Gene AqueK459 (A.queenslandica)

AqueK459

Species: A.queenslandica
Alias: AqueK459
External Links:
Annotation:

Classification

Group: TK
Family: TK-Unique

Sequence

Name Sequence Type Origin Length Description Download
AqueK459.AA Protein None 834 None Fasta, JSON
AqueK459.kin_dom Protein Kinase Domain None 372 None Fasta, JSON

Protein domain

Protein domains of AqueK459.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH AqueK459.AA PH 11-132 16 3.1e-10 39.56 Pfam 1-92 (92) Show / Hide 
Range on Protein: 11-132
Range on HMM: 1-92/92
Sequence Identity: 16% (20 aa)

GQLEGWLTVYKSRNPFMFSKQKVRRHLVPDKVLERAWCVFHSKTSKGPTISFFQDNRKEVRVLKRDKVDLLSVREITKIFGHPKHANCFTLKNKGKRNRF
  .||||....                   |   . |.|...      ......|        .. ...| .. ..||.    |. .|| ... .. ...
VIKEGWLHKKG-----------------KRKSWKKRWFVLFN-----NCLYYYKDDK----YRPKGSIPLSDC-QVTKVPDN-KRPHCFQIRT-DR-RTY

LFDCDSNIDLNNWLRTLSDALR
.| ..|  ..| |.. ...|.|
YFQAESEEEMNDWMQAIQSACR
PH AqueK459.AA PH 11-134 12 6e-06 27.03 SMART 1-82 (82) Show / Hide 
Range on Protein: 11-134
Range on HMM: 1-82/82
Sequence Identity: 12% (15 aa)

GQLEGWLTVYKSRNPFMFSKQKVRRHLVPDKVLERAWCVFHSKTSKGPTISFFQDNRKEVRVLKRDKVDLLSVREITKIFGHPKHANCFTLKNKGKRNRF
 ..||||....                       . |.|...      ......|        .. ...| .. ....         ||.... ..  ..
VIKEGWLYKKS------------------K-RWKKRWFVLFN-----DCLYYYKDK------KPKGSIPLSDC-TVRE-P-------CFEIHH-DR--TY

LFDCDSNIDLNNWLRTLSDALRLE
.| |.|  ... |.. . .|..  
YFQCESEEEMQEWMQAIQKAIHNN
WWE AqueK459.AA WWE 135-170 23 0.003969 13.99 Pfam 1-42 (81) Show / Hide 
Range on Protein: 135-170
Range on HMM: 1-42/81
Sequence Identity: 23% (10 aa)

FRL--EKVIWEFL---DETGLWQALSDRE-SYDIEAHYCDQH
.    ... ||.    |..| | . ...  . .||. || .|
YNHAGKVYHWEWERSDDSNGKWWPYDMHVDCCHIENAYCAKH
WWE AqueK459.AA WWE 222-300 22 6.9e-05 10.6 SMART 1-84 (84) Show / Hide 
Range on Protein: 222-300
Range on HMM: 1-84/84
Sequence Identity: 22% (19 aa)

DLPAIWEWGDPSNDEWHPFERDTNIQIEDMYDSGSQWAELILCM--PSPMLLLLNLQDMKLVNSKTQ---VRYSLRRFDNTANM
  .  ||| | ... |.|.. .. . ||| | .| .| |...|   .|    . ....|   .  |     |   |...  . .
HKKYVWEWEDRCHGGWWPYDPRVCHHIEDAYCRGKKWCEMCICGQDDSLYPYIIDFHQMTQYRQNTGNRTCRPVRRMLYDPYPK
WWE AqueK459.AA WWE 220-258 28 0.002662 14.61 Pfam 1-46 (81) Show / Hide 
Range on Protein: 220-258
Range on HMM: 1-46/81
Sequence Identity: 28% (13 aa)

MND--LPAIWEWG--DPSNDEWHPFERDT-NIQIEDMYDSGSQ--W
.|.   .. |||   | ||..|.|.. .  .. ||. | .. .  |
YNHAGKVYHWEWERSDDSNGKWWPYDMHVDCCHIENAYCAKHCRVW
Pkinase_Tyr AqueK459.AA Pkinase_Tyr 354-621 42 2.1e-114 388.06 Pfam 1-270 (270) Show / Hide 
Range on Protein: 354-621
Range on HMM: 1-270/270
Sequence Identity: 42% (120 aa)

