Gene AqueK596 (A.queenslandica)

AqueK596

Species: A.queenslandica
Alias: AqueK596
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-C

Sequence

Name Sequence Type Origin Length Description Download
AqueK596.AA Protein None 202 None Fasta, JSON
AqueK596.kin_dom Protein Kinase Domain None 196 None Fasta, JSON

Protein domain

Protein domains of AqueK596.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK596.AA TKL 1-197 20 2.8e-41 143.46 In-house 76-364 (364) Show / Hide 
Range on Protein: 1-197
Range on HMM: 76-364/364
Sequence Identity: 20% (61 aa)

MSISSRVRHPNLVQFIGATK--------------VGNPLILTELM-STSLYKKLQETQLTNEQILSIAQDVALGLNYLHLFKP-----QPIIHRDVSSPN
. . || ||||.|||.|. .               |.. | .|..   ||.  |.      .|....|.|.|.|.||||  .|      ||||||  |.|
IMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKN

VLLKPCTG---------AAGYEAKVADYGTAKLQQGTS--------------------TGTVMPGNPAYAAPEA---PIPDY-------------HSPAM
.|..             .| . .|..|.|...  ....                    |     |.|.. |||.    ...               |...
ILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKC

DVYSYSVLLMEMTLCSPPEMTTGEREVQ---------SGSV-----------------------SWSDMKSLIQRGLNANPRARPTMAQVIESL
||||. ..| |.  . .|.   ......         .. .                        . .||.|.|.  ...|..||.. .... |
DVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK596.AA MLK 5-147 28 2.1e-25 85.14 In-house 60-229 (291) Show / Hide 
Range on Protein: 5-147
Range on HMM: 60-229/291
Sequence Identity: 28% (48 aa)

SRVRHPN----LVQFIGA-TKVGN-PLILTELMST-SLYKKLQETQ---------------LTNEQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVL
....|||     .|| |. .. ..  .|..| ..  |||  | . .                . ......| ..| |..|||  .|.||||||  |.|.|
RILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNIL

LKP-CTGAAGYEAKVADYGTAK-LQQGTSTGTVMPGNPAYAAPEA----PIPDYHSPAMDVYSYSVLLMEM
.   |   ..  .|..| ||.. ..| ... . ..|..|. |||.    .   | | . ||.|. |.| ||
IDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKY-SEKCDVWSWGVVLWEM
Kinase AqueK596.AA TKL-Unique 2-147 27 3.2e-24 82.43 In-house 47-221 (290) Show / Hide 
Range on Protein: 2-147
Range on HMM: 47-221/290
Sequence Identity: 27% (48 aa)

SISSRVR-HPNLVQFIGATK---VGNP--LILTELMST-SLYKKLQ-----------ETQLTNEQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLL
..... . |||.|...|...   | .|   | .| ..  |||. |.           .. |...|....|.|.|.|..|||  .|  |||||  |.|.|.
NWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLV

KPCTGAAGYEAKVADYGTAKLQQGTSTGTVM----------PGNPAYAAPEAPIP--DYHSPAMDVYSYSVLLMEM
      | . .|..| |..|..   ...|.            |.. ..|||      .  |   ||||... | |.
DNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEI
Kinase AqueK596.AA CZAK 2-153 31 4.8e-23 80.61 In-house 52-221 (279) Show / Hide 
Range on Protein: 2-153
Range on HMM: 52-221/279
Sequence Identity: 31% (55 aa)

SISSRVRHPNLVQFIGATKVGN---PLILTELMS-TSLYKKLQETQLTNEQ----ILSIAQDVALGLNYLHL-FKPQPIIHRDVSSPNVLLKPCTG----
|| |  .||| |||.||   ..     | .| |   || . | .     .|     ...| |.| | ||||  .|| ||.||| || |.||         
SIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNP

----AAGYEAKVADYGTA--KLQQGTS-TGTVMPGNPAYAAPEAPIPDYHSPAMDVYSYSVLLMEMTLCSPP
         .|..|.|    .  |..  | |.  |  .. |||  . .  ..  ||||.  .| ..  |  |
VVSSRQDIICKINDFGLSREMMEQPFEMTQTM--GCLCWMAPECFKGENYTEKVDVYSFGMILWCIITCDQP
Kinase AqueK596.AA TK 8-197 14 4.9e-22 70.0 In-house 101-486 (486) Show / Hide 
Range on Protein: 8-197
Range on HMM: 101-486/486
Sequence Identity: 14% (56 aa)

RHPNLVQFIG-ATKVGN------------PLILTELMS-TS----LYKKLQET-----------------------------------------------
.|||.|...|  |....            ..|..|.|.  .    | . |..                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QLTNEQILSIAQDVALGLNYLHLFKP---QPIIHRDVSSPNVLLKPCTGAA------GYEAKVADYG---
                              ||| .| | .....| |. |||  .    | ..|||.   |.|.      .      |. .|.||.|   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----TAKLQQGTSTGTVMPGNPA---------------------------YAAPEAPI---------PDYHSPAMDVYSYSVLLMEMT-LC-SPPE--M
      |.  .  .  ... .  .                           . |||.              .... ||.|. ||. |.  ..  |.   |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TT------------------------------GEREVQS--GSVS-W------------SDMKSLIQRGLNANPRARPTMAQVIESL
.                               |.|  .      . |             ..  |.|.  ...|. |||..|. | |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK596.AA Dicty4 5-147 29 1.9e-16 51.52 In-house 53-210 (277) Show / Hide 
Range on Protein: 5-147
Range on HMM: 53-210/277
Sequence Identity: 29% (48 aa)

SRVRHPNLVQFIGA-T----KVGNPLILTELM-STSLYKKLQE------TQLTNE--QILS---IAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCT
.  ||||...| || |    . | ..| ||.| ...||. |           . .   |..   .| |.|.|.|.||   |  |||||  | | |     
CKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLV----

GAAGYEAKVADYGTAK-LQQGTSTGT---VMPGNPAYAAPEAPIPDYHSPAMDVYSYSVLLMEM
  . . .||.| | ..  . ... ..    . | |.. |||    .    . ||||.. .| |.
-DKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEI
Kinase AqueK596.AA TK-Unique 8-197 21 2.7e-16 52.82 In-house 62-294 (294) Show / Hide 
Range on Protein: 8-197
Range on HMM: 62-294/294
Sequence Identity: 21% (53 aa)

RHPNLVQFIGATK-VG-NPLILTELMSTS-LYKKLQETQ---------------------------LTNEQILSIAQDVALGLNYLHLFKPQPIIHRDVS
.|||.||..|..   . ...|. | .. . | . |....                           .. .. ...| ..| |..||.   .. |.|||..
DHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQ-RKKIVHRDLC

SPNVLLKPCTGAAGYEAKVADYGTAK-------LQQGTSTGTVMPGNPAYAAPEAPI---PDYHSPAMDVYSYSVLLME-MTLCSPP-----------EM
. ||||       ....|..|.| |.       ..  .| |...    .. |||..      ||..  ||.|. ||. | .|| ..|           ..
ARNVLLTE-----DKVCKICDFGMARDVYTNGVYSMMCSQGRIP---IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECI

TTGEREVQSGSVSWSDMKSLIQRGLNANPRARPTMAQVIESL
. | |  |  ...  .| .|... .. .|  ||. .|..  |
RDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK596.AA Pkinase 2-197 20 3.3e-16 58.41 Pfam 52-293 (293) Show / Hide 
Range on Protein: 2-197
Range on HMM: 52-293/293
Sequence Identity: 20% (51 aa)

SISSRVRHPNLVQFIGATK-VGNPLILTELMST-----SLYKKLQ---ETQL--TNEQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAA
.|  |..||| |.....    ... . .|..       .|.  ..   .. .  . ... ...  .. ||.|.|      |||||. . |.|..  .|  
QIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILID-NNGHI

GYEAKVADYGTAKL--QQGTSTGTVMPGNPAYAAPEAPI-PDYHSPAMDVYSYSVLLMEMTLCSPPEMTT---------------GEREVQSGSVSW---
.   |..| | ||.      |  |.  | | |.|||      |..|. |..|. ..| || .  ||                   ..... . .  |   
DACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSI

------------------SDMKSLIQRGLNANPRARPTMAQVIES--L
                  ...|..| . |. .|  ||| .|. ..  .
SYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK596.AA STE 1-124 21 5.7e-16 52.98 In-house 79-232 (359) Show / Hide 
Range on Protein: 1-124
Range on HMM: 79-232/359
Sequence Identity: 21% (36 aa)

MSISSRVR--HPNLVQFIGATKVG--------NPLILTELMS-TSLYKKLQ---ETQLT------------NEQILSIAQDVALG-LNYLHLFKPQPIIH
..| .. .  ||| |...|.  ..        .  |  |.|.  || . ..   ... .             .||  |....  | |.|||  .   |||
IKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIH

RDVSSPNVLLKPCTGAAGYEAKVADYGTAKLQQG---------------TSTGT--VMPGNPAYAAPE
||. . |.||          .| .| |...  .                |. .    . | | . |||
RDIKPANILL----------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase AqueK596.AA LRRK 1-124 31 1.8e-14 47.57 In-house 108-249 (351) Show / Hide 
Range on Protein: 1-124
Range on HMM: 108-249/351
Sequence Identity: 31% (46 aa)

MSISSRVRHPNLVQFIGATKVGNPLIL-TELMST-SLYKKLQ---ETQ-------LTNEQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLL-KPCT
..| |. .|||.|. .| .   .||.. .|...  .||. |.   ...       ..   .| || ..| |..||| ..| ||||||  |||.|| .  .
VWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQ

GA------AGYEAKVADYGTAK----LQQG-TSTGTVMPGNPAYAAPE
.       | . ||.||.|.      .. | ... .   ||| . |||
NHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV---GNPGWMAPE
Kinase AqueK596.AA Dicty4-Unclassified 7-147 26 4.6e-13 41.04 In-house 55-201 (263) Show / Hide 
Range on Protein: 7-147
Range on HMM: 55-201/263
Sequence Identity: 26% (42 aa)

VRHPNLVQFIGATKVGNP-------LILTELM-STSLYKKLQ------ETQLTNEQ--ILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAA
. |||||.  |.    ||        | .|.| .  |           .  .  .   |. .| |.| |. .||      .||||. | |.|.       
IQHPNLVKCYGYCI--NPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRN---FIHRDIKSSNILM-----DK

GYEAKVADYGTAKLQQGTSTGTVMPGNPAYAAPEAPIPDYHSPAMDVYSYSVLLMEM
 . .|.|| | .     . . |   | |.  .||         . ||||| ..| |.
HFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYEL
Kinase AqueK596.AA S_TKc 1-200 17 6.6e-13 12.37 SMART 19-231 (231) Show / Hide 
Range on Protein: 1-200
Range on HMM: 19-231/231
Sequence Identity: 17% (42 aa)

MSIS---------------------SRVRHPNLVQFIGATKVGNPLILTELMST---SLYKKLQETQ-------LTNEQILSIAQDVALGLNYLHLFKPQ
  ..                     .. .|||.|.....   ..  . .|....   .|.. ... .       ..  .. .... ....|.|.|  .  
RHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG--

PIIHRDVSSPNVLLKPCTGAAGYEAKVADYGTAKLQQGTSTGTVMPGNPAYAAPEAPIPDYHSP-AMDVYSYSVLLMEMTLCSPPEMTTGEREVQSGSVS
 |||||.   |.||         . |..| | |..       | . | | | |||      ... . |..|  ..| ||    ||   . ..  .     
-IIHRDLKPENILLDE-------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--

WSDMKSLIQRGLNANPRARPTMAQVIE------SLKRM
 ...|..|.. |. .|. |||  .. .      .   .
SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK596.AA Pkinase_Tyr 8-100 27 6.3e-12 41.01 Pfam 62-156 (270) Show / Hide 
Range on Protein: 8-100
Range on HMM: 62-156/270
Sequence Identity: 27% (28 aa)

RHPNLVQFIGATK-VGNP---LILTELMST-SLYKKLQET-----QLTNEQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGYEAKVA
.|||.|...|.    | |   .| .|.|   .|.. |..      .|| ...|......| |..||.  .   .||||.   |.|..      .  .|..
HHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE-----NNVVKIC

DYG
| |
DFG
Kinase AqueK596.AA TyrKc 3-197 16 1.8e-10 -53.38 SMART 1-280 (280) Show / Hide 
Range on Protein: 3-197
Range on HMM: 1-280/280
Sequence Identity: 16% (49 aa)

IS------------------------------------------SRV--RHPNLVQFIGATKV--------GNPLILTELMST-SLYKKLQETQ--LTNE
|.                                          ...  .|||.|...|.           . ..|..|.|.  .| . |....  |...
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

QILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGYEAKVADYGTAKLQQGT-------STGTVM---PGNP----AYAAPEAPIPDYH--
. ||.. ..| | .|||     ..||||    |.|..         .|..| | ..            .. ...    |.        |||.   .|.  
DLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKF

SPAMDVYSYSVLLMEM-TLCSPPEMT----------------TGEREVQSGSV-------SWSDMKSLIQRGLNANPRARPTMAQVIESL
... ||.|. |.. |. |.. .|                   .|.|  |  ..         ..| .....  ...|  |||.....| .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK596.AA MLK 172-197 30 2.5e-07 21.63 In-house 266-291 (291) Show / Hide 
Range on Protein: 172-197
Range on HMM: 266-291/291
Sequence Identity: 30% (8 aa)

MKSLIQRGLNANPRARPTMAQVIESL
.|.|...  |..|. ||...|... |
WKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK596.AA Dicty4 173-199 31 2.5e-05 13.92 In-house 249-277 (277) Show / Hide 
Range on Protein: 173-199
Range on HMM: 249-277/277
Sequence Identity: 31% (9 aa)

KSLIQRGLNANPRARPTMAQVIES--LKR
|.|||. .. .|  ||.....|.   |  
KHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK596.AA LRRK 162-199 23 3.4e-05 14.33 In-house 314-351 (351) Show / Hide 
Range on Protein: 162-199
Range on HMM: 314-351/351
Sequence Identity: 23% (9 aa)

VQSGSVSWSDMKSLIQRGLNANPRARPTMAQVIESLKR
.. . . | ....|||   ...|. ||.. |... |. 
YCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK596.AA TKL-Unique 175-197 34 0.000253 11.36 In-house 268-290 (290) Show / Hide 
Range on Protein: 175-197
Range on HMM: 268-290/290
Sequence Identity: 34% (8 aa)

LIQRGLNANPRARPTMAQVIESL
|||.. . .|  ||.  ..|..|
LIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK596.AA Dicty4-Unclassified 172-197 42 0.000307 10.38 In-house 238-263 (263) Show / Hide 
Range on Protein: 172-197
Range on HMM: 238-263/263
Sequence Identity: 42% (11 aa)

MKSLIQRGLNANPRARPTMAQVIESL
.|.||   .   |. |||| |.|. |
WKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase AqueK596.AA Pkinase_Tyr 169-197 24 0.078855 6.82 Pfam 242-270 (270) Show / Hide 
Range on Protein: 169-197
Range on HMM: 242-270/270
Sequence Identity: 24% (7 aa)

WSDMKSLIQRGLNANPRARPTMAQVIESL
. .. .|...  ...|  |||.....| |
PDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK596.AA CZAK 169-197 34 0.123447 1.9 In-house 251-279 (279) Show / Hide 
Range on Protein: 169-197
Range on HMM: 251-279/279
Sequence Identity: 34% (10 aa)

WSDMKSLIQRGLNANPRARPTMAQVIESL
| ..  || .  | ||  ||.  |... |
WKNLGELIEMCWNKNPDERPSFKQILQHL
Kinase AqueK596.AA Pkinase_Tyr 136-147 50 7.917708 0.04 Pfam 196-207 (270) Show / Hide 
Range on Protein: 136-147
Range on HMM: 196-207/270
Sequence Identity: 50% (6 aa)

DVYSYSVLLMEM
||.|. ||. |.
DVWSFGVLMWEI