |. .. |||. . . . |...||||. ..| |. . .|. . ..
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYM
EVQ---------AGSV-----------------------SWSDMKSLIQIGINASPRARLTMAQVIESL
... .. . . .||.|.| .. |..|... .... |
PMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | AqueK600.AA | MLK | 548-740 | 26 | 1.9e-34 | 116.93 | In-house | 1-229 (291) | Show / Hide |
Range on Protein: 548-740 Range on HMM: 1-229/291 Sequence Identity: 26% (61 aa) TLTKEELGRGSYAVVTVGIFRDLR-----VAVKSLHNIIISDYNLA-----LFSREMSIASRVRHPN----LVQFIGATKVD-N-PLILTELMST-SLNQ ...| .| ||. .| | .| . |||| . |. | . | .| ......||| .|| |. . . . .|..| .. ||. IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN ELRRNR---------------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKP-CTGAAGFEAKVADYGTAKLVQVD-STGTVMPGNVAY |. .| . ......| ..| |..||| .|.|||||| |.|.|. | .. .|..| ||.. .. .. . ..|..|. VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW AAPEAR---DPDQHSPAMDVYSYSVLLMEM |||.. .. | . ||.|. |.| || MAPEVIQQFRCEKYSEKCDVWSWGVVLWEM |
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| Kinase | AqueK600.AA | TK | 548-790 | 14 | 2.7e-30 | 98.15 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 548-790
Range on HMM: 1-486/486
Sequence Identity: 14% (69 aa)
TLTKEELGRGSYA---VVTVGIFRDL---------------------------RVAVKSLHNIIISDYNLAL---------------FSREMSIAS--RV
..||.| . .| |. |.. .|||| |. .. . . . .||.. .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
RHPNLVQFIG-ATKVDN------------PLILTELMS-TS----LNQELRRNR----------------------------------------------
.|||.|...| |.... ..|..|.|. . | . ||..|
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------LTNQQILSIAQDVALGLNYLHLFKP---QPIIHRDVSSPNVLLKPCTGAA------GFEAKVADYG---
|| .| | .....| |. ||| . | ..|||. |.|. . |. .|.||.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-----TAKLVQVDSTGTVMPGN---------------------------VAYAAPEARD---------PDQHSPAMDVYSYSVLLMEMT-LG-SPPE--M
|. .. |. ... . . . |||. . .... ||.|. ||. |. .| |. |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM
TM---------------------------------AEREVQAGSVSW------------SDMKSLIQIGINASPRARLTMAQVIESL
. ... .. .| .. |.| .. |. | |..|. | |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | AqueK600.AA | TKL-Unique | 550-740 | 28 | 4.6e-29 | 99.7 | In-house | 1-221 (290) | Show / Hide |
Range on Protein: 550-740
Range on HMM: 1-221/290
Sequence Identity: 28% (63 aa)
TKEELGRGSYAVVTVGIFRDLRVAVKSLH-NIIISDYNLALFSREMSIASRVR-HPNLVQFIGATK---VDNP--LILTELMST-SLNQELR--------
. .|.|.|..| |..| ||.|..| | .| . |..| .. .. . |||.|...|... |..| | .| .. ||. |
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN
---RNRLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGFEAKVADYGTAKLVQVDSTGTVM----------PGNVAYAAPEARD
. |..||....|.|.|.|..||| .| ||||| |.|.|. | . .|..| |..|. ....|. |. ..|||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR
P--DQHSPAMDVYSYSVLLMEM
.| | ||||... | |.
