Gene AqueK494 (A.queenslandica)

AqueK494

Species: A.queenslandica
Alias: AqueK494
External Links:
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
AqueK494.AA Protein None 2689 None Fasta, JSON
AqueK494.kin_dom Protein Kinase Domain None 270 None Fasta, JSON

Protein domain

Protein domains of AqueK494.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_TYP AqueK494.AA LRR_TYP 1262-1285 37 0.018149 14.12 SMART 1-24 (24) Show / Hide 
Range on Protein: 1262-1285
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

LKQLLYVDMKQNKLTGLPEALFEE
| .|   |   |.|| ||. .|. 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP AqueK494.AA LRR_TYP 1286-1309 25 0.300665 4.13 SMART 1-24 (24) Show / Hide 
Range on Protein: 1286-1309
Range on HMM: 1-24/24
Sequence Identity: 25% (6 aa)

LSQVKNLQLGQNCFISLPLEIGLC
|.. . | |. | . .|| ..  .
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK494.AA LRR_1 1264-1286 29 0.810215 7.07 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1264-1286
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

QLLYVDMKQ-N--KLT-GLPEALFEEL
.| . |.   |  .||  .|.  |  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK494.AA LRR_1 1288-1309 14 27.690704 1.63 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1288-1309
Range on HMM: 1-26/26
Sequence Identity: 14% (4 aa)

QVKNLQLGQ-N--CFI-SLPLE-IGLC
. . | |.  |  ..  ..| . .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK494.AA LRR_1 1311-1326 40 0.847894 7.0 Pfam 1-20 (26) Show / Hide 
Range on Protein: 1311-1326
Range on HMM: 1-20/26
Sequence Identity: 40% (8 aa)

NLVELDLAG-N--SIA-EFP
|| .||| | |  ..  ..|
NLQHLDLSGCNCCNLTGHIP
LRR_TYP AqueK494.AA LRR_TYP 1332-1355 41 0.023111 13.26 SMART 1-24 (24) Show / Hide 
Range on Protein: 1332-1355
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

LSHLIKFNLSNNSLTVFPIGLNGD
|..| . .|||| ||  | |. ..
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK494.AA LRR_1 1334-1352 30 0.313943 8.53 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1334-1352
Range on HMM: 1-26/26
Sequence Identity: 30% (8 aa)

HLIKFNLSN-N--SLT-VFPI---GL
.| . .||. |  .||  .|    .|
NLQHLDLSGCNCCNLTGHIPPSCFNL
LRR_1 AqueK494.AA LRR_1 1382-1404 25 0.003163 15.61 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1382-1404
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLQELHISR-N--SIV-ELPFAFLAGL
.||.|..|. |  ... ..|   . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP AqueK494.AA LRR_TYP 1380-1403 37 0.006944 16.83 SMART 1-24 (24) Show / Hide 
Range on Protein: 1380-1403
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

LKSLQELHISRNSIVELPFAFLAG
| .|.||. |.| . .||   ..|
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP AqueK494.AA LRR_TYP 1404-1427 29 0.160223 6.37 SMART 1-24 (24) Show / Hide 
Range on Protein: 1404-1427
Range on HMM: 1-24/24
Sequence Identity: 29% (7 aa)

LNSLKVLDASRNCIEFISGEAAEY
| .|..|| |.| .. .  .| . 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP AqueK494.AA LRR_TYP 1357-1378 25 0.46475 2.58 SMART 1-24 (24) Show / Hide 
Range on Protein: 1357-1378
Range on HMM: 1-24/24
Sequence Identity: 25% (6 aa)

FPALRILMLNSNSISLIEDK--DL
 |.|| | |..| .. . .   . 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK494.AA LRR_1 1406-1424 26 5.023634 4.26 Pfam 1-23 (26) Show / Hide 
Range on Protein: 1406-1424
Range on HMM: 1-23/26
Sequence Identity: 26% (6 aa)

SLKVLDASR-N--CIE-FISGEA
.|..|| |. |  ...  |. ..
NLQHLDLSGCNCCNLTGHIPPSC
LRR_1 AqueK494.AA LRR_1 1359-1380 22 45.917849 0.85 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1359-1380
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

ALRILMLNS-N--SIS-LIEDK-DLKL
 |..| |.. |  ...  | .    .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK494.AA LRR_1 1430-1451 22 39.048155 1.1 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1430-1451
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

SLQDLKIGH-N--KLV-EKEHE-FQTF
.|| | ... |  .|. .  .. |  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK494.AA LRR_1 1506-1527 29 0.003375 15.51 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1506-1527
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

HLERLVLSE-N--KL-KELPVD-IGKL
.|..| ||  |  .| ...| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK494.AA LRR_1 1529-1551 29 0.012613 13.48 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1529-1551
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

TLTSLDISH-N-KDI-RHLPNE-MGKL
.|..||.|. |   . .|.|..   .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP AqueK494.AA LRR_TYP 1527-1551 36 0.118949 7.43 SMART 1-24 (24) Show / Hide 
Range on Protein: 1527-1551
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LKTLTSLDISHNKDIRHLPNEMGKL
|  |..|| |.|. ..|||...   
LPNLRELDLSNNQ-LTHLPPGAFQG
LRR_TYP AqueK494.AA LRR_TYP 1504-1526 37 0.132727 7.04 SMART 1-24 (24) Show / Hide 
Range on Protein: 1504-1526
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

WPHLERLVLSENKLKELPVDI-GK
 |.|..| || |.|..|| .. . 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP AqueK494.AA LRR_TYP 1480-1502 21 0.783699 0.72 SMART 2-24 (24) Show / Hide 
Range on Protein: 1480-1502
Range on HMM: 2-24/24
Sequence Identity: 21% (5 aa)

RGLKHLILGSNKISSLDLSDCNK
. |..| |..|....|    .. 
PNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK494.AA LRR_1 1481-1503 22 0.910675 6.89 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1481-1503
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

GLKHLILGS-N--KIS-SLDLSDCNKF
 |.|| |.. |  ... ..  | . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
COR AqueK494.AA COR 1734-2064 17 4.4e-50 160.46 In-house 1-434 (434) Show / Hide 
Range on Protein: 1734-2064
Range on HMM: 1-434/434
Sequence Identity: 17% (78 aa)

LDHLRNKIKEKIDSAKLRGQKIMGELVPASYLELSNILEEESRRLNKVKSNFRVIRRSQLDELMRRSS----LTQGMDSI----ELEQAVKFLHECGTLL
. . . |||.|   .       |.. || |.... ..|||. | .. ..... ....... .... .     | .. ..|    ||......||. |...
IRKTAKKIKHKQMFED-----YMCQPVPQSWWKCKQKLEEM-RKWMNRHNEKPWMSWKEFCQICQEHGPPKRL-RHQNIIIDEDELHTVAMYLHDLGHII

HYD--DIQSNLSDLYFLDPQWLCSVMAKIITMKHLT----IISKGM-LRKKDLPLILRGS----------QFPPDFSSEYIRLMEWFDVALQYSN-----
|..  |  . |.|...|||||.| .|..|.. |...    .  ||  ....||  |....          ..|. ..  ...||| |........     
HFKIWDHDPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPDWTHF

-----ELILIPSYLPKEKPDSI-TLHP--------SDNKIIRRYKM------IFIPPGFWPRLIIRLLSFPKKAI------------KHAYFMIEQLESS
     .. |||..||...|..  ....        ... . |.|..       |.|.|||||.. ||..| ..                 ..|  . |  
WHQETTTYLIPQLLPDDRPQHWEWWQWPQWETNEHDCRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKCFYERSCCEWMYWRNGMVLKWEGH

------------KNEFDITVPNTTL-----GIRLLCSVVDNVETLIDEWF--PGLRSISITSGDALVSPSALCPLC-----P-AFSIHAFPMREL-QLIS
            .|. .|||          . .|. .. .... . ..|.  |||...       ..    .|| |     .    | .. .... .. .
NKNEALVKCDNHDNKIYITVRGCQDCWIDMCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHW---VCREWIPCPHCIQDHWDTCCDICYYQYDWCIRAEE

LKQDEIMCPIHK------------------------DTV-PLEL
 ..|.. ||  .                         .. ... 
MGMDSYPCPKCDQYCDAFEMMCCYQHHWHYSHDQNGQWIQRISD
ROC AqueK494.AA ROC 1590-1740 26 2.2e-38 126.26 In-house 1-215 (215) Show / Hide 
Range on Protein: 1590-1740
Range on HMM: 1-215/215
Sequence Identity: 26% (56 aa)

CHVMKLTVVGSAAKGKTTLLHNIINDKST--------KIENTATLGVQ-IRKWTYQQR------PGVQYSINCWDFAGQEEFYSTHQCFLTP-RTIYILA
|. |||  .| .  |||.|. ... ||.         | .. .| |.. |  |... .      .  .  .| |||.|||....||| |||. | .|.| 
CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSCDKGNHPTTHGIEPIQQWVLDCKDMMFRKKEDEIKFNVWDFGGQEIYHATHQFFLTNHRSVYLLV

YNISK----AESE----LDG--LVPWLMNIEARAPG--------SPVIVVGTH--------------------RDMIADGFPHD----------VTFAEV
.....     ..|    .    | .|| .|..|.|.        ||||.||||                    .... . ||            ..|  |
WDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEHHCMQPSPVIIVGTHWDKVPRQDNKVYQHKQCCRMWQKLRNKFPNICHSWMQIEHYQGFFHV

SCVGQKAGLDHLRNK
.| ..  |.| ||..
DCETGCKGIDKLRHH
Miro AqueK494.AA Miro 1594-1710 18 1.5e-16 61.28 Pfam 1-140 (140) Show / Hide 
Range on Protein: 1594-1710
Range on HMM: 1-140/140
Sequence Identity: 18% (27 aa)

KLTVVGSAAKGKTTLLHNII-NDKS------------TKIENTATLGVQIRKWTYQQRPGVQYS----------INCWDFAGQEEFYSTHQCF--LTPRT
|. |.|.   ||....| ..  ...            ..  .. |..|.     . | ..  .|          .. ||..|.|.....|. |  .. ..
KVVVCGDKGCGKSSFIHQYCGEEFPPNIPRVLPDKTMPREMHGHTYYVD-----TMQVDWDTQSENVDRVKMCYFHIWDCGGREYWKFEHMHFACMKWAD

IYILAYNISKAE--SELDGLVPWLMNIEARAPG-SPVIVVGTHRD
 ... |  .. |  .... . .|| ...... . .||||||...|
AICFVYDCTDYESFNRVSNYMAWLPHFRKWGKKAIPVIVVGNKCD
RAB AqueK494.AA RAB 1593-1739 21 0.000343 -90.33 SMART 1-172 (172) Show / Hide 
Range on Protein: 1593-1739
Range on HMM: 1-172/172
Sequence Identity: 21% (40 aa)

MKLTVVGSAAKGKTTLLHNIINDKSTKIENTATLGV--QIRKWTYQQRPGVQYSINCWDFAGQEEFYSTHQCFLTPRTIY------ILAYNISKAESELD
.|. ..|  . ||. |||   .||       .| ||  ...  ..   .| .     || |||| | |  . .      |      || | |.. ||  .
FKIILIGDSGVGKSCLLHRFTDDKFSEQYK-HTIGVDFKTKTIEV---DGKRVKLQIWDTAGQERFRSITSSY------YRGAHGCILVYDITNRES-FE

GLVPWLMNIEARAPG----SPVIVVGTHRDMIA---------DGF------PHDVTFA---------EVSCVGQKAGLDHLRN
..  ||  |.  |.      ....||   |. .           |       | . |           |... |.   . ...
NVKNWLKEIRMHANPPPENVVIMLVGNKCDLEHQRQVSTEEAQKFCCDCAEKHGMPFMFETSAKTNTNVEEAFQCLARKIYQR
RHO AqueK494.AA RHO 1595-1751 18 0.000927 -101.75 SMART 1-180 (180) Show / Hide 
Range on Protein: 1595-1751
Range on HMM: 1-180/180
Sequence Identity: 18% (38 aa)

LTVVGSAAKGKTTLLHNIINDK------STKIEN-TATLGVQIRKWTYQQRPGVQYSINCWDFAGQEEF-------YSTHQCFLTPRTIYILAYNISKAE
. |||  | ||| ||.   ...       |  || .|.. |           | ... . || ||||..       |.   .||       . . ..  .
CVVVGDGACGKTCLLICYTTNYFPEDYVPTVFENYVANVMV---------PDGKPINLGLWDTAGQEDYDRLRPLSYPQTDVFL-------ICFSVDSPD

SELDGLVPWLMNIEARAPGSPVIVVGTHRDMIADGFPHDVTFAEVSCVGQKAGLDH---------------LRNKIK--------------------EKI
|       |.  .   .|. |.|.|||  |.            . ..| . ..  .               ....|.                    | |
SFENVKEKWYPEVKHHCPNVPIILVGTKCDLR----------NDPDTVEELREQKQEPITYEQGQKNEKIQMAKQIGAVKYMECSAKTQQNVRQVFEEAI

DSAKLR
  |   
RAALNP
Kinase AqueK494.AA LRRK 2087-2353 26 3.8e-78 265.94 In-house 1-351 (351) Show / Hide 
Range on Protein: 2087-2353
Range on HMM: 1-351/351
Sequence Identity: 26% (96 aa)

MDEGNPATVLGKGGFG-EVFKALYNE----------------------------KSVAIKVFSPR-----------------------------VAELHS
. ...    .|.|||| .|..| ..                             ..||||..                                . . ..
LKIEEQ---IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDC

TTPNQLIRQEVSILSQMDHPNIIGLVGVCLRPKPMLLIEYAELGSLSSFSP----YS-----TV-SPSLKHRIAMQVASALAFLHKNN--IIYRDLKPSN
..  .. |.||.|.| ..||||. |.|.|..| ...  ||| .|.|..|      ..     .. |..||..||.|.|.....||..|  ||.||||. |
CRAFREFRHEVWIMSHLNHPNIVSLKGFCIHP-LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPN

ILIFSLS-------LNSPVNAKLSDYGIST--FATTTG-LNQDIGTAGYKAPEILKAK-TSKMPYNTMVDIYSFGIVLFQLVTDGHTPFEELM-P-----
||..|..       .| .|.||..|.|||.  .....| ..   |. |. ||||...  ..   |.. ||.||||..|. |.| .| ||.|.  .     
ILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEE--YTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQW

HEKDKA-VEEGRL--IKDPSYYGG-APWPDMHDIIRHCLQYVPNNRPRAQDIFDRMCM
.|...  . ||.   |.   |... .||... | | || |  |..|| ...|..|.  
MEQIEDKIIEGLRPTIPQH-YCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK494.AA TKL 2096-2351 20 1.3e-72 247.57 In-house 1-364 (364) Show / Hide 
Range on Protein: 2096-2351
Range on HMM: 1-364/364
Sequence Identity: 20% (77 aa)

LGKGGFGEVFKALYNE----------KSVAIKVFSPRVAEL----------------------HSTTPNQLIRQEVSILSQMDHPNIIGLVG--------
.|.||||||.|. ..           | ||.|.|. .   .                      ..   .. ...|. ..|. .||||. ..|        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-VCLRP-----KPMLLIEYAELGS-LSSFSPYSTVSPSLKHRIAMQVASALAFLHKNN--------IIYRDLKPSNILIFSL---------SLNSPVNAK
 ||..|     ....  ||.. || |. .       .....|.|...|.....|| .|        ||.||||..|||...          . |.....|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

LSDYGISTFATTTG---------------------LNQDIGTAGYKAPEILKAKTSKM------------PYNTMVDIYSFGIVLFQLVTDGHTPFEELM
..|.|.|.| ...|                     ..  .|| .. |||.|. ..               .|.. .|.|||||||. ..|  .  ... .
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

PHEK---------DKAVEEGRLIKDPS--------YYGGAPWPDMHDIIRHCLQYVPNNRPRAQDIFDRM
. ..          .....|.    |.        .     .|.| ... .| .. |..|| .|.| .|.
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK494.AA S_TKc 2090-2356 25 2e-58 201.33 SMART 1-231 (231) Show / Hide 
Range on Protein: 2090-2356
Range on HMM: 1-231/231
Sequence Identity: 25% (73 aa)

GNPATVLGKGGFGEVFKALYNE--KSVAIKVFSPRVAELHSTTPNQLIRQEVSILSQMDHPNIIGLVGVCLRPKPMLLIEYAEL--GSLSSFSPYST---
     ..|||.||.|.|.  ..  . ||||. .            . ||.|..||.. .||||. | .|.   .  .  ||..   |.| ..        
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHG

----VSPSLKHRIAMQVASALAFLHKNNIIYRDLKPSNILIFSLSLNSPVNAKLSDYGISTFATTTGLNQDIGTAGYKAPEILKAKTSKMPYNT-MVDIY
     ..    ... |...||...|...||.|||||.|||. .       . |..| |....      .  .||  | |||.|       .|..  .|..
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-----TTFCGTPWYMAPEVL-------GYGKCKCDWW

SFGIVLFQLVTDGHTPFEELMPHEKDKAVEEGRLIKDPSYYGGAPWPDMHDIIRHCLQYVPNNRPRAQDIFD----RMCMPDF
|.|..|. ... | .||.           .  ..|.          |.. |.||.|||. |..|| | ...      .|.| |
SCGCILYEMLC-GYPPFP--------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK494.AA TKL-Unique 2092-2297 26 1.4e-42 147.73 In-house 1-237 (290) Show / Hide 
Range on Protein: 2092-2297
Range on HMM: 1-237/290
Sequence Identity: 26% (63 aa)

PATVLGKGGFGEVFKALYNEKSVAIKVFSPRVAELHSTTPNQLIRQEVSILSQMD-HPNIIGLVGVCL--RPKPM---LLIEYAELGSLSSFSP------
.  ..| ||.|.|.|. .. ..||||.|.|  ......    ... ||....  . ||||  ..|.|    ..|    .  || ..||| . .       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFEN-EVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

-----YSTVSPSLKHRIAMQVASALAFLHKNN--IIYRDLKPSNILIFSLSLNSPVNAKLSDYGISTFAT--TTGLNQDI---------GTAGYKAPEIL
      .. ..... ..| ..|... .|| ..  || ||||.||.|. . |   ..|.|..| |.|.|..  ... |  .         |.. . |||.|
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

KAKTSKMPYNTMVDIYSFGIVLFQLVTDGHT------PFEEL
.       |.. .|.|||||||  ..| ..       |....
RMNF--CQYSEKSDVYSFGIVLWEIAT-RKITKTYKKPYQGM
Kinase AqueK494.AA Ciliate-E2 2095-2353 19 3e-41 139.34 In-house 6-365 (365) Show / Hide 
Range on Protein: 2095-2353
Range on HMM: 6-365/365
Sequence Identity: 19% (74 aa)

VLGKGGFGEVFKA-LYNE------------------------KSVAIKVFSPR--VAELHSTTPNQLIR------QEVSILSQMDHPNIIGLVGVCL---
..|.|.|| |.|.  ...                        | .|.|.....   . .     .. |.      .| .||.|..||||| .. .     
KIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKD

RPKPMLLIEYAELGSLSS--------FSPY---STVSPSLKHRIAM--QVAS---------------ALAFLHKNN-IIYRDLKPSNILIFSLSLNSPVN
. .  |  ||.. |.| .        .         ....|... .  |...               || .||..| ||.||.||.|||.          
DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------

AKLSDYGISTFATT---------------------------------TGLNQDIGTAGYKAPEILKAKT-----SKMPYNTMVDIYSFGIVLFQLVTDGH
 |..| |.|.....                                    |. .||.||.|||||. |       . .|....||.|.|..|..... | 
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF-GK

TPFEELMPHEKDKAVEEGRLIKD-PSYYGGAPW------------------PDMHDIIRH----CLQYVPNNRPR-AQDIFDRMCM
.||               . ||. .  .  . |                  ... |.|.     .||. |..|.  ...|..   .
PPF--------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase AqueK494.AA Pkinase 2090-2351 21 3.4e-41 146.76 Pfam 1-293 (293) Show / Hide 
Range on Protein: 2090-2351
Range on HMM: 1-293/293
Sequence Identity: 21% (67 aa)

GNPATVLGKGGFGEVFKALYNEKS--VAIKVFSPRVAELHSTTPNQLIR-QEVSILSQMDHPNIIGLVGVCL-RPKPMLLIEYAELG----SLS----SF
     ..|.|.||.|.|.     .  ||.|... |  . .|  . ...| .|..|.  ..||||. | ...  .... .  ||.| |    .|.      
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-

SPYSTV--SPSLKHRIAMQVASALAFLHKNNIIYRDLKPSNILIFSLSLNSPVNA----KLSDYGIST---FATTTGLNQDIGTAGYKAPEILKAKTSKM
. . ..  |.    ... |....|...|...||.|||||.||||     ..  .     |..| |..        . ..   || .| |||...   .  
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI-----DNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQ

PYNTMVDIYSFGIVLFQLVTDGHTPFEEL----MPHEKDKAVEEGRLIKDPSYYGGAPW-------------------PDMHDIIRHCLQYVPNNRPRAQ
.| . ||..|.|..|..... |..|| .       |.... ... .  . .. .                        ... |.|. ||.. |. || |.
YYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

DIFDR--M
.|.    .
QILQHPWF
Kinase AqueK494.AA MLK 2090-2299 25 3.4e-41 140.66 In-house 1-242 (291) Show / Hide 
Range on Protein: 2090-2299
Range on HMM: 1-242/291
Sequence Identity: 25% (64 aa)

GNPATVLGKGGFGEVFKALYNEKS-----VAIKVFSPRVAELHSTTP--NQLIRQEVSILSQMDHPN----IIGLVGVCLRP-K-PMLLIEYAELGSLSS
 .  ...|.|.||.|.|. .  |      ||.| .  |     | |    . ...|. .|. ..|||    || ..||||.| .   .. ||.| |||..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

FSPYST---------------VSPSLKHRIAMQVASALAFLHKNN---IIYRDLKPSNILIFSLSLN-----SPVNAKLSDYGISTFATTTGLN---QDI
.    .               ...... ..|.|.|.....||..    || ||||..||||    ..        ..| .| |.|.. ....       .
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILI----DEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNA

GTAGYKAPEILKAKTSKMPYNTMVDIYSFGIVLFQLVTDGHTPFE-ELMP
||. . |||... .    .|.  .|..|.|.|| ...| . .|.. ...|
GTYAWMAPEVIQ-QFRCEKYSEKCDVWSWGVVLWEMLT-REVPYKQHYDP
Kinase AqueK494.AA TK 2095-2351 13 3.9e-41 135.13 In-house 6-486 (486) Show / Hide 
Range on Protein: 2095-2351
Range on HMM: 6-486/486
Sequence Identity: 13% (65 aa)

VLGKGGFG---EVFKALYNEK---------------------------SVAIKVFSPRVAELHSTTPNQLIR---------QEVSILSQMD-----HPNI
.||.| ||   ||.|......                            ||.|.  .  |.       . ..         .|......|.     ||||
KLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNI

IGLVGVCLRPK-------------PMLLIEYAELGS----LSSFSPYST---------------------------------------------------
. |.|||....             .|.. ||...|.    | ..   .                                                    
VRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLI

--------------------------VSPSLKHRIAMQVASALAFLHKN------NIIYRDLKPSNILIFSLSL------NSPVNAKLSDYGIST-----
                          ...  .. ...|.|.....||..      |.. |||   |.|...         ...  .|..|.| |      
KDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGV

FATTTGLNQDIGTAG-------------------------------YKAPEILKAKTS-----KMPYNTMVDIYSFGIVLFQLVTDGHTPFEELMPHEK-
 |   . ..|  ...                               . ||| |. ..      .  . |  |..|||.... ..| | .|. . |.... 
LARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDV

---------DKAVEEG-------------RLIKDPSYYGG-----------APWPDMHDIIRHCLQYVPNNRPRAQDIFDRM
          . ...|             |. . .  .             .| ....|... | .| |. ||. ... ...
WKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK494.AA CAMK 2095-2347 18 4.4e-38 119.82 In-house 1-419 (425) Show / Hide 
Range on Protein: 2095-2347
Range on HMM: 1-419/425
Sequence Identity: 18% (76 aa)

VLGKGGFGEVFKALYNEKS--------------VAIKVFSPRVAELH-----------------------STTPNQLIRQEVSILSQ-------MDHPNI
.||.|.||.|...   .                ||||. . . .  .                       .    . .|.|..|...       .|||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IGLVGVCL------------RPKP--------MLLI----EYAELG----SLSSFS---PY-------------STVSPSLKHRIAMQVASALAFLHKNN
| |  |                .         | ..    ||.. |     | ..    ..               .. .  .|.  |..||....|..|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIYRDLKPSNILIFSLSLNSP------------VNAKLSDYGISTFATTTG-------------------------LNQDIGTAGYKA-PEILKAKTS--
|. ||||| |||. . . .|.             | |..| | ... .                            ..   || .| | ||.|. |.   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------KMPYNTMVDIYSFGIVLFQLVTDGHTPFE-----ELM--------PHEKDKAVEEGRLIKDPSYYGGAP-------WP------------DM
        | .|.  .|. | |..|. ... |. ||.     | .        ..|  . . .|.   .|.|  . .       |             . 
MQNATDEEKPYYGPKCDMWSCGVILYIMLC-GYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

HDIIRHCLQYVPNNRPRAQDI
 | ||..||. |..|. ....
KDLIRKMLQVDPEKRMTIEQC
Kinase AqueK494.AA STE 2095-2288 21 1.7e-33 115.66 In-house 6-263 (359) Show / Hide 
Range on Protein: 2095-2288
Range on HMM: 6-263/359
Sequence Identity: 21% (59 aa)

VLGKGGFGEVFKALYNEKS-----------------VAIKVFSPRVA------------ELHSTTPNQLIRQEVSILSQMD--HPNIIGLVGVCL-----
..|||.||.|.||......                 .|||. . .              |   ..  | | .|..|.....  ||||.   | ..     
KIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHN

---RPKPMLLIEYAELGSLSSFSP-YSTVSPSLK--------------HRIAMQVASA-LAFLHKNNIIYRDLKPSNILIFSLSLNSPVNAKLSDYGIST
   . .  .  || . |||...   .  .  .|.               .|. |.  . |..||...|| ||.||.|||.          .||.| |...
HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----------VKLCDFGVCG

FATTT------------------GLNQDIGTAGYKAPEILKAKTSK--MPYNTMVDIYSFGIVLFQLVT
  | .                    | ..||  . |||...  ...   .|.| .||.|.|...  ..|
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMAT
TyrKc AqueK494.AA TyrKc 2085-2351 23 9.2e-30 106.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 2085-2351
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)

IVMDEGNPATVLGKGGFGEVFKALYNEKSVAIKVFSPRVAELHSTTPNQLIRQEVSILSQM--DHPNIIGLVGVCLR--------PKPMLLIEYAELGSL
|....     .|| | ||||.|. ..   ||.|.  .           . ...| .|...   .||||. |.|||.         . .|.. ||...|.|
ITLGK-----KLGEGAFGEVYKGTWK-IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

SSFSPYST--VSPSLKHRIAMQVASALAFLHKNNIIYRDLKPSNILIFSLSLNSPVNAKLSDYGISTFATTT---GLNQDIGTA----GYK--------A
 ..  ..   .... .. .. |.|.  ..||..|.| |||   |.|. .        .| || | | . .     | ..|  ..    | |        |
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEILKAKTSKMPYNTMVDIYSFGIVLFQLVTDGHTPFEE-----LMPHEKDKAVEEGRLIKDPSY-YGGAP------WPDMHDIIRHCLQYVPNNRPRAQ
|| .     .  ..|  |..|||.... . |.| .| ..     . . |  . |..|.  . | . |   |       ..|..|.. | .. |..||. .
PECI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---PMSFVCCPDEMYQIMKQCWHEDPEDRPTFS

DIFDRM
.| ...
EIHECF
Kinase AqueK494.AA RIPK 2096-2296 24 2.1e-29 97.32 In-house 1-230 (290) Show / Hide 
Range on Protein: 2096-2296
Range on HMM: 1-230/290
Sequence Identity: 24% (59 aa)

LGKGGFGEVFKALYNE-KSVAIKVFSP---RVAELHSTTPNQLIRQEVSILSQMDHPNIIGLVGVCLRP------K-PMLLIEYAELGSLSSFSPYST--
.|.|||||||||     . ...|  .|   . ...     .. . .|. .. .... .|  . |.|  .      | . . .|| | |||. |    .  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHM-DDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPY

----VSPSLKHRIAMQVASALAFLHKNN--IIYRDLKPSNILIFSLSLNSPVNAKLSDYGISTFATTTGLNQ--------DI-------GTAGYKAPEIL
    .  .|. |.  .....  .|| .|  || |||||.|||     . .  ..|..| | .|. ..  ..|        ..       ||  |..|| .
QHHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENIL-----VDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHF

K--AKTSKMPYNTMVDIYSFGIVLFQLVTDGHTPFEE
    | . .  ..  |.|||.||.... | .  |.|.
RTDNKKPIKVVTPKYDVYSFAIVMWEVLT-QKHPYED
Kinase AqueK494.AA ULK 2191-2353 25 6.3e-24 81.83 In-house 131-324 (324) Show / Hide 
Range on Protein: 2191-2353
Range on HMM: 131-324/324
Sequence Identity: 25% (51 aa)

IAMQVASALAFLHKNNIIYRDLKPSNILIFSLS---------LNSPVNAKLSDYGISTFATTTGLNQDI-----------GTAGYKAPEILKAKTSKMPY
. .| .... .|||.||| ||.||.||||               ..| .|..| | . .    ...|..           ||  | ||.||. .  ..||
FFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGV-LKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPY

NTM-VDIYSFGIVLFQLVTDGHTPFEELMPHEKD----KAVEEG---------RLIKDPSYYGGAPW--PDMHDIIRHCLQYVPNNRPRAQDIFDRMCM
..  .||.|.|........ | .||..  . . .    | .. |         . |. |..   .|   |...|.|| .||| .. |   ..||.  ..
YDYKCDIWSLGCIFYEMLY-GKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPP-KDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Pkinase_Tyr AqueK494.AA Pkinase_Tyr 2085-2212 24 1.1e-21 74.07 Pfam 1-137 (270) Show / Hide 
Range on Protein: 2085-2212
Range on HMM: 1-137/270
Sequence Identity: 24% (36 aa)

IVMDEGNPATVLGKGGFGEVFKALYN------EKSVAIKVFSPRVAELHSTTPN---QLIRQEVSILSQM-DHPNIIGLVGVCL---RP-KPMLLIEYAE
|....      ||.| ||||.|. ..      .  ||.|.  .     ... ..   .   .|..|..|. .||||. |.|||.   .| ....  ||..
ITFGKK-----LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMP

LGSLSSF--SP---YSTVSPSLKHRIAMQVASALAFLHKNNIIYRDL
.|.| ..  ..      .... .  ...|.|.....|. .|.| |||
HGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase AqueK494.AA Pkinase_Tyr 2257-2351 22 2.5e-07 25.46 Pfam 182-270 (270) Show / Hide 
Range on Protein: 2257-2351
Range on HMM: 182-270/270
Sequence Identity: 22% (22 aa)

APEILKAKTSKMPYNTMVDIYSFGIVLFQLVTDGHTP-FEELMPHEKDKAV-EEGRLIKDPSYYGGAP--WPDMHDIIRHCLQYVPNNRPRAQDIFDRM
||| .. .     ..|  |..|||.... ..| | .| .... ..|  ... |.|.  . |      .  .....|....| .| |..||. ..|  ..
APECINYGK----FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCP------ENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK494.AA ULK 2095-2153 26 2e-06 18.58 In-house 6-80 (324) Show / Hide 
Range on Protein: 2095-2153
Range on HMM: 6-80/324
Sequence Identity: 26% (20 aa)

VLGKGGFG-EVFKAL-YNE----KSVAIKVFS-PRVAELHSTTP----NQLIRQEVSILSQMD---HPN--IIGL
.|||| ||  |.|.   .     . ||.|. .     .  .  .     ||...|..|. ...   |||  |. |
CLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKL
Kinase AqueK494.AA STE 2324-2346 47 0.007074 6.14 In-house 328-350 (359) Show / Hide 
Range on Protein: 2324-2346
Range on HMM: 328-350/359
Sequence Identity: 47% (11 aa)

PDMHDIIRHCLQYVPNNRPRAQD
|...| |..|||. ||.|| |..
PEFKDFINKCLQKDPNKRPTASQ
Kinase AqueK494.AA RIPK 2322-2351 27 0.044737 2.83 In-house 255-290 (290) Show / Hide 
Range on Protein: 2322-2351
Range on HMM: 255-290/290
Sequence Identity: 27% (10 aa)

PWPD------MHDIIRHCLQYVPNNRPRAQDIFDRM
.||       | . ...| |. ||.||  |.. .. 
YWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT