Gene AqueK556 (A.queenslandica)

AqueK556

Species: A.queenslandica
Alias: AqueK556
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-B

Sequence

Name Sequence Type Origin Length Description Download
AqueK556.AA Protein None 207 None Fasta, JSON
AqueK556.kin_dom Protein Kinase Domain None 195 None Fasta, JSON

Protein domain

Protein domains of AqueK556.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK556.AA TKL 6-201 19 1.4e-33 117.9 In-house 1-291 (364) Show / Hide 
Range on Protein: 6-201
Range on HMM: 1-291/364
Sequence Identity: 19% (57 aa)

LGKGAWGEVEVTHFHG----------LKVAAKSLYEILISSYNI-------------------------KIFSGEMNILSKIRHPNCLQFIGATTEGN--
.|.|. |||   ...|            || | . .   .. ..                         . .  |....|..|||| .||.|. ....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PIILTELM-ATSLRKEIESGGLAYPTILSISLDVACALNYLHLFKP-----HPILHRDVSSSSVLLQQVGR-----------VWRAKV
            . | .|..   ||.  .       . .....||.|...||||  .|      ||.|||  |. .|. . ..            |..|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

SGYTSANFQHLRRTSYDDSY------------------PGSPIYSAPEA--GNP--------------REHSPAMDVFSYGVLLVQMLVCEFPYTE
. .  . | . .  . | ..                   |.| . |||.  |..              .| |...||.|.|..|  .| .. || .
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD
Kinase AqueK556.AA TKL-Unique 5-189 23 1.2e-14 48.23 In-house 4-218 (290) Show / Hide 
Range on Protein: 5-189
Range on HMM: 4-218/290
Sequence Identity: 23% (51 aa)

VLGKGAWGEVEVTHFHGLKVAAKSLY-EILISSYNIKIFSGEMNILSKIR-HPNCLQFIGATT-----EGNPIILTE-LMATSLRKEIE-----------
..| |. |.|  . ..| .|| |..  . ..|.  .. |. | |...|.. ||| ....|...     ..| .| .| .   ||.. .            
KIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNN

SGGLAYPTILSISLDVACALNYLHLFKPHPILHRDVSSSSVLLQQV--GRVWRAKVSGYTSANFQH--LRRTSY------DDSYPGSPIYSAPEAGNP--
.  | .  .... .|.| ...|||  .|  |.|||  ||..|. .      |..|...   . |.   .. |.       ...  ||....|||  .   
NCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF

REHSPAMDVFSYGVLL
   |   ||.|.|. |
CQYSEKSDVYSFGIVL
Kinase AqueK556.AA MLK 2-128 20 1.4e-14 47.12 In-house 3-160 (291) Show / Hide 
Range on Protein: 2-128
Range on HMM: 3-160/291
Sequence Identity: 20% (33 aa)

TEVVLGKGAWGEVEVTHFHGLK-----VAAKSLY----EILISSYNIKIFSGEMNILSKIRHPN----CLQFIGATTE-GN-PIILTELMAT-SLRKEIE
.. ..|.|. |.|. . ...       || |       .. ...  .. |  | ..|....|||      || |. .. ..   |..| ..  ||   . 
FHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLH

SG---------------GLAYPTILSISLDVACALNYLHLFKPHPILHRDVSSSSVLL
..                     .....|..| ...|||  .|.|| |||  |. .|.
GARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILI
Kinase AqueK556.AA Dicty4 2-120 30 2.1e-13 41.26 In-house 3-139 (277) Show / Hide 
Range on Protein: 2-120
Range on HMM: 3-139/277
Sequence Identity: 30% (42 aa)

TEVVLGKGAWGEVEVTHFHGLKVAAKSL--YEILISSYNIKIFSGEMNILSKIRHPNCLQFIGATT-----EGNPIILTELM-ATSLRKEIES------G
.|. .|||. |||      | .|| | |    .  ... .. |  | .|..|||||| ..| || |      | . | ||.|  ..| . . .       
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

GLAYP--TILS---ISLDVACALNYLHLFKPHPILHRD
    .  .|..   . .|.|  .|.||   |  |.|||
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRD
Kinase AqueK556.AA CZAK 3-76 32 3.1e-12 40.89 In-house 4-84 (279) Show / Hide 
Range on Protein: 3-76
Range on HMM: 4-84/279
Sequence Identity: 32% (26 aa)

EVVLGKGAWGEVEVTHFHGLKVAAKSLYEILISSYNI----KIFSGEMNILSKIRHPNCLQFIGATTEGN---PIILTELM
. . |.|  |||      |  || | .. .            .|  |  |.|| .||||.||.|| .|..     | .| |
GQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWM
Kinase AqueK556.AA TK 45-189 13 1e-11 34.78 In-house 91-384 (486) Show / Hide 
Range on Protein: 45-189
Range on HMM: 91-384/486
Sequence Identity: 13% (40 aa)

EMNILS--KIRHPNCLQFIGATTEGN-------------PIILTELMA-TS----LRKEIESGG------------------------------------
|| ...  . .||| ....|. |.|              ..|..|.|.  .    ||.   .                                      
EMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHES

-----------------------------------------LAYPTILSISLDVACALNYLHLFKPHPI----LHRDVSSSSVLLQQVGR--------VW
                                         |  .. | .....||.. |||  .         |||.    .|. . ..        . 
NSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGP

RAKVSGYTSANFQ---HLRRTSYDDSYPGSPIY------------------------------SAPEAGN---------PREHSPAMDVFSYGVLL
 .|.. .  .  .   . |.  .|| |  .  |                               |||. |          . .... ||.|.|||.
VCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM
Kinase AqueK556.AA S_TKc 1-206 17 1.9e-11 -9.16 SMART 2-231 (231) Show / Hide 
Range on Protein: 1-206
Range on HMM: 2-231/231
Sequence Identity: 17% (46 aa)

MTEVVLGKGAWGEVEVTHFHG--LKVAAKSLYEILISSYNIKIFSGEMNILSKIRHPNCLQFIGATTEGNPIILTELMAT---SLRKEIESGG-------
    ..|||| |.|   . ..   .|| | .          . .  |..||.| .|||  .....  ...  . .|.. .   .|.. |.. |       
EILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LAYPTILSISLDVACALNYLHLFKPHPILHRDVSSSSVLLQQVGRVWRAKVSGYTSANFQHLRRTSYDDSYPGSPIYSAPEAGNPREHSP-AMDVFSYGV
.   .. ..   ..|||.|.|  .   |.|||.  . .|| .     . |..   .| .         ... |.| | |||      ... . |. | |.
FPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-----HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

LLVQMLVCEFPYT----------------------------------EK-------KSCS
.|  ||. . |.                                    .           
ILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase AqueK556.AA LISK 5-139 29 2.9e-11 32.64 In-house 1-146 (296) Show / Hide 
Range on Protein: 5-139
Range on HMM: 1-146/296
Sequence Identity: 29% (44 aa)

VLGKGAWGEV-EVTHF-HGLKVAAKSLY---EILISSYNIKIFSGEMNILSKIRHPNCLQFIGATTE--GNPIILTELMAT-SLRKEIESG-----GLAY
..|||. |.|  .||.  |  .| | .    . ..   ..| .  |. .. ..|||| .||.|.  .  |   |.||..    |.  . .       |  
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

PTILSISLDVACALNYLHLFKPHPILHRDVSSSSVLLQQV-GRVWRAKV
|  ..|.||.||.. |||  .   |.|||  |  .|. .   ..||.||
PQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKV
Kinase AqueK556.AA CZAK 95-128 51 2.8e-10 33.7 In-house 108-142 (279) Show / Hide 
Range on Protein: 95-128
Range on HMM: 108-142/279
Sequence Identity: 51% (18 aa)

LSISLDVACALNYLHL-FKPHPILHRDVSSSSVLL
... .|.|   ||||  .|| |||||| ||. .||
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILL
Kinase AqueK556.AA Pkinase_Tyr 5-121 25 1.2e-09 33.33 Pfam 6-137 (270) Show / Hide 
Range on Protein: 5-121
Range on HMM: 6-137/270
Sequence Identity: 25% (35 aa)

VLGKGAWGEVEVTHFH------GLKVAAKSLYEILISSY--NIKIFSGEMNILSKI-RHPNCLQFIGATT-EGNP---IILTELMAT-----SLRKE-IE
.||.|| |||   . .      ...|| |.| |   ..     . .. |..|.... .||| ....|. | .| |   .| .|.|.       |||   .
KLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHRED

SGGLAYPTILSISLDVACALNYLHLFKPHPILHRDV
 . |  ...|......|....||.  .   . |||.
KQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDL
Kinase AqueK556.AA NZAK 40-128 28 4.4e-09 26.12 In-house 43-138 (329) Show / Hide 
Range on Protein: 40-128
Range on HMM: 43-138/329
Sequence Identity: 28% (28 aa)

KIFSGEMNILSKIRHPNCLQFIG-----ATTEGNPIILTELMA-----TSLRKEIESGGLAYPTILSISLDVACALNYLHLFKPHPILHRDVSSSSVLL
. |  |  ||.||||.|  ...      |  . .  |  | |        | ..   .      | .. .|.|  . |||    | |.|||. |. |.|
DFFYHETDILEKIRHFNIPRYYSACIKHAEDDNYHCIYMEWMEGGNLTQFLMNDKKQLRFKEHRIIKMIADIAETMSYLHK---HHIIHRDIKSNNVIL
Kinase AqueK556.AA DRK 1-120 31 7.2e-09 26.2 In-house 2-125 (258) Show / Hide 
Range on Protein: 1-120
Range on HMM: 2-125/258
Sequence Identity: 31% (39 aa)

MTEVVLGKGAWGEVEVTHFHGLKVAAKSLYEILIS-SYNIKIFSGEMNILSKIRHPNCLQFIGATTE-GNPIILTELMAT-SLRKEI--ESGGLAYPTIL
   .  |.| .|||      | .|| | |    |     .. |  | |.... ||||  ||.|. ..   . | .| |   || .    ||  .  | ..
KIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMK

SISLDVACALNYLHLFKPHPILHRD
.. .|.|  ..|||   |  |.|||
QMMFDCAKGMIYLHCCNPI-IIHRD
Kinase AqueK556.AA HH498 92-133 42 1.1e-08 23.21 In-house 121-162 (284) Show / Hide 
Range on Protein: 92-133
Range on HMM: 121-162/284
Sequence Identity: 42% (18 aa)

PTILSISLDVACALNYLHLFKPHPILHRDVSSSSVLLQQVGR
. .. ||.|||   ||||   .||| |||  |  .|. . |.
QSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGH
Kinase AqueK556.AA Pkinase 45-121 18 2.2e-08 30.71 Pfam 50-134 (293) Show / Hide 
Range on Protein: 45-121
Range on HMM: 50-134/293
Sequence Identity: 18% (16 aa)

EMNILSKIRHPNCLQFIGAT-TEGNPIILTELMAT-----SLRKEIE---SGGL--AYPTILSISLDVACALNYLHLFKPHPILHRDV
|  |. ...||| ......  ..... . .|..       .|   |.   .|..   . .. .. . ....|.|.|      |.|||.
EIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDL
Kinase AqueK556.AA TyrKc 5-197 18 9.9e-08 -97.64 SMART 6-280 (280) Show / Hide 
Range on Protein: 5-197
Range on HMM: 6-280/280
Sequence Identity: 18% (57 aa)

VLGKGAWGEVEVTHFHGLKVAAKSLYEILISSYNIKIFSGEMNILSKI--RHPNCLQFIGATTE--------GNPIILTELMA-----TSLRKEIESGGL
.|| || |||   .   ..|| |.| |       .. |  |..|..|.  .||| ....|. |.        . . |..|.|.       |||  .   |
KLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--L

AYPTILSISLDVACALNYLHLFKPHPILHRDVSSSSVLLQQVGRVWRAKVSGYTSANFQHLR-------RTSYDD--------SYP------G---SPI-
  .. ||.....||  .|||    ... |||     .|.   .                . .       |  |||         |       |    || 
CMKDLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENH----------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

YSAPEAGNPREHSPAMDVFSYGVLL--------------------------------------V-------------------------------QMLVC
  |||. | .. ... ||.|.||..                                                                      . .. 
WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

EF
.|
CF
Kinase AqueK556.AA Pkinase 161-199 35 0.00141 13.73 Pfam 173-212 (293) Show / Hide 
Range on Protein: 161-199
Range on HMM: 173-212/293
Sequence Identity: 35% (14 aa)

GSPIYSAPEAGN-PREHSPAMDVFSYGVLLVQMLVCEFPY
|.| | |||  .  ....|. |..|.|..| .||  ..|.
GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPF
Kinase AqueK556.AA MLK 158-199 37 0.001673 8.17 In-house 192-236 (291) Show / Hide 
Range on Protein: 158-199
Range on HMM: 192-236/291
Sequence Identity: 37% (17 aa)

SYPGSPIYSAPEA---GNPREHSPAMDVFSYGVLLVQMLVCEFPY
| .|.... |||.         | . ||.|.||.| .|| .| ||
SNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPY
Kinase AqueK556.AA HH498 45-64 35 0.036731 2.2 In-house 52-71 (284) Show / Hide 
Range on Protein: 45-64
Range on HMM: 52-71/284
Sequence Identity: 35% (7 aa)

EMNILSKIRHPNCLQFIGAT
|  |...  ||.  ||..|.
EVSIMCRLNHPCVVQFVYAC
Kinase AqueK556.AA CZAK 165-199 31 0.140794 1.69 In-house 188-222 (279) Show / Hide 
Range on Protein: 165-199
Range on HMM: 188-222/279
Sequence Identity: 31% (11 aa)

YSAPEAGNPREHSPAMDVFSYGVLLVQMLVCEFPY
. |||       ..  ||.|.| .|  .. |. ||
WMAPECFKGENYTEKVDVYSFGMILWCIITCDQPY