Gene AqueK448 (A.queenslandica)

AqueK448

Species: A.queenslandica
Alias: AqueK448
External Links:
Annotation:

Classification

Group: TK
Family: Tec

Sequence

Name Sequence Type Origin Length Description Download
AqueK448.AA Protein None 751 None Fasta, JSON
AqueK448.kin_dom Protein Kinase Domain None 252 None Fasta, JSON

Protein domain

Protein domains of AqueK448.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH AqueK448.AA PH 13-117 24 7e-18 66.65 SMART 1-82 (82) Show / Hide 
Range on Protein: 13-117
Range on HMM: 1-82/82
Sequence Identity: 24% (26 aa)

ELKVDYMVKRSQGKSALGATNFKKRVFVLTNNKLSYYDGNLEKRGGLKGQVDLNSVKVIEKVSDSAFDKPSFQVVHGDLTLYVIADDEAQRHDWLELLRQ
 .|  .. |.|         ..||| |||.|. |.||.        .|| ..|....| | .        .|...| | |.|. ...| ....|.. ...
VIKEGWLYKKS-------K-RWKKRWFVLFNDCLYYYKDK-----KPKGSIPLSDCTVRE-P--------CFEIHH-DRTYYFQCESEEEMQEWMQAIQK

YCRSN
 ...|
AIHNN
PH AqueK448.AA PH 13-115 28 1.7e-12 47.73 Pfam 1-92 (92) Show / Hide 
Range on Protein: 13-115
Range on HMM: 1-92/92
Sequence Identity: 28% (30 aa)

ELKVDYMVKRSQGKSALGATNFKKRVFVLTNNKLSYYDGNLEKRGGLKGQVDLNSVKVIEKVSDSAFDKPSFQVVHGDL-TLYVIADDEAQRHDWLELLR
  |  .. |..      .  ..||| |||.||.|.||.        .|| ..|...  ..||.|.  .. .||... |  |.|. |..| ...||.. ..
VIKEGWLHKKG------KRKSWKKRWFVLFNNCLYYYKDDK---YRPKGSIPLSDC-QVTKVPDN-KRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQ

QYCR
. ||
SACR
BTK AqueK448.AA BTK 122-149 42 2e-06 29.82 Pfam 1-28 (32) Show / Hide 
Range on Protein: 122-149
Range on HMM: 1-28/32
Sequence Identity: 42% (12 aa)

DFYHPGLFVNSKWSCCDHKSKHSTGCSP
 .|||....| .||||  ..|  .||.|
QKYHPCFWMNGHWSCCHQTDKNAPGCQP
BTK AqueK448.AA BTK 117-153 29 5e-06 24.23 SMART 1-37 (37) Show / Hide 
Range on Protein: 117-153
Range on HMM: 1-37/37
Sequence Identity: 29% (11 aa)

NGKLQDFYHPGLFVNSKWSCCDHKSKHSTGCSPAFIK
| ..   |||. ... .|.||   .| ..||.|   .
NNHRMQKYHPCFWMDGHWLCCQQTCKNAPGCCPCHPH
SH3 AqueK448.AA SH3 311-367 34 1.4e-18 68.95 SMART 1-58 (58) Show / Hide 
Range on Protein: 311-367
Range on HMM: 1-58/58
Sequence Identity: 34% (20 aa)

FEVMAMYDYPGIEKGDLPLCKGQKVVIFDNSRDHWWRARDD-RGNEGFVPSNYVKKVG
..| |.||| . . ..|.. ||... . . . |.||..| .  |.||..|||||... 
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 AqueK448.AA SH3_1 314-360 32 1.3e-16 58.98 Pfam 1-49 (49) Show / Hide 
Range on Protein: 314-360
Range on HMM: 1-49/49
Sequence Identity: 32% (16 aa)

MAMYDYPGIEKGDLPLCKGQKVVIFDNSRD-HWWRARDDRGN-EGFVPS
 | |||.. . ..|.. || .. . . | | .||..|..... ||..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 AqueK448.AA SH3_2 312-366 20 3.1e-10 38.74 Pfam 1-68 (68) Show / Hide 
Range on Protein: 312-366
Range on HMM: 1-68/68
Sequence Identity: 20% (14 aa)

EVMAMYDYPG-IEKGD-----LPLCKGQKVVIF---DNSRDHWWRA-RD-DRGNE--GFVPSNYVKKV
 . .. || .   ...     | ..||......   | ..|.||.. .  ..| .  |..||..|...
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 AqueK448.AA SH2 373-448 34 6.2e-37 110.27 Pfam 1-81 (81) Show / Hide 
Range on Protein: 373-448
Range on HMM: 1-81/81
Sequence Identity: 34% (28 aa)

WFFPTLSRARAENILKQ-ENKEGAFVVRNSSR-DNMYTLSICHEG---QVRHYHIKDDEEKKYFISEKHRFPTITELIEYH
|... .||. ||..|.. .|..|.|.|| |..  . |||| ...|   .|.||.|. .....|.|...|.|... ||.|..
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 AqueK448.AA SH2 371-454 34 3.6e-33 117.45 SMART 1-87 (87) Show / Hide 
Range on Protein: 371-454
Range on HMM: 1-87/87
Sequence Identity: 34% (30 aa)

EDWFFPTLSRARAENILKQE-NKEGAFVVRNSSR-DNMYTLSICHEGQVRHYHIKDDEEKKYFISE--KHRFPTITELIEYHKLNGGG
. |..  .||. ||..||.. ...|.|.|| |..  . |.||....|.|.||.|. ....||.| |  ...||.. ||..... | .|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase AqueK448.AA Tec 488-740 54 5e-157 527.96 In-house 1-254 (254) Show / Hide 
Range on Protein: 488-740
Range on HMM: 1-254/254
Sequence Identity: 54% (139 aa)

LSLGKELGSGQFGRVVAGQWRNKVDVAIKMMKEGAMNEDDFIEEAKVMQKFQHDNLVKLYGVCIKQGAVYIITELMVNGCLLQYLRNNKHLVEKTD-IIL
| . ||||||||| |  |.||.. ||||||.|||.| |.||||||||| | .| .||.|||||..|  .||.|| | .|||| ||| .||  .|   | |
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL

DMAIQICAAMKFLEQSGFIHRDLAARNCLVGDRNIVKVGDFGLARFVTDDEYTASEGTKFPIKWAAPEVITHARFSSKSDVWSYGILLWELWSGGKTPYP
.| ...| .| .||...||||||||||||||| ..||| |||..|.| ||.|| | |||||.||..|||    |.|||||||..|.| || .|.|| ||.
EMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYE

AFTNPQVLDEVLRGYRLENPKLCPPEVYDLMKKSWQANPEDRPSFAVLSDSLKA
...| .| ..| .|.||. |.||. ..|. |.. |.  ||.||.|..| .... 
NMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase AqueK448.AA Pkinase_Tyr 488-738 46 1.4e-140 476.73 Pfam 1-270 (270) Show / Hide 
Range on Protein: 488-738
Range on HMM: 1-270/270
Sequence Identity: 46% (125 aa)

LSLGKELGSGQFGRVVAGQWR-----NKVDVAIKMMKEGAMNE----DDFIEEAKVMQKF-QHDNLVKLYGVCI-KQGA--VYIITELMVNGCLLQYLRN
...||.||.|.||.|. | |.     .|..||.||.||||| |    .||..|||.| .. .|.|.|.|||||. ...   .||..|.| .|.|| |||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---KHLVEKTDIILDMAIQICAAMKFLEQSGFIHRDLAARNCLVGDRNIVKVGDFGLARFV-TDDEY-TASEGTKFPIKWAAPEVITHARFSSKSDVWS
.   |. .   | .|.|..||...| .||. ..||||||||||||.. |.||..|||||| .  ||.| ....|.|.|||| |||.| . .|..||||||
HREDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

YGILLWELWSGGKTP-YPAFTNPQVLDEV-LRGYRLENPKLCPPEVYDLMKKSWQANPEDRPSFAVLSDSL
.|.|.||. . |..| ||  .| .|.. .  .|||.. |..||.|.|||||. |...|||||.|. .   |
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK448.AA TyrKc 488-738 39 3.3e-137 463.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 488-738
Range on HMM: 1-280/280
Sequence Identity: 39% (113 aa)

LSLGKELGSGQFGRVVAGQWRNKVDVAIKMMKEGAMNEDDFIEEAKVMQKF--QHDNLVKLYGVCIKQ-------GAVYIITELMVNGCLLQYLRNNKHL
..|||.||.|.||.|. |.|.  ..||.||.||.|  . ||..||..| |.  .|.|.|.|||||..|       . ..|..|.| .|.|..|||.... 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

VEKTDIILDMAIQICAAMKFLEQSGFIHRDLAARNCLVGDRNIVKVGDFGLARFVTDD--------EYTASE--GTK--FPIKWAAPEVITHARFSSKSD
  ...  |....||.. | .|.. ..|||||||||||||....||..||||.|...||         |...|  |.|  .||.| |||.| . .|..|||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSYGILLWELWSGGKTPYPA-----FTNPQVLDEVLRGYRLENPKL--------CPPEVYDLMKKSWQANPEDRPSFAVLSDSL
|||.|...||. . |..|||       .| .|.  | .|||.. |.         ||.|.|..||. |...|||||.|. . . .
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK448.AA Src 488-738 47 2.8e-131 442.45 In-house 1-255 (255) Show / Hide 
Range on Protein: 488-738
Range on HMM: 1-255/255
Sequence Identity: 47% (122 aa)

LSLGKELGSGQFGRVVAGQWRNKVDVAIKMMKEGAMNEDDFIEEAKVMQKFQHDNLVKLYGVCIKQGAVYIITELMVNGCLLQYLR-NNKHLVEKTDIIL
. | ..||.|||| |  | |.....||.| .|.| |  ..| .||..| |..|..||.|| || .   .||.||.| .|.||.||. . .    .  . .
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DMAIQICAAMKFLEQSGFIHRDLAARNCLVGDRNIVKVGDFGLARFVT--DDEYTASEGTKFPIKWAAPEVITHARFSSKSDVWSYGILLWELWSGGKTP
||| |. . |..||.  .||||||||| |||. |..||.|||||| .   ||||.|..| |||||| ||| |.. ||. ||||||.||||.|. . |..|
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YPAFTNPQVLDEVLRGYRLENPKLCPPEVYD-LMKKSWQANPEDRPSFAVLSDSL
||  ||..||..| ||||. .|. ||.|.|. .|.. |.. ||.|| |. | . |
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK448.AA SFK-Src 488-742 50 1.4e-126 377.33 In-house 1-259 (259) Show / Hide 
Range on Protein: 488-742
Range on HMM: 1-259/259
Sequence Identity: 50% (130 aa)

LSLGKELGSGQFGRVVAGQWRNKVDVAIKMMKEGAMNEDDFIEEAKVMQKFQHDNLVKLYGVCIKQGAVYIITELMVNGCLLQYLRNNKHLVEKTDIILD
  | | ||||||| |  | | |. .||.| .| ||| .. | .|| || | .|.||..|| ||     .||||||| .| || ||.. .    .     |
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MAIQICAAMKFLEQSGFIHRDLAARNCLVGDRNIVKVGDFGLARFV-TDDE-YTASEGTKFPIKWAAPEVITHARFSSKSDVWSYGILLWELWSGGKTPY
|| |. . | .||   |.|||||||| |||| |..||||||..| .  ||| ||| || |||||| |||  .  ||| ||||||.|||. |.   |  ||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PAFTNPQVLDEVLR--GYRLENPKLCPPEVYDLMKKSWQANPEDRPSFAVLSDSLKAMV
|  ||  ||  | |  |||.. |. ||.| | .|   || .|.||| |  |   .    
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase AqueK448.AA TK 488-738 24 4.90000000001e-117 394.08 In-house 1-486 (486) Show / Hide 
Range on Protein: 488-738
Range on HMM: 1-486/486
Sequence Identity: 24% (117 aa)

LSLGKELGSGQFG---RVVAGQWRNK--------------------------VDVAIKMMKEG-AMNEDDFIE--------------EAKVMQKFQ----
. |||.||.||||   .|  |.||..                          ..||.||.||| ||....|..              || .|....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HDNLVKLYGVCIKQ------------GAVYIITELMVNGC----LLQYLRNNKHLVEK-----------------------------------------
 |.|.|.||||| ..            . ..|..|.| .|.    |..|||....   .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------TDIILD-------------------MAIQICAAMKFLEQS------GFIHRDLAARNCLVGDRNI-----------VKVGDFG----
             |   |.                   |. ||...| .|..       .|.||||||||||||..|.           .|..|||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LARFV-TDDEYTASE------------------------GTKFPIKWAAPEVIT---------HARFSSKSDVWSYGILLWELWSGGKTPYPA-FT
    ||| .  ||.|....                        |.|.||.| |||...         . .|..||||||.|.|.||... |..||.   .
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

N---------PQVLDEVLRG--------------YRLENPKLCP--------------PEVYDLMKKSWQANPEDRPSFAVLSDSL
|          .|.. . ||              .|.. |..||              .|.||||.. |...|||||.|. | . |
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK448.AA Src-Unclassified 488-738 43 4.8e-109 368.58 In-house 1-284 (284) Show / Hide 
Range on Protein: 488-738
Range on HMM: 1-284/284
Sequence Identity: 43% (124 aa)

LSLGKELGSGQFGRVVAGQWRNKVDVAIKMMKEG---AMNEDDFI--------EEAKVMQKFQHDNLVKLYGVCIKQGAVYIITELMVNGCLLQYLRNNK
. | ..|| |||| |  | ||.|||||.| |..|    |    |         .||..| |..| |||.||.|| .    |||||.|.|| |||.||   
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

-HLVEKTDI-----------ILDMAIQICAAMKFLEQSGFIHRDLAARNCLVGDRN-----IVKVGDFGLA--RFVTDDEYTASEGTKFPIKWAAPEVIT
  .    |              |.| |.   |  ||  . .|||||||| |.|. |     .||| |||||  . . ||.| .  | .||.|| ||| ..
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

HARFSSKSDVWSYGILLWELWSGGKTPYPAFTNPQVLDEVLRGYRLENP--KLCPPEVYD-LMKKSWQANPEDRPSFAVLSDSL
   || |||||||||||||.   |.||||   |  || .| ||||.  |  ..||  .|. .||| | . |. || |  |   .
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase AqueK448.AA Abl 488-738 48 2e-108 362.95 In-house 1-252 (252) Show / Hide 
Range on Protein: 488-738
Range on HMM: 1-252/252
Sequence Identity: 48% (123 aa)

LSLGKELGSGQFGRVVAGQW-RNKVDVAIKMMKEGAMNEDDFIEEAKVMQKFQHDNLVKLYGVCIKQGAVYIITELMVNGCLLQYLRNNKHLVEKTDIIL
... . || ||.| |  | | | .  ||.| .|| .|. ..|..|| .|.. .| |||.| ||| .    ||||| | .| ||.|||....   .  ..|
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

DMAIQICAAMKFLEQSGFIHRDLAARNCLVGDRNIVKVGDFGLARFVTDDEYTASEGTKFPIKWAAPEVITHARFSSKSDVWSYGILLWELWSGGKTPYP
 || ||  .|..||.  ||||||||||||||. .|||| ||||||...|| |||  | |||||| ||| . . .|||||||| .|.||||.   | .|||
YMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYP

AFTNPQVLDEVLRGYRLENPKLCPPEVYDLMKKSWQANPEDRPSFAVLSDSL
.    .| . . .|||.| |. |||.||.||.. || .. |||||. .   .
GIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase AqueK448.AA UTK 488-738 36 2.3e-103 349.73 In-house 1-296 (296) Show / Hide 
Range on Protein: 488-738
Range on HMM: 1-296/296
Sequence Identity: 36% (107 aa)

LSLGKELGSGQFGRVVAGQWRN------KVDVAIKMMKEGAM---NED---DFIEEAK---VMQKFQ-HDNLVKLYGVCIKQGAVYIITELMVNGCLLQY
. ||..||.|.|| |  . ...      ..|||.|  ...|.   ...   ||.|||.   .|..|. | |...|.||| ...  .|.||.|.|| |..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRNNKH------LVEKTDIILDMAIQICAAMKFLEQSGFIHRDLAARNCLVGDR-------NIVKVGDFG---LARFVT----------DDEYTASEGTK
||....      .  . .  |.|| .| ..| .|.. ||.|||||||||||..        ...|..|||   ..| |           ...|.|.. ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

FPIKWAAPEVITHA-RFSSKSDVWSYGILLWELWSGGKTPYPAFTNPQVLDEVLRG--YRLENPKLCPPEVYDLMKKSWQANPEDRPSFAVLSDSL
 ||.| |||..||. ||..||||||.|...||.|..|..|||  .|.||. .|..|  ||.. |. || .||.||.. |...|..||.|  | . .
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase AqueK448.AA Frk 488-742 46 7.4e-103 348.01 In-house 1-260 (260) Show / Hide 
Range on Protein: 488-742
Range on HMM: 1-260/260
Sequence Identity: 46% (120 aa)

LSLGKELGSGQFGRVVAGQWRNKVDVAIKMMKEGAMNEDDFIEEAKVMQKFQHDNLVKLYGVCIKQGAVYIITELMVNGCLLQYLR--NNKHLVEKTDII
. | ..||||||| |  |.| |.. ||.| .| |.|. .||. ||..|.| .|  |..|| ||  .  .||||||| .| |..||.  |.|    .  ..
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

LDMAIQICAAMKFLEQSGFIHRDLAARNCLVGDRNIVKVGDFGLAR-FVTDDE--YTASEGTKFPIKWAAPEVITHARFSSKSDVWSYGILLWELWSGGK
.||| |. | | .||.  .||||||||| |||. ||.|. |||||| .. |.|  | .  | .||||| ||| .   .|. ||||||.|||| |.   |.
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

TPYPAFTNPQVLDEVLRGYRLENPKLCPPEVYDLMKKSWQANPEDRPSFAVLSDSLKAMV
 |||  || .||. | .|||. .|  ||...|..| . |...|. || |  |   |.   
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase AqueK448.AA SFK-Abl 490-738 48 5.1e-102 333.79 In-house 3-251 (251) Show / Hide 
Range on Protein: 490-738
Range on HMM: 3-251/251
Sequence Identity: 48% (120 aa)

LGKELGSGQFGRVVAGQWRNKVDVAIKMMKEGAMNEDDFIEEAKVMQKFQHDNLVKLYGVCIKQGAVYIITELMVNGCLLQYLRNNKHLVEKTDI-ILDM
||  || ||.| |  | | |.  ||||  |...|   ||  || .| . || |||.| ||| . |  ||..| | .| || ||.  .  ..   .  .  
LGHRLGEGQYGEVYKGIWNNHR-VAIKTIKDESMETKDFMKEAHIMKRMQHPNLVRLIGVCTREGPMYIVQEFMNYGNLLDYLQSPQSRIQIDHVSMMHC

AIQICAAMKFLEQSGFIHRDLAARNCLVGDRNIVKVGDFGLARFVTDDEYTASEGTKFPIKWAAPEVITHARFSSKSDVWSYGILLWELWSGGKTPYPAF
| ||   | |||   |||||||||||||||   .|| |||.||||  | |.|  |||.|||| |||    . |. ||||||.|| |||    |  |||  
AQQIADGMSFLEEQHFIHRDLAARNCLVGDNLQIKVADFGMARFVDSDFYEARIGTKMPIKWTAPESLCYDIFTIKSDVWSFGITLWEIATYGDVPYPGI

TNPQVLDEVLRGYRLENPKLCPPEVYDLMKKSWQANPEDRPSFAVLSDSL
   .|..    |||.  |. || |.|. |   |  ||. ||||  |   |
HHRDVINQLMMGYRMQRPQDCPMEIYNIMTQCWDVNPDERPSFHDLQHQL
Kinase AqueK448.AA SrcB 488-739 48 4e-100 338.95 In-house 1-251 (251) Show / Hide 
Range on Protein: 488-739
Range on HMM: 1-251/251
Sequence Identity: 48% (121 aa)

LSLGKELGSGQFGRVVAGQWRNKVDVAIKMMKEGAMNEDDFIEEAKVMQKFQHDNLVKLYGVCIKQGAVYIITELMVNGCLLQYLRNNKHLVEKTDIILD
| | | ||.|||| |  | ..|.. ||.| ||.|.|  . |..|| ||.. ||| ||.|| |  |   .||||| | .|||| .|. ..    . . ..|
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID

MAIQICAAMKFLEQSGFIHRDLAARNCLVGDRNIVKVGDFGLARFVTDDEYTASEGTKFPIKWAAPEVITHARFSSKSDVWSYGILLWELWSGGKTPYPA
|. ||   | ..|.  .||||| | | || .  . |. |||||| . |.|||| || |||||| ||| | .  |  ||||||.|||| |.   |. ||| 
MSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPG

FTNPQVLDEVLRGYRLENPKLCPPEVYDLMKKSWQANPEDRPSFAVLSDSLK
 |||.|.  . ||||.  |  ||.|.|..|.. |.  ||.|| |  |   | 
MTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase AqueK448.AA S_TKc 488-739 25 2.3e-56 194.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 488-739
Range on HMM: 1-231/231
Sequence Identity: 25% (67 aa)

LSLGKELGSGQFGRVVAGQWRN-KVDVAIKMMKEGAMNEDDFIEEAKVMQKFQHDNLVKLYGVCIKQGAVYIITELMVN--GCLLQYLRNNKH----LVE
  .....|.| ||.|  ..... .  ||||..|      .... | ....| .|.|.||||.|.   . .|...|.. .  | |..|......     . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

KTDIILDMAIQICAAMKFLEQSGFIHRDLAARNCLVGDRNIVKVGDFGLARFVTDDEYTASEGTKFPIKWAAPEVITHARFSS-KSDVWSYGILLWELWS
    .  .. ||| |.... . |.|||||   | |. .   .|..||||||..                . ||||.    ..  |.|.|| |..|.|. .
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GGKTPYPAFTNPQVLDEVLRGYRLENPKLCPPEVYDLMKKSWQANPEDRPSFAVLS-------DSLK
 |..|.|  .  .... ..           .||. |...| .| .||.||.  .|        .   
-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase AqueK448.AA Pkinase 488-738 22 1.6e-49 175.62 Pfam 1-293 (293) Show / Hide 
Range on Protein: 488-738
Range on HMM: 1-293/293
Sequence Identity: 22% (66 aa)

LSLGKELGSGQFGRVVAGQWRNKVD-VAIKMMKEGAMNEDDFIE-----EAKVMQKFQHDNLVKLYGVCIKQGAVYIITELMVNG----CLLQYLR--NN
. .|. .||| ||.|  .....  . ||.| .|    ...  ..     |...|....|.| |.||...   . .|...|.. .|     |  |..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KHLVEKTDIILDMAIQICAAMKFLEQSGFIHRDLAARNCLVGDRNIV----KVGDFGLAR---FVTDDEYTASEGTKFPIKWAAPEVIT-HARFSSKSDV
. .    . . ... ||. ..... . |.|||||   |.|. ... .    |..|||||.      .  .|   || .   ..|||||  .   ..|.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGPKVDM

WSYGILLWELWSGGKTPYPAF------TNPQVLDEVLR-GYRLENPKLCP-------------------PEVYDLMKKSWQANPEDRPSFAVLSDS--L
||.|..|.|. . |..|.|        .  |.......  .. . |..|.                   .|  |..|. .. .|..||... .  .  .
WSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF