Gene AqueK512 (A.queenslandica)

AqueK512

Species: A.queenslandica
Alias: AqueK512
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a1

Sequence

Name Sequence Type Origin Length Description Download
AqueK512.AA Protein None 491 None Fasta, JSON
AqueK512.kin_dom Protein Kinase Domain None 227 None Fasta, JSON

Protein domain

Protein domains of AqueK512.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
AAA AqueK512.AA AAA 104-169 45 3.8e-21 78.54 Pfam 88-150 (150) Show / Hide 
Range on Protein: 104-169
Range on HMM: 88-150/150
Sequence Identity: 45% (31 aa)

IGTKRYESHSGGEREIQRTMLELLNQLDGFDSRGD-VKVIMATNR-IETLDPSLIRPGRIDRKIEFPL
|..||     .. .| .|.. .||.|.|||..... | ||.|||| ....|| |.||||.||.|.|||
ICPKR-----SEHEERRRVVNQLLTQMDGFQNNNGKVIVIAATNRPPDMIDPALRRPGRFDRHIYFPL
Kinase AqueK512.AA TKL 215-436 23 4.9e-42 145.98 In-house 70-364 (364) Show / Hide 
Range on Protein: 215-436
Range on HMM: 70-364/364
Sequence Identity: 23% (69 aa)

QKFNEEILLHSQQRHPNIVQLIG-VYYPPR----------SQVPMLVMEYLPF-TLRESLEHDGLPLQMKYSILSDVAKGLCYLHSNS------PPIVHR
....|||...|. |||||||..| . .||           .  ...|||| |  .|.. |      .. . ..  |.|.|..||||.       |||.||
FFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHR

DLTANNVLLTSFYV--------------AKISDLGVSRLVGKFK-----------------SHQKLTQAPGNAIVMPPEALAAKP---------------
||. .|.|. . .               .||.|.| || . . .                 .....    |.   |.||.|  ..               
DLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGF

VYNEKVDVFSYGCLILHILTCQFPEP-TDAFVQYFR----IWQSKVAEWDRRSKYI---------QKIPEDEKELLPLAKQCLQDRPYSRPDMLTVLQAV
 |.||.||.|.| ..  |||.. |.   . . ..|.    .....|..  .|             .. |   ...  |...| .  | .|| ....|.  
EYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK512.AA LRRK 228-374 34 3.5e-28 96.81 In-house 115-282 (351) Show / Hide 
Range on Protein: 228-374
Range on HMM: 115-282/351
Sequence Identity: 34% (60 aa)

RHPNIVQLIGVYYPPRSQVPMLVMEYLPF-TLRESLE---HDG-------LPLQMKYSILSDVAKGLCYLHSNSPPIVHRDLTANNVLLTSF--------
.|||||.|.|.   |.    ..||||.|. .| . |.   .||       .. ..|. |  ..|||. ||||..|||.||||.  |.|| |.        
NHPNIVSLKGFCIHPL----CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNY

----YVAKISDLGVSRLVGKFKSHQKLTQAPGNAIVMPPEALAAK--PVYNEKVDVFSYGCLILHILTCQ-FP
    ..|||.| | ||.  .   .  .    || . | || . .    .|.||||..|.| .. ..|| | .|
PNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP
Kinase AqueK512.AA TKL-Unique 207-362 28 1.9e-27 93.93 In-house 32-215 (290) Show / Hide 
Range on Protein: 207-362
Range on HMM: 32-215/290
Sequence Identity: 28% (52 aa)

ADIKESTLQKFNEEILLHSQQR-HPNIVQLIGVYY---PPRSQVPMLVMEYLPF-TLRESLE-----------HDGLPLQMKYSILSDVAKGLCYLHSNS
.|.  . .|.|..|. . .  . |||||...|.     .. ..   .||||.|  .|.. |            .  |..|.....  |.|.|..|||...
EDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNM-CIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCE

PPIVHRDLTANNVLLTSF-----YVAKISDLGVSRLVGKF--KSHQKL-----TQAPGNAIVMPPEALAAK-PVYNEKVDVFSYG
||| ||||.  |.|....     . .||.| | |..  |   ..   .     .   |... |.|| |      |.||.||.|.|
PPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFG
Kinase AqueK512.AA MLK 207-374 25 2.6e-27 91.88 In-house 37-235 (291) Show / Hide 
Range on Protein: 207-374
Range on HMM: 37-235/291
Sequence Identity: 25% (53 aa)

ADI-----KESTLQKFNEEILLHSQQRHPN----IVQLIGV-YYPPRSQVPMLVMEYLPFTLRESLEHDG----------------LPLQMKYSILSDVA
|.|     ...  ..|..|. . .  .|||    |.|. ||   ||  .   .||||...    .. |..                 ... . ..  ..|
ARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP--CHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCA

KGLCYLHSNSP-PIVHRDLTANNVLLTS------FYVAKISDLGVSRLVGKFKSHQK-LTQAPGNAIVMPPEAL--AAKPVYNEKVDVFSYGCLILHILT
.|. ||||. | ||.||||   |.|..         ..||.| |.||   .......  . ..|... | ||..  .    |.||.||.|.| ..  .||
RGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR---DWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLT

CQFP
.. |
REVP
Kinase AqueK512.AA TK 219-365 16 1.4e-26 85.54 In-house 92-384 (486) Show / Hide 
Range on Protein: 219-365
Range on HMM: 92-384/486
Sequence Identity: 16% (50 aa)

EEILLHSQQRHPNIVQLIGVYYPPRS----------QVPMLVMEYLPFT-----LRESLEHDG-------------------------------------
.....||  .|||||.|.||   ...          . .|.|||| |       ||. |                                         
MKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESN

----------------------------------------LPLQMKYSILSDVAKGLCYLHSNSP----PIVHRDLTANNVLLTSFYV-----------A
                                        |... .  .  ..|.|. ||||.       .||||| | |.|... .|           .
SPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVC

KISDLG--------VSRLVGK--FKSHQKLTQAPGNAIV-----------------------MPPEALAAKP--------VYNEKVDVFSYGCLI
||.| |         .| ...      ..   .....                         |.||.|. .         .. .| ||.|.|.|.
KIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM
Kinase AqueK512.AA HH498 269-374 40 2.1e-24 73.94 In-house 120-225 (284) Show / Hide 
Range on Protein: 269-374
Range on HMM: 120-225/284
Sequence Identity: 40% (43 aa)

LQMKYSILSDVAKGLCYLHS-NSPPIVHRDLTANNVLLTSFYVAKISDLGVSRLVGKFKSHQKLTQAPGNAIVMPPEALAAKPVYNEKVDVFSYGCLILH
|| |  |  |||.|  |||.   .||.||||.  |.|.  .  |.. | | || |        .|  |||   | ||       | .|||||||.  |  
LQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMH-DDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWE

ILTCQFP
..|   |
MHTREVP
Kinase AqueK512.AA Dicty4 211-372 33 4.6e-24 77.28 In-house 39-214 (277) Show / Hide 
Range on Protein: 211-372
Range on HMM: 39-214/277
Sequence Identity: 33% (60 aa)

ESTLQKFNEEILLHSQQRHPNIVQLIGVYYPPRSQV--PMLVMEYLPFTLRESLEHD---------GLP----LQ-MKYSILSDVAKGLCYLHSNSPPIV
|..|. |  |. . .. |||||... |    |||.   .. |.||.| .  .|| ||          |.    .. |.. .  |.|.|. .||.  | |.
ENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAF--DAARGMNWLHCCNPVII

HRDLTANNVLLTSFYVAKISDLGVSRLVGKFKSHQK-LTQAPGNAIVMPPEALAAKPVYNEKVDVFSYGCLILHILTCQ
|||| . | |    ...|..|.| |..  | ..|.  .. | | .  | || .. .| ||||.||.|.| .   |||.|
HRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQP-YNEKADVYSFGIVLWEILTRQ
Kinase AqueK512.AA Pkinase_Tyr 211-322 31 6e-22 74.95 Pfam 42-161 (270) Show / Hide 
Range on Protein: 211-322
Range on HMM: 42-161/270
Sequence Identity: 31% (39 aa)

EST--LQKFNEEILLHSQQ-RHPNIVQLIGVYYPPRSQ-VPMLVMEYLPF-TLRESLEHD-----GLPLQMKYSILSDVAKGLCYLHSNSPPIVHRDLTA
..   ...| .|. . .|  .|||||.|.|| .. . .  ...|||| |   |.. |         |..... ..  ..|||. ||.|.   ..|||| |
HEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAA

NNVLLTSFYVAKISDLGVSRLV
 |.|.|.  |.||.| | .|..
RNCLVTENNVVKICDFGLARDI
S_TKc AqueK512.AA S_TKc 172-441 21 9.5e-21 76.17 SMART 1-231 (231) Show / Hide 
Range on Protein: 172-441
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

EKTKRRIFQIHTSKMTLADDVDLEEYIMAKDDLSGADIKESTLQKFNEEILLHSQQRHPNIVQLIGVYYPPRSQVPMLVMEYLPF---TLRESLEHDG--
 .  | | .   .|  .. ...  ..   |             ...  || .... .|||||.|..|..    .   .||||..    .|.. ... |  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LPLQMKYSILSDVAKGLCYLHSNSPPIVHRDLTANNVLLTSFYVAKISDLGVSRLVGKFKSHQKLTQAPGNAIVMPPEALAAKPVYNE-KVDVFS
     .|  .  ...  ....| |.||.   |.||||   |.||..  . ||.| |..|..         |   |    |.|| |     |.  |.|. |
GLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCKCDWWS

YGCLILHILTCQFPEPTDAFVQYFRIWQSKVAEWDRRSKYIQKIPEDEKELLPLAKQCLQDRPYSRPDMLTVLQ----AVEEKCI
 ||..   |. . | |     . |..                      .|.. . ..|||  |  ||    .||    .     .
CGCILYEMLCGYPPFP--QMQMMFKKIG-------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK512.AA TK-Unique 228-365 30 1.6e-20 67.54 In-house 62-229 (294) Show / Hide 
Range on Protein: 228-365
Range on HMM: 62-229/294
Sequence Identity: 30% (52 aa)

RHPNIVQLIGVYYPPRSQVPMLVMEYLPFT-----LRESL-------------------EHDGL--PLQMK--YSILSDVAKGLCYLHS--NSPPIVHRD
.||||||..|.   .  . .|..|||.|       ||..                    ... .  |...|  |... ..|.|. ||.|      |||||
DHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKK--IVHRD

LTANNVLLTSFYVAKISDLGVSRLVGKFKSHQKL-TQAPGNAIVMPPEALA--AKPVYNEKVDVFSYGCLI
| | |||||. .|.||.|.| .| | . . ...  .| .     |.||.|    .. ...| || |.|.|.
LCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLM
Kinase AqueK512.AA Ciliate-E2 229-365 20 2.2e-19 63.18 In-house 91-286 (365) Show / Hide 
Range on Protein: 229-365
Range on HMM: 91-286/365
Sequence Identity: 20% (41 aa)

HPNIVQLIGVYYPPRSQVPMLVMEYLPF-TLRE--------SLEH---DGLPLQMKYS--ILSDVAK---------------GLCYLHSNSPPIVHRDLT
||||.... ...    .   |||||.   .|..        ....   | ... .|    |   ...               .| ||||. . |.|||. 
HPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIK

ANNVLLTSFYVAKISDLGVSRLVGKF------KSHQKLTQAPG------------------------NAIVMPPEALAAKPV--------YNEKVDVFSY
 .|.|.      ||.|.| |. . ..      |...|. .  .                        ..  |.|| |  |.         |..|.|..| 
PENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL

GCLI
|...
GVIL
Kinase AqueK512.AA STE 208-374 24 2.8e-19 64.81 In-house 66-267 (359) Show / Hide 
Range on Protein: 208-374
Range on HMM: 66-267/359
Sequence Identity: 24% (51 aa)

DIKESTLQKFNEEILLHSQQR--HPNIVQLIGVYY-----PPRSQVPMLVMEYLPF-TLRESLEH-----DGLP----------LQMKYSILSDVAKG-L
.. .. .|.. .|| .... .  |||||. .| |.         .   ..|||..  .|.. ..|     ..|.           .    |. .. || |
NKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLL

CYLHSNSPPIVHRDLTANNVLLTSFYVAKISDLGVSR-LVGKFK-------------SHQKLTQAPGNAIVMPPEALAA-----KPVYNEKVDVFSYGCL
 ||||.   |.|||. . |.||     .|..| ||.  |. .               . || .   |    | || .       .. |..|.|. | ||.
YYLHSHH--IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCT

ILHILTCQFP
|.. .| . |
IIEMATGKPP
Kinase AqueK512.AA Pkinase 220-374 26 6.5e-17 60.89 Pfam 50-211 (293) Show / Hide 
Range on Protein: 220-374
Range on HMM: 50-211/293
Sequence Identity: 26% (44 aa)

EILLHSQQRHPNIVQLIGVYYPPRSQVPMLVMEYLPF-----TLRESLE---HDGL--PLQMKYSILSDVAKGLCYLHSNSPPIVHRDLTANNVLLTSFY
|| ..   .|||||.|.....   .. . .||||..       | . ..   | ..  . .   ...  ...|| |.||.   |.||||   |.|. . .
EIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNG

VA----KISDLGVSRLVGKFKSHQKLTQAPGNAIVMPPEALAAKPVYNEKVDVFSYGCLILHILTCQFP
.     ||.| |.....    . . .|   |    |.|| .   . |  |||..|.||..   |. ..|
HIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPP
TyrKc AqueK512.AA TyrKc 192-436 23 2e-16 42.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 192-436
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

VDLEEYI--------------------MAKDDLSGADIKESTLQKFNEEILLHSQQ--RHPNIVQLIGVYYPP-----RSQVPMLVMEYLPF-----TLR
. |.. .                    | |.|          .. | .|. . ..   .|||||.|.||   .      .. .|.|||| |       ||
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

ESLEHDGLPLQMKYSILSDVAKGLCYLHSNSPPIVHRDLTANNVLLTSFYVAKISDLGVSRLVGKF------KSHQKLTQ-APGN--AIV--MPPEALAA
.. ..  |... . |.  ..|.|  ||||.  ...|||| | |.|... ...|||| | || ..        |.  . ..   |.    .  |.||..  
KHRPK--LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-N

KPVYNEKVDVFSYGCLILHILT-CQFPEPTDAFVQYFRIWQSKVAEWDRRSKYIQKIPE--------DEKELLPLAKQCLQDRPYSRPDMLTVLQAV
. ....| ||.|.| ..  |.| .| | | ...     .  . | |. .. ..  . |.          .|.  . ||| .  | .|| . .. .  
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK512.AA TK 414-436 26 0.050468 1.71 In-house 464-486 (486) Show / Hide 
Range on Protein: 414-436
Range on HMM: 464-486/486
Sequence Identity: 26% (6 aa)

LAKQCLQDRPYSRPDMLTVLQAV
| .|| .  |  ||.. ..... 
LMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK512.AA LRRK 403-438 18 0.110533 1.71 In-house 309-351 (351) Show / Hide 
Range on Protein: 403-438
Range on HMM: 309-351/351
Sequence Identity: 18% (8 aa)

KIPED-EKE------LLPLAKQCLQDRPYSRPDMLTVLQAVEE
.||.. ...      .. | ..| |  | .|| . ....  ..
TIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK512.AA TK-Unique 416-436 28 0.130814 1.47 In-house 274-294 (294) Show / Hide 
Range on Protein: 416-436
Range on HMM: 274-294/294
Sequence Identity: 28% (6 aa)

KQCLQDRPYSRPDMLTVLQAV
|.|.|. | .||.  ....  
KSCWQWEPEERPSFRQIKHRL
Kinase AqueK512.AA MLK 416-436 33 0.160763 1.2 In-house 271-291 (291) Show / Hide 
Range on Protein: 416-436
Range on HMM: 271-291/291
Sequence Identity: 33% (7 aa)

KQCLQDRPYSRPDMLTVLQAV
||| .. | .||..  ..|  
KQCWNQDPHKRPSFRQIVQHL
Kinase AqueK512.AA Pkinase_Tyr 341-365 36 0.491012 4.13 Pfam 181-204 (270) Show / Hide 
Range on Protein: 341-365
Range on HMM: 181-204/270
Sequence Identity: 36% (9 aa)

MPPEALAAKPVYNEKVDVFSYGCLI
|.||... .  ...| || |.| |.
MAPECINYGK-FTTKSDVWSFGVLM