Gene AqueK486 (A.queenslandica)

AqueK486

Species: A.queenslandica
Alias: AqueK486
External Links:
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
AqueK486.AA Protein None 2136 None Fasta, JSON
AqueK486.kin_dom Protein Kinase Domain None 139 None Fasta, JSON

Protein domain

Protein domains of AqueK486.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kelch_2 AqueK486.AA Kelch_2 13-69 19 0.000862 18.53 Pfam 1-51 (51) Show / Hide 
Range on Protein: 13-69
Range on HMM: 1-51/51
Sequence Identity: 19% (11 aa)

ERYGHSTVRVGDYLYMWGGDQPDLPRVHNNEKKKSMCSVMEVCHLRTGRWEQKPTTG
 ||.|... .|. .|..||         ..  . . .... .....| ||.  |  .
PRYCHASCVPGGKIYVFGGYC------RHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_1 AqueK486.AA Kelch_1 13-69 17 0.927071 6.49 Pfam 1-45 (45) Show / Hide 
Range on Protein: 13-69
Range on HMM: 1-45/45
Sequence Identity: 17% (10 aa)

ERYGHSTVRVGDYLYMWGGDQPDLPRVHNNEKKKSMCSVMEVCHLRTGRWEQKPTTG
 |.||. . .....|  ||  .            .  .  |. ...|..|.. |. .
PRCGHGVCVHNGKIYVIGGCDG------------QYLNSVECYDPETNQWTRCPPMP
Kelch_1 AqueK486.AA Kelch_1 74-121 18 4e-06 25.71 Pfam 1-45 (45) Show / Hide 
Range on Protein: 74-121
Range on HMM: 1-45/45
Sequence Identity: 18% (9 aa)

GVRSYAAAAIGREIFYFGGYCNHEDCYYNSLYSFNVDTFKWKKLSPIY
  ......... .|. .||...    | || ......| .|....|  
PRCGHGVCVHNGKIYVIGGCDG---QYLNSVECYDPETNQWTRCPPMP
Kelch_2 AqueK486.AA Kelch_2 74-121 21 0.339168 8.67 Pfam 1-51 (51) Show / Hide 
Range on Protein: 74-121
Range on HMM: 1-51/51
Sequence Identity: 21% (11 aa)

GVRSYAAAAIGREIFYFGGY---CNHEDCYYNSLYSFNVDTFKWKKLSPIY
.  . |.. .|  |. ||||     . ||. .... .. .| .|...... 
PRYCHASCVPGGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_2 AqueK486.AA Kelch_2 152-201 16 27.585398 1.41 Pfam 1-51 (51) Show / Hide 
Range on Protein: 152-201
Range on HMM: 1-51/51
Sequence Identity: 16% (9 aa)

GLGPMASSNNTPPQPGAQYSGGGF-----ITYQRCNEIHFYKLSTGQWISPTVTG
.....||.       |  |. ||.     .   ... |... ..| .|   .. .
PRYCHASCVP----GGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_2 AqueK486.AA Kelch_2 262-307 20 0.014082 13.92 Pfam 1-51 (51) Show / Hide 
Range on Protein: 262-307
Range on HMM: 1-51/51
Sequence Identity: 20% (11 aa)

GRHAHSSVLISTSLGPYLLVVGGA---------GTDDIWIFNINNKSWKEQEQVN
.|. |.|. .    |  ..|.||.          . |||... . ..|..  .. 
PRYCHASCVP----GGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_1 AqueK486.AA Kelch_1 272-307 10 1.253711 6.02 Pfam 7-45 (45) Show / Hide 
Range on Protein: 272-307
Range on HMM: 7-45/45
Sequence Identity: 10% (4 aa)

STSLGPYLLVVGGAG---TDDIWIFNINNKSWKEQEQVN
..... .. |.||     ........  ...|..    .
VCVHNGKIYVIGGCDGQYLNSVECYDPETNQWTRCPPMP
Kinase AqueK486.AA TKL 524-584 21 7.2e-11 35.39 In-house 1-96 (364) Show / Hide 
Range on Protein: 524-584
Range on HMM: 1-96/364
Sequence Identity: 21% (21 aa)

LGKGGWGEVKVAGFRG----------LKVAAKCLYEVIISPYNI-------------------------EIFSREMNIASKLRHPNLLQFIGATTE
.|.|| |||  . .||            || | . .   .  ..                         . . .|... |.|||||..||.|. ..
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCC
Kinase AqueK486.AA LISK 523-581 31 1.3e-09 27.24 In-house 1-64 (296) Show / Hide 
Range on Protein: 523-581
Range on HMM: 1-64/296
Sequence Identity: 31% (20 aa)

VLGKGGWGEVKVAGFR--GLKVAAKCLY---EVIISPYNIEIFSREMNIASKLRHPNLLQFIGA
..|||. |.|     |  |  .| | .    .. . | ..  . ||. .  .||||| .||.|.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGV
Kinase AqueK486.AA Dicty4 520-583 37 2.1e-09 27.71 In-house 3-68 (277) Show / Hide 
Range on Protein: 520-583
Range on HMM: 3-68/277
Sequence Identity: 37% (25 aa)

TEVVLGKGGWGEVKVAGFRGLKVAAKCL--YEVIISPYNIEIFSREMNIASKLRHPNLLQFIGATT
.|. .|||. |||  .  || .|| | |    .  . . .. | .| .| .|.||||...| || |
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACT
Kinase AqueK486.AA CAMK 523-579 18 1.3e-07 19.87 In-house 1-104 (425) Show / Hide 
Range on Protein: 523-579
Range on HMM: 1-104/425
Sequence Identity: 18% (19 aa)

VLGKGGWGEVKVAGFR-G-------------LKVAAKCLYEVIIS--------------------------PYNIEIFSREMNIASK-------LRHPNL
.||.|. |.|| .  .                |||.| .    ..                          |.. . . ||..| .|       |.|||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LQFI
....
IKLY
Kinase AqueK486.AA TKL-Unique 523-583 31 4.8e-07 21.07 In-house 4-66 (290) Show / Hide 
Range on Protein: 523-583
Range on HMM: 4-66/290
Sequence Identity: 31% (20 aa)

VLGKGGWGEVKVAGFRGLKVAAKCLY-EVIISPYNIEIFSREMNIASKLR-HPNLLQFIGATT
..| || |.|. . .|| .|| | .  .  .|.  .. |..| |. .||. |||.....|...
KIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCM
Kinase AqueK486.AA MLK 518-584 21 0.000875 9.16 In-house 1-80 (291) Show / Hide 
Range on Protein: 518-584
Range on HMM: 1-80/291
Sequence Identity: 21% (17 aa)

TMTEVVLGKGGWGEVKVAGFRGLK-----VAAKCLY----EVIISPYNIEIFSREMNIASKLRHPN----LLQFIGATTE
  .. ..|.|. |.|  . .|.       || |       .. ..   .. | .| .....|.|||      || |. ..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQ
Kinase AqueK486.AA STE 519-581 17 0.003989 7.03 In-house 1-98 (359) Show / Hide 
Range on Protein: 519-581
Range on HMM: 1-98/359
Sequence Identity: 17% (17 aa)

MTE-VVLGKGGWGEVKVA-----------------GFRGLKVAAKCLYEVIISP---------------YNIEIFSREMNIASKLR--HPNLLQFIGA
 .   ..|||. |.|  |                 |  |  .| | .     ..                ... . .|..| .|..  |||  ...|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC
Kinase AqueK486.AA TK 562-585 20 0.012149 3.82 In-house 87-115 (486) Show / Hide 
Range on Protein: 562-585
Range on HMM: 87-115/486
Sequence Identity: 20% (6 aa)

REMNIASKLR-----HPNLLQFIGATTEV
.|........     |||.....|. |..
EEAEEMKMMCHSLGHHPNIVRLYGVCTQG
Pkinase_Tyr AqueK486.AA Pkinase_Tyr 517-581 29 0.015319 9.23 Pfam 1-72 (270) Show / Hide 
Range on Protein: 517-581
Range on HMM: 1-72/270
Sequence Identity: 29% (22 aa)

ITMTEVVLGKGGWGEVKVAGFR------GLKVAAKCLYEVIISPYN--IEIFSREMNIASKL-RHPNLLQFIGA
||. .. ||.|  |||. .  .      ...|| |.|     .. .  .| | ||..| ..| .|||.....|.
ITFGKK-LGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGV
Kinase AqueK486.AA MLK 517-581 27 0.087834 1.41 In-house 1-69 (280) Show / Hide 
Range on Protein: 517-581
Range on HMM: 1-69/280
Sequence Identity: 27% (19 aa)

ITMTEVVLGKGGWGEVKVAGFRGLKVAAKCL---YEVIISPY--NIEIFSREMNIASKLRHPNLLQFIGA
... | ..| || |.|  | ..|  || |      |  ..     .|   .| ..   |.|||  .  |.
LKIKE-IIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGV
Kinase AqueK486.AA LRRK 562-584 34 0.310537 0.1 In-house 106-128 (351) Show / Hide 
Range on Protein: 562-584
Range on HMM: 106-128/351
Sequence Identity: 34% (8 aa)

REMNIASKLRHPNLLQFIGATTE
.|. | |.|.|||... .| . .
HEVWIMSHLNHPNIVSLKGFCIH
Kinase AqueK486.AA Pkinase 518-581 20 0.849886 3.9 Pfam 1-68 (293) Show / Hide 
Range on Protein: 518-581
Range on HMM: 1-68/293
Sequence Identity: 20% (14 aa)

TMTEVVLGKGGWGEVKVAGFRGLK--VAAKCLYEVIISP-YNIEIFS-REMNIASKLRHPNLLQFIGA
  .. ..|.|. |.|. .  .|    || |..  . ...  ... .  .|  |  .|.||| ......
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDW
Ank AqueK486.AA Ank 635-667 42 4.9e-10 40.47 Pfam 1-33 (33) Show / Hide 
Range on Protein: 635-667
Range on HMM: 1-33/33
Sequence Identity: 42% (14 aa)

SGYTPLHEAVSGNRYEVISYLVELGANVNARAN
 |.|||| |.. ...||...|.. ||.|||. .
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK486.AA Ank 668-700 51 5.7e-10 40.21 Pfam 1-33 (33) Show / Hide 
Range on Protein: 668-700
Range on HMM: 1-33/33
Sequence Identity: 51% (17 aa)

FGYTPLHLAASAGHIECVKALLYCSADISLIDS
 |.||||||.. ||.|.|| ||.. ||. . | 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
LRR_TYP AqueK486.AA LRR_TYP 923-946 33 0.001785 18.79 SMART 1-24 (24) Show / Hide 
Range on Protein: 923-946
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

LKQVVKLDLQHNELVTVPHCLFEL
| .  .|||..| | ..|. .|. 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK486.AA LRR_1 1016-1038 33 0.004022 15.24 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1016-1038
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLQHLNISF-N-RNI-RSLPVE-MGRL
.||||..|  |  |. ...| .    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK486.AA LRR_1 948-968 33 0.015628 13.15 Pfam 1-26 (26) Show / Hide 
Range on Protein: 948-968
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLNELNLSN-N--KLI-EIPD--VHEW
|| .|.||. |  .|  .||.      
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP AqueK486.AA LRR_TYP 970-992 39 0.017647 14.22 SMART 2-24 (24) Show / Hide 
Range on Protein: 970-992
Range on HMM: 2-24/24
Sequence Identity: 39% (9 aa)

PGLTVLNLSSNELSSLPADIVTP
| |..|.||.| |..||...  .
PNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK486.AA LRR_1 993-1015 18 0.040071 11.7 Pfam 1-26 (26) Show / Hide 
Range on Protein: 993-1015
Range on HMM: 1-26/26
Sequence Identity: 18% (5 aa)

SIRTLNISY-N--HFC-TVPLSVCSFM
....|..|. |  ... ..| | .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK486.AA LRR_1 971-992 25 0.082391 10.59 Pfam 1-26 (26) Show / Hide 
Range on Protein: 971-992
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

GLTVLNLSS-N--ELS-SLPAD-IVTP
 |..|.||. |   |. ..| . .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP AqueK486.AA LRR_TYP 947-969 47 0.343112 3.66 SMART 2-24 (24) Show / Hide 
Range on Protein: 947-969
Range on HMM: 2-24/24
Sequence Identity: 47% (11 aa)

PNLNELNLSNNKLIEIPDVHEWS
||| ||.||||.| ..|.   ..
PNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK486.AA LRR_1 925-946 25 0.378998 8.24 Pfam 1-26 (26) Show / Hide 
Range on Protein: 925-946
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

QVVKLDLQH-N--ELV-TVPHC-LFEL
.  .|||.. |   |. ..|.  .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP AqueK486.AA LRR_TYP 1014-1038 24 0.667746 1.29 SMART 1-24 (24) Show / Hide 
Range on Protein: 1014-1038
Range on HMM: 1-24/24
Sequence Identity: 24% (6 aa)

FMSLQHLNISFNRNIRSLPVEMGRL
  .|..|. |.|. ...|| .. . 
LPNLRELDLSNNQ-LTHLPPGAFQG
LRR_1 AqueK486.AA LRR_1 901-922 18 55.053107 0.57 Pfam 1-26 (26) Show / Hide 
Range on Protein: 901-922
Range on HMM: 1-26/26
Sequence Identity: 18% (5 aa)

WVKRLRLAR-N--GF-RAIPNE-IGGY
  ..| | . |   . . ||.. . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
ROC AqueK486.AA ROC 1079-1249 27 9.7e-45 147.72 In-house 1-215 (215) Show / Hide 
Range on Protein: 1079-1249
Range on HMM: 1-215/215
Sequence Identity: 27% (59 aa)

FYRMKLMLVGKQNRGKTTLVTRLQGLDVS----------INQSTVGVD-VSEWHYAGGLG-----RRKYQFSIWDFGGVEKYYATHQCFLSE-RSMYLLL
 ..|||||.|... |||.|. .| .   |           ...|.|.. . .| . .  .      .. .|..||||| | |.|||| ||.. || ||| 
CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSCDKGNHPTTHGIEPIQQWVLDCKDMMFRKKEDEIKFNVWDFGGQEIYHATHQFFLTNHRSVYLLV

WNVQH----GEEG----IQE--LKPWLDAIALRAPR--------SCVLIVGTHLDCVEESD-------RPE--VDKLLGKVAELAQTYQNKLLVPEVLAV
|. .     |..     ...  |..||  |. |.|.        |.|.|||||.| |.. |        ..  ..||  |.    . .  ..  .... |
WDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEHHCMQPSPVIIVGTHWDKVPRQDNKVYQHKQCCRMWQKLRNKFPNICHSWMQIEHYQGFFHV

GLMNRLENIRTLREA
    . ..|. ||..
DCETGCKGIDKLRHH
COR AqueK486.AA COR 1246-1465 20 9.3e-36 113.22 In-house 1-262 (434) Show / Hide 
Range on Protein: 1246-1465
Range on HMM: 1-262/434
Sequence Identity: 20% (56 aa)

LREAIYNQAT-----EYRGNRSLPIMGQEIPASYFELNKELEKVQEEVRKGLRAPVMNAAQFRELVHRLNLPD-------ICSDEELRTATLFLNDIRTI
.|. ....       .         |.| .| |...... ||.  .  .   ..|.|   .|....   . |        | ...||.|.. .|.|  .|
IRKTAKKIKHKQMFED--------YMCQPVPQSWWKCKQKLEEMRKWMNRHNEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHI

LHYD--DRSHAINELYFIDPQWLCKIMSQIVTVREKNPF---IKNGI-LHSRNVPFIFCDP----------RFQWKYFEQYLSLLDRFGIALPLDN----
.|..  |     ......||||.|..|..|....| ..|    ..|| .. . .  |. .|          |.. .. |....|. .|....|.|.    
IHFKIWDHDPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPDWTH

------RQILIPSMLPDKRPEKAD---IPD----DKSAPFYIRFINF-----QSSTPPGFWSRLISRIMH
      .. |||..||| ||. ..   .|.    ...     |  ..         |.|||.|.. |. |
FWHQETTTYLIPQLLPDDRPQHWEWWQWPQWETNEHDCRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLHH
Miro AqueK486.AA Miro 1083-1198 17 1.8e-11 43.12 Pfam 1-140 (140) Show / Hide 
Range on Protein: 1083-1198
Range on HMM: 1-140/140
Sequence Identity: 17% (24 aa)

KLMLVGKQNRGKTTLVTRLQGLDVS---------------INQSTVGVDVSEWHYAGGLGRR----KYQFSIWDFGGVEKYYATHQCF--LSERSMYLLL
|....|..  ||.... .. |.. .               .. .|..||  .   .... .      . |.|||.|| |. ...|. |  . ... ....
KVVVCGDKGCGKSSFIHQYCGEEFPPNIPRVLPDKTMPREMHGHTYYVDTMQVDWDTQSENVDRVKMCYFHIWDCGGREYWKFEHMHFACMKWADAICFV

WNVQHGE--EGIQELKPWLDAIALRAPR-SCVLIVGTHLD
  .  .|  .   ....||. .  ..   . | .||...|
YDCTDYESFNRVSNYMAWLPHFRKWGKKAIPVIVVGNKCD
RAB AqueK486.AA RAB 1082-1253 21 0.000428 -91.54 SMART 1-172 (172) Show / Hide 
Range on Protein: 1082-1253
Range on HMM: 1-172/172
Sequence Identity: 21% (40 aa)

MKLMLVGKQNRGKTTLVTRLQGLDVSINQ-STVGVDVSEWHYAGGLGRRKYQFSIWDFGGVEKYYATHQCFLSERSMY-------LLLWNVQHGEEGIQE
.|..|.|  . ||. |. |      | .. .|.|||    .     . ..    |||  | |.       | |  |.|       .|   . . .|  . 
FKIILIGDSGVGKSCLLHRFTDDKFSEQYKHTIGVDFKTKTIEV--DGKRVKLQIWDTAGQER-------FRSITSSYYRGAHGCILVYDITN-RESFEN

LKPWLDAIALRAPR----SCVLIVGTHLDCVEESDRPEVDKLLGKVAELAQ--TYQNKLLVP-EVLAVGLMNRLENIRTLREAIYNQ
.| ||. |   |.      ....||   |...  .| .|..  ..  ....    .....   |. |   .|  |  ..| . ||..
VKNWLKEIRMHANPPPENVVIMLVGNKCDLEH--QR-QVSTEEAQ--KFCCDCAEKHGMPFMFETSAKTNTNVEEAFQCLARKIYQR
Kinase AqueK486.AA LRRK 1703-1834 26 4.2e-38 132.39 In-house 1-204 (351) Show / Hide 
Range on Protein: 1703-1834
Range on HMM: 1-204/351
Sequence Identity: 26% (54 aa)

EDKDSLLGEGGFG-KVYRGKCRG----------------------------KSVAIKKYLTR----------------------------------TEEA
  . ...|.|||| .|||.|.||                            ..|||||...                                   . .|
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

FNELRSEAKVLQESHHPFLVCLVGVSVHPLMALILEEAPMGSFERHLIKKS-TP-------IPRLTMFRIAAQVAAALRFLHQHG--IIFRDLKAANVLL
|.|.| |. .. . .|| .| |.|.. |||. ...| || |.  ..| .|. ..       |.. .  .|| |.| ....|| |   ||.||||  |.||
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLC-MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

WSLDE
||...
WSSPQ
Kinase AqueK486.AA TKL 1709-1831 22 4.2e-30 105.6 In-house 1-175 (364) Show / Hide 
Range on Protein: 1709-1831
Range on HMM: 1-175/364
Sequence Identity: 22% (41 aa)

LGEGGFGKVYRGKCRG----------KSVAIKKYLT---------------------------RTEEAFNELRSEAKVLQESHHPFLVCLVG--------
.|.||||.||.||.||          | ||.||. .                            .. .. ... |....   .|| .| ..|        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-VSVHP-----LMALILEEAPMGS-FERHLIKKSTPIPRLTMFRIAAQVAAALRFLHQHG--------IIFRDLKAANVLLWS
 |..||      .... | .| || .....           ..|.| ..| .. .||...        || |||| .|.|...
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDE
Kinase AqueK486.AA Pkinase 1703-1829 22 1.9e-26 94.6 Pfam 1-141 (293) Show / Hide 
Range on Protein: 1703-1829
Range on HMM: 1-141/293
Sequence Identity: 22% (32 aa)

EDKDSLLGEGGFGKVYRGKCRGKS--VAIKKYLTRTEEAFNE--LRS--EAKVLQESHHPFLVCLVGVSV-HPLMALILEEAPMG----SFERHLI-KKS
  . . .|.|.||.||... .| .  ||.|.   |.|.   .  .|   |...... .||. | | ..   .. . ...| ...|    .  ...  ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TPI--PRLTMFRIAAQVAAALRFLHQHGIIFRDLKAANVLL
...  .  .  ... |.. .| ..|..||| |||| .|.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI
Pkinase_Tyr AqueK486.AA Pkinase_Tyr 1699-1829 27 9.9e-23 77.6 Pfam 1-144 (270) Show / Hide 
Range on Protein: 1699-1829
Range on HMM: 1-144/270
Sequence Identity: 27% (40 aa)

IKFQEDKDSLLGEGGFGKVYRGKCR------GKSVAIKKYLTRTEEA---FNELRSEAKVLQES-HHPFLVCLVGVSV--HPL--MALILEEAPMGSFER
|.| .     |||| ||.||.|...      .  ||.|.    . .      .. .|||.. .  ||| .|.|.|| .       . ...| .| |.   
ITFGKK----LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

HLIKK---STPIPRLTMFRIAAQVAAALRFLHQHGIIFRDLKAANVLL
.| |.     |..  ..  ...|.|... .|.....| ||| | |.|.
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLV
Kinase AqueK486.AA TK 1703-1829 14 1e-22 72.27 In-house 1-273 (486) Show / Hide 
Range on Protein: 1703-1829
Range on HMM: 1-273/486
Sequence Identity: 14% (41 aa)

EDKDSLLGEGGFG---KVYRGKCRGKS-----------------------------VAIKK--YLTRTEEAFN-------------ELRSEAKVLQE--S
      |||| ||   .||.|. ||..                             |...|    .  || |              |. .|.|....   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHPFLVCLVGVSVH-------------PLMALILEEAPMGS----FERHLIKKSTP--------------------------------------------
||| .| |.||...             . . ...| .| |.       .| |.. .                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IPRLTMFRIAAQVAAALRFLHQH------GIIFRDLKAANVLL
                               ..  ..  ...|.|.....||..      ... ||| | |.|.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLV
Kinase AqueK486.AA TKL-Unique 1707-1829 29 1.1e-20 69.84 In-house 3-145 (290) Show / Hide 
Range on Protein: 1707-1829
Range on HMM: 3-145/290
Sequence Identity: 29% (43 aa)

SLLGEGGFGKVYRGKCRGKSVAIKKYLTRTEEAFNE----LRSEAKVLQESH-HPFLVCLVGVSV----HPL-MALILEEAPMGSFERHLI---------
...||||.|.||.|| ||..||||.     |.  ||    ...| ...   | ||..| ..|...    .|  | ...|  |.||   .|          
NKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

KKSTPIPRLTMFRIAAQVAAALRFLHQHG--IIFRDLKAANVLL
....... . . ..| ..| .. .||  .  || ||||  |.|.
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLV
Kinase AqueK486.AA MLK 1704-1829 32 1.6e-20 64.38 In-house 2-136 (280) Show / Hide 
Range on Protein: 1704-1829
Range on HMM: 2-136/280
Sequence Identity: 32% (45 aa)

DKDSLLGEGGFGKVYRGKCRGKSVAIKKY-------LTRTEEAFNELRSEAKVLQESHHPFLVCLVGVSVH-PLMALILEEAPMGSFERHLIKKSTPIPR
.   ..| ||||||||.  .|. ||.|           .|.|  ...| ||. ..  .||  . | ||  . | . |..| .  || .| .  |   || 
KIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGK--RIPP

LTMFRIAAQVAAALRFLHQHG---IIFRDLKAANVLL
  .   | |.|  . .||. .   || ||||. |.|.
HVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILI
Kinase AqueK486.AA MLK 1699-1829 24 4.5e-20 66.41 In-house 1-160 (291) Show / Hide 
Range on Protein: 1699-1829
Range on HMM: 1-160/291
Sequence Identity: 24% (40 aa)

IKFQEDKDSLLGEGGFGKVYRGKCRGKS-----VAIKKYLTRTEEAFNE-------LRSEAKVLQESHHPF----LVCLVGV-SVHPL-MALILEEAPMG
|.|.|     .|.|.||||..|..|.|      ||.|.. .|.. .  .       .. |.. |    ||      . ..|| . .|   ....| .. |
IQFHE----WIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGG

SFERHLIKKST-------------PIPRLTMFRIAAQVAAALRFLHQHG---IIFRDLKAANVLL
|  . |  ...              ..   ....| |.| .. .||..    || ||||  |.|.
SLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILI
Kinase AqueK486.AA Dicty4 1704-1828 29 7.5e-17 52.9 In-house 2-146 (277) Show / Hide 
Range on Protein: 1704-1828
Range on HMM: 2-146/277
Sequence Identity: 29% (43 aa)

DKDSLLGEGGFGKVYRGKCRGKSVAIKKY--LTRT--EEAFNELRSEAKVLQESHHPFLVCLVGVSV----HP-LMALILEEAPMGSFERHLIK------
......|.|.||.||.|..||| ||.||   .  .  |.  ||.| |.. .    || .. . | .     ||  |    |  | |. .. | .      
NIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQ

KSTPIPRLTMFR---IAAQVAAALRFLHQ--HGIIFRDLKAANVL
.|....  .. |   .|  .|  .  ||     || ||||..| |
QSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLL
Kinase AqueK486.AA CAMK 1708-1829 16 5.9e-16 47.2 In-house 1-212 (425) Show / Hide 
Range on Protein: 1708-1829
Range on HMM: 1-212/425
Sequence Identity: 16% (35 aa)

LLGEGGFGKVYRGKCRGKS--------------VAIKKYLTR----------------------------TEEAFNELRSEAKVLQESH-------HPFL
 ||.|.||||.... .                 |||| . ..                            ...   ..|.| ....  .       || .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VCLVGVSVHPL--------------------MALIL---EEAPMG----S-FERHLIKKS-------------TPIPRLTMFRIAAQVAAALRFLHQHGI
. |  |   |                     | ...   | .. |      |..   ...               ..     |.  |.. |....|.|.|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IFRDLKAANVLL
. ||||  |.||
VHRDLKPENILL
Kinase AqueK486.AA STE 1703-1829 20 7.6e-16 52.54 In-house 1-185 (359) Show / Hide 
Range on Protein: 1703-1829
Range on HMM: 1-185/359
Sequence Identity: 20% (37 aa)

EDKDSLLGEGGFGKVYRGKCR-----------------GKSVAIKKYLTRTE-----------------EAFNELRSEAKVLQESH--HPFLVCLVGVSV
 .. . .|.|.||.||.....                 |. .|||.   ...                 | ....  | |......  ||. |   |  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HPL--------MALILEEAPMGSFERHLIKKS-------------TPIPRLTMFRIAAQVAAA-LRFLHQHGIIFRDLKAANVLL
.            ...|  . ||..  . .|              ...|     .|. |.  . | .||.|.|| ||.|.||.||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL
Kinase AqueK486.AA S_TKc 1703-1999 15 6.7e-12 -2.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 1703-1999
Range on HMM: 1-231/231
Sequence Identity: 15% (51 aa)

EDKDSLLGEGGFGKVYRGKCRG--KSVAIKKYLTRTEEAFNELRSEAKVLQESHHPFLVCLVGVSVHPLMALILEEAPM--GSFERHLIKKSTP-----I
 ..  ..|.|.|||||... ..  . ||||.         . .|.| ..|.. |||..| | .| ..  . ...| ..   |.  ... |. ..     .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PRLTMFRIAAQVAAALRFLHQHGIIFRDLKAANVLLWSLDETSLCH--------SKKEKCMVVSGAKGFQSP--LEGYPLDDFPQTEEDKSQPLDN-SGE
|  .  ....|.. || ..|.|||| |||| .|.|| .       |        ...   . . |   . .|  |                 . .  .  
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL--TTFCGTPWYMAPEVL-----------------GYGKCKCD

M-----ILWEAYSRATLRQMKIIEEESPGYLDNHKTVARMIKNFKFKDDTHIVEDLTATTTDESESSPSASADDTRETFKPFETSYTPNDHSPDPRSSII
.     ||.| ... .. .             ..... ..|.                                                 ||. .. .|
WWSCGCILYEMLCGYPPFP-------------QMQMMFKKIG-------------------------------------------------SPEAKD-FI

SSMSSAEESQ-MQSESGED-------VPLY
. .   . .. .               |  
RKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK486.AA TyrKc 1703-1901 15 2.8e-11 -40.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 1703-1901
Range on HMM: 1-280/280
Sequence Identity: 15% (43 aa)

EDKDSLLGEGGFGKVYRGKCRGKSVAIKKYLTRTEEAFNELRSEAKVLQES--HHPFLVCLVGVSVH--------PLMALILEEAPMGSFERHLIKKSTP
  ..  |||| ||.||.|. .   ||.|.    .     ....||... .   ||| .|.|.|| ..        . . ...| .| |.   .| |.   
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

IPRLTMFRIAAQVAAALRFLHQHGIIFRDLKAANVLLWSLD----------ETSLCH--------SKKE----KCM------------------------
..  ..  .. |.|.  ..||....| ||| | |.|. .                 .         ..      .                         
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

---------VVSGAKGFQSP-----LEGYPLDDFPQTEEDKSQPLD--------NSGEMIL-------WEAYSRATLRQMKIIE
         . .  .   .      .. . .  . .. .   || .         . ||          .. .| | .. . . 
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK486.AA LISK 1708-1767 31 2.6e-10 29.51 In-house 1-67 (296) Show / Hide 
Range on Protein: 1708-1767
Range on HMM: 1-67/296
Sequence Identity: 31% (21 aa)

LLGEGGFGKVYRGKCR--GKSVAIKKYLT-----RTEEAFNELRSEAKVLQESHHPFLVCLVGVSVH
 .|.|.|||||.|  |  |. .|||.  .       .|..  .  | .....  ||. |  .||..|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYH
Kinase AqueK486.AA LISK 1800-1829 43 5.3e-09 25.18 In-house 105-134 (296) Show / Hide 
Range on Protein: 1800-1829
Range on HMM: 105-134/296
Sequence Identity: 43% (13 aa)

RIAAQVAAALRFLHQHGIIFRDLKAANVLL
.||  .| ....||  .||.||||. |.|.
KIALDIACGMSYLHSMNIIHRDLKSKNCLV