Gene AqueK447 (A.queenslandica)

AqueK447

Species: A.queenslandica
Alias: AqueK447
External Links:
Annotation:

Classification

Group: TK
Family: Tec

Sequence

Name Sequence Type Origin Length Description Download
AqueK447.AA Protein None 766 None Fasta, JSON
AqueK447.kin_dom Protein Kinase Domain None 251 None Fasta, JSON

Protein domain

Protein domains of AqueK447.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK447.AA TK 1-117 17 8.3e-23 72.61 In-house 131-384 (486) Show / Hide 
Range on Protein: 1-117
Range on HMM: 131-384/486
Sequence Identity: 17% (44 aa)

MLVMEYLPL-----SLTQCLE--REE--------------------------------------------------------------------------
|.|||| |.     || . |   |..                                                                          
MIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKH

-LSLQMKYSLLLDVAKGLCYLHGKRP----PLVHRDLTANNVLLTSSYS-----------AKLSDLGVSR-----LADTFKKDHLTTAPGNASV------
 |... .    ...|.|. ||| |.      .||||| | |.|.....            .|..| | ||     ||    .|.  .. .. ..      
QLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWP

----------------------MPPEALEDNP--------VYDHKLDVFSYGCLL
                      |.||.|.|.         .. .| ||.|.|.|.
FEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM
Kinase AqueK447.AA Pkinase_Tyr 1-117 29 1.1e-16 57.11 Pfam 83-204 (270) Show / Hide 
Range on Protein: 1-117
Range on HMM: 83-204/270
Sequence Identity: 29% (37 aa)

MLVMEYLPL-SLTQCLERE-----ELSLQMKYSLLLDVAKGLCYLHGKRPPLVHRDLTANNVLLTSSYSAKLSDLGVSRLADTFKKDHL--TTAPGNASV
..|||| |. .|   | .       |..... .  ...|||. ||. |.  ..|||| | |.|.|..  .| .| | .|.   ...|    ..  |   .
YIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPI

--MPPEALEDNPVYDHKLDVFSYGCLL
  |.||.. ..  . .| || |.| |.
KWMAPECINYGK-FTTKSDVWSFGVLM
Kinase AqueK447.AA UTK 30-117 28 4.4e-15 48.06 In-house 125-230 (296) Show / Hide 
Range on Protein: 30-117
Range on HMM: 125-230/296
Sequence Identity: 28% (31 aa)

LDVAKGLCYLHGKRPPLVHRDLTANNVLLTSS-------YSAKLSDLG---VSRLADT------FKKDHLTTAPGNASV----MPPEALEDNPVYDHKLD
.|.| |. |||...  .||||| | |.|....       ...|..|.|    ||.. |       . . . .| .. ..    | |||| ..  . .| |
WDIARGMQYLHSCG--FVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSD

VFSYGCLL
|.|.| ..
VWSFGVVC
Kinase AqueK447.AA Pkinase 2-128 25 1.5e-13 49.0 Pfam 77-213 (293) Show / Hide 
Range on Protein: 2-128
Range on HMM: 77-213/293
Sequence Identity: 25% (36 aa)

LVMEYLPL-----SLTQCLE-REELSL--QMKY--SLLLDVAKGLCYLHGKRPPLVHRDLTANNVLLTSSYSA----KLSDLGVSRLADTFKKDHLTTAP
.||||..      .|   .. ... ..  ...   . .. ...|| |.| .    .||||   |.|. . .      |..| |.....|. ..  .||  
MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC

GNASVMPPEALEDNPVYDHKLDVFSYGCLLLHVLTGQLPKP
|    |.|| . ... |..| |..|.||.|  .|.|..| |
GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP
Kinase AqueK447.AA Csk 30-73 45 9e-10 29.57 In-house 104-145 (251) Show / Hide 
Range on Protein: 30-73
Range on HMM: 104-145/251
Sequence Identity: 45% (20 aa)

LDVAKGLCYLHGKRPPLVHRDLTANNVLLTSSYSAKLSDLGVSR
.||..| ||| .|   .||||| | |.|.     || || | ..
MDVCEGMCYLEQKK--FVHRDLAARNILVSEDCVAKVSDFGLAK
Kinase AqueK447.AA SRM 32-126 37 2.4e-09 27.27 In-house 106-198 (253) Show / Hide 
Range on Protein: 32-126
Range on HMM: 106-198/253
Sequence Identity: 37% (38 aa)

VAKGLCYLHGKRPPLVHRDLTANNVLLTSSYSAKLSDLGVSRLADTFKKDHLTTAPGNASVMP-----PEALEDNPVYDHKLDVFSYGCLLLHVLT-GQL
|| |.|||  ..   .|||| | ||| .     |  | |  ||    | |    .|   .  |     |||.    .|  | || |.| ||  . | ||.
VAEGMCYLEEQN--YIHRDLAARNVLVGDNNLCKVGDFGLARL---IKDDIY--SPSHDHNIPYKWTAPEAANYR-HYSQKSDVWSFGILLHEMFTYGQC

P
|
P
Kinase AqueK447.AA Src 32-74 41 1.4e-07 21.75 In-house 106-146 (255) Show / Hide 
Range on Protein: 32-74
Range on HMM: 106-146/255
Sequence Identity: 41% (18 aa)

VAKGLCYLHGKRPPLVHRDLTANNVLLTSSYSAKLSDLGVSRL
||.| .||  ..  ..|||| | |||   .  .|  | |  ||
VAEGMAYLESMN--YIHRDLAARNVLVGENNVCKVADFGLARL
Kinase AqueK447.AA Frk 32-128 33 2.6e-07 21.01 In-house 107-204 (260) Show / Hide 
Range on Protein: 32-128
Range on HMM: 107-204/260
Sequence Identity: 33% (34 aa)

VAKGLCYLHGKRPPLVHRDLTANNVLLTSSYSAKLSDLGVSR-LADTFK--KDHLTTAPGNASVMPPEALEDNPVYDHKLDVFSYGCLLLHVLT-GQLPK
|| |. ||  .    .|||| | |||.  . . |. | |. | |    .   .  . |        ||| . |  .  | ||.|.| ||  ..| |..| 
VAAGMAYLESQN--YIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYN-KFTIKSDVWSFGILLTEIITYGRMPY

P
|
P
Kinase AqueK447.AA SFK-Src 31-73 44 6e-07 15.99 In-house 104-144 (259) Show / Hide 
Range on Protein: 31-73
Range on HMM: 104-144/259
Sequence Identity: 44% (19 aa)

DVAKGLCYLHGKRPPLVHRDLTANNVLLTSSYSAKLSDLGVSR
.|| |. || ..    ||||| | |||   .   |  | | ||
QVAHGMAYLEAQN--FVHRDLAARNVLVGDNNVCKVGDFGMSR
Kinase AqueK447.AA Abl 32-74 34 0.000139 10.66 In-house 106-146 (252) Show / Hide 
Range on Protein: 32-74
Range on HMM: 106-146/252
Sequence Identity: 34% (15 aa)

VAKGLCYLHGKRPPLVHRDLTANNVLLTSSYSAKLSDLGVSRL
.| |. ||  .    .|||| | | |.      |. | |..|.
IASGMSYLEKRH--FIHRDLAARNCLVGEHHIVKVADFGLARM
Kinase AqueK447.AA Src-Unclassified 32-57 57 0.000597 9.36 In-house 128-151 (284) Show / Hide 
Range on Protein: 32-57
Range on HMM: 128-151/284
Sequence Identity: 57% (15 aa)

VAKGLCYLHGKRPPLVHRDLTANNVL
|| |  ||  |.  .||||| | |||
VASGMMYLESKK--YVHRDLAARNVL
Kinase AqueK447.AA Tec 30-73 38 0.001094 8.85 In-house 104-145 (254) Show / Hide 
Range on Protein: 30-73
Range on HMM: 104-145/254
Sequence Identity: 38% (17 aa)

LDVAKGLCYLHGKRPPLVHRDLTANNVLLTSSYSAKLSDLGVSR
.|| .|  ||  .    .|||| | | |  .    | || | .|
QDVCEGMAYLERHC--FIHRDLAARNCLVGDQCVVKVSDFGMTR
SH2 AqueK447.AA SH2 388-463 34 4.3e-32 96.04 Pfam 1-81 (81) Show / Hide 
Range on Protein: 388-463
Range on HMM: 1-81/81
Sequence Identity: 34% (28 aa)

WFFPTLSRVEAEAILKQ-ENKDGTFVVRNSS-QE-NYAISVFSQN--GNVYHYPIKNDKEKKYFVSEKHRFPTVIKLIEYY
|... .|| ||| .|.. .|.||||.|| |. ..  |..||. ..   .|.|| |.......|.....|.|...  |.|.|
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 AqueK447.AA SH2 386-469 34 1.4e-29 105.53 SMART 1-87 (87) Show / Hide 
Range on Protein: 386-469
Range on HMM: 1-87/87
Sequence Identity: 34% (31 aa)

EDWFFPTLSRVEAEAILKQE-NKDGTFVVRNSSQ--ENYAISVFSQNGNVYHYPIKNDKEKKYFVSE--KHRFPTVIKLIEYYKLNGGG
. |..  .|| |||..||.. ..||.|.|| |..    |..||... | |.|| |. ....||.. |  ...||..  |...|. | .|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase AqueK447.AA Tec 503-755 51 1.9e-133 449.6 In-house 1-254 (254) Show / Hide 
Range on Protein: 503-755
Range on HMM: 1-254/254
Sequence Identity: 51% (131 aa)

LSFGKELGSGEFKRVVAGQWRNKGDIAIKMIKEDTMNEEHLIEEAILMLKFQHDNLVKLYGVCIGQGPVYIITELMANGCLLQYLRNNQHLVKKTD-IML
| | |||||| |  |  |.||.. |.||||||| .| ||  ||||  | | .| .||.|||||. | |.||.|| |..|||| ||| ..|  .|   | |
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL

DMAIQICDAMKFFEQSGFIHRDLAARNCLVGYSNIVKVGGFSLARFVPDDQYTASEGAKYAVKWSPPEVITHGRFSSKSDVWSYGILLWELWSSGKNPYL
.| ...| .| . |...||||||||||||||  ..|||  | ..|.| ||||| | |.|. |||.||||    |.|||||||..|.| || .| || || 
EMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYE

GISNPLVLDKVLSGYRLEKPKLCPSKVYDLMKRSWQVNPSDRPSFAVLLDSLKA
  ||  | ..|  |.||..|.||. ..|. |.. |.  | .||.|..||.... 
NMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase AqueK447.AA Pkinase_Tyr 503-753 42 7.1e-120 406.61 Pfam 1-270 (270) Show / Hide 
Range on Protein: 503-753
Range on HMM: 1-270/270
Sequence Identity: 42% (114 aa)

LSFGKELGSGEFKRVVAGQWR-----NKGDIAIKMIKEDTMNE----EHLIEEAILMLKF-QHDNLVKLYGVCI-GQGP--VYIITELMANGCLLQYLRN
..|||.||.|.| .|. | |.     .| . |.||.||..| |    | ...|| .| .. .|.|.|.|||||.  ..|  .||..|.|..|.|| |||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---QHLVKKTDIMLDMAIQICDAMKFFEQSGFIHRDLAARNCLVGYSNIVKVGGFSLARFV-PDDQY-TASEGAKYAVKWSPPEVITHGRFSSKSDVWS
.   .. ..  | .|.|..||...| . |. ..||||||||||||. .|.||.. | ||| . .||.| ....|.|  .|| .||.| .|.|..||||||
HREDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

