Gene AqueK590 (A.queenslandica)

AqueK590

Species: A.queenslandica
Alias: AqueK590
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-C

Sequence

Name Sequence Type Origin Length Description Download
AqueK590.AA Protein None 202 None Fasta, JSON
AqueK590.kin_dom Protein Kinase Domain None 193 None Fasta, JSON

Protein domain

Protein domains of AqueK590.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK590.AA TKL 1-197 20 3.2e-39 136.63 In-house 76-364 (364) Show / Hide 
Range on Protein: 1-197
Range on HMM: 76-364/364
Sequence Identity: 20% (60 aa)

MSIASRVRHPNLVQFIGATK--------------VGNPLILTELM-STSLYKKLQETKLTNQQILSIAQDVALGLNYLHLFKP-----QPIIHRDVSSPN
. . || ||||.|||.|. .               |.. | .|..   ||.  |.      .|....|.|.|.|.||||  .|      ||||||  |.|
IMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKN

VLLKPCTG---------AAGYEAKVADYGTAKLQQGTS--------------------TGTVMPGNVAYAAPEARDPD----------------QHSPAM
.|..             .| . .|..|.|...  ....                    |     |. .. |||. . .                . |...
ILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKC

DVYSYTVLLMEMTLYSPPEMTTGEREVQ---------SGSV-----------------------SWSDMKSLIQRGLNANPRARPIMAQVIESL
||||. ..| |.    .|.   ......         .. .                        . .||.|.|.  ...|..|| . .... |
DVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK590.AA MLK 3-147 27 8.6e-28 93.56 In-house 58-229 (291) Show / Hide 
Range on Protein: 3-147
Range on HMM: 58-229/291
Sequence Identity: 27% (47 aa)

IASRVRHPN----LVQFIGA-TKVGN-PLILTELMST-SLYKKLQETK---------------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPN
......|||     .|| |. .. ..  .|..| ..  |||  | . .                . ......| ..| |..|||  .|.||||||  |.|
HLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHN

VLLKP-CTGAAGYEAKVADYGTAK-LQQGTSTGTVMPGNVAYAAPEAR---DPDQHSPAMDVYSYTVLLMEM
.|.   |   ..  .|..| ||.. ..| ... . ..|..|. |||..     .. | . ||.|. |.| ||
ILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEM
Kinase AqueK590.AA TKL-Unique 2-147 28 9.6e-25 84.29 In-house 47-221 (290) Show / Hide 
Range on Protein: 2-147
Range on HMM: 47-221/290
Sequence Identity: 28% (51 aa)

SIASRVR-HPNLVQFIGATK---VGNP--LILTELMST-SLYKKLQ-----------ETKLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLL
.. .. . |||.|...|...   | .|   | .| ..  |||. |.           ..||..||....|.|.|.|..|||  .|  |||||  |.|.|.
NWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLV

KPCTGAAGYEAKVADYGTAKLQQGTSTGTVM----------PGNVAYAAPEARDP--DQHSPAMDVYSYTVLLMEM
      | . .|..| |..|..   ...|.            |.  ..|||      .| |   ||||. . | |.
DNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEI
Kinase AqueK590.AA CZAK 2-147 31 5.9e-23 80.29 In-house 52-215 (279) Show / Hide 
Range on Protein: 2-147
Range on HMM: 52-215/279
Sequence Identity: 31% (53 aa)

SIASRVRHPNLVQFIGATKVGN---PLILTELMS-TSLYKKLQETKLTNQQ----ILSIAQDVALGLNYLHL-FKPQPIIHRDVSSPNVLLKPCTG----
|| |  .||| |||.||   ..     | .| |   || . | .     .|     ...| |.| | ||||  .|| ||.||| || |.||         
SIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNP

----AAGYEAKVADYGTA--KLQQGTS-TGTVMPGNVAYAAPEARDPDQHSPAMDVYSYTVLLMEM
         .|..|.|    .  |..  | |.  | ... |||    .  ..  ||||.  .| ..
VVSSRQDIICKINDFGLSREMMEQPFEMTQTM--GCLCWMAPECFKGENYTEKVDVYSFGMILWCI
Kinase AqueK590.AA TK 8-147 14 2.1e-17 54.18 In-house 101-387 (486) Show / Hide 
Range on Protein: 8-147
Range on HMM: 101-387/486
Sequence Identity: 14% (41 aa)

RHPNLVQFIG-ATKVGN------------PLILTELMS-TS----LYKKLQETK----------------------------------------------
.|||.|...|  |....            ..|..|.|.  .    | . |.. .                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTNQQILSIAQDVALGLNYLHLFKP---QPIIHRDVSSPNVLLKPCTGAA------GYEAKVADYG---
                               || .| | .....| |. |||  .    | ..|||.   |.|.      .      |. .|.||.|   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----TAKLQQGTSTGTVMPGN---------------------------VAYAAPEARD---------PDQHSPAMDVYSYTVLLMEM
      |.  .  .  ... .                            . . |||. .            .... ||.|. ||. |.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
Kinase AqueK590.AA Dicty4 5-124 29 9.9e-16 49.1 In-house 53-187 (277) Show / Hide 
Range on Protein: 5-124
Range on HMM: 53-187/277
Sequence Identity: 29% (41 aa)

SRVRHPNLVQFIGA-T----KVGNPLILTELM-STSLYKKLQE------TKLTNQ--QILS---IAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCT
.  ||||...| || |    . | ..| ||.| ...||. |         . . .   |..   .| |.|.|.|.||   |  |||||  | | |     
CKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLV----

GAAGYEAKVADYGTAK-LQQGTSTGT---VMPGNVAYAAPE
  . . .||.| | ..  . ... ..    . | ... |||
-DKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPE
Kinase AqueK590.AA HH498 2-147 31 2.3e-15 44.81 In-house 54-219 (284) Show / Hide 
Range on Protein: 2-147
Range on HMM: 54-219/284
Sequence Identity: 31% (55 aa)

SIASRVRHPNLVQFIGATKVGNP---LILTELMST-SLYKKL--------------QETK-----LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSS
|| .|  ||. |||..|. .  |   .| |.  .  ||.  |               . |     .  | .. |. ||| | ||||   ..||||||  |
SIMCRLNHPCVVQFVYAC-CDDPSQFAIVTQYCDNGSLFSILNTIPIGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNS

PNVLLKPCTGAAGYEAKVADYGTA--KLQQGTSTGTVMPGNVAYAAPEARD-PDQHSPAMDVYSYTVLLMEM
 |.|.     . |  |.|||.|    . . .  . |  |||  . |||      . |   ||.||   . ||
HNILIH----EDGH-AVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEM
Kinase AqueK590.AA STE 1-124 20 5.1e-15 49.58 In-house 79-232 (359) Show / Hide 
Range on Protein: 1-124
Range on HMM: 79-232/359
Sequence Identity: 20% (36 aa)

MSIASRVR--HPNLVQFIGATKVG--------NPLILTELMS-TSLYKKLQ---ETKLT------------NQQILSIAQDVALG-LNYLHLFKPQPIIH
..| .. .  ||| |...|.  ..        .  |  |.|.  || . ..   ... .             .||  |....  | |.|||  .   |||
IKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIH

RDVSSPNVLLKPCTGAAGYEAKVADYGTAKLQQG----------------------TSTGTVMPGNVAYAAPE
||. . |.||          .| .| |...  .                       | .||       . |||
RDIKPANILL----------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP------WMAPE
Kinase AqueK590.AA LRRK 1-144 29 8.3e-14 45.21 In-house 108-272 (351) Show / Hide 
Range on Protein: 1-144
Range on HMM: 108-272/351
Sequence Identity: 29% (50 aa)

MSIASRVRHPNLVQFIGATKVGNPLIL-TELMST-SLYKKLQETK----------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLL-KPCT
..| |. .|||.|. .| .   .||.. .|...  .||. |...|          .. . .| || ..| |..||| ..| ||||||  |||.|| .  .
VWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQ

GA------AGYEAKVADYGTAK----LQQG-TSTGTVMPGNVAYAAPEARDPD---QHSPAMDVYSYTVLL
.       | . ||.||.|.      .. | ... .   ||  . ||| .  .   . .   |.||. ..|
NHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV---GNPGWMAPEIMRYNGEEEYTEKVDCYSFGMIL
Kinase AqueK590.AA Dicty4-Unclassified 7-147 27 1.2e-13 43.06 In-house 55-201 (263) Show / Hide 
Range on Protein: 7-147
Range on HMM: 55-201/263
Sequence Identity: 27% (43 aa)

VRHPNLVQFIGATKVGNP-------LILTELMST----SLYK-----KLQETKLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAA
. |||||.  |.    ||        | .|.|       .       . |  ||    |. .| |.| |. .||      .||||. | |.|.       
IQHPNLVKCYGYCI--NPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRN---FIHRDIKSSNILM-----DK

GYEAKVADYGTAKLQQGTSTGTVMPGNVAYAAPEARDPDQHSPAMDVYSYTVLLMEM
 . .|.|| | .     . . |   | ..  .||         . ||||| ..| |.
HFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYEL
Kinase AqueK590.AA Pkinase 6-153 24 1.3e-12 45.67 Pfam 56-211 (293) Show / Hide 
Range on Protein: 6-153
Range on HMM: 56-211/293
Sequence Identity: 24% (40 aa)

RVRHPNLVQFIGATK-VGNPLILTELMST-----SLYKKLQ---ETKL--TNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGYEA
|..||| |.....    ... . .|..       .|.  ..   ....  . ... ...  .. ||.|.|      |||||. . |.|..  .|  .   
RLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILID-NNGHIDACV

KVADYGTAKL--QQGTSTGTVMPGNVAYAAPEA-RDPDQHSPAMDVYSYTVLLMEMTLYSPP
|..| | ||.      |  |.  |   |.|||  |.   ..|. |..|. ..| || .  ||
KICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPP
Kinase AqueK590.AA Pkinase_Tyr 8-100 27 2.5e-12 42.39 Pfam 62-156 (270) Show / Hide 
Range on Protein: 8-100
Range on HMM: 62-156/270
Sequence Identity: 27% (28 aa)

RHPNLVQFIGATK-VGNP---LILTELMST-SLYKKLQET-----KLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGYEAKVA
.|||.|...|.    | |   .| .|.|   .|.. |..      .|| ...|......| |..||.  .   .||||.   |.|..      .  .|..
HHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE-----NNVVKIC

DYG
| |
DFG
Kinase AqueK590.AA S_TKc 1-200 15 4e-12 0.9 SMART 19-231 (231) Show / Hide 
Range on Protein: 1-200
Range on HMM: 19-231/231
Sequence Identity: 15% (38 aa)

MSIA---------------------SRVRHPNLVQFIGATKVGNPLILTELMST---SLYKKLQETK-------LTNQQILSIAQDVALGLNYLHLFKPQ
  .                      .. .|||.|.....   ..  . .|....   .|.. ... .       ..  .. .... ....|.|.|  .  
RHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG--

PIIHRDVSSPNVLLKPCTGAAGYEAKVADYGTAKLQQGTSTGTVMPGNVAYAAPEARDPDQHSP-AMDVYSYTVLLMEMTL----YSPPEMTTGEREVQS
 |||||.   |.||         . |..| | |..       | . |   | |||     .... . |..|  ..| ||      ..  .... .. .  
-IIHRDLKPENILLDE-------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--

GSVSWSDMKSLIQRGLNANPRARPIMAQVIE------SLKRM
     ...|..|.. |. .|. ||   .. .      .   .
----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK590.AA TyrKc 1-197 14 3.4e-10 -57.77 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-197
Range on HMM: 1-280/280
Sequence Identity: 14% (43 aa)

MSIA----------------------------------------SRV--RHPNLVQFIGATKV--------GNPLILTELMST-SLYKKLQETK--LTNQ
 .                                          ...  .|||.|...|.           . ..|..|.|.  .| . |....  |...
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

QILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGYEAKVADYGTAKLQQGT-------STGTV-----MP--GNVAYAAPEARDPDQHSP
. ||.. ..| | .|||     ..||||    |.|..         .|..| | ..            .. ..           .   |||. .    ..
DLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

AMDVYSYTVLLMEM-----TLYSP-----PEMTTGEREVQSG------SV--------SWSDMKSLIQRGLNANPRARPIMAQVIESL
. ||.|. |.. |.     . |.       . .   . |..|                  ..| .....  ...|  || .....| .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK590.AA MLK 172-197 30 4e-06 17.39 In-house 266-291 (291) Show / Hide 
Range on Protein: 172-197
Range on HMM: 266-291/291
Sequence Identity: 30% (8 aa)

MKSLIQRGLNANPRARPIMAQVIESL
.|.|...  |..|. || ..|... |
WKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK590.AA HH498 174-197 33 0.000367 8.65 In-house 261-284 (284) Show / Hide 
Range on Protein: 174-197
Range on HMM: 261-284/284
Sequence Identity: 33% (8 aa)

SLIQRGLNANPRARPIMAQVIESL
.|||.. ...|  ||  .|..  |
NLIQMCWHPCPENRPDFDQIVTIL
Kinase AqueK590.AA LRRK 162-199 23 0.000989 9.06 In-house 314-351 (351) Show / Hide 
Range on Protein: 162-199
Range on HMM: 314-351/351
Sequence Identity: 23% (9 aa)

VQSGSVSWSDMKSLIQRGLNANPRARPIMAQVIESLKR
.. . . | ....|||   ...|. || . |... |. 
YCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK590.AA Dicty4 173-199 31 0.002373 7.23 In-house 249-277 (277) Show / Hide 
Range on Protein: 173-199
Range on HMM: 249-277/277
Sequence Identity: 31% (9 aa)

KSLIQRGLNANPRARPIMAQVIES--LKR
|.|||. .. .|  || ....|.   |  
KHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK590.AA Dicty4-Unclassified 172-197 38 0.005664 5.98 In-house 238-263 (263) Show / Hide 
Range on Protein: 172-197
Range on HMM: 238-263/263
Sequence Identity: 38% (10 aa)

MKSLIQRGLNANPRARPIMAQVIESL
.|.||   .   |. || | |.|. |
WKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase AqueK590.AA TKL-Unique 175-197 34 0.009424 5.75 In-house 268-290 (290) Show / Hide 
Range on Protein: 175-197
Range on HMM: 268-290/290
Sequence Identity: 34% (8 aa)

LIQRGLNANPRARPIMAQVIESL
|||.. . .|  ||   ..|..|
LIQQCWHHDPSQRPSFDEIIHRL