Gene AqueK479 (A.queenslandica)

AqueK479

Species: A.queenslandica
Alias: AqueK479
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK

Sequence

Name Sequence Type Origin Length Description Download
AqueK479.AA Protein None 586 None Fasta, JSON
AqueK479.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of AqueK479.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK479.AA IRAK 318-517 29 2.4e-35 122.76 In-house 8-229 (317) Show / Hide 
Range on Protein: 318-517
Range on HMM: 8-229/317
Sequence Identity: 29% (67 aa)

GSGGFGKVFLANNLRSKGTK--AAVK---EGAQALIGSTPSAQIKA---ELSALMKFRHENVLEVMGFCFSENFRALIYQYMANDTLFA--WIHQPSKS-
|.|||| |. .   . |.|    |||   |.|   ...    .  .   || .. ..||.|.... |.|. . .  |.|.||.| .|..  | . .. . 
GEGGFGCVYRG---QWKNTTGIYAVKKLKEMADMSWNEH-WQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPP

--LGFTVRKSILIDMFRGVSYLHAGQ----LIHQDIKS-NILLDEHFNARVGDFGIAYEV-PSSISGRTLV---TAPLLARSDGYYPPKILT---GKVSA
  |    |.||..   .|. .||  .    .||.|||| |||||.||..  .||| . .  | | . .. .    . ..  .  | ||  ..   |. . 
KPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTK

LSDVYSCGVVVLEVYCGM-VAYQKDR
 .||||.|.|.|||  |  ..|  ..
KTDVYSFGIVLLEVLTGCRAVYDDRP
Kinase AqueK479.AA TKL 317-516 19 3.9e-30 105.72 In-house 1-292 (364) Show / Hide 
Range on Protein: 317-516
Range on HMM: 1-292/364
Sequence Identity: 19% (57 aa)

FGSGGFGKVFLANNLRSK-------GTKAAVKEGAQ----------------------ALIGSTPS---AQIKAELSALMKFRHENVLEVMGFCFSENF-
 ||||||.|. ..            |.  |||   .                       |.  ..|    ... |.  . ..||.|..  ||.|..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RALIYQYMANDTLFAWIHQPSKSLGFTVRKSILIDMFRGVSYLHA--------GQLIHQDIKS-NILLDEHFN--------------A
             .....|. . .|.  .|       . .| .. .|. ||..|||.         ..|| |.|| |||.||...              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

RVGDFGIAYEVPSSI-SGRTLVT------------APLLAR-SDGYYPPKILT-----------------GKVSALSDVYSCGVVVLEVYCGMVAYQKD
 ..|||.. ..  |  . .|  |            .    . . .. .| .|                  .. |  .|||| |.|  |.... . |...
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY
Kinase AqueK479.AA Pkinase 318-456 22 6.2e-18 64.49 Pfam 8-159 (293) Show / Hide 
Range on Protein: 318-456
Range on HMM: 8-159/293
Sequence Identity: 22% (34 aa)

GSGGFGKVFLANNLRSKGTKAAVKEGAQALIGSTPSAQIKA--ELSALMKFRHENVLEVMGFCFSENFRALIYQYMAND----TLFAWIH-QPSKSL--G
|||.||.|... .  .   . |||.     . |    .     |.. . ...|.|...  ... ...   ..  |. ..     ||..|. . ....   
GSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFS

FTVRKSILIDMFRGVSYLHAGQLIHQDIK-SNILLDEHFNA----RVGDFGIA
  . |...  ..||. |.|.   || |.| .|||.|.. .     ...|||.|
EWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA
Kinase AqueK479.AA RIPK 317-456 27 1e-17 56.93 In-house 1-156 (290) Show / Hide 
Range on Protein: 317-456
Range on HMM: 1-156/290
Sequence Identity: 27% (44 aa)

FGSGGFGKVFLANNLRSKGTKAAVKE--GAQ--ALIGSTPSAQIKAELSALMKFRHENVLEVMGFCFSENF------RALIYQYMANDTLFAWIHQPS--
 |.||||.||.|   |. |. .|.|   . .  . . .  . ..| |  .. | |.|... . |||  |..       ..  .||.|  |    |  .  
VGGGGFGEVFKARH-RHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPY

----KSLGFTVRKSILIDMFRGVSYLHAGQ--LIHQDIK-SNILLDEHFNARVGDFGIA
      .  . |  ..  . .|. |||  .  .|| | | .|||.| .|.. . ||| |
QHHPDPWPLRCR--MIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLA
Kinase AqueK479.AA RAF 311-456 28 6.1e-17 51.19 In-house 1-150 (282) Show / Hide 
Range on Protein: 311-456
Range on HMM: 1-150/282
Sequence Identity: 28% (43 aa)

VKLAPNFGSGGFGKVFLANNLRSKGTKAAVKEGAQALIGSTPSA--QIKAELSALMKFRHENVLEVMGFCFSEN--FRALIYQYMANDTLFAWIHQPSK-
|.. .  ||| || |. ..     |. |  .   ...  .   |    | |.... | || |.|  ||.    .    | . |.    .|.  ||     
VMVMTRIGSGSFGTVYRGHWH---GDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETR

-SLGFTVRKSILIDMFRGVSYLHAGQLIHQDIKS-NILLDEHFNARVGDFGIA
  .       |.  .  | .|||| . || |.|| ||.|.|    ..|||| .
EKFDMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLM
S_TKc AqueK479.AA S_TKc 311-580 18 1.3e-16 62.47 SMART 1-231 (231) Show / Hide 
Range on Protein: 311-580
Range on HMM: 1-231/231
Sequence Identity: 18% (54 aa)

VKLAPNFGSGGFGKVFLANNLRSKGTKAAVKEGAQALIGSTPSAQIKAELSALMKFRHENVLEVMGFCFSENFRALIYQYMAN--DTLFAWIHQPSKS--
 ..    |.|.||||... . .  | . |.|.            .|. |.. |.| .|.|.    ... . ..  ..  |. .   .||  |..  .   
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LGFTVRKSILIDMFRGVSYLHAGQLIHQDIK-SNILLDEHFNARVGDFGIAYEVPSSISGRTLVTAPLLARSDGYYPPKILTGKVSA-LSDVYSCGV
   .   . ....  ..... |.|  . || |.| .||||||  .  ..|||.| ..      .|..  |       | .| .|  . .   .|..|||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTP------WYMAPEVL--GYGKCKCDWWSCGC

VVLEVYCGMVAYQKDRADPDLVNFTEDQRADSKAFFSMADIHVRESLSQEDAEMFRSVVNGCVQ-RYSKRWTATKVLD---------VL
.. | .||   ..    .  . .                             . ... ...| |   .||.|| ..|           .
ILYEMLCGYPPFP---QMQMMFKKIG-------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK479.AA TKL-Unique 318-515 23 2.9e-16 54.03 In-house 6-232 (290) Show / Hide 
Range on Protein: 318-515
Range on HMM: 6-232/290
Sequence Identity: 23% (55 aa)

GSGGFGKVFLANNLRSKGTKAAVKEGA-QALIGSTPSAQIKAELSALMKFR-HENVLEVMGFCF----SENFRALIYQYMANDTLFAWIH---------Q
|.||.|.|. .     .|.. |.|  . .... .. .   . |.. . |.. |.|..  ||.|.    ... . ..  |.   .|   .|          
GEGGYGQVYKGKW---RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

PSKSLGFTVRKSILIDMFRGVSYLHAGQ--LIHQDIKS-NILLDEH-----FNARVGDFGIAYEVPSSISGRTLVTA-----PLLARSDGYYPPKILTG-
... | . .| .. ||. .|  |||  .   || |.|| |.|.|..     .|... |||..  . |.|.  |. .      .    |  . .| .|.. 
NNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLS-KFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMN

--KVSALSDVYSCGVVVLEVYCGMV--AYQK
  . |  ||||| |.|. | . ...   | |
FCQYSEKSDVYSFGIVLWEIATRKITKTYKK
Kinase AqueK479.AA Dicty4-Unclassified 421-459 50 8.7e-14 43.57 In-house 120-159 (263) Show / Hide 
Range on Protein: 421-459
Range on HMM: 120-159/263
Sequence Identity: 50% (20 aa)

RGVSYLHAGQLIHQDIK-SNILLDEHFNARVGDFGIAYEV
.|  .||   .|| ||| ||||.| |||....||||. ..
QGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVI
Kinase AqueK479.AA Dicty4 400-456 30 5.7e-12 36.39 In-house 93-161 (277) Show / Hide 
Range on Protein: 400-456
Range on HMM: 93-161/277
Sequence Identity: 30% (21 aa)

IHQ------PSKSLGFTVRKS---ILIDMFRGVSYLHA--GQLIHQDIKS-NILLDEHFNARVGDFGIA
.|       .|..| .. .|.   . .|  ||. .||.     || |.|| |.| |..... |.|||..
LHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLS
Kinase AqueK479.AA STE 318-456 20 6.4e-12 38.49 In-house 8-194 (359) Show / Hide 
Range on Protein: 318-456
Range on HMM: 8-194/359
Sequence Identity: 20% (40 aa)

GSGGFGKVFLANNLR-----SKGTK---------AAVKEGA----QALIGS------------TPSAQIKAELSALMKFR--HENVLEVMGFCFSE----
|.|.||.|..| |       ..| .          |.|.      .. . .            .   ||. |.. ..|..  |.|. .  | .| |    
GKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNH

---NFRALIYQYMANDTLFAWIHQPSKSLG-------------FTVRKSILIDMFRG-VSYLHAGQLIHQDIK-SNILLDEHFNARVGDFGIA
   .   ..  ||.. .|   |..  . ..              .. . |. .  .|  .|||  . || ||| .||||     .   |||..
KNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC
Kinase AqueK479.AA MLK 311-456 22 7.7e-12 37.47 In-house 1-180 (291) Show / Hide 
Range on Protein: 311-456
Range on HMM: 1-180/291
Sequence Identity: 22% (41 aa)

VKLAPNFGSGGFGKVFLANNLRSKGTK-----AAVKEGAQALIGSTPSA-----QIKAELSALMKFRHEN----VLEVMGFCFSE-NFRALIYQYMANDT
 ..    |||.||||...   | ...       |||. ..  . .  ..     ... |   | ...|.|    . ...| | .. .  ... .|...  
IQFHEWIGSGSFGKVWKG---RWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGS

LFAWIHQ-PSKSLG------------FTVRKSILIDMFRGVSYLHAGQ---LIHQDIKS-NILLDE------HFNARVGDFGIA
|.  .|  .||. .            . .  ..  .. ||..|||. .   .|| |.|| |||.||      | .... |||..
LYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTS
Kinase AqueK479.AA MELK 312-516 23 7.7e-12 36.42 In-house 2-203 (254) Show / Hide 
Range on Protein: 312-516
Range on HMM: 2-203/254
Sequence Identity: 23% (48 aa)

KLAPNFGSGGFGKVFLANNLRSKGTKAAVKEGAQALIGSTPSAQIKAELSALMKFRHENVLEVMGFCFSENFRALIYQYMANDTLFAWIHQPSKSLGFTV
..  . |.|||.|| ||  .   . . |.|   .  .|.    ..|.|. || ..||... ..  .   |.   .. .| .   .| .| .  . |    
EVHDEIGTGGFAKVKLACHILT-NQMVAIKIMDKNQLGHD-LPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDR-LEEEE

RKSILIDMFRGVSYLHAGQLIHQDIK-SNILLDEHFNARVGDFGIAYEVPSSISGRTLVTAPLLARSDGYYPPKILTGK--VSALSDVYSCGVVVLEVYC
 . ..  .   ..|.|.    |.|.|  |.|.||... .. |||.       .    | |      |  |  | .. ||  . .  ||.| |...  . |
TRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTC---CGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMC

GMVAYQKD
|.. .. |
GFLPFDDD
Kinase AqueK479.AA TyrKc 311-580 18 7.3e-11 -47.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 311-580
Range on HMM: 1-280/280
Sequence Identity: 18% (56 aa)

VKLAPNFGSGGFGKVFLANNLRSKGTKAAVKEGAQALIGSTPSAQIKAELSALMKF--RHENVLEVMGFCFSE-------NFRALIYQYMANDTLFAWIH
..|    |.| ||.|...       .. |||            . .  |.. ..|.  .|.|..   | | ..           ..  ||..  |   ..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

QPSKSLGFTVRKSILIDMFRGVSYLHAGQLIHQDIKS-NILLDEHFNARVGDFGIAYEVPSS-ISGRTLVTAPLLARSDGYYP------PK---------
 . . |      |. ..  .| .|||  ..|| |.   |.|..| . ....||| . .. .   .|           |. ||        |         
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG----------ESKDYYRKKEHKGGKTMLPIRWMA

---ILTGKVSALSDVYSCGVVVLEVY-CGMVAYQKD----RADPDLVNFTEDQRADSKAFF----SMADIHVRESLSQEDAEMFRSVVNGCVQR-YSKRW
   | .|| .  |||.| ||.  |..  |.  |  .      . ..... .. .   .       |        .     .||.. .   | ..  ..| 
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------F-VCCPDEMYQ-IMKQCWHEDPEDRP

TATKVLDVL
| . . . .
TFSEIHECF
Kinase AqueK479.AA Pkinase_Tyr 318-456 20 0.000159 15.95 Pfam 8-158 (270) Show / Hide 
Range on Protein: 318-456
Range on HMM: 8-158/270
Sequence Identity: 20% (31 aa)

GSGGFGKVFLANNL---RSKGTKAAVKEGAQALIGSTPS----AQIKAELSALMKF-RHENVLEVMGFCF-SENF--RALIYQYMANDTLFAWIHQP---
|.| ||.|...       ..... |||   .   |....    .   .|.. .... .|.|..  .| |   .      ..  ||..  |    ...   
GEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHRED

SKSLGFTVRKSILIDMFRGVSYLHAGQLIHQDIKS-NILLDEHFNARVGDFGIA
 ..|      .. ..  .| .||.. ..|| |.   |.|..| . ....||| |
KQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase AqueK479.AA Pkinase 491-509 36 0.578764 4.49 Pfam 190-208 (293) Show / Hide 
Range on Protein: 491-509
Range on HMM: 190-208/293
Sequence Identity: 36% (7 aa)

SALSDVYSCGVVVLEVYCG
.  .|..|||... |..||
GPKVDMWSCGCILYEMLCG