MNFCQYSEKSDVYSFGIVLWEI
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| Kinase | AqueK600.AA | S_TKc | 548-796 | 19 | 1.6e-27 | 98.65 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 548-796
Range on HMM: 1-231/231
Sequence Identity: 19% (52 aa)
TLTKEELGRGSYAVVTVGIFRD--LRVAVKSLHNIIISDYNLALFSREMSIASRVRHPNLVQFIGATKVDNPLILTELMST---SLNQELRRNR------
...|.|....| .. .. .||.| .. . ||..| .. .|||.|..... |. . .|.... .| . .....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF
-LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGFEAKVADYGTAKLVQVDSTGTVMPGNVAYAAPEARDPDQHSP-AMDVYSYS
.. .. .... ....|.|.| . |||||. |.|| . |..| | |... | . | | ||| .... . |..|
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG
VLLMEMTLGSPPEMTMAEREVQAGSVSWSDMKSLIQIGINASPRARLTMAQVIE---SLKRINIF
..| || | || .. . ...|..|. . |. |.| .. . | |
CILYEMLCGYPPFP-QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | AqueK600.AA | CZAK | 549-740 | 29 | 6.9e-25 | 87.39 | In-house | 1-215 (279) | Show / Hide |
Range on Protein: 549-740 Range on HMM: 1-215/279 Sequence Identity: 29% (63 aa) LTKE-ELGRGSYAVVTVGIFRDLRVAVKSLHNIIISDYNL----ALFSREMSIASRVRHPNLVQFIGATKVDN---PLILTELMS-TSLNQELR-RNRLT |. . . |.| . | . | ||.| .| . . | .| || | .||| |||.|| |. | .| | || . | . . LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYH NQ---QILSIAQDVALGLNYLHL-FKPQPIIHRDVSSPNVLLKPCTG--------AAGFEAKVADYGTAKLVQVDSTG-TVMPGNVAYAAPEARDPDQHS | ...| |.| | |||| .|| ||.||| || |.|| .|..|.| .. . | | ... ||| . . KQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYT PAMDVYSYSVLLMEM . ||||. .| .. EKVDVYSFGMILWCI |
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| Kinase | AqueK600.AA | Dicty4 | 550-668 | 32 | 3.3e-22 | 71.02 | In-house | 3-139 (277) | Show / Hide |
Range on Protein: 550-668 Range on HMM: 3-139/277 Sequence Identity: 32% (45 aa) TKEELGRGSYAVVTVGIFRDLRVAVKSL--HNIIISDYNLALFSREMSIASRVRHPNLVQFIGA-T----KVDNPLILTELM-STSLNQELRR------N . ...|.||.. | |. | |||| | ||. . . | | .| .| . ||||...| || | . ..| ||.| ...| |. IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ RLTNQ--QILS---IAQDVALGLNYLHLFKPQPIIHRD . . . |.. .| |.|.|.|.|| | ||||| SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRD |
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| Kinase | AqueK600.AA | STE | 549-750 | 17 | 6.7e-22 | 74.19 | In-house | 1-271 (359) | Show / Hide |
Range on Protein: 549-750 Range on HMM: 1-271/359 Sequence Identity: 17% (50 aa) LTK-EELGRGSYAVVTVGIFR-----------------DLRVAVKSLH---------------NIIISDYNLALFSREMSIASRVR--HPNLVQFIGATK ... |..|.|.. .| .. . ..|.| .. . .. . .. . .|..| .. . ||| |...|. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF VD--------NPLILTELMS-TSLNQELRRN---------------RLTNQQILSIAQDVALG-LNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGFEAK .. . | |.|. || . .... |. .|| |.... | |.||| . |||||. . |.|| .| KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL----------VK VADYGTAKLVQ-----------------VDSTGTVMPGNVAYAAPEARDP------DQHSPAMDVYSYSVLLMEMTLGSPPEMTM .| |... .. .. . . | . ||| .. .... |..| ...|| | || ..| LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDM |
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| Pkinase_Tyr | AqueK600.AA | Pkinase_Tyr | 547-740 | 24 | 1.4e-21 | 73.68 | Pfam | 1-207 (270) | Show / Hide |
Range on Protein: 547-740 Range on HMM: 1-207/270 Sequence Identity: 24% (54 aa) VTLTKEELGRGSYAVVTVGIFR------DLRVAVKSLHNIIISDYN--LALFSREMSIASRV-RHPNLVQFIGATK-VDNP---LILTELMST-SLNQEL .|. ..||.|.. .| |. . .. ||||.| . .. . .. | ||..| . .|||.|...|. . | .| .|.| .| | ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL RRN-----RLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGFEAKVADYGTAKLVQVDSTG-TVMP---GNVAYAAPEARDPDQ |.. .|| ...|......| |..||. . .||||. |.|.. .. .|..| | |.... |.. .. . |||. RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE-----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK HSPAMDVYSYSVLLMEM . . ||.|. ||. |. FTTKSDVWSFGVLMWEI |
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| Kinase | AqueK600.AA | Dicty5 | 585-740 | 28 | 1.1e-19 | 64.43 | In-house | 38-196 (260) | Show / Hide |
Range on Protein: 585-740 Range on HMM: 38-196/260 Sequence Identity: 28% (47 aa) YNLALFSREMSIASRVR--HPNLVQFIGATKVDNPL--ILTELMST-SLNQELR--RN----RLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPN ... | || | | . |||.. . || . . ..||. . || |. |. . |.|..| |.| .. .|| |||||. | | FDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMN---IIHRDLKSMN VLLKPCTGAAGFEAKVADYGTAKLVQVDSTGTVMPGNVAYAAPEARDPDQHSPAMDVYSYSVLLMEM .|. ...|. |.|| | |. | .. |.| ||||. . | || FLI-----TENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEM |
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| Kinase | AqueK600.AA | Pkinase | 548-746 | 24 | 4.3e-18 | 65.05 | Pfam | 1-211 (293) | Show / Hide |
Range on Protein: 548-746 Range on HMM: 1-211/293 Sequence Identity: 24% (53 aa) TLTKEELGRGSYAVVTVGIFRDLR--VAVKSLHNIIISDYNLALFSR--EMSIASRVRHPNLVQFIGATK-VDNPLILTELMST-----SLNQELR---R ... .|.||...| .. .. . |||| . ... . | | .| |..||| |..... |.. . .|.. .| .. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH NRL--TNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGFEAKVADYGTAKL--VQVDSTGTVMPGNVAYAAPEA-RDPDQHSPAMD ... . ... ... .. ||.|.| |||||. . |.|.. .| . |..| | ||. .| |. | |.||| |. ..|. | GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD VYSYSVLLMEMTLGSPP ..|. ..| || .| || MWSCGCILYEMLCGRPP |
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| Kinase | AqueK600.AA | TK-Unique | 548-746 | 22 | 4.7e-18 | 58.94 | In-house | 1-239 (294) | Show / Hide |
Range on Protein: 548-746 Range on HMM: 1-239/294 Sequence Identity: 22% (56 aa) TLTKEELGRGSYAVVTVGIFR--------DLRVAVKSLHNIIISDYNLALFSREMSIASRVR-HPNLVQFIGATK-VD-NPLILTELMSTS-LNQELRRN ....|.|.. | | .. . .|||| .... .| . | .| .. . . |||.||..|.. | ...|. | .. . | ||.. LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVK-MLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC R---------------------------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGFEAKVADYGTAKLVQ----VDSTG | .. .. ...| ..| |..||. .. |.|||... |||| ....|..|.| |. |. ..... RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQ-RKKIVHRDLCARNVLLTE-----DKVCKICDFGMARDVYTNGVYSMMC TVMPGNVAYAAPEA-R--DPDQHSPAMDVYSYSVLLME-MTLGSPP . . ... |||. . . |.. ||.|. ||. | .|||..| SQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACP |
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| Kinase | AqueK600.AA | LRRK | 548-737 | 21 | 6e-18 | 60.06 | In-house | 1-272 (351) | Show / Hide |
Range on Protein: 548-737
Range on HMM: 1-272/351
Sequence Identity: 21% (60 aa)
TLTKEELGRGSYA-VVTVGIFRD----------------------------LRVAVKSLHN--------------------------------IIISDYN
|..|||... .| ...|. ||.|... .. . .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA
LALFSREMSIASRVRHPNLVQFIGATKVDNPLIL-TELMST-SLNQELR---RNR-------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNV
. .| .|..| |. .|||.|. .| . .||.. .|... .|.. |. ... .. . .| || ..| |..||| ..| |||||| |||.
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNI
LL-KPCTGA------AGFEAKVADYGTAKLVQVDSTG--TVMPGNVAYAAPEARDPD---QHSPAMDVYSYSVLL
|| . .. | ||.||.|. . |.. .| . || . ||| . . . . |.||. ..|
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMIL
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| Kinase | AqueK600.AA | TyrKc | 548-790 | 21 | 3e-17 | 56.15 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 548-790
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)
TLTKEELGRGSYAVVTVGIFRDLRVAVKSLHNIIISDYNLALFSREMSIASRV--RHPNLVQFIGATKV--------DNPLILTELMST-SLNQELRRNR
...||.| . .| |. . . ||||.|.. .. | ||..| ... .|||.|...|. . ..|..|.|. .|.. ||..|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR
--LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGFEAKVADYGTAKLVQVD-------STGTV-----MP--GNVAYAAPEARD
|.... ||.. ..| | .||| ..|||| |.|.. .|..| | .. . | .. .. . |||. .
PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN
PDQHSPAMDVYSYSVLLMEM-TLGSPPE-------MTMAE--REVQAG------SV--------SWSDMKSLIQIGINASPRARLTMAQVIESL
... ||.|. |.. |. |.| .| |. .| . |..| ..| .... .. | | |.....| .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | AqueK600.AA | MLK | 765-790 | 26 | 0.005621 | 6.32 | In-house | 266-291 (291) | Show / Hide |
Range on Protein: 765-790 Range on HMM: 266-291/291 Sequence Identity: 26% (7 aa) MKSLIQIGINASPRARLTMAQVIESL .|.|... |. |. | ...|... | WKKLMKQCWNQDPHKRPSFRQIVQHL |
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