YGILLWELWSSGKNP-YLGISNPLVLDKV-LSGYRLEKPKLCPSKVYDLMKRSWQVNPSDRPSFAVLLDSL
.|.|.||. . |. | | |.||  |....  .|||...|..|| ..|||||. |. .|.|||.|. ..  |
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK447.AA TyrKc 503-753 36 1.5e-115 391.09 SMART 1-280 (280) Show / Hide 
Range on Protein: 503-753
Range on HMM: 1-280/280
Sequence Identity: 36% (104 aa)

LSFGKELGSGEFKRVVAGQWRNKGDIAIKMIKEDTMNEEHLIEEAILMLKF--QHDNLVKLYGVCIGQ-------GPVYIITELMANGCLLQYLRNNQHL
...||.||.|.| .|. |.|.   . |.||.|||.  .| ...|| .| |.  .|.|.|.|||||. |       .|..|..|.|..|.|..|||.... 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

VKKTDIMLDMAIQICDAMKFFEQSGFIHRDLAARNCLVGYSNIVKVGGFSLARFVPDD--------QYTASE--GAK--YAVKWSPPEVITHGRFSSKSD
  ... .|....||.. | . .. ..|||||||||||||  ..||.. | |.|.. ||         |...|  |.|    ..| .||.| .|.|..|||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSYGILLWELWSSGKNPYLG-----ISNPLVLDKVLSGYRLEKPKL--------CPSKVYDLMKRSWQVNPSDRPSFAVLLDSL
|||.|...||. . |. || |     .||  |. .| .|||...|.         ||...|..||. |. .|.|||.|. . . .
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK447.AA Src 503-753 42 1.6e-107 363.5 In-house 1-255 (255) Show / Hide 
Range on Protein: 503-753
Range on HMM: 1-255/255
Sequence Identity: 42% (109 aa)

LSFGKELGSGEFKRVVAGQWRNKGDIAIKMIKEDTMNEEHLIEEAILMLKFQHDNLVKLYGVCIGQGPVYIITELMANGCLLQYLR-NNQHLVKKTDIML
. . ..||.| |  |  | |... . |.| .|..||  | . .|| .| |..|..||.|| ||    |.||.||.|..|.||.||. . .    .  . .
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DMAIQICDAMKFFEQSGFIHRDLAARNCLVGYSNIVKVGGFSLARFVP--DDQYTASEGAKYAVKWSPPEVITHGRFSSKSDVWSYGILLWELWSSGKNP
||| |. . |.. |.  .||||||||| ||| .|..||. | ||| .   || |.|..|||  .||  || |..|||. ||||||.||||.|. . |. |
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YLGISNPLVLDKVLSGYRLEKPKLCPSKVYD-LMKRSWQVNPSDRPSFAVLLDSL
| | .|. ||..|  |||. .|. || ..|. .|.. |.  | .|| |. | . |
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK447.AA SFK-Src 503-757 43 1.1e-104 311.2 In-house 1-259 (259) Show / Hide 
Range on Protein: 503-757
Range on HMM: 1-259/259
Sequence Identity: 43% (112 aa)

LSFGKELGSGEFKRVVAGQWRNKGDIAIKMIKEDTMNEEHLIEEAILMLKFQHDNLVKLYGVCIGQGPVYIITELMANGCLLQYLRNNQHLVKKTDIMLD
    | |||| |  |  | | |. ..|.|  |  .| .|   .|| .| | .|.||..|| ||    |.|||||||..| || ||.. .    .   . |
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MAIQICDAMKFFEQSGFIHRDLAARNCLVGYSNIVKVGGFSLARFVPDDQ--YTASEGAKYAVKWSPPEVITHGRFSSKSDVWSYGILLWELWSSGKNPY
|| |.   | . |   |.|||||||| ||| .|..||| | ..| . .|.  ||| ||||. .||  ||  .  ||| ||||||.|||. |.   |  ||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

LGISNPLVLDKVLS--GYRLEKPKLCPSKVYDLMKRSWQVNPSDRPSFAVLLDSLKAMV
 | .|  || .|    |||...|. || . | .|   || .|.||| |  |.  .    
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase AqueK447.AA TK 503-753 21 4.5e-97 325.97 In-house 1-486 (486) Show / Hide 
Range on Protein: 503-753
Range on HMM: 1-486/486
Sequence Identity: 21% (104 aa)

LSFGKELGSGEFK---RVVAGQWRNKG--------------------------DIAIKMIKED-TMNEEHLIE--------------EAILMLKFQ----
. .||.||.|.|    .|  |.||...                          . |.||.||. .|..|  ..              ||  | ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HDNLVKLYGVCIGQ------------GPVYIITELMANGC----LLQYLRNNQHLVKK-----------------------------------------
 |.|.|.|||||  .            .|..|..|.|..|.    |..|||.. .  ..                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------TDIMLD-------------------MAIQICDAMKFFEQS------GFIHRDLAARNCLVGYSNI-----------VKVGGFS----
             |  .|.                   |. ||...| . ..       .|.|||||||||||| .|.           .|.. |     
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LARFVPDD-QYTASE------------------------GAKYAVKWSPPEVIT---------HGRFSSKSDVWSYGILLWELWSSG-KNPYLGIS
    ||| ...|  |....                        |.|  ..| .||...         .|.|..||||||.|.|.||... | . .| |.|
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

N---------PLVLDKVLSG--------------YRLEKPKLCP--------------SKVYDLMKRSWQVNPSDRPSFAVLLDSL
|           |.... .|              .|...|..||                .||||.. |. .|.|||.|. |.. |
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK447.AA Abl 503-753 46 4.5e-95 317.65 In-house 1-252 (252) Show / Hide 
Range on Protein: 503-753
Range on HMM: 1-252/252
Sequence Identity: 46% (117 aa)

LSFGKELGSGEFKRVVAGQWRNKGD-IAIKMIKEDTMNEEHLIEEAILMLKFQHDNLVKLYGVCIGQGPVYIITELMANGCLLQYLRNNQHLVKKTDIML
..  . || | .  |  | |.  .  .|.| .|||||. .  ..|| .| . .| |||.| |||    | ||||| |..| ||.|||....   .  ..|
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

DMAIQICDAMKFFEQSGFIHRDLAARNCLVGYSNIVKVGGFSLARFVPDDQYTASEGAKYAVKWSPPEVITHGRFSSKSDVWSYGILLWELWSSGKNPYL
 || ||  .|.. |.  ||||||||||||||  .||||  | |||.. || |||  |||. .||  || . . .|||||||| .|.||||.   |  || 
YMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYP

GISNPLVLDKVLSGYRLEKPKLCPSKVYDLMKRSWQVNPSDRPSFAVLLDSL
||    | .|.  |||.|.|. || |||.||.. || ...|||||. .   .
GIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase AqueK447.AA Src-Unclassified 503-753 39 1.1e-85 290.95 In-house 1-284 (284) Show / Hide 
Range on Protein: 503-753
Range on HMM: 1-284/284
Sequence Identity: 39% (113 aa)

LSFGKELGSGEFKRVVAGQWRNKGDIAIKMIKED---TMNEEHLI--------EEAILMLKFQHDNLVKLYGVCIGQGPVYIITELMANGCLLQYLRNNQ
.   ..|| | |  |  | ||.| |.|.|  ...   ||  |           .|| .| |..| |||.||.||    | |||||.| || |||.||   
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

HLVKKTDIM------------LDMAIQICDAMKFFEQSGFIHRDLAARNCLVGYSN-----IVKVGGFSLA--RFVPDDQYTASEGAKYAVKWSPPEVIT
        |             |.| |.   |   |  . .|||||||| |.|  |     .|||  | ||  . . || | .  ||.  .||  || ..
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

HGRFSSKSDVWSYGILLWELWSSGKNPYLGISNPLVLDKVLSGYRLEKP--KLCPSKVYD-LMKRSWQVNPSDRPSFAVLLDSL
 | || |||||||||||||.   |. || |  |  ||  | .|||. ||  ..||  .|. .||. |   |  || |  |   .
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase AqueK447.AA Frk 503-757 40 6.5e-83 281.76 In-house 1-260 (260) Show / Hide 
Range on Protein: 503-757
Range on HMM: 1-260/260
Sequence Identity: 40% (105 aa)

LSFGKELGSGEFKRVVAGQWRNKGDIAIKMIKEDTMNEEHLIEEAILMLKFQHDNLVKLYGVCIGQGPVYIITELMANGCLLQYLR--NNQHLVKKTDIM
. . ..|||| |  |  |.| |.  .|.| .|  ||. . .. || .| | .|  |..|| ||  . |.||||||| .| |..||.  |..    .  ..
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

LDMAIQICDAMKFFEQSGFIHRDLAARNCLVGYSNIVKVGGFSLAR-FVPDDQ--YTASEGAKYAVKWSPPEVITHGRFSSKSDVWSYGILLWELWSSGK
.||| |.   | . |.  .||||||||| ||| .||.|.  | ||| .. |..  | .  ||.. .||  || .   .|. ||||||.|||| |.   |.
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

NPYLGISNPLVLDKVLSGYRLEKPKLCPSKVYDLMKRSWQVNPSDRPSFAVLLDSLKAMV
 || |. |  ||. |  |||. .|  || ..|..|   |...|  || |  |   |.   
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase AqueK447.AA SRM 503-754 41 8.8e-82 273.32 In-house 1-253 (253) Show / Hide 
Range on Protein: 503-754
Range on HMM: 1-253/253
Sequence Identity: 41% (104 aa)

LSFGKELGSGEFKRVVAGQWRNKGDIAIKMIKEDT-MNEEHLIEEAILMLKFQHDNLVKLYGVCIGQGPVYIITELMANGCLLQYLRNNQHLVKKTDIML
  ... ||.| |  |  | |. .  .||| || |  |  . |  |   | |  |  ...|. || .  |||||||||. | |.||||     . .   .|
FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLL

DMAIQICDAMKFFEQSGFIHRDLAARNCLVGYSNIVKVGGFSLARFVPDDQYTASEGAKYAVKWSPPEVITHGRFSSKSDVWSYGILLWELWSSGKNPYL
|.| |.   | . |   .||||||||| |||  |. ||| | ||| . || |  | . .  .||  || .  . .| ||||||.||||.|. . |  || 
DFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYP

GISNPLVLDKVLSGYRLEKPKLCPSKVYDLMKRSWQVNPSDRPSFAVLLDSLK
| .|   . ..  |||.  |  ||  |. ||   |.  | .||.|. |   | 
GMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase AqueK447.AA Csk 503-753 39 1.1e-79 271.07 In-house 1-251 (251) Show / Hide 
Range on Protein: 503-753
Range on HMM: 1-251/251
Sequence Identity: 39% (102 aa)

LSFGKELGSGEFKRVVAGQWRNKGDIAIKMIKED-TMNEEHLIEEAILMLKFQHDNLVKLYGVCIGQG-PVYIITELMANGCLLQYLRNNQHLVKKTDIM
|  |.. | |||  |  |...|.  .|.|.||.|     . .. ||  | . .|.|||.| || ..|.  .||..| |..| |. |||   . | ... .
LHLGECIGHGEFGDVMQGEYQNR-KVAVKCIKCDGNGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVITRRQL

LDMAIQICDAMKFFEQSGFIHRDLAARNCLVGYSNIVKVGGFSLARFVPDDQYTASE---GAKYAVKWSPPEVITHGRFSSKSDVWSYGILLWELWSSGK
|  |. .| .| . ||  |.|||||||| ||   .. ||  | ||.    .  . ..   . |  .||  ||   |..||.||||||.||||||..| | 
LKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAK----EECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFGR

NPYLGISNPLVLDKVLSGYRLEKPKLCPSKVYDLMKRSWQVNPSDRPSFAVLLDSL
 ||  |.   |  .|  ||| | |  || .|| .||  |..|| .||.|. ..  |
VPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase AqueK447.AA UTK 503-753 33 1.1e-79 270.98 In-house 1-296 (296) Show / Hide 
Range on Protein: 503-753
Range on HMM: 1-296/296
Sequence Identity: 33% (98 aa)

LSFGKELGSGEFKRVVAGQWRN------KGDIAIKMIKEDTM---NEE---HLIEEAI---LMLKFQ-HDNLVKLYGVCIGQGPVYIITELMANGCLLQY
. .|..||.|.|  |  . ...      . | |.|  ... .   ..|    ..|||    .| .|. | |...|.|||  ..| .|.||.|.|| |..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRNNQH------LVKKTDIMLDMAIQICDAMKFFEQSGFIHRDLAARNCLVGYS-------NIVKVGGFS---LARFVP----------DDQYTASEGAK
||.. .      .  . . .|.|| .| ..| . .. ||.|||||||||||. .       ...|...|    ..| |.          .. |.|..  .
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

YAVKWSPPEVITHG-RFSSKSDVWSYGILLWELWSSGKNPYLGISNPLVLDKVLSG--YRLEKPKLCPSKVYDLMKRSWQVNPSDRPSFAVLLDSL
 ...|  ||..||. ||..||||||.|...||.|. |. || |.||. |.  |. |  ||...|. ||  ||.||.| |. .|..||.|  |.. .
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase AqueK447.AA S_TKc 503-756 22 9.9e-41 142.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 503-756
Range on HMM: 1-231/231
Sequence Identity: 22% (61 aa)

LSFGKELGSGEFKRVVAGQWRN-KGDIAIKMIKEDTMNEEHLIEEAILMLKFQHDNLVKLYGVCIGQGPVYIITELMAN--GCLLQYLRNNQH----LVK
  .....|.| | .|  ..... .   |||.||      ||.. |  .. | .|.|.||||.|.   . .|...|.. .  | |..|......     . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

KTDIMLDMAIQICDAMKFFEQSGFIHRDLAARNCLVGYSNIVKVGGFSLARFVPDDQYTASEGAKYAVKWSPPEVITHGRFSS-KSDVWSYGILLWELWS
       .. |||.|...  . |.|||||   | |.     .|.. | |||..                . .|||.    ..  |.|.|| |..|.|. .
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

SGKNPYLGISNPLVLDKVLSGYRLEKPKLCPSKVYDLMKRSWQVNPSDRPSFAVLLD------SLKAM
 |. |.      ....|..           .. . |.... .|..|..||.   .|       .   .
-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK447.AA Pkinase 503-753 20 3.5e-31 111.34 Pfam 1-293 (293) Show / Hide 
Range on Protein: 503-753
Range on HMM: 1-293/293
Sequence Identity: 20% (61 aa)

LSFGKELGSGEFKRVVAGQWRNKGD-IAIKMIKEDTMNEEHLIE-----EAILMLKFQHDNLVKLYGVCIGQGPVYIITELMANG----CLLQYLR--NN
. .|. .||| | .|  ..... |.  |.| || .. ... ...     |. .|....|.| |.||...   . .|...|.. .|     |  |..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QHLVKKTDIMLDMAIQICDAMKFFEQSGFIHRDLAARNCLVGYSNIV----KVGGFSLAR---FVPDDQYTASEGAKYAVKWSPPEVIT-HGRFSSKSDV
  .    .   ... ||. ....  . |.|||||   |.|.   . .    |.. | ||.     ..  .|   |  .   . .||||  .   ..|.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGPKVDM

WSYGILLWELWSSGKNPYLGI------SNPLVLDKVLS-GYRLEKPKLCP-------------------SKVYDLMKRSWQVNPSDRPSFAVLLDS--L
||.|..|.|. . |. |. |       .   .......  .. . |..|.                   .   |..|. ....|..||... .| .  .
WSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF