Gene AqueK546 (A.queenslandica)

AqueK546

Species: A.queenslandica
Alias: AqueK546
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-B

Sequence

Name Sequence Type Origin Length Description Download
AqueK546.AA Protein None 129 None Fasta, JSON
AqueK546.kin_dom Protein Kinase Domain None 129 None Fasta, JSON

Protein domain

Protein domains of AqueK546.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK546.AA TKL 1-129 21 4.8e-24 83.47 In-house 89-282 (364) Show / Hide 
Range on Protein: 1-129
Range on HMM: 89-282/364
Sequence Identity: 21% (43 aa)

QFIGATREGN--------------PIILTELM-PSSLRKELETGLPLPYPAILSISLDVACALNYLHLFKP-----HPIIHRDISSGNVLLQIGWR----
||.|.  ...              . | .|..   ||.  |        . .....||.|...||||  .|      ||||||. | |.|.   |.    
QFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSN

----------AKVSDYGSANLQNLIA--------------------TTENPG-NRVYSAPEA--GNP--------------REHSPAMDVFSYGVLLIEM
          .|..|.| .   .                       || ... .  . |||.  |..              .| |...||.|.|..| |.
YMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase AqueK546.AA Dicty5 28-129 33 8.5e-17 54.33 In-house 97-196 (260) Show / Hide 
Range on Protein: 28-129
Range on HMM: 97-196/260
Sequence Identity: 33% (35 aa)

TGLPLPYPAILSISLDVACALNYLHLFKPHPIIHRDISSGNVLLQIGWRAKVSDYG-SANLQNLIATTENPGNRVYSAPEAGNPREHSPAMDVFSYGVLL
|| |. |. .|.. .|.| .. .||      |||||. | |.|.   | .|. |.| | .  |    | . |   . |.|  | .      ||.|.|. |
TGQPIAYFQQLHMAIDIAQSMRHLHSMN---IIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVL

IEM
 ||
WEM
Kinase AqueK546.AA TKL-Unique 1-129 24 1e-15 52.02 In-house 60-221 (290) Show / Hide 
Range on Protein: 1-129
Range on HMM: 60-221/290
Sequence Identity: 24% (40 aa)

QFIGATR-----EGNPIILTELMP-SSLRKELE----------TGLPLPYPAILSISLDVACALNYLHLFKPHPIIHRDISSGNVLLQIG-----WRAKV
...|..      ..| .| .| .| .||.. |             ..|..  .... .|.| ...|||  .|  |||||. | |.|.  .     |..|.
HYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKI

SDYGSANLQNLIATTENP-----------GNRVYSAPEAGNP--REHSPAMDVFSYGVLLIEM
.| | . ... | .. |            |.  ..|||  .      |   ||.|.|. |.|.
CDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEI
Kinase AqueK546.AA HH498 35-129 38 1.2e-15 45.65 In-house 121-219 (284) Show / Hide 
Range on Protein: 35-129
Range on HMM: 121-219/284
Sequence Identity: 38% (38 aa)

PAILSISLDVACALNYLHLFKPHPIIHRDISSGNVLLQIGWRAKVSDYGSANLQNLIAT---TENPGNRVYSAPEAGN-PREHSPAMDVFSYGVLLIEM
. .. ||.|||   ||||   .|||||||  | |.|.    .|.| |.|     . .     |  |||  . |||        |   |||||.  . ||
QSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEM
Kinase AqueK546.AA MLK 1-129 25 2e-15 50.12 In-house 73-229 (291) Show / Hide 
Range on Protein: 1-129
Range on HMM: 73-229/291
Sequence Identity: 25% (40 aa)

QFIGA-TREGN-PIILTELMP-SSLRKELETG--------------LPLPYPAILSISLDVACALNYLHLFKPHPIIHRDISSGNVLLQI------GWRA
|| |. .....   |..| .. .||   | ..                 .   .....|..| ...|||  .|.||||||. | |.|.        .  .
QFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTL

KVSDYGSAN-LQNLIA-TTENPGNRVYSAPEA---GNPREHSPAMDVFSYGVLLIEM
|..| | .  ...  .  . |.|.  . |||.         | . ||.|.||.| ||
KICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEM
Kinase AqueK546.AA CZAK 38-129 28 2.7e-12 41.08 In-house 108-215 (279) Show / Hide 
Range on Protein: 38-129
Range on HMM: 108-215/279
Sequence Identity: 28% (31 aa)

LSISLDVACALNYLHL-FKPHPIIHRDISSGNVLLQIGWR-------------AKVSDYGSANLQNLIAT--TENPGNRVYSAPEAGNPREHSPAMDVFS
... .|.|   ||||  .|| ||.||| || |.||                  .|..|.|   .    ..  |   |   . |||       ..  ||.|
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYTEKVDVYS

YGVLLIEM
.| .| ..
FGMILWCI
Kinase AqueK546.AA Pkinase 6-129 21 1.4e-11 42.04 Pfam 70-205 (293) Show / Hide 
Range on Protein: 6-129
Range on HMM: 70-205/293
Sequence Identity: 21% (30 aa)

TREGNPIILTELMPS-----SLRKELE--TGLPL--PYPAILSISLDVACALNYLHLFKPHPIIHRDISSGNVLLQIGWRA----KVSDYGSAN---LQN
...... . .|...      .|   ..   . ..  ..  . .. . ....|.|.|      |||||. . |.|.          |..| |.|    . |
EDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-N

LIATTENPGNRVYSAPEAGN-PREHSPAMDVFSYGVLLIEM
   .|   | . | |||  .  ....|. |..|.|..|.||
NS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase AqueK546.AA TK 1-129 13 1.5e-11 34.24 In-house 107-387 (486) Show / Hide 
Range on Protein: 1-129
Range on HMM: 107-387/486
Sequence Identity: 13% (38 aa)

QFIG-ATREGN------------PIILTELMP-SS----LRKELETGLP---------------------------------------------------
...|  |....            ..|..|.||  .    ||. | .  |                                                   
RLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIK

-------------------------LPYPAILSISLDVACALNYLHLFKPHPI----IHRDISSGNVLLQIGWR-----------AKVSDYGSAN-----
                         |. .  | .....||.. |||  .        .|||.   |.|.  . .           .|..|.| .      
DHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGV

LQNLIATTENPGNRV-------------------------------YSAPEAGN---------PREHSPAMDVFSYGVLLIEM
|   |   ..   .                                . |||. |          . .... ||.|.|||. |.
LARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
Kinase AqueK546.AA IRAK 38-128 30 5.4e-11 35.37 In-house 112-216 (317) Show / Hide 
Range on Protein: 38-128
Range on HMM: 112-216/317
Sequence Identity: 30% (32 aa)

LSISLDVACALNYLHLFKPH-PIIHRDISSGNVLLQIGWRAKVSDYG--------SANLQNLI---ATTENPGNRVYSAPEAGN--PREHSPAMDVFSYG
.||..  ||....|| . |  ||||.||.| |.||     .| .| |        |....  .    |    |   | .||. .   .. ..  ||.| |
CSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFG

VLLIE
. | |
IVLLE
Kinase AqueK546.AA TK-Unique 31-129 26 1.1e-09 29.66 In-house 127-232 (294) Show / Hide 
Range on Protein: 31-129
Range on HMM: 127-232/294
Sequence Identity: 26% (28 aa)

PLPYPAILSISLDVACALNYLHLFKPHPIIHRDISSGNVLLQIGWRAKVSDYGSA-----NLQNLIATTENPGNRVYSAPEAGN--PREH-SPAMDVFSY
|. .   ...  ..||...||.   .. |.|||... ||||. . ..|..|.| |     | ..   .....    . |||.     . . ..  || |.
PISPKDLYHFAWQIACGMEYLASQ-RKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSF

GVLLIEM
|||. |.
GVLMWEI
Kinase AqueK546.AA LISK 28-83 41 3.9e-08 22.32 In-house 91-150 (296) Show / Hide 
Range on Protein: 28-83
Range on HMM: 91-150/296
Sequence Identity: 41% (26 aa)

TGL---PLPYPAILSISLDVACALNYLHLFKPHPIIHRDISSGNVLLQIG----WRAKVSDYG
...   ||| |  ..|.||.||.. |||  .   |||||  | |.|. .     ||.|| | |
MDKHKIPLPWPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFG
Kinase AqueK546.AA Pkinase_Tyr 1-83 26 7.7e-08 27.18 Pfam 68-156 (270) Show / Hide 
Range on Protein: 1-83
Range on HMM: 68-156/270
Sequence Identity: 26% (24 aa)

QFIGATR-EGNP---IILTELMPS-SLRKELET----GLPLPYPAILSISLDVACALNYLHLFKPHPIIHRDISSGNVLLQIGWRAKVSDYG
...|.   .| |   .| .|.||  .|.. | .    . ||. . .|......|....||.  .   .||||.   |.|.  .  .|..| |
RLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFG
Kinase AqueK546.AA LISK 118-129 58 0.005324 5.36 In-house 221-232 (296) Show / Hide 
Range on Protein: 118-129
Range on HMM: 221-232/296
Sequence Identity: 58% (7 aa)

DVFSYGVLLIEM
||||.|..|.|.
DVFSFGIVLCEI
Kinase AqueK546.AA Pkinase_Tyr 118-129 58 1.204569 2.81 Pfam 196-207 (270) Show / Hide 
Range on Protein: 118-129
Range on HMM: 196-207/270
Sequence Identity: 58% (7 aa)

DVFSYGVLLIEM
|| |.|||. |.
DVWSFGVLMWEI