Gene AqueK450 (A.queenslandica)
AqueK450
Species: A.queenslandica
Alias: AqueK450
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| AqueK450.AA | Protein | None | 764 | None | Fasta, JSON |
| AqueK450.kin_dom | Protein Kinase Domain | None | 211 | None | Fasta, JSON |
Protein domains of AqueK450.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | AqueK450.AA | TK | 455-519 | 22 | 3.1e-18 | 57.03 | In-house | 372-486 (486) | Show / Hide |
Range on Protein: 455-519 Range on HMM: 372-486/486 Sequence Identity: 22% (26 aa) TEASDVWSFGLTAWQILTLG-EPLPENKDE---------------------------------LRKP--GTCP--------------DSLFELIQWCLES |..||||||| . | |.|.| || ... . .|.| || . ...|.| | . TTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHY NPKKRPIFSKIVLEI .|..|| || .. .. DPEDRPTFSQLHEQL |
|||||||||
| Kinase | AqueK450.AA | TKL | 446-519 | 26 | 7.3e-17 | 57.25 | In-house | 259-364 (364) | Show / Hide |
Range on Protein: 446-519 Range on HMM: 259-364/364 Sequence Identity: 26% (28 aa) EMEIQGSESTEASDVWSFGLTAWQILTLGEPLPENK------------------DELRKP---------------GTCPDSLFELIQWCLESNPKKRPIF | ...|.| .|..||.|||. | ||| .| ... |. ..| .||.|. .|.|.| ...|.||| | E-FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSF SKIVLEI ..|. .. QEILKRL |
|||||||||
| Kinase | AqueK450.AA | TyrKc | 276-519 | 21 | 1.3e-14 | 13.4 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 276-519 Range on HMM: 1-280/280 Sequence Identity: 21% (65 aa) LQMNTFLADGPCTEVYQGNYCEPQPHNTCVTHFVAVKRFKVADDSTLVCKYLKQLLRLNKA--THLNVLKLVGVAYGPK------DNVLIAYPYFSEHNL .... | | |||.| . |||| | . .. . . | | |...|.||. .. . ..| | . .| ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL LSYLRKLRLDSKKITDVEKLVDLMHQISKGMNAMARKGLVYGMLSVQTCLIDSEGTVVVGD--LSYYSLVN--------CVKI----NLP--------PP ..|||| | . ...|.. ..||..||. ..|... | ||.....|| ..| || . . . .| KDYLRKHRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP EMEIQGSESTEASDVWSFGLTAWQILTLGEPLPEN-----------------KDELRKPGT--------CPDSLFELIQWCLESNPKKRPIFSKIVLEI | |. .. |..||||||| . | |.|.|.. ... . ...| ||| .......| . .|..|| || |. .. EC-INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||
| Kinase | AqueK450.AA | Jak | 367-521 | 21 | 3.9e-13 | 42.67 | In-house | 98-299 (299) | Show / Hide |
Range on Protein: 367-521 Range on HMM: 98-299/299 Sequence Identity: 21% (44 aa) LLSYLRKLRLDSKKITDV--EKLVDLMHQISKGMNAMARKGLVYGMLSVQTCLIDSEGT------------VVVGDLSYYSLVNCV-KINLP--PPEMEI |..||.|.. .|. . .......|| .||. . .|... | .. |.|.|| .. . .|... .. .. | .|| . LDDYLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPEC-L QGSESTE--ASDVWSFG-LTAWQIL----------------TLG-EPLP-----------ENKDELRKPGTCPDSLFELIQWCLESNPKKRPIFSKIVLE . ..... |.|.|||| | |.|. | .|. ||. | | .|.| ...|.| |.. .| .|| | |. TNCKFYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRD IDS ... LNQ |
|||||||||
| Kinase | AqueK450.AA | TK-Unique | 455-519 | 28 | 1.2e-11 | 36.61 | In-house | 217-294 (294) | Show / Hide |
Range on Protein: 455-519 Range on HMM: 217-294/294 Sequence Identity: 28% (22 aa) TEASDVWSFGLTAWQILTLGEP------------LPENKDELRKPGTC-PDSLFELIQWCLESNPKKRPIFSKIVLEI |. ||||||| . | |.|||.. .... . . .| | .. ...|.. |. ..|..|| |..|. .. TTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
|||||||||
| Kinase | AqueK450.AA | TK-Unique | 276-429 | 20 | 7.5e-11 | 33.77 | In-house | 1-177 (294) | Show / Hide |
Range on Protein: 276-429 Range on HMM: 1-177/294 Sequence Identity: 20% (36 aa) LQMNTFLADGPCTEVYQGNYCEPQPHNTCVTHFVAVKRFKVADDSTLVCKYLKQLLRLNKAT-HLNVLKLVGVAYGPKDNVLIAYPYFSEHNLLSYLRKL | .. . .| . .|. | .... . . .. |||| | . | . ..|| . ... . | |.....|. . ....|...| . ||..|||. LEVGDVIGEGAFGQVWRGEVWGIW-KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC RLD------------------SKKITD-VE--KLVDLMHQISKGMNAMAR--KGLVYGMLSVQTCLIDSEGTVVVGDL | . .|. |. . |. . || .||. .|. |. |.. |. .|. . ... ..|. RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDF |
|||||||||
| Kinase | AqueK450.AA | TK | 276-407 | 12 | 8e-11 | 31.73 | In-house | 1-262 (486) | Show / Hide |
Range on Protein: 276-407
Range on HMM: 1-262/486
Sequence Identity: 12% (34 aa)
LQMNTFLADGPCT---EVYQGNYCEPQPHN------------------TCVTHFVAVKRFKVADDSTLVCKYL----------------KQLLRLN--KA
... | | |||.| . .. | | . ... |||| | |... . . . .. .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
THLNVLKLVGVAYGPKDN-----------VLIAYPYFSEHN----LLSYLRKLRLDSKK-----------------------------------------
| |...|.|| .. . ..| | . . |..|||| | . ..
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
------------------------------ITDVEKLVDLMHQISKGMNAMARK------GLV
. ... |. ..||..|| ...| ..|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFV
|
|||||||||
| Kinase | AqueK450.AA | Axl | 455-517 | 40 | 4.7e-10 | 31.58 | In-house | 193-267 (267) | Show / Hide |
Range on Protein: 455-517 Range on HMM: 193-267/267 Sequence Identity: 40% (30 aa) TEASDVWSFGLTAWQILTLGE-PLP--ENKD---------ELRKPGTCPDSLFELIQWCLESNPKKRPIFSKIVL | ||||.|| | | | | | | | ||.. |..| | | |..|. | | .||.|| ||.. . TSKSDVWAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPSFSVLRE |
|||||||||
| Kinase | AqueK450.AA | S_TKc | 276-522 | 16 | 6.3e-10 | -31.35 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 276-522 Range on HMM: 1-231/231 Sequence Identity: 16% (44 aa) LQMNTFLADGPCTEVYQGNYCEPQPHNTCVTHFVAVKRFKVADDSTLVCKYLKQLLRLNKATHLNVLKLVGVAYGPKDNVLIAYPYFSE--HNLLSYLRK .. . | .||.. . . ||.|. | .. .. . | | | |. || .| . |.. . | . .|..|..| YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKK LRL-DSKKITDVEKLVDLMHQISKGMNAMARKGLVYGMLSVQTCLIDSEGTVVVGDLSYYSLVNCVKINLPPPEMEIQGSES---------TE-ASDVWS . .. . .|.|| .... . ..| .. | . |.|. .. ..| .. . . |. . ..|.|| RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVLGYGKCKCDWWS FGLTAWQILTLGEPLPENKDELRKPGTCPDSLFELIQWCLESNPKKRPIFSKIVL-E-----IDSM .| . . |. | | . ... | .... ..|. ||. .|.||| .. | . CGCILYEMLCGYPPFP-QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | AqueK450.AA | Dicty4 | 487-521 | 37 | 2.3e-09 | 27.6 | In-house | 241-277 (277) | Show / Hide |
Range on Protein: 487-521 Range on HMM: 241-277/277 Sequence Identity: 37% (14 aa) PGTCPDSLFELIQWCLESNPKKRPIFSKIVLE--IDS | ||.|. .|||||.. .|..|| |. |. . .. PDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
|||||||||
| Kinase | AqueK450.AA | Met | 484-513 | 41 | 3.9e-09 | 25.8 | In-house | 241-271 (271) | Show / Hide |
Range on Protein: 484-513 Range on HMM: 241-271/271 Sequence Identity: 41% (13 aa) LRKPGTCPDSLF-ELIQWCLESNPKKRPIFS |..| |||.| .. . | ..|| .|| || LPQPEYCPDHLYTDVMLCCWHANPEDRPQFS |
|||||||||
| Kinase | AqueK450.AA | TKL | 309-399 | 16 | 4.1e-08 | 25.31 | In-house | 29-146 (364) | Show / Hide |
Range on Protein: 309-399 Range on HMM: 29-146/364 Sequence Identity: 16% (21 aa) VAVKRFKVAD--------------------------DSTLVCKYLKQLLRLNKATHLNVLKLVGVAYGPKD------------NVLIAYPYFSEHNLLSY ||||.||. . | . . .... ... | |.....|.. |.. . | . | . .||.| VAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHY LRKLRLDSKKITDVEKLVDLMHQISKGMN | .........|..||| LH-----------WHQRCRWALDIARGMN |
|||||||||
| Kinase | AqueK450.AA | InsR | 484-521 | 36 | 5.6e-08 | 22.79 | In-house | 241-278 (278) | Show / Hide |
Range on Protein: 484-521 Range on HMM: 241-278/278 Sequence Identity: 36% (14 aa) LRKPGTCPDSLFELIQWCLESNPKKRPIFSKIVLEIDS ||.| ||. ..|| . | .|| || | |. . LRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD |
|||||||||
| Kinase | AqueK450.AA | MLK | 487-519 | 39 | 1.2e-07 | 22.73 | In-house | 259-291 (291) | Show / Hide |
Range on Protein: 487-519 Range on HMM: 259-291/291 Sequence Identity: 39% (13 aa) PGTCPDSLFELIQWCLESNPKKRPIFSKIVLEI | |||... .|.. | ...|.||| |. || . PSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
|||||||||
| Kinase | AqueK450.AA | Pkinase_Tyr | 484-519 | 33 | 6.3e-07 | 24.09 | Pfam | 235-270 (270) | Show / Hide |
Range on Protein: 484-519 Range on HMM: 235-270/270 Sequence Identity: 33% (12 aa) LRKPGTCPDSLFELIQWCLESNPKKRPIFSKIVLEI . .| ||| . .|.. | . .|..|| || |. .. MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
|||||||||
| Kinase | AqueK450.AA | Pkinase_Tyr | 338-399 | 32 | 2e-06 | 22.12 | Pfam | 63-125 (270) | Show / Hide |
Range on Protein: 338-399 Range on HMM: 63-125/270 Sequence Identity: 32% (21 aa) HLNVLKLVGVAYGPKDN--VLIAYPYFSEHNLLSYLRKLRLDSKKITDVEKLVDLMHQISKGMN | |...|.|| . .. ..| .| .||.|||| | ..|. ... |.. .||.|||. HPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR-EDKQPLTMKDLLQMCWQIAKGME |
|||||||||
| Kinase | AqueK450.AA | UTK | 484-519 | 27 | 6e-06 | 16.36 | In-house | 261-296 (296) | Show / Hide |
Range on Protein: 484-519 Range on HMM: 261-296/296 Sequence Identity: 27% (10 aa) LRKPGTCPDSLFELIQWCLESNPKKRPIFSKIVLEI ...| ||.....| . | ...| .|| | .| .. MPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
|||||||||
| Kinase | AqueK450.AA | MLK | 445-472 | 36 | 8e-06 | 16.28 | In-house | 202-231 (291) | Show / Hide |
Range on Protein: 445-472 Range on HMM: 202-231/291 Sequence Identity: 36% (11 aa) PEME--IQGSESTEASDVWSFGLTAWQILT ||. .... .|..||||.|. |..|| PEVIQQFRCEKYSEKCDVWSWGVVLWEMLT |
|||||||||
| Kinase | AqueK450.AA | UTK | 338-429 | 24 | 0.000121 | 11.81 | In-house | 69-169 (296) | Show / Hide |
Range on Protein: 338-429 Range on HMM: 69-169/296 Sequence Identity: 24% (25 aa) HLNVLKLVGVAYGPKDNVLIAYPYFSEHNLLSYLRKLRL---DSKKITDVEKLVDLMHQISKGMNAMARKGLVYGMLSVQTCLIDSEG-------TVVVG | |||.|||| . .|.. | .. .|.||||. | . . . ..... . .|. ||. ....|.| . | . ||... . ..... HPNVLRLVGVCTQEEP-WMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIA DL |. DF |
|||||||||
| Kinase | AqueK450.AA | InsR | 457-475 | 63 | 0.000327 | 9.94 | In-house | 201-219 (278) | Show / Hide |
Range on Protein: 457-475 Range on HMM: 201-219/278 Sequence Identity: 63% (12 aa) ASDVWSFGLTAWQILTLGE .||||||| | . |||| HSDVWSFGVVLWEMVTLGE |
|||||||||
| Kinase | AqueK450.AA | Axl | 309-428 | 22 | 0.000347 | 10.47 | In-house | 30-156 (267) | Show / Hide |
Range on Protein: 309-428 Range on HMM: 30-156/267 Sequence Identity: 22% (29 aa) VAVKRFKVADDSTL-VCKYLKQLLRLNKATHLNVLKLVGVAYGPKD-----NVLIAYPYFSEHNLLSYLRKLRLDSK-KITDVEKLVDLMHQISKGMNAM |||| .|.. . . .|. . | ||..|.||. .. . .. |. | ..| ||. . . . || | | || . VAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLYSRLGDQPFYLPLQMLVKFMVDIACGMEYL ARKGLVYGMLSVQTCLIDSEGTVVVGD . . . | |.. . || | | SNRNFIHRDLAARNCMLREDMTVCVAD |
|||||||||
| Kinase | AqueK450.AA | Pkinase | 444-510 | 20 | 0.000366 | 15.8 | Pfam | 179-282 (293) | Show / Hide |
Range on Protein: 444-510 Range on HMM: 179-282/293 Sequence Identity: 20% (21 aa) PPEMEIQ-GSESTEASDVWSFGLTAWQILTLGEPLPEN----------KDELRKP--------GTCP-------------------DSLFELIQWCLESN .|| |. |.. . ..|.||.|.. .. |. | |. . ..... .|. ... ..| |||. . APEV-IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKD PKKRP ||||| PKKRP |
|||||||||
| Kinase | AqueK450.AA | Dicty4 | 455-476 | 54 | 0.001758 | 7.67 | In-house | 195-216 (277) | Show / Hide |
Range on Protein: 455-476 Range on HMM: 195-216/277 Sequence Identity: 54% (12 aa) TEASDVWSFGLTAWQILTLGEP .|..|| |||. |.||| || NEKADVYSFGIVLWEILTRQEP |
|||||||||
| Kinase | AqueK450.AA | UTK | 455-474 | 60 | 0.002321 | 7.36 | In-house | 218-237 (296) | Show / Hide |
Range on Protein: 455-474 Range on HMM: 218-237/296 Sequence Identity: 60% (12 aa) TEASDVWSFGLTAWQILTLG |..||||||| . | |.| | TTKSDVWSFGVVCWEIWTWG |
|||||||||
| Kinase | AqueK450.AA | Pkinase_Tyr | 455-479 | 51 | 0.002598 | 11.84 | Pfam | 192-218 (270) | Show / Hide |
Range on Protein: 455-479 Range on HMM: 192-218/270 Sequence Identity: 51% (14 aa) TEASDVWSFGLTAWQILTLG-EP-LPE |..||||||| . | |.|.| .| |. TTKSDVWSFGVLMWEIFTYGEQPTYPG |
|||||||||
| Kinase | AqueK450.AA | Met | 455-472 | 55 | 0.013786 | 3.97 | In-house | 197-214 (271) | Show / Hide |
Range on Protein: 455-472 Range on HMM: 197-214/271 Sequence Identity: 55% (10 aa) TEASDVWSFGLTAWQILT | .||||||| | .| TTKSDVWSFGVVMWELMT |
|||||||||
| Kinase | AqueK450.AA | Met | 338-428 | 30 | 0.026395 | 3.03 | In-house | 60-147 (271) | Show / Hide |
Range on Protein: 338-428 Range on HMM: 60-147/271 Sequence Identity: 30% (28 aa) HLNVLKLVGVAYGPKD-NVLIAYPYFSEHNLLSYLRKLRLDSKKITDVEKLVDLMHQISKGMNAMARKGLVYGMLSVQTCLIDSEGTVVVGD | |||.|.|.. | . .. || |... | .. .. | |.. ||. |||. || . | | |..| . || |.| HPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRN---PQNNPC-VRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVAD |
|||||||||