INTRELLGEGAFGEVYLADATGLPGTQGTVEVAVKQLKSRHGQHSQQ--MEDFLREAKEMAKV-DHHRVVKLIAVCT-LDFP--LLLIEEYMNQGDLLAV
|   . ||||||||||.. ..|  . .....|||| ||   | ...|  .|||.|||| | .  .|. .|.|..|||  . |  .... |||  ||||  
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LKEG---RPSMPLVQQLSFSWQVADGMNYLATDLQCVHRDLAARNVMVHKTESGEMLAKIADFGLSRHL-YSEMY-KHQGNKPRPLPAKWMALESLMYFI
|..    ... .. . |...||.|.||.||. . .|.||||||||..|..    .. .||.||||.| .   . | . .|. .  || ||||.|...| .
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLE-SKNCIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGK--LPIKWMAPECINYGK

FTTKSDVWSFGVMLWEIMTLGRTP-YPGVENRELLEQIEEHGLKLNKPKGCPQSIYDSILDCTQHEPDDRPTFGELKFKL
|||||||||||| .|||.|.|..| |||. | |..|.| |.|  . .|..||. ||| ...| ...|.||||| |.  .|
FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
TyrKc AqueK459.AA TyrKc 354-621 38 3.7e-114 386.49 SMART 1-280 (280) Show / Hide 
Range on Protein: 354-621
Range on HMM: 1-280/280
Sequence Identity: 38% (116 aa)

INTRELLGEGAFGEVYLADATGLPGTQGTVEVAVKQLKSRHGQHSQQMEDFLREAKEMAKV--DHHRVVKLIAVCTLD-------FPLLLIEEYMNQGDL
|   . ||||||||||.. ..        ..|||| ||. .      .|||.|||. | |.  .|  .|.|..||| .        ||... |||  |||
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

LAVLKEGRPSMPLVQQLSFSWQVADGMNYLATDLQCVHRDLAARNVMVHKTESGEMLAKIADFGLSRHLYSE--------MYKHQG--NKPRPLPAKWMA
.  |.. ||  .. . |||.||.|.||.||. . .|.||||||||..|..       .||.|||||| .|..        .|....  ..  .|| .|||
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLH-SKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

LESLMYFIFTTKSDVWSFGVMLWEIMTLGRTPYPG-----VENRELLEQIEEHGLKLNKPKG--------CPQSIYDSILDCTQHEPDDRPTFGELKFKL
.|...| .||||||||||||..|||.|.| .||||     ..|.|..|.... |  . .|.         ||. .|. ...| ...|.||||| |.. ..
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ-GYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK459.AA TK 354-621 23 4.90000000001e-108 363.38 In-house 1-486 (486) Show / Hide 
Range on Protein: 354-621
Range on HMM: 1-486/486
Sequence Identity: 23% (115 aa)

INTRELLGEGAFG---EVYLADATGLP--------------------GTQGTVEVAVKQLKSRHGQHSQQMED-----------FLREAKEMAKVD----
|   . ||||.||   |||.. . |..                    ...|...||||.||. .........|           ||.|| ||.. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HHRVVKLIAVCTLD------------FPLLLIEEYMNQGD----LLAVLKEGRPS--------------------------------------------
 |  .|.|..||| .             |.....|||. ||    |.  |.. ||                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------MPLVQQLSFSWQVADGMNYLATDL-----QCVHRDLAARNVMVHKTESGE-------MLAKIADFG---
                               ... |.| ..||.|.|| ||.        ..|||||||||..|..            . .||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRHLYS--EMYKHQGNK---------------------PRPLPAKWMALESLM---------YFIFTTKSDVWSFGVMLWEIMTLGRTPYPG-V
     |.| .||  . |.... .                      . || .||| |.|.         | .||||||||||||..|||.|.|..||.| .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

EN---------RELLEQIE-------------EHGLKLNKPKGCPQ-------------SIYDS-ILDCTQHEPDDRPTFGELKFKL
 |         .|..|...             .... . .|..||               .|.  ...| ...|.||||| .|. .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK459.AA UTK 354-621 37 4.1e-95 322.28 In-house 1-296 (296) Show / Hide 
Range on Protein: 354-621
Range on HMM: 1-296/296
Sequence Identity: 37% (112 aa)

INTRELLGEGAFGEVYLADATGLPGTQGTVEVAVKQLKSRHGQHSQQME---DFLREAK---EMAKVD-HHRVVKLIAVCTLDFPLLLIEEYMNQGDLLA
.  ...||.||||||..|..|  ..  ... ||||... .|.   |..|   ||..||.    |.... |  |..|..||| . |.... ||| .|||..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ-HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRS

VLKEGRPSMP-------LVQQLSFSWQVADGMNYLATDLQCVHRDLAARNVMVHKTESGE----MLAKIADFG---LSRHLY----------SEMYKHQG
.|   ||. |       | |.|...|..|.||.||..  ..|||||||||. ||. ..      |..||||||   .|| ..          |..|..|.
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHS-CGFVHRDLAARNCLVHMHRM-MWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQH

NKPRPLPAKWMALESLMYF-IFTTKSDVWSFGVMLWEIMTLGRTPYPGVENRELLEQIEEHG-LKLNKPKGCPQSIYDSILDCTQHEPDDRPTFGELKFK
.  ...| .||| |.| .   |||||||||||| .|||.| ||.||||  |.....|... | . ...|..|| ..|.  ..| . .|..||.| .|  .
Q--DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQ

L
.
M
Kinase AqueK459.AA Src 354-621 40 1.8e-91 310.18 In-house 1-255 (255) Show / Hide 
Range on Protein: 354-621
Range on HMM: 1-255/255
Sequence Identity: 40% (112 aa)

INTRELLGEGAFGEVYLADATGLPGTQGTVEVAVKQLKSRHGQHSQQMEDFLREAKEMAKVDHHRVVKLIAVCTLDFPLLLIEEYMNQGDLLAVLK-EGR
|   . ||.| ||||. .        .|...|||| ||. .     . |.||.||. | |..| ..|.| |||. . | . . |||..| ||. || .|.
IKLCRKLGQGQFGEVWMGYW------NGNTKVAVKTLKPGT----MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGE

PS-MPLVQQLSFSWQVADGMNYLATDLQCVHRDLAARNVMVHKTESGEMLAKIADFGLSRHLY--SEMY-KHQGNKPRPLPAKWMALESLMYFIFTTKSD
 . ..| |......|||.||.||    . .||||||||| | ..     ..|.||||| | .    . |  ..|.|   .| ||.| | . |  ||.|||
GRHLHLPQLIDMAAQVAEGMAYLESM-NYIHRDLAARNVLVGENN----VCKVADFGLARLIKEDDDEYCARHGAK---FPIKWTAPEAINYGRFTIKSD

VWSFGVMLWEIMTLGRTPYPGVENRELLEQIEEHGLKLNKPKGCPQSIYD-SILDCTQHEPDDRPTFGELKFKL
|||||. |.||.| ||.|||| .|.| |.|. |.| .. .|..||...|.  .| | . .|..||||  |  .|
VWSFGILLTEIVTYGRVPYPGMTNHEVLQQV-ERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK459.AA TK-Unique 354-621 34 4.3e-90 305.6 In-house 1-294 (294) Show / Hide 
Range on Protein: 354-621
Range on HMM: 1-294/294
Sequence Identity: 34% (104 aa)

INTRELLGEGAFGEVYLADATGLPGTQGTV-EVAVKQLKSRHGQHSQQMEDFLREAKEMAKVD-HHRVVKLIAVCTLDF-PLLLIEEYMNQGDLLAVLKE
..  ...||||||.|. ....|......    ||||.|| .. ....|  |||.|.. | ... |  .|... .|| .. | ..| ||. .|.|.  |..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQ--DFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRT

GRP----------------SMPLVQQ---LS------FSWQVADGMNYLATDLQ-CVHRDLAARNVMVHKTESGEMLAKIADFGLSRHLYSEMYKHQGN-
 ||                .||  ..   .|      | ||.| ||.|||  .. .|||||.||||..         .||.|||..|..|    ... . 
CRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE----DKVCKICDFGMARDVYT-NGVYSMMC

KPRPLPAKWMALESLM--YFIF-TTKSDVWSFGVMLWEIMTLGRTPYPGVENRELLEQIEEHGLKLNKPKGC-PQSIYDSILDCTQHEPDDRPTFGELKF
.  ..| .|||.|||   . .. ||||||||||| .|||.||| .||||. .....|.|.. |  ...|..| .. .|  .  |.|.||..||.| ..|.
SQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRD-GYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKH

KL
.|
RL
Kinase AqueK459.AA Src-Unclassified 354-622 38 7.6e-82 278.22 In-house 1-284 (284) Show / Hide 
Range on Protein: 354-622
Range on HMM: 1-284/284
Sequence Identity: 38% (114 aa)

INTRELLGEGAFGEVYLADATGLPGTQGTVEVAVKQLKSRHGQHSQQM--EDFL--------REAKEMAKVDHHRVVKLIAVCTLDFPLLLIEEYMNQGD
.     || | ||||...         | |.|||| ..     || .|  | ||        .||. | | .| ..|.| |||. . | . | |||  | 
VHLLRKLGRGQFGEVWYGKW------RGKVDVAVKTMRP---GHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGS

LLAVLKEGRPSMPLVQQL-------------SFSWQVADGMNYLATDLQCVHRDLAARNVMVHKTES-GEMLAKIADFGLS--RHLYSEMY-KHQGNKPR
||. |.||  . .  | .             . . ||| ||.||    . |||||||||| .    | |  ..|..||||   .    . |   .|..  
LLQWLREGGGQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLE-SKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAM--

PLPAKWMALESLMYFIFTTKSDVWSFGVMLWEIMTLGRTPYPGVENRELLEQIEEHGLKLNKP--KGCPQSIYD-SILDCTQHEPDDRPTFGELKFKLY
 .| |||| |   | .|..||||||.|. ||||||.|.|||||  ||| ||.. | |  . ||  ..|| .||.   . |    |. ||||  | ..  
-FPWKWMAPECFIYGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHV-ERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTL-YHYF
Kinase AqueK459.AA SFK-Src 354-625 42 2.9e-81 240.46 In-house 1-259 (259) Show / Hide 
Range on Protein: 354-625
Range on HMM: 1-259/259
Sequence Identity: 42% (118 aa)

INTRELLGEGAFGEVYLADATGLPGT-QGTVEVAVKQLKSRHGQHSQQMEDFLREAKEMAKVDHHRVVKLIAVCTLDFPLLLIEEYMNQGDLLAVLKE--
|  .. ||.| ||.|.        |.  .| ||||| ||.  |  |.  | ||.||  | |  | . ..| ||||   |.  | | |  | ||  |.|  
IRLEKKLGSGQFGDVWK-------GRWNNTTEVAVKTLKP--GAMSA--EEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPH

GRPSMPLVQQLSFSWQVADGMNYLATDLQCVHRDLAARNVMVHKTESGEMLAKIADFGLSRHLYSEMY---KHQGNKPRPLPAKWMALESLMYFIFTTKS
|| |. . |      ||| || ||  .   ||||||||||.|          |..|||.|| |  .      |.| |    | || | |   .  | .||
GR-SLRMPQLVDMAAQVAHGMAYLEAQ-NFVHRDLAARNVLVGDNN----VCKVGDFGMSRVLAQDDEGYTAHEGAK---FPIKWTAPEAMNMNRFSIKS

DVWSFGVMLWEIMTLGRTPYPGVENRELLEQIEE-HGLKLNKPKGCPQSIYDSILDCTQHEPDDRPTFGELKFKLYNLY
||||||... || |.|| ||||  | | | |..   |  . .|..||   |   .|| ||||||||||. ||... . .
DVWSFGILMMEIVTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase AqueK459.AA Fer 354-622 34 2.4e-75 256.01 In-house 1-283 (283) Show / Hide 
Range on Protein: 354-622
Range on HMM: 1-283/283
Sequence Identity: 34% (98 aa)

INTRELLGEGAFGEVYLA--DATGLPGTQGTV---EVAVKQLKSRHGQHSQQMEDFLREAKEMAK-VDHHRVVKLIAVCTLDFPLLLIEEYMNQGDLLAV
..  . ||||||||||..  . . . |.. .|   .|.|| .|. . .   |...|..||. | .  ||  |||.. ||... |.... |..|.|.|.  
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATK-EQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSY

LKEGRP-SMPLVQQLSFSWQVADGMNYLATDLQCVHRDLAARNVMVHKTESGEMLAK--IADFGLSRHLYSEMYKHQGN-KPRPLPAKWMALESLMYFIF
||.    .... . . .. |.|.||.||    .|.|||.||||. .||   ..   |  |.|||.||..  ..|. .   | . .| .|.| |.. ..|.
LKKNKNKTVSDNEKIRMCYQAACGMEYLHS-KNCIHRDIAARNCLYHK---DKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIY

TTKSDVWSFGVMLWEIMTLGRTPYPG----VENREL----LEQIEEHGLKLNKPKGCPQSIYDSIL-DCTQHEPDDRPTFGELKFKLY
..|.||||||||.|||.| | .||||    . . ..     ..|.. |  .  |...|  |.  .. .| |..|.||||. |.. ||.
SPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase AqueK459.AA Ack 354-621 37 1.7e-72 243.86 In-house 1-266 (266) Show / Hide 
Range on Protein: 354-621
Range on HMM: 1-266/266
Sequence Identity: 37% (103 aa)

INTRELLGEGAFGEVYLADATGLPGTQGTVEVAVKQLKSRHGQHSQQMEDFLREAKEMAKVDHHRVVKLIAVCTLDFPL-LLIEEYMNQGDLLAVLKEGR
|   |.||.| || |  .. |  || . ...|||| |.|  .|  . |.|||||.  | . ||  .|.|  |  || |.  .. |    | ||  |... 
ITLCEKLGDGCFGVVWRGEWTN-PGGK-HIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVV-LDQPMLMMVTELAPCGSLLDCLRKHC

P-SMPLVQQLS-FSWQVADGMNYLATDLQCVHRDLAARNVMVHKTESGEMLAKIADFGLSRHLYSE--MYKHQGNKPRPLPAKWMALESLMYFIFTTKSD
. . .|.  |. |. |.|.|| ||     |.||||||||. .   .    ..||.||||.| |  .  .|. ....  ..|  |.| |.| .  |. .||
RTAFFLIHTLCDFCMQIAMGMRYLEMK-RCIHRDLAARNILLFSDD---RKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASD

VWSFGVMLWEIMTLGRTPYPGVENRELLEQIEEHGLKLNKPKGCPQSIYDSILDCTQHEPDDRPTFGELKFKL
||.||| |||  . |. |. |.   . |..|.  |  | .|. ||. ||.  . | ||.| |||||.... .|
VWMFGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase AqueK459.AA Trk 354-621 37 2.1e-71 241.28 In-house 1-275 (275) Show / Hide 
Range on Protein: 354-621
Range on HMM: 1-275/275
Sequence Identity: 37% (107 aa)

INTRELLGEGAFGEVYLADATGLPGTQGTVEVAVKQLKSRHGQHSQQMEDFLREAKEMAKVDHHRVVKLIAVCTLDFPLLLIEEYMNQGDL---------
|  .  ||||||| |.||.   |...|. . |||| ||       . ..|| |||. . . .|. .||.  ||| ..|||.. |||. |||         
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKDASE---NARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGP

-LAVLKEGRP---SMPLVQQ--LSFSWQVADGMNYLATDLQCVHRDLAARNVMVHKTESGEMLAKIADFGLSRHLYS--EMYKHQGNKPRPLPAKWMALE
   .. .. |     ||...  |    |.| || |.| ..  ||||.|.|| .|     .. . ||.|||.|| .||  . |.  .     ||  ||  |
DAMCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMA-SQHFVHRDMATRNCLV----GQNLIVKIGDFGMSRDVYSHTDYYRVGHHT--MLPIRWMPPE

SLMYFIFTTKSDVWSFGVMLWEIMTLGRTPYPGVENRELLEQIEEHGLKLNKPKGCPQSIYDSILDCTQHEPDDRPTFGELKFKL
| ||  ||. ||||||||..||..| |. |. .  | |  | | .  ..|..|..||| .||  | | | ||  | .  ..   .
SIMYRKFTYESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase AqueK459.AA FGFR 462-621 46 6.5e-57 192.49 In-house 140-293 (293) Show / Hide 
Range on Protein: 462-621
Range on HMM: 140-293/293
Sequence Identity: 46% (76 aa)

SFSWQVADGMNYLATDLQCVHRDLAARNVMVHKTESGEMLAKIADFGLSRHL-YSEMYKHQGNKPRPLPAKWMALESLMYFIFTTKSDVWSFGVMLWEIM
|. .||| ||.|||    |.||||||||| |  |.  .|  ||.||||.|   . . |.  .|  | || ||||.|.|   ..|..|||||.|| |||||
SCAYQVARGMEYLAS-RKCIHRDLAARNVLV--TDDYVM--KICDFGLARDIHCIDYYRKTTN-GR-LPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIM

TLGRTPYPGVE-NRELLEQIEEHGLKLNKPKGCPQSIYDSILDCTQHEPDDRPTFGELKFKL
|.| .|||..    || .   | |  . ||. |.| ||  . .|   .|..|||| .|   |
TYGGQPYPHIPSVEELYKYLKE-GHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase AqueK459.AA S_TKc 354-622 23 8.3e-41 142.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 354-622
Range on HMM: 1-231/231
Sequence Identity: 23% (67 aa)

INTRELLGEGAFGEVYLADATGLPGTQGTVEVAVKQLKSRHGQHSQQMEDFLREAKEMAKVDHHRVVKLIAVCTLDFPLLLIEEYMNQ--GDLLAVLKEG
    ...|.||||.||..  ..        .||.|..|          |...|| . . | .|  .|||. |.     | .. ||...  |||. ..|. 
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

RPS-----MPLVQQLSFSWQVADGMNYLATDLQCVHRDLAARNVMVHKTESGEMLAKIADFGLSRHLYSEMYKHQGNKPRPLPAKWMALESLMYFIFTT-
..      .|  .  .. .|......|.    . .||||   |... .        ||.||||.|.|          .       .|| | |    ... 
GRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE------HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKC

KSDVWSFGVMLWEIMTLGRTPYPGVENRELLEQIEEHGLKLNKPKGCPQSIYDSILDCTQHEPDDRPTFGELK--------FKLY
|.|.||.|..|.| .. |..|.|  .  .....|             ...  | |  | | .|..|||  |.             
KCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK459.AA Pkinase 354-621 21 3.4e-29 104.32 Pfam 1-293 (293) Show / Hide 
Range on Protein: 354-621
Range on HMM: 1-293/293
Sequence Identity: 21% (65 aa)

INTRELLGEGAFGEVYLA--DATGLPGTQGTVEVAVKQLKSRHGQHSQQMEDFL-REAKEMAKVDHHRVVKLIAVCTLDFPLLLIEEYMNQG----DLLA
. . . .|.|.||.||..    ||        .||||..| ||  ......... .|.. |....|  .|.|. ... .  . .. ||.. |    || .
YHIGRKIGSGSFGCVYKCHHKGTGK-------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

VLK-EGRPSM--PLVQQLSFSWQVADGMNYLATDLQCVHRDLAARNVMVH-KTESGEMLAKIADFGLSRHLYSEMYKHQGNKPRPLPAKWMALESLM-YF
... . . ..  .  .  .. .|.. |..|.     ..||||   |.... . . .... ||.||||.....    . . .. .     .|| | .. . 
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACV-KICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQ

IFTTKSDVWSFGVMLWEIMTLGRTPYPGV------ENRELLEQIEEHGLKLNKPKGCP-------------------QSIYDSILDCTQHEPDDRPTFGE
  ..|.|.||.|..|.| .. ||.|.||       . ......| .  |. . |. |.                   ..  | | .| .  | .|||. .
YYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

LKFK--L
..    .
ILQHPWF
Kinase AqueK459.AA FGFR 358-453 36 4.5e-14 44.32 In-house 5-101 (293) Show / Hide 
Range on Protein: 358-453
Range on HMM: 5-101/293
Sequence Identity: 36% (36 aa)

ELLGEGAFGEVYLADATGLPGT--QGTVEVAVKQLKSRHGQHSQQMEDFLREAKEMAKV--DHHRVVKLIAVCTLDFPLLLIEEYMNQGDLLAVLKEGRP
. ||||.||.| .| | |..    . .. |||| ||. |  . . . |  .|  || |.   |  ...|. .|| . ||  | ||   | |   |.. ||
KMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNH--TDKDLSDLVSEM-EMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARRP