AqueK599

Species: A.queenslandica
Alias: AqueK599
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-C

Sequence

Name Sequence Type Origin Length Description Download
AqueK599.AA Protein None 230 None Fasta, JSON
AqueK599.kin_dom Protein Kinase Domain None 199 None Fasta, JSON

Protein domain

Protein domains of AqueK599.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK599.AA TKL 26-218 22 3e-41 143.37 In-house 1-288 (364) Show / Hide
Range on Protein: 26-218
Range on HMM: 1-288/364
Sequence Identity: 22% (66 aa)

LGRGSYAVVTVGIFRG----------LRVAVKSLHTIIISDYNL-------------------------GMFSREMSIASRLHHPNLVQFIGATK-----
.|.|....|  |..||            |||| ...   .  ..                           . .|. . |||.|||.|||.|. .     
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------VGNPLILTELI-STSLNQELHRNQLTNQQILSIAQDVALGLNYLHLFKP-----QPIIHRDVSSPNVLLKPCIGP---------AGYEAKV
          |.. | .|..   ||   ||      .|....|.|.|.|.||||  .|      ||||||  |.|.|..    .         | . .|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

ADYGTAKVVQGTS--------------------TGTVMPGNVAYAAPEAPIPD----------------QHSPAMDVYSYSVLLMEMNLRCPP
.|.|.........                    |     |. .. |||.   .                . |...||||. ..| |.  ||.|
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP

Kinase AqueK599.AA MLK 20-212 26 6.1e-32 108.13 In-house 1-229 (291) Show / Hide
Range on Protein: 20-212
Range on HMM: 1-229/291
Sequence Identity: 26% (62 aa)

TLTKEELGRGSYAVVTVGIFRGLR-----VAVKSLHTIIISDYNL-----GMFSREMSIASRLHHPN----LVQFIGA-TKVGN-PLILTELIST-SLNQ
 ...| .| ||. .|  | .|. .     ||||  .. |. |          | .|  ....| |||     .|| |. .. ..  .|..| ..  ||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ELHRNQ---------------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKP-CIGPAGYEAKVADYGTAKVVQGT-STGTVMPGNVAY
 || ..                . ......| ..| |..|||  .|.||||||  |.|.|.   |   ..  .|..| ||.. .. . .. . ..|..|.
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW

AAPEAP---IPDQHSPAMDVYSYSVLLMEM
 |||.      .. | . ||.|. |.| ||
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEM

Kinase AqueK599.AA TKL-Unique 22-212 29 1.8e-30 104.76 In-house 1-221 (290) Show / Hide
Range on Protein: 22-212
Range on HMM: 1-221/290
Sequence Identity: 29% (66 aa)

TKEELGRGSYAVVTVGIFRGLRVAVKSLHTIIISDYNLG---MFSREMSIASRLH-HPNLVQFIGATK---VGNP--LILTELIST-SLNQELH------
  . .|.|.|..|  |..||  ||.|..|    .| ..     |..| .. ..|| |||.|...|...   | .|   | .| ..  ||.  ||      
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

-----RNQLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCIGPAGYEAKVADYGTAKVVQGTSTGTVM----------PGNVAYAAPEA
      . |..||....|.|.|.|..|||  .|  |||||  |.|.|.      | . .|..| |..|.    ...|.            |.  ..||| 
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

PIP--DQHSPAMDVYSYSVLLMEM
     .| |   ||||... | |.
LRMNFCQYSEKSDVYSFGIVLWEI

Kinase AqueK599.AA TK 20-212 14 1.6e-25 81.86 In-house 1-387 (486) Show / Hide
Range on Protein: 20-212
Range on HMM: 1-387/486
Sequence Identity: 14% (56 aa)

TLTKEELGRGSYA---VVTVGIFRGL---------------------------RVAVKSLH---TIIISDYNLGMFS------------REMSIAS--RL
    ..||.| .    .|  |. ||.                           .|||| |.   .    .  . ..             .||.. .   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHPNLVQFIG-ATKVGN------------PLILTELIS-TS----LNQELHRN-----------------------------------------------
||||.|...|  |....            ..|..|. .  .    | . |...                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QLTNQQILSIAQDVALGLNYLHLFKP---QPIIHRDVSSPNVLLK-PCI-----GPAGYEAKVADYG---
                              ||| .| | .....| |. |||  .    | ..|||.   |.|.    .     .  |. .|.||.|   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----TAKVVQGTSTGTVMPGN---------------------------VAYAAPEAPI---------PDQHSPAMDVYSYSVLLMEM
      |. ..  .  ... .                            . . |||.              .... ||.|. ||. |.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI

Kinase AqueK599.AA Dicty4 22-140 32 3e-22 71.15 In-house 3-139 (277) Show / Hide
Range on Protein: 22-140
Range on HMM: 3-139/277
Sequence Identity: 32% (45 aa)

TKEELGRGSYAVVTVGIFRGLRVAVKSL--HTIIISDYNLGMFSREMSIASRLHHPNLVQFIGA-T----KVGNPLILTELI-STSLNQELHR------N
. ...|.||.. |  |. ||  |||| |  | .  . . |  | .| .| . . |||...| || |    . | ..| ||.  ...|   ||        
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

QLTNQ--QILS---IAQDVALGLNYLHLFKPQPIIHRD
  . .   |..   .| |.|.|.|.||   |  |||||
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRD

Kinase AqueK599.AA LRRK 20-189 22 2.2e-21 72.42 In-house 1-249 (351) Show / Hide
Range on Protein: 20-189
Range on HMM: 1-249/351
Sequence Identity: 22% (57 aa)

TLTKEELGRGSYA-VVTVGIFRG----------------------------LRVAVKSLHTI----------------------------------IISD
    |..|||... .|  ...||                              ||.|.....                                   .  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

YNLGMFSREMSIASRLHHPNLVQFIGATKVGNPLIL-TELIST-SLNQELH---RNQ-------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSP
...  | .|..| |.|.|||.|. .| .   .||.. .|...  .|.. ||   ...       .. . .| || ..| |..||| ..| ||||||  ||
FRE--FRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSP

NVLLKPCIGP-------AGYEAKVADYGTAK---VVQGTSTGTVMPGNVAYAAPE
|.||.    .       | . ||.||.|.     ... . . ..  ||  . |||
NILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV-GNPGWMAPE

Kinase AqueK599.AA HH498 22-212 31 6.5e-21 62.67 In-house 3-219 (284) Show / Hide
Range on Protein: 22-212
Range on HMM: 3-219/284
Sequence Identity: 31% (71 aa)

TKEELGRGSYAVVTVGIFRGLRVAVKSLHTIIISDYNL------GMFSREMSIASRLHHPNLVQFIGATKVGNP---LILTELIST-SLNQEL-------
..|  | ||.  |  | .|.  ||||      ..           || || || .|| ||. |||..|. .  |   .| |. ..  ||   |       
FHEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYAC-CDDPSQFAIVTQYCDNGSLFSILNTIPIGG

-------HRNQ-----LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCIGPAGYEAKVADYGTAKVVQ--GTSTGTVMPGNVAYAAPEA
       | ..     .  | .. |. ||| | ||||   ..||||||  | |.|.      .   |.|||.|    |.  .  . |  |||  . ||| 
AGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIH-----EDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEV

PI-PDQHSPAMDVYSYSVLLMEM
     . |   ||.||   . ||
FSQCQKYSIKVDVFSYAMCIWEM

Kinase AqueK599.AA STE 21-189 17 9.6e-21 70.06 In-house 1-232 (359) Show / Hide
Range on Protein: 21-189
Range on HMM: 1-232/359
Sequence Identity: 17% (44 aa)

LTK-EELGRGSYAVVTVGIFR-----------------GLRVAVKSLH---------------TIIISDYNLGMFSREMSIASRLH--HPNLVQFIGATK
... |..|.|.. .|  .. .                 | ..|.| ..               . .. . ..  . .|..| ....  ||| |...|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG--------NPLILTELIS-TSLNQELHRN-----QLT----------NQQILSIAQDVALG-LNYLHLFKPQPIIHRDVSSPNVLLKPCIGPAGYEAK
..        .  |  |...  || . ....     .|.           .||  |....  | |.|||  .   |||||. . |.||          .|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL----------VK

VADYGTAKVVQG----------------------TSTGTVMPGNVAYAAPE
 .| |... ..                       | .||       . |||
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP------WMAPE

Kinase AqueK599.AA CZAK 115-212 31 7.6e-20 68.86 In-house 108-215 (279) Show / Hide
Range on Protein: 115-212
Range on HMM: 108-215/279
Sequence Identity: 31% (35 aa)

LSIAQDVALGLNYLHL-FKPQPIIHRDVSSPNVLLKPCIG--------PAGYEAKVADYGTA--KVVQGTS-TGTVMPGNVAYAAPEAPIPDQHSPAMDV
...| |.| | ||||  .|| ||.||| || |.||   .              .|..|.|    .  |..  | |.  | ... |||  . .  ..  ||
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTM--GCLCWMAPECFKGENYTEKVDV

YSYSVLLMEM
||.  .| ..
YSFGMILWCI

Pkinase_Tyr AqueK599.AA Pkinase_Tyr 19-212 24 3.8e-19 65.45 Pfam 1-207 (270) Show / Hide
Range on Protein: 19-212
Range on HMM: 1-207/270
Sequence Identity: 24% (54 aa)

VTLTKEELGRGSYAVVTVGIFR------GLRVAVKSLHTIIISDYN--LGMFSREMSIASRL-HHPNLVQFIGATK-VGNP---LILTELIST-SLNQEL
.|.  ..||.|.. .|  |. .      .. ||||.|     .. .  . .| ||..| . | ||||.|...|.    | |   .| .|.    .|   |
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

HRN-----QLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCIGPAGYEAKVADYGTAKVVQGTSTG-TVMP---GNVAYAAPEAPIPDQ
...     .|| ...|......| |..||.  .   .||||.   |.|..      .  .|..| | |. .. ...  ..       .   |||.     
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE-----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK

HSPAMDVYSYSVLLMEM
 . . ||.|. ||. |.
FTTKSDVWSFGVLMWEI

Kinase AqueK599.AA Dicty4-Unclassified 23-212 26 4.1e-19 62.09 In-house 4-201 (263) Show / Hide
Range on Protein: 23-212
Range on HMM: 4-201/263
Sequence Identity: 26% (56 aa)

KEELGRGSYAVVTVGIFRGLRVAVKSLHTIIISDY--NLGMFSREMSIASRLHHPNLVQFIGATKVGNP-------LILTELI-STSLNQELH-----RN
  ..|.|  . |  |. .|  |||| .     .     .  | .|  |   . |||||.  |.    ||        | .|.. .  |    |     ..
DQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCI--NPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQ

Q---LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCIGPAGYEAKVADYGTAKVVQGTSTGTVMPGNVAYAAPEAPIPDQHSPAMDVYS
|   |    |. .| |.| |. .||      .||||. | |.|.        . .|.|| | . |.  . . |   | ..  .||         . ||||
QPIKLDDTLIIKYAFDIAQGMQHLHTRN---FIHRDIKSSNILMD-----KHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYS

YSVLLMEM
| ..| |.
YAMMLYEL

Kinase AqueK599.AA Pkinase 20-218 22 1.8e-14 52.28 Pfam 1-211 (293) Show / Hide
Range on Protein: 20-218
Range on HMM: 1-211/293
Sequence Identity: 22% (50 aa)

TLTKEELGRGSYAVVTVGIFRGLR--VAVKSLHTIIISDYNLGMFSR--EMSIASRLHHPNLVQFIGATK-VGNPLILTELIST-----SLNQELH---R
  ... .|.||...|  .. .| .  |||| .    ...  .    |  | .|  ||.||| |.....    ... . .|.        .|   ..   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NQL--TNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLK-PCIGPAGYEAKVADYGTAKVVQGTSTGTVMPGNVA---YAAPEAPI-PDQHSPA
. .  . ... ...  .. ||.|.|      |||||. . |.|..  .  .|    |..| | ||... .  .. | . .    |.|||       ..|.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

MDVYSYSVLLMEMNLRCPP
 |..|. ..| || .. ||
VDMWSCGCILYEMLCGRPP

Kinase AqueK599.AA S_TKc 20-229 16 2.1e-14 34.45 SMART 1-231 (231) Show / Hide
Range on Protein: 20-229
Range on HMM: 1-231/231
Sequence Identity: 16% (44 aa)

TLTKEELGRGSYAVVTVGIFRG--LRVAVKSLHTIIISDYNLGMFSREMSIASRLHHPNLVQFIGATKVGNPLILTELIST---SLNQELHRNQ------
    ...|.|....|  .. ..   .||.| ..          .. ||..| .. ||||.|.....   ..  . .|....   .| . .....      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCIGPAGYEAKVADYGTAKVVQGTSTGTVMPGNVAYAAPEAPIPDQHSP-AMDVYSYS
 ..  .. .... ....|.|.|  .   |||||.   |.||         . |..| | |...      | . |   | |||     .... . |..|  
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

VLLMEMNLRCP--------------------------------PGINDKRE-------KSTI
..| ||  ..|                                |.. .  .          .
CILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase AqueK599.AA TyrKc 20-230 18 1.3e-12 -18.77 SMART 1-280 (280) Show / Hide
Range on Protein: 20-230
Range on HMM: 1-280/280
Sequence Identity: 18% (53 aa)

TLTKEELGRGSYAVVTVGIFRGLRVAVKSLHTIIISDYNLGMFSREMSIASRL--HHPNLVQFIGATKV--------GNPLILTELIST-SLNQELHRNQ
   ...||.| . .|  |. . . ||||.|.        . .| ||..| ..|  ||||.|...|.           . ..|..|. .  .|.. |....
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCIGPAGYEAKVADYGTAKVVQGT-------STGTV-----MP--GNVAYAAPEAPI
  |.... ||.. ..| | .|||     ..||||    |.|..     ... .|..| | .. .          .. ..           .   |||.  
PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVG-----ENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

PDQHSPAMDVYSYSVLLMEM---------N--------------------LRCPPG--------INDKREK-------------------STIW
    ... ||.|. |.. |.         .                    ...||           |.  .                     ..
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase AqueK599.AA CZAK 21-89 35 1.8e-08 27.08 In-house 1-74 (279) Show / Hide
Range on Protein: 21-89
Range on HMM: 1-74/279
Sequence Identity: 35% (26 aa)

LTKE-ELGRGSYAVVTVGIFRGLRVAVKSLHTIIISDYNL----GMFSREMSIASRLHHPNLVQFIGATKVGNP
|. . . |.| .  |  .  ||  ||.| .| .   .        || .| || | | ||| |||.||   ..|
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGP