Gene AqueK551 (A.queenslandica)

AqueK551

Species: A.queenslandica
Alias: AqueK551
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-B

Sequence

Name Sequence Type Origin Length Description Download
AqueK551.AA Protein None 612 None Fasta, JSON
AqueK551.kin_dom Protein Kinase Domain None 170 None Fasta, JSON

Protein domain

Protein domains of AqueK551.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kelch_1 AqueK551.AA Kelch_1 33-47 20 51.21769 0.24 Pfam 31-45 (45) Show / Hide 
Range on Protein: 33-47
Range on HMM: 31-45/45
Sequence Identity: 20% (3 aa)

FNVDTFKWKELSPTT
....| .|....| .
YDPETNQWTRCPPMP
Kelch_2 AqueK551.AA Kelch_2 52-127 13 0.034114 12.46 Pfam 1-51 (51) Show / Hide 
Range on Protein: 52-127
Range on HMM: 1-51/51
Sequence Identity: 13% (10 aa)

PRMKHLCDMIAIKVNSEDYLVVVGGYGSTSNNTPKQPGAQYSEIEDIFSIETNQRCNEIHFYKLSTGQWISPTVTG
||. |.. ..      .. ..|.|||                     .. . . ... |... ..| .|   .. .
PRYCHASCVP------GGKIYVFGGYC-------------------RHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_1 AqueK551.AA Kelch_1 199-238 17 0.000217 19.51 Pfam 8-45 (45) Show / Hide 
Range on Protein: 199-238
Range on HMM: 8-45/45
Sequence Identity: 17% (7 aa)

TSSGPHLLVVGGTAGLFVSISDIWIFDTNNKSWKELDNVP
.. . .. |.||  |   . ......|. ...|... . |
CVHNGKIYVIGGCDG--QYLNSVECYDPETNQWTRCPPMP
Kelch_2 AqueK551.AA Kelch_2 188-238 23 0.001589 17.52 Pfam 1-51 (51) Show / Hide 
Range on Protein: 188-238
Range on HMM: 1-51/51
Sequence Identity: 23% (13 aa)

ERSAHSSVLINTSSGPHLLVVGGT----AGLFVSISDIWIFDTNNKSWKELDNVP
 |. |.|. .    |  ..|.||      .   ...|||..|.. ..|...  .|
PRYCHASCVP----GGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kinase AqueK551.AA TKL 438-608 18 3e-32 113.42 In-house 110-364 (364) Show / Hide 
Range on Protein: 438-608
Range on HMM: 110-364/364
Sequence Identity: 18% (49 aa)

EGYPIILTELM-PTSLRKELESGGVAYPAILSISLDVACALNYLHLFKP-----HPILHRDVSSANVLLQSIGN-----------CWRAKVSDYGTVS-L
.|.. | .|..   ||.  |       . .....||.|...||||  .|      ||.|||  |.|.|. . ..            |..|..|.|.   .
WGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFM

QPLT--------------------KTSNPG-NPVYSAPES-----PYPN-----------QHSPAMDVFSYGVLLIEMVVCE--FPDVGKR---------
.. .                    .|.... .| . |||      .|..           . |...||.|.|..| |.. ..  . | . .         
SQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFE

---VAQIKAIKRPTLK--------------------NLIERCLIENYKDRPTMSDIIKEL
   .  ..  .||...                    .|...|  .. ..||....|.|.|
EMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK551.AA HH498 464-566 37 7e-17 49.67 In-house 121-225 (284) Show / Hide 
Range on Protein: 464-566
Range on HMM: 121-225/284
Sequence Identity: 37% (40 aa)

PAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQSIGNCWRAKVSDYG----TVSLQPLTKTSNPGNPVYSAPESPY-PNQHSPAMDVFSYGVLLI
. .. ||.|||   ||||   .||| |||  | |.|.   |   .|.| |.|      ..   . |. |||. . |||      . |   |||||.  . 
QSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDG---HAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIW

EMVVCEFP
||   | |
EMHTREVP
Kinase AqueK551.AA MLK 466-566 32 1.7e-16 53.84 In-house 126-235 (291) Show / Hide 
Range on Protein: 466-566
Range on HMM: 126-235/291
Sequence Identity: 32% (36 aa)

ILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQS----IGNCWRAKVSDYGTVS-LQPL-T-KTSNPGNPVYSAPESP---YPNQHSPAMDVFSYGV
.....|..| ...|||  .|.|| |||  | |.|.      ...   .|..| ||.  ..   | ..||.|.. . |||       .. | . ||.|.||
AMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHG-TLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGV

LLIEMVVCEFP
.| ||. .| |
VLWEMLTREVP
Kinase AqueK551.AA CZAK 467-566 31 4.3e-16 55.06 In-house 108-221 (279) Show / Hide 
Range on Protein: 467-566
Range on HMM: 108-221/279
Sequence Identity: 31% (36 aa)

LSISLDVACALNYLHL-FKPHPILHRDVSSANVLLQSIGN----------CWRAKVSDYGTV---SLQPLTKTSNPGNPVYSAPESPYPNQHSPAMDVFS
... .|.|   ||||  .|| |||||| || |.|| .                .|..|.|       ||   |.  |   . |||       ..  ||.|
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYTEKVDVYS

YGVLLIEMVVCEFP
.| .| ... |. |
FGMILWCIITCDQP
Kinase AqueK551.AA TKL-Unique 466-561 27 3.4e-15 50.21 In-house 112-222 (290) Show / Hide 
Range on Protein: 466-561
Range on HMM: 112-222/290
Sequence Identity: 27% (31 aa)

ILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQSI--GNCWRAKVSDYGTVSLQP--LTKTSN----------PGNPVYSAPESPYP--NQHSPAMD
.... .|.| ...|||  .|  |.|||  | |.|. .    . |..|..| |.. ..   ...|.|           |.. ..|||      .| |   |
RVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSD

VFSYGVLLIEMV
|.|.|. |.|..
VYSFGIVLWEIA
Kinase AqueK551.AA TK 438-608 12 1.1e-13 41.52 In-house 127-486 (486) Show / Hide 
Range on Protein: 438-608
Range on HMM: 127-486/486
Sequence Identity: 12% (45 aa)

EGYPIILTELMP-TS----LRKELESGG------------------------------------------------------------------------
.. ..|..|.||  .    ||. | .                                                                          
QEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCL

-----VAYPAILSISLDVACALNYLHLFKPHPI----LHRDVSSANVLLQSIGNC--------WRAKVSDYG--------TVSLQPL----TKTSNPGNP
     .  .  | .....||.. |||  .         |||.   |.|. . ..|          .|..|.|             .     ...|..| .
TCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTG

V-------------------------YSAPESPY---------PNQHSPAMDVFSYGVLLIEMVV-C-EFPDVGKR-------------VAQIKAI----
.                         . |||.            . .... ||.|.|||. |..  . | .  |               . ....     
RPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLC

-------------KRPTLKN-------------------LIERCLIENYKDRPTMSDIIKEL
             ..| .                     |. .|  .. .||||.|.. ..|
RSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK551.AA LRRK 469-537 33 1e-11 37.71 In-house 169-249 (351) Show / Hide 
Range on Protein: 469-537
Range on HMM: 169-249/351
Sequence Identity: 33% (28 aa)

ISLDVACALNYLHLFKPHPILHRDVSSANVLLQSIG---------NCWRAKVSDYGTVS----LQP-LTKTSNPGNPVYSAPE
|.|..| ...||| ..| ||.|||  | |.||.|.          .   ||..|.|. .    ... ..|..  |||.. |||
IALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV-GNPGWMAPE
S_TKc AqueK551.AA S_TKc 342-612 15 1.2e-11 -6.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 342-612
Range on HMM: 1-231/231
Sequence Identity: 15% (47 aa)

NRLQQQL---------QGRERQ---------LQQAQQQGQERERQAREREQDLQRLLQEKERQIQEAQQLQSRERESQEREQQLQRQVEGGQQREQDLQR
 .. ...         ..|..          .                                           |. .|| |. ..      .   . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------------------------------EHIRREIQILKK------HHPNIVK

QLQEREQQLEEREREGYPIILTELMPT---SLRKELESGG-------VAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQSIGNCWRAKVSD
 .   .         ..  . .|....   .|.. ... |            . ..   ..|||.|.|  .   |.|||.  .|.|| .     . |..|
LYDVFQD--------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-----HIKICD

YGTVSLQPLTKTSNPGNPVYSAPESPYPNQHSP-AMDVFSYGVLLIEMVVCEFPDVGKRVAQIKAIKRPTLKNLIERCLIENYKDRPTMSDIIK-----E
 |   .     |.  | | | |||     .... . |. | |..|.||.. . |      . .| |. | .|..|..||  . ..|||  .. .      
FGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

LNESI
. . .
CHPWF
Kinase AqueK551.AA STE 476-606 19 1.3e-11 37.42 In-house 163-353 (359) Show / Hide 
Range on Protein: 476-606
Range on HMM: 163-353/359
Sequence Identity: 19% (39 aa)

A-LNYLHLFKPHPILHRDVSSANVLLQSIGNCWRAKVSDYGTVS-LQP------------------LTKTSNPGNPVYSAPESPYP------NQHSPAMD
. |.|||  .   | |||. .||.||        .| .| |. . |..                     ..  | | . |||   .      ....   |
GLLYYLHSHH---IIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCD

VFSYGVLLIEMVVCEFP----DVGKRVAQIKAI--------------------KR----------------------PTLKNLIERCLIENYKDRPTMSD
. | | ..|||.  . |       .   .|                       .                       | .|. |..||. ....||| |.
IWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ

IIK
 .|
LLK
Kinase AqueK551.AA Dicty5 461-560 31 4e-11 34.54 In-house 101-196 (260) Show / Hide 
Range on Protein: 461-560
Range on HMM: 101-196/260
Sequence Identity: 31% (32 aa)

VAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQSIGNCWRAKVSDYGT---VSLQPLTKTSNPGNPVYSAPESPYPNQHSPAMDVFSYGVLL
.||. .|.. .|.| .. .||      | |||. | |.|   |   | .|. |.||   | .. .  | . | . . |.|    .      ||.|.|. |
IAYFQQLHMAIDIAQSMRHLHSMN---IIHRDLKSMNFL---ITENWKIKIIDFGTSRFVDNR-YHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVL

IEM
 ||
WEM
Pkinase AqueK551.AA Pkinase 436-612 18 9.9e-11 39.02 Pfam 70-293 (293) Show / Hide 
Range on Protein: 436-612
Range on HMM: 70-293/293
Sequence Identity: 18% (42 aa)

EREGYPIILTELMPT-----SLRKELE---SGGV--AYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQSIGNC-WRAKVSDYGTVS---LQP
|..... . .|...      .|   ..   .|..   .  . .. . ....|.|.|      |.|||. ..|.|. . |..  . |..| |      . .
EDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-N

LTKTSNPGNPVYSAPESPY-PNQHSPAMDVFSYGVLLIEMVVCEFPDVGK----------RVAQIKA-------IKR---------------------PT
 . |.  | | | |||     . ..|. |..|.|..|.||.  ..|  |.          ....|.         .                      ..
NSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEE

LKNLIERCLIENYKDRPTMSDIIKELNES--I
.| .|..||  . |.|||    .... ..  .
CKDFIKWCLCKDPKKRPT----AEQILQHPWF
Kinase AqueK551.AA TK-Unique 467-561 25 4.6e-10 31.03 In-house 134-233 (294) Show / Hide 
Range on Protein: 467-561
Range on HMM: 134-233/294
Sequence Identity: 25% (27 aa)

LSISLDVACALNYLHLFKPHPILHRDVSSANVLLQSIGNCWRAKVSDYGTVS------LQPLTKTSNPGNPVYSAPESPY--PNQH-SPAMDVFSYGVLL
...  ..||...||.   .. | |||... ||||.. ..|   |..|.|          .  ......    . ||||..   ... ..  || |.|||.
YHFAWQIACGMEYLASQ-RKKIVHRDLCARNVLLTEDKVC---KICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLM

IEMV
 |..
WEIF
TyrKc AqueK551.AA TyrKc 387-608 17 3.8e-08 -90.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 387-608
Range on HMM: 1-280/280
Sequence Identity: 17% (52 aa)

IQEAQQLQS------------------RERESQEREQQLQRQVEGGQQREQDLQRQLQEREQQ--------------LEERERE---GYPIILTELMPT-
|.  ..| .                    .|.                 ..|. | ..   .               ... ..    . . |..|.||  
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA----------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

SLRKELESGG--VAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQSIGNCWRAKVSDYG-TVSLQPL--------TKTSN---PGN---PV-
.|.. | . .  .  .  ||.....||  .|||    ... |||    |.|. . .   ..|.|| | .  .           ....     |.   |. 
DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

YSAPESPYPNQH--SPAMDVFSYGVLLIEMV-------------------VCEFPDVGKRVAQIKA-------IKRPTLKNLIERCLIENYKDRPTMSDI
  |||.   | .  ... ||.|.||.. |.                    | |. . |.|  | .        .  . . .....|  |. .||||.|.|
WMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

IKEL
....
HECF
Kinase AqueK551.AA LRRK 581-610 33 6e-06 17.03 In-house 322-351 (351) Show / Hide 
Range on Protein: 581-610
Range on HMM: 322-351/351
Sequence Identity: 33% (10 aa)

PTLKNLIERCLIENYKDRPTMSDIIKELNE
. ...||. |  .. |.||..|.|.| | .
HMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK551.AA MLK 581-608 25 8e-06 16.27 In-house 264-291 (291) Show / Hide 
Range on Protein: 581-608
Range on HMM: 264-291/291
Sequence Identity: 25% (7 aa)

PTLKNLIERCLIENYKDRPTMSDIIKEL
. .|.|...|  .. ..||... |...|
EHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK551.AA TKL-Unique 583-608 30 9e-06 16.61 In-house 265-290 (290) Show / Hide 
Range on Protein: 583-608
Range on HMM: 265-290/290
Sequence Identity: 30% (8 aa)

LKNLIERCLIENYKDRPTMSDIIKEL
...||..|   .  .||. ..||..|
YRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK551.AA TK-Unique 580-608 24 0.000133 11.93 In-house 266-294 (294) Show / Hide 
Range on Protein: 580-608
Range on HMM: 266-294/294
Sequence Identity: 24% (7 aa)

RPTLKNLIERCLIENYKDRPTMSDIIKEL
.... ||...|. .. ..||. ..|...|
SHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK551.AA Pkinase_Tyr 452-515 24 0.000484 14.31 Pfam 98-156 (270) Show / Hide 
Range on Protein: 452-515
Range on HMM: 98-156/270
Sequence Identity: 24% (16 aa)

LRKE-LESGGVAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQSIGNCWRAKVSDYG
|||   . . .  . .|......|....||.  .   . |||.   |.|. .  |   .|..| |
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE--NN-VVKICDFG
Kinase AqueK551.AA Pkinase_Tyr 581-608 32 0.001238 12.93 Pfam 243-270 (270) Show / Hide 
Range on Protein: 581-608
Range on HMM: 243-270/270
Sequence Identity: 32% (9 aa)

PTLKNLIERCLIENYKDRPTMSDIIKEL
. . .|. .|  .. .||||.|.|. .|
DEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK551.AA Dicty5 585-612 32 0.022888 3.95 In-house 233-260 (260) Show / Hide 
Range on Protein: 585-612
Range on HMM: 233-260/260
Sequence Identity: 32% (9 aa)

NLIERCLIENYKDRPTMSDIIKELNESI
|||. |  .  . ||.   |.| ..  |
NLIKKCWQQKPHNRPSFKEICKYFESII
Kinase AqueK551.AA HH498 585-608 33 0.152047 0.21 In-house 261-284 (284) Show / Hide 
Range on Protein: 585-608
Range on HMM: 261-284/284
Sequence Identity: 33% (8 aa)

NLIERCLIENYKDRPTMSDIIKEL
||| .|   .  .||. ..|.  |
NLIQMCWHPCPENRPDFDQIVTIL
Kinase AqueK551.AA CZAK 583-608 38 0.280333 0.59 In-house 254-279 (279) Show / Hide 
Range on Protein: 583-608
Range on HMM: 254-279/279
Sequence Identity: 38% (10 aa)

LKNLIERCLIENYKDRPTMSDIIKEL
|  |||.|   |   ||. . |.  |
LGELIEMCWNKNPDERPSFKQILQHL
Kinase AqueK551.AA Pkinase_Tyr 549-561 53 1.447269 2.54 Pfam 196-208 (270) Show / Hide 
Range on Protein: 549-561
Range on HMM: 196-208/270
Sequence Identity: 53% (7 aa)

DVFSYGVLLIEMV
|| |.|||. |..
DVWSFGVLMWEIF