Gene AqueK584 (A.queenslandica)

AqueK584

Species: A.queenslandica
Alias: AqueK584
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-C

Sequence

Name Sequence Type Origin Length Description Download
AqueK584.AA Protein None 321 None Fasta, JSON
AqueK584.kin_dom Protein Kinase Domain None 171 None Fasta, JSON

Protein domain

Protein domains of AqueK584.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK584.AA TKL 155-319 21 7.9e-34 118.7 In-house 1-244 (364) Show / Hide 
Range on Protein: 155-319
Range on HMM: 1-244/364
Sequence Identity: 21% (54 aa)

LGRGSYAVVTVGIFRG----------LRVAVKSLHTIIISDYNL-------------------------RLFSREMSIASRVRHPNLVQFIGATK-----
.|.|....|  |..||            |||| ...   .  ..                           . .|. . || ||||.|||.|. .     
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------VGNPLVLTELM-STSLNQELRRNRLTNQQILSIAQDVALGLNYLHLFKP-----QPIIHRDVSSPNVLLKPCTGP---------AGYEAKV
          |..   .|..   ||   |       .|....|.|.|.|.||||  .|      ||||||  |.|.|..    .         | . .|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

ADYGTAKVVQAEN--------------------TGTVMPGNVAYAAPEA
.|.|...... ..                    |     |. .. |||.
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEV
Kinase AqueK584.AA MLK 149-319 25 1.5e-31 106.78 In-house 1-204 (291) Show / Hide 
Range on Protein: 149-319
Range on HMM: 1-204/291
Sequence Identity: 25% (52 aa)

TLTKEELGRGSYAVVTVGIFRGLR-----VAVKSLHTIIISDYNL-----RLFSREMSIASRVRHPN----LVQFIGA-TKVGN-PLVLTELMST-SLNQ
 ...| .| ||. .|  | .|. .     ||||  .. |. |        . | .|  ......|||     .|| |. .. ..  ....| ..  ||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ELRRNR---------------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKP-CTGPAGYEAKVADYGTAKVVQAE-NTGTVMPGNVAY
 |. .|                . ......| ..| |..|||  .|.||||||  |.|.|.   |   ..  .|..| ||.. ..    . . ..|..|.
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW

AAPEA
 |||.
MAPEV
Kinase AqueK584.AA TKL-Unique 151-318 27 1.2e-25 87.57 In-house 1-196 (290) Show / Hide 
Range on Protein: 151-318
Range on HMM: 1-196/290
Sequence Identity: 27% (55 aa)

TKEELGRGSYAVVTVGIFRGLRVAVKSLHTIIISDYNLR---LFSREMSIASRVR-HPNLVQFIGATK---VGNP--LVLTELMST-SLNQELR------
  . .|.|.|..|  |..||  ||.|..|    .| ...    |..| .. .. . |||.|...|...   | .|     .| ..  ||.  |       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

-----RNRLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGPAGYEAKVADYGTAKVVQAENTGTVM----------PGNVAYAAPE
      . |..||....|.|.|.|..|||  .|  |||||  |.|.|.      | . .|..| |..|.   .|..|.            |.  ..|||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE
Kinase AqueK584.AA TK 149-319 14 5e-24 76.79 In-house 1-356 (486) Show / Hide 
Range on Protein: 149-319
Range on HMM: 1-356/486
Sequence Identity: 14% (50 aa)

TLTKEELGRGSYA---VVTVGIFRGL---------------------------RVAVKSLHTIIISDYNLRL---------------FSREMSIAS--RV
    ..||.| .    .|  |. ||.                           .|||| |.    .. . ..               . .||.. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNLVQFIG-ATKVGN------------PLVLTELMS-TS----LNQELRRNR----------------------------------------------
.|||.|...|  |....            .....|.|.  .    | . ||..|                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTNQQILSIAQDVALGLNYLHLFKP---QPIIHRDVSSPNVLLKPCTG------PAGYEAKVADYG---
                               || .| | .....| |. |||  .    | ..|||.   |.|.             |. .|.||.|   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----TAKVVQAENTGTVMPGN---------------------------VAYAAPEA
      |. .. .   ... .                            . . |||.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPEC
Kinase AqueK584.AA Dicty4 151-269 32 1.1e-21 69.27 In-house 3-139 (277) Show / Hide 
Range on Protein: 151-269
Range on HMM: 3-139/277
Sequence Identity: 32% (45 aa)

TKEELGRGSYAVVTVGIFRGLRVAVKSL--HTIIISDYNLRLFSREMSIASRVRHPNLVQFIGA-T----KVGNPLVLTELM-STSLNQELRR------N
. ...|.||.. |  |. ||  |||| |  | .  . . |  | .| .| .  ||||...| || |    . | ..  ||.| ...|   |.        
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

RLTNQ--QILS---IAQDVALGLNYLHLFKPQPIIHRD
. . .   |..   .| |.|.|.|.||   |  |||||
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRD
Kinase AqueK584.AA STE 150-318 17 7.4e-21 70.46 In-house 1-232 (359) Show / Hide 
Range on Protein: 150-318
Range on HMM: 1-232/359
Sequence Identity: 17% (42 aa)

LTK-EELGRGSYAVVTVGIFR-----------------GLRVAVKSLH---------------TIIISDYNLRLFSREMSIASRVR--HPNLVQFIGATK
... |..|.|.. .|  .. .                 | ..|.| ..               . .. . ..  . .|..| .. .  ||| |...|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG--------NPLVLTELMS-TSLNQELRRN---------------RLTNQQILSIAQDVALG-LNYLHLFKPQPIIHRDVSSPNVLLKPCTGPAGYEAK
..        .  .  |.|.  || . ....               |.  .||  |....  | |.|||  .   |||||. . |.||          .|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL----------VK

VADYGTAKVVQAENTGT-----------------VMPGNVAYAAPE
 .| |... .. ....                   . |   . |||
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase AqueK584.AA CZAK 150-318 30 1.9e-20 71.07 In-house 1-192 (279) Show / Hide 
Range on Protein: 150-318
Range on HMM: 1-192/279
Sequence Identity: 30% (59 aa)

LTKE-ELGRGSYAVVTVGIFRGLRVAVKSLHTIIISDYNL----RLFSREMSIASRVRHPNLVQFIGATKVGN---PLVLTELMS-TSLNQELR-RNRLT
|. . . |.| .  |  .  ||  ||.| .| .   .         | .| || |  .||| |||.||   ..     . .| |   || . |  .  . 
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYH

NQ---QILSIAQDVALGLNYLHL-FKPQPIIHRDVSSPNVLLKPCTG--------PAGYEAKVADYGTA---KVVQAENTGTVMPGNVAYAAPE
 |     ...| |.| | ||||  .|| ||.||| || |.||                  .|..|.|     .    | | |.  | ... |||
KQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTM--GCLCWMAPE
Kinase AqueK584.AA LRRK 149-318 22 8.6e-20 66.69 In-house 1-249 (351) Show / Hide 
Range on Protein: 149-318
Range on HMM: 1-249/351
Sequence Identity: 22% (56 aa)

TLTKEELGRGSYA-VVTVGIFRG----------------------------LRVAVKSLHT--------------------------------IIISDYN
    |..|||... .|  ...||                              ||.|....                                .. .  .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LRLFSREMSIASRVRHPNLVQFIGATKVGNPLVL-TELMST-SLNQELR---RNR-------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNV
.|.| .|..| |. .|||.|. .| .   .|| . .|...  .|.. |.   ...       .. . .| || ..| |..||| ..| ||||||  |||.
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNI

LLKPCTGP-------AGYEAKVADYGTAK---VVQAENTGTVMPGNVAYAAPE
||.  . .       | . ||.||.|.     ... . . ..  ||  . |||
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV-GNPGWMAPE
Pkinase_Tyr AqueK584.AA Pkinase_Tyr 148-319 24 5.8e-19 64.85 Pfam 1-185 (270) Show / Hide 
Range on Protein: 148-319
Range on HMM: 1-185/270
Sequence Identity: 24% (47 aa)

VTLTKEELGRGSYAVVTVGIFR------GLRVAVKSLHTIIISDYN--LRLFSREMSIASRV-RHPNLVQFIGATK-VGNP---LVLTELMST-SLNQEL
.|.  ..||.|.. .|  |. .      .. ||||.|     .. .  .. | ||..| .   .|||.|...|.    | |   .. .|.|   .|   |
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RRN-----RLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGPAGYEAKVADYGTAKVVQAENTG-TVMP---GNVAYAAPEA
|..     .|| ...|......| |..||.  .   .||||.   |.|..      .  .|..| | |. .. . .  ..       .   |||.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE-----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPEC
Kinase AqueK584.AA LISK 154-303 31 3.8e-17 52.08 In-house 1-159 (296) Show / Hide 
Range on Protein: 154-303
Range on HMM: 1-159/296
Sequence Identity: 31% (51 aa)

ELGRGSYAVVTVGIFR--GLRVAVKSLHT---IIISDYNLRLFSREMSIASRVRHPNLVQFIGATKV-GNPL-VLTELMST-SLNQELRRN-----RLTN
|.|.|... |  |  |  |  .|.| .|.     . . ... . ||. .  . |||| |||.|. .     |  .||...   | | |...      |. 
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

QQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGPAGYEAKVADYGTAKVVQAEN
.| ..|| |.|.|. |||    . |||||  | |.|..   .  ....||.| | |.... ||
PQRVKIALDIACGMSYLHS---MNIIHRDLKSKNCLVREN-DNNQWRIKVCDFGFARMMDCEN
Kinase AqueK584.AA Dicty5 166-318 28 2.3e-15 49.35 In-house 18-173 (260) Show / Hide 
Range on Protein: 166-318
Range on HMM: 18-173/260
Sequence Identity: 28% (46 aa)

GIFRGLRVAVKSLHTIIISDYNLRLFSREMSIASRVR--HPNLVQFIGATKVGNPL--VLTELMST-SLNQELR--RN----RLTNQQILSIAQDVALGL
||..|  ||.| .       ...  | ||  | | .   |||.. . || .        .||. .  ||   |.  |.     .   |.|..| |.| ..
GIYKGMDVAIKVYSQENCMCFDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSM

NYLHLFKPQPIIHRDVSSPNVLLKPCTGPAGYEAKVADYGTAKVVQAENTGTVMPGNVAYAAPE
 .||      |||||. | |.|.        ...|. |.||   | .    |.  |  .. |.|
RHLHSMN---IIHRDLKSMNFLIT-----ENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACE
Kinase AqueK584.AA Pkinase 149-270 20 6.4e-12 43.24 Pfam 1-134 (293) Show / Hide 
Range on Protein: 149-270
Range on HMM: 1-134/293
Sequence Identity: 20% (29 aa)

TLTKEELGRGSYAVVTVGIFRGLR--VAVKSLHTIIISD----YNLRLFSREMSIASRVRHPNLVQFIGATK-VGNPLVLTELMST-----SLNQELR--
  ... .|.||...|  .. .| .  |||| .    ...    ...||  .| .|  |..||| |.....    ... . .|..       .|   ..  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

-RNRL--TNQQILSIAQDVALGLNYLHLFKPQPIIHRDV
 ....  . ... ...  .. ||.|.|      |||||.
RHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDL
Kinase AqueK584.AA S_TKc 149-321 13 8.9e-10 -33.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 149-321
Range on HMM: 1-231/231
Sequence Identity: 13% (36 aa)

TLTKEELGRGSYAVVTVGIFRG--LRVAVKSLHTIIISDYNLRLFSREMSIASRVRHPNLVQFIGATKVGNPLVLTELMST---SLNQELRRNR------
    ...|.|....|  .. ..   .||.| ..         . . ||..| .. .|||.|.....   ..  . .|....   .| . .....      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGPAGYEAKVADYGTAKVVQAENTGTVMPGNVAYAAPE----AP------------
 ..  .. .... ....|.|.|  .   |||||.   |.||         . |..| | |...      | . |   | |||     .            
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-------HIKICDFGLARQL------TTFCGTPWYMAPEVLGYGKCKCDWWSCGCIL

---------------------------------------------------------I
                                                         .
YEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase AqueK584.AA TyrKc 149-321 15 1.2e-09 -66.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 149-321
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)

TLTKEELGRGSYAVVTVGIFRGLRVAVKSLHTIIISDYNLRLFSREMSIASRV--RHPNLVQFIGATKV--------GNPLVLTELMST-SLNQELRRNR
   ...||.| . .|  |. . . ||||.|.        .. | ||..| ...  .|||.|...|.           . .....|.|.  .|.. ||..|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGPAGYEAKVADYGTAKVVQAE-------NTGTV-----MP--GNVAYAAPEAP-
  |.... ||.. ..| | .|||     ..||||    |.|..         .|..| | .. .  .        . ..           .   |||.  
PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

---------------------------------------------------------------------------------------------I
                                                                                             .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF