Gene AqueK482 (A.queenslandica)

AqueK482

Species: A.queenslandica
Alias: AqueK482
External Links:
Annotation:

Classification

Group: TKL
Family: LISK
Subfamily: TESK

Sequence

Name Sequence Type Origin Length Description Download
AqueK482.AA Protein None 472 None Fasta, JSON
AqueK482.kin_dom Protein Kinase Domain None 149 None Fasta, JSON

Protein domain

Protein domains of AqueK482.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK482.AA TESK 59-199 62 6.9e-89 280.81 In-house 1-145 (292) Show / Hide 
Range on Protein: 59-199
Range on HMM: 1-145/292
Sequence Identity: 62% (90 aa)

EKIGQGFFAEVFKVTHKNTGEVMVLKLNK---SRNNSKQMLAEIQLLNRLSHSNILGFKGSCVHEGSLHALTEYINGGTLEELLS-SDPHLSWSKRIKIA
|||| ||| ||.||.|. .| |||||.||    | | ..|| |.||.|.|.| ||| | | |||.| |||||||||||.||.||. |. ||||  .|. |
EKIGSGFFSEVYKVRHRASGQVMVLKMNKQKIWRANRHNMLREVQLMNKLQHPNILRFMGVCVHQGQLHALTEYINGGCLEQLLADSELHLSWTQKIHLA

HDIANGMAYLHNRGVFHRDLTSKNCLIQKSDDGSLNCVVADFGLA
 ||| || ||| .|||||||||||||... |.  .  ||.|||||
YDIARGMSYLHSKGVFHRDLTSKNCLVRQRDNNQYEAVVGDFGLA
Kinase AqueK482.AA LISK 60-199 44 2e-75 244.51 In-house 1-152 (296) Show / Hide 
Range on Protein: 60-199
Range on HMM: 1-152/296
Sequence Identity: 44% (68 aa)

KIGQGFFAEVFKVTHKNTGEVMVLKLNK-------SRNNSKQMLAEIQLLNRLSHSNILGFKGSCVH-EGSLHALTEYINGGTLEELLSSDP----HLSW
.||.|||..|.|.||. ||.||..| ..        . . | || |.|....|.| ||. | | |.| .|.||..|||||||.|...|.. .    .|.|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

SKRIKIAHDIANGMAYLHNRGVFHRDLTSKNCLIQKSDDGSLNCVVADFGLA
..|.||| ||| ||.||| ....||||.|||||. ..|..  . .|.|||.|
PQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFA
Kinase AqueK482.AA TKL 61-199 26 1.4e-44 154.47 In-house 1-201 (364) Show / Hide 
Range on Protein: 61-199
Range on HMM: 1-201/364
Sequence Identity: 26% (54 aa)

IGQGFFAEVFKVTHKN--------TGEVMVLKLNKSRNNS-----------------------------KQMLAEIQLLNRLSHSNILGFKGSCVHEGS-
||.|.|.||.| ....        ||.... |  ||.|..                             ..   || ...||.| ||. |.|.|  ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LHALTEYINGGTLEELLSSDPHLSWSKRIKIAHDIANGMAYLHN--------RGVFHRDLTSKNCLIQKSDD----------GSLNCV
            |.  .||. ||.|...|       |..|...|.||| ||.|||.        ... ||||.|||.|. .                .| 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

VADFGLA
..||||.
ICDFGLS
Kinase AqueK482.AA LIMK 59-199 42 9.9e-44 146.82 In-house 5-144 (287) Show / Hide 
Range on Protein: 59-199
Range on HMM: 5-144/287
Sequence Identity: 42% (61 aa)

EKIGQGFFAEVFKVTHKNTGEVMVLK--LNKSRNNSKQMLAEIQLLNRLSHSNILGFKGSCVHEGSLHALTEYINGGTLEELLSS-DPHLSWSKRIKIAH
|. |.|||  ..||||. ||||||.|     .    .  | |.  .  | | ..| | |       |. .|||| ||.|...... |  . |. |...| 
EVLGKGFFGQAIKVTHRQTGEVMVMKELHRCDEETQRTFLKEVKVMRCLDHPHVLKFIGVLYKDKRLNMVTEYIKGGCLKNIIHDMDQPFPWQQRVRFAR

DIANGMAYLHNRGVFHRDLTSKNCLIQKSDDGSLNCVVADFGLA
||| ||.|||  .. |||| | |||.   .|.|   ||||||||
DIACGMSYLHSMCIIHRDLNSHNCLVR--EDRSV--VVADFGLA
Kinase AqueK482.AA Pkinase 59-210 28 4.4e-31 110.97 Pfam 5-169 (293) Show / Hide 
Range on Protein: 59-210
Range on HMM: 5-169/293
Sequence Identity: 28% (48 aa)

EKIGQGFFAEVFKVTHKNTGEVMVLKLNKSRNNSKQML------AEIQLLNRLSHSNILGFKGSCVHEGSLHALTEYINGG----TLEELLS--SDPHL-
.|||.| |..|.| .||.||.. ..|  | |.......      .|||...||.| ||. .....  .....  .|| .||     | ...|  ..  . 
RKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY

-SWSKRIKIAHDIANGMAYLHNRGVFHRDLTSKNCLIQKSDDGSLNC----VVADFGLAAKI-VDPDGRPT
 |.   ....  |. |..|.|..|. |||| . |.||    |   ..     ..|||||...   ... .|
FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI----DNNGHIDACVKICDFGLAKQFDY-NNS-MT
Kinase AqueK482.AA STE 56-204 22 8e-31 106.11 In-house 1-199 (359) Show / Hide 
Range on Protein: 56-204
Range on HMM: 1-199/359
Sequence Identity: 22% (47 aa)

FTR-EKIGQGFFAEVFKVTHKN---------------TGEVMVLK-LNKSRNN------------------SKQMLAEIQLLNRLS--HSNILGFKGSCV
... ||||.| | .|.|  ...               |||.|  | .|....|                   .| | ||.......  | ||  . |...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HEG-------SLHALTEYINGGTLEELLS-------SDP-------HLSWSKRIKIAHDIANG-MAYLHNRGVFHRDLTSKNCLIQKSDDGSLNCVVADF
.||       .|.   ||..||.|....        ...       ... |  ..|...|  | ..|||. .. |||. . | |.         .  .||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDF

GLAAKIVD
|......|
GVCGQLTD
Kinase AqueK482.AA TK 55-199 14 2.6e-29 94.8 In-house 1-298 (486) Show / Hide 
Range on Protein: 55-199
Range on HMM: 1-298/486
Sequence Identity: 14% (43 aa)

DFTREKIGQGFFA---EVFKVTHKNTG--------------------------EVMVLKLNKSRNNSKQM------------------LAEIQLLN--RL
    .|.|.| |    ||.| . .. .                          .| |  | .  ..|...                  ..|.....   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

SHSNILGFKGSCVHE------------GSLHALTEYINGGT----LEELLSSDPH---------------------------------------------
 | ||. . | |...            . .  ..|| ..|     | . | . ..                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSWSKRIKIAHDIANGMAYLHNR------GVFHRDLTSKNCLIQKSDDGS-------LNCVVADFGLA
                               |.   .. ....||.||.||| .      .. ||||   |||. ...          . | .|||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS
Kinase AqueK482.AA TKL-Unique 57-199 28 3e-29 100.38 In-house 1-164 (290) Show / Hide 
Range on Protein: 57-199
Range on HMM: 1-164/290
Sequence Identity: 28% (47 aa)

TREKIGQGFFAEVFKVTHKNTGEVMVLKLNK---SRNNSKQ-MLAEIQLLNRLS-HSNILGFKGSCV----HEGSLHALTEYINGGTLEELLS-------
  .|||.| ...|.|.... . .| . ....   |.| ..|    |. ....|  | ||. . | |.    ... .   .||..||.| ..|.       
FWNKIGEGGYGQVYKGKWRGY-PVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

---SDPHLSWSKRIKIAHDIANGMAYLHNRG--VFHRDLTSKNCLIQKS-DDGSLNCVVADFGLA
   .   |....|.|.|.||| || |||...  . ||||.|.| |.        .|  ..||||.
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLS
Kinase AqueK482.AA Pkinase_Tyr 59-199 27 4e-29 99.26 Pfam 5-158 (270) Show / Hide 
Range on Protein: 59-199
Range on HMM: 5-158/270
Sequence Identity: 27% (43 aa)

EKIGQGFFAEVFKVTHK-----NTGEVMVLKL--NKSRNN--SKQMLAEIQLLNRL-SHSNILGFKGSCV-HEGS--LHALTEYINGGTLEELLSS----
.|.|.| | ||.| | |     .. .| | .|  . .  .  .. ...|....  | .| ||. . | |. ....  .   .||  .| | . | .    
KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHRED

DPHLSWSKRIKIAHDIANGMAYLHNRGVFHRDLTSKNCLIQKSDDGSLNCVVADFGLA
...|. .  ......||.||.||....  ||||  .|||. .    .. . ..|||||
KQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----NNVVKICDFGLA
Kinase AqueK482.AA LISK-DD1 98-199 36 4.7e-29 102.27 In-house 44-174 (290) Show / Hide 
Range on Protein: 98-199
Range on HMM: 44-174/290
Sequence Identity: 36% (48 aa)

EIQLLNR---LSHSNILGFKGSCVH-------------EGSLHALTEYINGGTLEELLSSDP-------------HLSWSKRIKIAHDIANGMAYLHNRG
||. |     ..| ||  | | |.|             |.||. .||.|.|| | ..| . |             ...|..|.||| ||| .||||| ..
EIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWYLKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSKN

VFHRDLTSKNCLIQKSDDGSLNCVVADFGLA
. |||| ||| |. .. |.     | |||.|
IIHRDLKSKNILVDENGDSQWRIKVCDFGFA
Kinase AqueK482.AA MLK 57-199 25 1.2e-25 86.01 In-house 3-180 (291) Show / Hide 
Range on Protein: 57-199
Range on HMM: 3-180/291
Sequence Identity: 25% (46 aa)

TREKIGQGFFAEVFKVTHKNTG----EVMVLKLN-------KSRNNSKQMLAEIQLLNRLSHSN----ILGFKGSCVHEGS-LHALTEYINGGTLEELL-
. |.|| | | .|.| . .|.     .| | . .       ..   ....  |. .|..||| |    |  |.| |  ... .  ..||. || | ..| 
FHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLH

--SSDPH-----------LSWSKRIKIAHDIANGMAYLHNRG---VFHRDLTSKNCLIQ---KSDDGSLNCVVADFGLA
  .| .             . .  ...|...|.||.|||.     . |||| |.| ||    . | . ......|||..
GARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHGTLKICDFGTS
Kinase AqueK482.AA TK-Unique 56-199 22 5.9e-22 72.58 In-house 2-180 (294) Show / Hide 
Range on Protein: 56-199
Range on HMM: 2-180/294
Sequence Identity: 22% (42 aa)

FTREKIGQGFFAEVFKVTHKNTG------EVMVLKLNKSRNNSKQ---MLAEIQLLNRLS-HSNILGFKGSCVHEG-SLHALTEYINGGTLEELLS----
.  ..||.| | .|.. . ...        . ..|..| ...  .   .| |||... |  | ||. . | |.  . . . . ||. .|.|. .|     
EVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRP

----------------SDPHLSWSKRIK------IAHDIANGMAYLHN--RGVFHRDLTSKNCLIQKSDDGSLNCVVADFGLA
                ..|.      |.      .| .||.||.||.   ....|||| ..|.|..      ..| ..|||.|
AMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE----DKVCKICDFGMA
Kinase AqueK482.AA S_TKc 55-431 11 1.1e-14 38.17 SMART 1-231 (231) Show / Hide 
Range on Protein: 55-431
Range on HMM: 1-231/231
Sequence Identity: 11% (48 aa)

DFTREKIGQGFFAEVFKVTHKNTGEVMVLKLNKSRNNSKQMLAEIQLLNRLSHSNILGFKGSCVHEGSLHALTEYING--GTLEELLSSDPH------LS
    .|||.| |..|.|..||.||... .|  |     .... |||.| .  | ||  ....... ..|.  .||..|  |.| ... . ..      ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

WSKRIKIAHDIANGMAYLHNRGVFHRDLTSKNCLIQKSDDGSLNCVVADFGLAAKI----------------VDP----------------DGRPTFDEI
     .... |.....|.|..|. ||||   | |. .      .  ..|||||...                 ..                 |.| |...
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFPQM

VQMLDPLVSAYQSNSTPPPAPPIAPLSNPSSPSKVELPAELCPSPQSPSSSLLSSLLGGSVERDGIIRERKISTVSLDSGCGPERVDPSSYWKNIGFYKT
 .|.. ..                                                                                            
QMMFKKIG--------------------------------------------------------------------------------------------

PSLTDGKTTPLTPSSTHFRQISDSSEVSFQLPSPSFAWAPPPSPSTSLYRLSLTSPIDTPSHQVGASREGSLSSPEHSPITGEDSDHTPSPDPISGNQFD
                                                                                                   .
---------------------------------------------------------------------------------------------------S

LEDWNIIRATCT------------N-------MSLV
 | ...||  ..            .       .  .
PEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase AqueK482.AA TyrKc 55-255 18 3.7e-13 -9.86 SMART 1-280 (280) Show / Hide 
Range on Protein: 55-255
Range on HMM: 1-280/280
Sequence Identity: 18% (54 aa)

DFTREKIGQGFFAEVFKVTHKNTGEVMVLKLNKSRNNSKQMLAEIQLLNRL--SHSNILGFKGSCVHE-------GSLHALTEYINGGTLEELL-SSDPH
    .|.| |.| ||.| | |   .| | .|...    . .. |.... .|  .| ||. . | |...       . |  ..||  .| | . | .. |.
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LSWSKRIKIAHDIANGMAYLHNRGVFHRDLTSKNCLIQKSDDGSLNCVVADFGLAAKIVDP----------------DGR--------------------
|.... ......||.||.||| ... ||||   |||. .       . ..||||. .| |                 .|.                    
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

----------------------PT----FDEIVQMLDPLVSAYQSNSTPP--------PAPPIAPL------SNPSS-PSKVELPAEL
                      |     . .  ...  . . |     |           . .  .       .|.. |.  |.  ..
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK482.AA LISK 203-218 62 3e-06 16.26 In-house 281-296 (296) Show / Hide 
Range on Protein: 203-218
Range on HMM: 281-296/296
Sequence Identity: 62% (10 aa)

VDPDGRPTFDEIVQML
.||. ||.|.|||| |
YDPKNRPSFKEIVQWL
Kinase AqueK482.AA LISK-DD1 203-218 62 5e-06 18.11 In-house 275-290 (290) Show / Hide 
Range on Protein: 203-218
Range on HMM: 275-290/290
Sequence Identity: 62% (10 aa)

VDPDGRPTFDEIVQML
.||..||.|.|||| |
YDPNNRPSFKEIVQTL
Kinase AqueK482.AA TKL 204-218 53 5.7e-05 13.86 In-house 350-364 (364) Show / Hide 
Range on Protein: 204-218
Range on HMM: 350-364/364
Sequence Identity: 53% (8 aa)

DPDGRPTFDEIVQML
||. ||.|.||.. |
DPEKRPSFQEILKRL
Kinase AqueK482.AA MLK 204-218 60 0.000114 12.27 In-house 277-291 (291) Show / Hide 
Range on Protein: 204-218
Range on HMM: 277-291/291
Sequence Identity: 60% (9 aa)

DPDGRPTFDEIVQML
||  ||.|..||| |
DPHKRPSFRQIVQHL
Kinase AqueK482.AA TK 204-218 46 0.000123 10.62 In-house 472-486 (486) Show / Hide 
Range on Protein: 204-218
Range on HMM: 472-486/486
Sequence Identity: 46% (7 aa)

DPDGRPTFDEIVQML
||. ||||......|
DPEDRPTFSQLHEQL
Kinase AqueK482.AA TKL-Unique 204-218 60 0.000315 11.02 In-house 276-290 (290) Show / Hide 
Range on Protein: 204-218
Range on HMM: 276-290/290
Sequence Identity: 60% (9 aa)

DPDGRPTFDEIVQML
||. ||.||||.  |
DPSQRPSFDEIIHRL
Kinase AqueK482.AA TK-Unique 204-218 40 0.000718 9.37 In-house 280-294 (294) Show / Hide 
Range on Protein: 204-218
Range on HMM: 280-294/294
Sequence Identity: 40% (6 aa)

DPDGRPTFDEIVQML
.|. ||.|..|...|
EPEERPSFRQIKHRL
Kinase AqueK482.AA Pkinase_Tyr 204-218 60 0.00209 12.16 Pfam 256-270 (270) Show / Hide 
Range on Protein: 204-218
Range on HMM: 256-270/270
Sequence Identity: 60% (9 aa)

DPDGRPTFDEIVQML
||. |||| ||...|
DPEDRPTFSEIHEQL
Kinase AqueK482.AA TESK 204-220 47 0.00285 5.68 In-house 276-292 (292) Show / Hide 
Range on Protein: 204-220
Range on HMM: 276-292/292
Sequence Identity: 47% (8 aa)

DPDGRPTFDEIVQMLDP
||  ||.| ||.. |. 
DPKDRPVFHEITKHLEW
Kinase AqueK482.AA LIMK 204-218 60 0.01596 4.36 In-house 273-287 (287) Show / Hide 
Range on Protein: 204-218
Range on HMM: 273-287/287
Sequence Identity: 60% (9 aa)

DPDGRPTFDEIVQML
||| || ||.  | |
DPDMRPCFDKLHQWL