Gene AqueK548 (A.queenslandica)

AqueK548

Species: A.queenslandica
Alias: AqueK548
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-B

Sequence

Name Sequence Type Origin Length Description Download
AqueK548.AA Protein None 166 None Fasta, JSON
AqueK548.kin_dom Protein Kinase Domain None 163 None Fasta, JSON

Protein domain

Protein domains of AqueK548.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK548.AA TKL 19-161 18 1.2e-28 100.28 In-house 134-364 (364) Show / Hide 
Range on Protein: 19-161
Range on HMM: 134-364/364
Sequence Identity: 18% (43 aa)

ILSISLDVACALNYLHLFKP-----HPILHRDVSSANVLLQPVGV-----------GWRAKVSDYGTVS-LQPLTS--------------------TCSP
.....||.|...||||  .|      ||.|||  |.|.|.   .             |..|..|.|.   ... ..                    |...
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQ

G-NPVYSAPEA--GNP--------------REHSPAMDVFSYGVLLIEMVVCQ--FPDVGKR------------VAQIKAIKRPTLK-------------
. .| . |||.  |..              .| |...||.|.|..| |.. ..  . | . .            .  ..  .||...             
CGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCP

-------NLIERCLIEIYKDRPTMSDIIKEI
       .|...|  .  ..||....|.|..
DCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK548.AA HH498 17-113 37 9.3e-15 42.82 In-house 121-219 (284) Show / Hide 
Range on Protein: 17-113
Range on HMM: 121-219/284
Sequence Identity: 37% (38 aa)

PAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPVGVGWRAKVSDYG----TVSLQPLTSTCSPGNPVYSAPEAGN-PREHSPAMDVFSYGVLLI
. .. ||.|||   ||||   .||| |||  | |.|.   |   .|.| |.|      ..   . |  |||. . |||        |   |||||.  . 
QSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDG---HAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIW

EM
||
EM
Kinase AqueK548.AA CZAK 20-119 31 1e-14 49.99 In-house 108-221 (279) Show / Hide 
Range on Protein: 20-119
Range on HMM: 108-221/279
Sequence Identity: 31% (36 aa)

LSISLDVACALNYLHL-FKPHPILHRDVSSANVLLQPVGV----------GWRAKVSDYGTV---SLQPLTSTCSPGNPVYSAPEAGNPREHSPAMDVFS
... .|.|   ||||  .|| |||||| || |.||                  .|..|.|       ||   | . |   . |||       ..  ||.|
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYTEKVDVYS

YGVLLIEMVVCQFP
.| .| ... |  |
FGMILWCIITCDQP
Kinase AqueK548.AA MLK 19-114 30 3e-14 45.94 In-house 126-230 (291) Show / Hide 
Range on Protein: 19-114
Range on HMM: 126-230/291
Sequence Identity: 30% (33 aa)

ILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQP------VGVGWRAKVSDYGTVS-LQPL-T-STCSPGNPVYSAPEA---GNPREHSPAMDVFSY
.....|..| ...|||  .|.|| |||  | |.|.         |.   .|..| ||.  ..   |  .. .|.. . |||.         | . ||.|.
AMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGT---LKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSW

GVLLIEMV
||.| ||.
GVVLWEML
Kinase AqueK548.AA Dicty5 14-113 31 1.4e-11 36.14 In-house 101-196 (260) Show / Hide 
Range on Protein: 14-113
Range on HMM: 101-196/260
Sequence Identity: 31% (32 aa)

VAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPVGVGWRAKVSDYGT---VSLQPLTSTCSPGNPVYSAPEAGNPREHSPAMDVFSYGVLL
.||. .|.. .|.| .. .||      | |||. | |.|.      | .|. |.||   | .. .  |   | . . |.|  | .      ||.|.|. |
IAYFQQLHMAIDIAQSMRHLHSMN---IIHRDLKSMNFLIT---ENWKIKIIDFGTSRFVDNR-YHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVL

IEM
 ||
WEM
Kinase AqueK548.AA TKL-Unique 19-114 25 2.1e-11 36.66 In-house 112-222 (290) Show / Hide 
Range on Protein: 19-114
Range on HMM: 112-222/290
Sequence Identity: 25% (29 aa)

ILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPV--GVGWRAKVSDYGTVSLQP--LTSTCS----------PGNPVYSAPEAGNP--REHSPAMD
.... .|.| ...|||  .|  |.|||  | |.|.        |..|..| |.. ..   ...| .           |.. ..|||  .      |   |
RVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSD

VFSYGVLLIEMV
|.|.|. |.|..
VYSFGIVLWEIA
Kinase AqueK548.AA TK 20-161 13 5.2e-11 32.37 In-house 238-486 (486) Show / Hide 
Range on Protein: 20-161
Range on HMM: 238-486/486
Sequence Identity: 13% (35 aa)

LSISLDVACALNYLHLFKPHPI----LHRDVSSANVLLQPVGV--------GWRAKVSDYG--------TVSLQPLTSTCSPGNPVY-------------
| .....||.. |||  .         |||.   |.|.   .|        |  .|..|.|             .  .     .. .             
L-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPW

----------------SAPEAGN---------PREHSPAMDVFSYGVLLIEMVV---CQFPDVGKR------------VAQIKAI---------------
                 |||. |          . .... ||.|.|||. |..     ...                 . ....                
QDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRM

--KRPTLKN-------------------LIERCLIEIYKDRPTMSDIIKEI
  ..| .                     |. .|  .  .||||.|.. ...
RMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK548.AA LRRK 22-110 31 1.7e-10 33.33 In-house 169-272 (351) Show / Hide 
Range on Protein: 22-110
Range on HMM: 169-272/351
Sequence Identity: 31% (33 aa)

ISLDVACALNYLHLFKPHPILHRDVSSANVLL----QP-----VGVGWRAKVSDYGTVS----LQP-LTSTCSPGNPVYSAPEAGNPR---EHSPAMDVF
|.|..| ...||| ..| ||.|||  | |.||    |.     ..    ||..|.|. .    ... ....|  |||.. |||  .     | .   |..
IALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV-GNPGWMAPEIMRYNGEEEYTEKVDCY

SYGVLL
|.|..|
SFGMIL
Kinase AqueK548.AA STE 29-159 19 3.7e-09 28.63 In-house 163-353 (359) Show / Hide 
Range on Protein: 29-159
Range on HMM: 163-353/359
Sequence Identity: 19% (39 aa)

A-LNYLHLFKPHPILHRDVSSANVLLQPVGVGWRAKVSDYGTVS-LQP------------------LTSTCSPGNPVYSAPEAGNP------REHSPAMD
. |.|||  .   | |||. .||.||        .| .| |. . |..                    ..   | | . |||  ..       ...   |
GLLYYLHSHH---IIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCD

VFSYGVLLIEMVVCQFP----DVGKRVAQIKAI--------------------KR----------------------PTLKNLIERCLIEIYKDRPTMSD
. | | ..|||.  . |       .   .|                       .                       | .|. |..||.  ...||| |.
IWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ

IIK
 .|
LLK
Kinase AqueK548.AA IRAK 20-53 45 1.7e-08 26.37 In-house 112-146 (317) Show / Hide 
Range on Protein: 20-53
Range on HMM: 112-146/317
Sequence Identity: 45% (16 aa)

LSISLDVACALNYLHLFKPH-PILHRDVSSANVLL
.||..  ||....|| . |  || |.|..|||.||
CSICWGTACGIQFLHQNHPCTPIIHGDIKSANILL
Pkinase AqueK548.AA Pkinase 10-165 18 1.5e-07 27.79 Pfam 99-293 (293) Show / Hide 
Range on Protein: 10-165
Range on HMM: 99-293/293
Sequence Identity: 18% (38 aa)

ESGGV--AYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQ-PVGVGWRAKVSDYGTVS---LQPLTSTCSP-GNPVYSAPEAGN-PREHSPAM
..|..   .  . .. . ....|.|.|      |.|||. ..|.|.     .. . |..| |      . . . . .. | | | |||  .  ....|. 
RHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVFSYGVLLIEMVVCQFPDVGK----------RVAQIKA-------IKR---------------------PTLKNLIERCLIEIYKDRPTMSDIIKEIKE
|..|.|..|.||.  ..|  |.          ....|.         .                      ...| .|..||    |.|||    ...|..
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT----AEQILQ

K--L
   .
HPWF
S_TKc AqueK548.AA S_TKc 1-162 16 9.1e-07 -77.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-162
Range on HMM: 1-231/231
Sequence Identity: 16% (42 aa)

M--------------------------------------------------------------------PT---SLRKELESGG-------VAYPAILSI
                                                                     ..   .|.. ... |            . ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

SLDVACALNYLHLFKPHPILHRDVSSANVLLQPVGVGWRAKVSDYGTVSLQPLTSTCSPGNPVYSAPEAGNPREHSP-AMDVFSYGVLLIEMVVCQFPDV
   ..|||.|.|  .   |.|||.  .|.||       . |..| |   .   |. |  | | | |||      ... . |. | |..|.||.. . |  
MYQICCALEYCHSHG---IIHRDLKPENILLDE-----HIKICDFGLARQL--TTFC--GTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP

GKRVAQIKAIKRPTLKNLIERCLIEIYKDRPTMSDIIK--------EIK
    . .| |. | .|..|..||    ..|||  .. .        .  
-QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
TyrKc AqueK548.AA TyrKc 3-161 15 9e-06 -129.31 SMART 1-280 (280) Show / Hide 
Range on Protein: 3-161
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)

TSLRKELESG-------------------------------------G------------------------------------------------VAYP
 .| |.| .|                                     |                                                .  .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

AILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPVGVGWRAKVSDYGTVSLQPLT--------STCS----PGN---PV-YSAPEAGNPREHSPAM
  ||.....||  .|||    ... |||    |.|.   .   ..|.|| |                   .     |.   |.   |||. | .. ... 
DLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVFSYGVLLIEMV-------------------VCQFPDVGKRVAQIKA-------IKRPTLKNLIERCLIEIYKDRPTMSDIIKEI
||.|.||.. |.                    | .. . |.|  | .        .  . . .....|  |  .||||.|.|....
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK548.AA LRRK 134-163 30 9.1e-05 12.77 In-house 322-351 (351) Show / Hide 
Range on Protein: 134-163
Range on HMM: 322-351/351
Sequence Identity: 30% (9 aa)

PTLKNLIERCLIEIYKDRPTMSDIIKEIKE
. ...||. |  .  |.||..|.|.| ...
HMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK548.AA MLK 134-161 21 0.001684 8.16 In-house 264-291 (291) Show / Hide 
Range on Protein: 134-161
Range on HMM: 264-291/291
Sequence Identity: 21% (6 aa)

PTLKNLIERCLIEIYKDRPTMSDIIKEI
. .|.|...|  .  ..||... |... 
EHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK548.AA TKL-Unique 136-161 26 0.002433 7.85 In-house 265-290 (290) Show / Hide 
Range on Protein: 136-161
Range on HMM: 265-290/290
Sequence Identity: 26% (7 aa)

LKNLIERCLIEIYKDRPTMSDIIKEI
...||..|      .||. ..||...
YRDLIQQCWHHDPSQRPSFDEIIHRL
Pkinase_Tyr AqueK548.AA Pkinase_Tyr 5-53 24 0.002762 11.75 Pfam 98-144 (270) Show / Hide 
Range on Protein: 5-53
Range on HMM: 98-144/270
Sequence Identity: 24% (12 aa)

LRKE-LESGGVAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLL
|||   . . .  . .|......|....||.  .   . |||.   |.|.
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLV
Kinase AqueK548.AA Pkinase_Tyr 134-161 28 0.037583 7.91 Pfam 243-270 (270) Show / Hide 
Range on Protein: 134-161
Range on HMM: 243-270/270
Sequence Identity: 28% (8 aa)

PTLKNLIERCLIEIYKDRPTMSDIIKEI
. . .|. .|  .  .||||.|.|. ..
DEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK548.AA IRAK 88-112 29 0.152541 1.44 In-house 190-216 (317) Show / Hide 
Range on Protein: 88-112
Range on HMM: 190-216/317
Sequence Identity: 29% (8 aa)

APEAGN--PREHSPAMDVFSYGVLLIE
.||. .   .. ..  ||.| |. | |
PPEFIRDPQGQLTKKTDVYSFGIVLLE
Kinase AqueK548.AA Pkinase_Tyr 102-114 53 1.447269 2.54 Pfam 196-208 (270) Show / Hide 
Range on Protein: 102-114
Range on HMM: 196-208/270
Sequence Identity: 53% (7 aa)

DVFSYGVLLIEMV
|| |.|||. |..
DVWSFGVLMWEIF