Gene AqueK414 (A.queenslandica)

AqueK414

Species: A.queenslandica
Alias: AqueK414
External Links:
Annotation:

Classification

Group: TK
Family: Src
Subfamily: Src-Aque1

Sequence

Name Sequence Type Origin Length Description Download
AqueK414.AA Protein None 1070 None Fasta, JSON
AqueK414.kin_dom Protein Kinase Domain None 130 None Fasta, JSON

Protein domain

Protein domains of AqueK414.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Death AqueK414.AA Death 78-100 30 1.016905 4.68 Pfam 65-87 (87) Show / Hide 
Range on Protein: 78-100
Range on HMM: 65-87/87
Sequence Identity: 30% (7 aa)

QTLASAFRKLEAKAVAENIEKTM
..|..|.||..   .||.|.  .
DHLIEALRKMGRRDCAEKIQSWL
Kinase AqueK414.AA SFK-Src 784-904 44 4.3e-47 137.24 In-house 98-221 (259) Show / Hide 
Range on Protein: 784-904
Range on HMM: 98-221/259
Sequence Identity: 44% (55 aa)

LVDITIQVINGMIYLGEQDYIHCDLRAINILLGDHNTVKIANFHLAQHLNGNKY-WTVEKGTKLAIRWTAPEGYTLNQLSIKSDVWSFGILLWELATKGK
||| . ||  || || .| ..| || | |.| || |..|.. | ..  |  .   .| ..| |  |.|||||  . |. ||||||||||||. |. | | 
LVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGR

EPYPDISKLNEIVQILKQ---YRFP
 |||  .   |..| . .   || |
IPYPGMTNM-EVLQQVDRPEGYRMP
Kinase AqueK414.AA Src 782-904 43 1.9e-44 148.87 In-house 97-220 (255) Show / Hide 
Range on Protein: 782-904
Range on HMM: 97-220/255
Sequence Identity: 43% (54 aa)

TELVDITIQVINGMIYLGEQDYIHCDLRAINILLGDHNTVKIANFHLAQHLN--GNKYWTVEKGTKLAIRWTAPEGYTLNQLSIKSDVWSFGILLWELAT
..|.|.. || .|| ||... ||| ||.| |.| |..| .|.| | ||. .    . | . ..| |. |.|||||  . .. .||||||||||||.|. |
PQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEY-CARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVT

KGKEPYPDISKLNEIVQILKQYRFP
.|. |||  ..   . |. . || |
YGRVPYPGMTNHEVLQQVERGYRMP
Kinase AqueK414.AA SrcA 783-904 48 2.5e-40 124.81 In-house 96-216 (250) Show / Hide 
Range on Protein: 783-904
Range on HMM: 96-216/250
Sequence Identity: 48% (59 aa)

ELVDITIQVINGMIYLGEQDYIHCDLRAINILLGDHNTVKIANFHLAQHLNGNKYWTVEKGTKLAIRWTAPEGYTLNQLSIKSDVWSFGILLWELATKGK
.|||.. || .|| |.    ||| |||| ||| |..   ||| | ||  .. | | | ..|.|  |.|||||        |||||||||||| || |||.
QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEY-TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGR

EPYPDISKLNEIVQILKQYRFP
 ||| . .   . |. . |. |
VPYPGMNNREVLEQVERGYHMP
Kinase AqueK414.AA Frk 782-905 45 1.5e-38 131.01 In-house 98-223 (260) Show / Hide 
Range on Protein: 782-905
Range on HMM: 98-223/260
Sequence Identity: 45% (57 aa)

TELVDITIQVINGMIYLGEQDYIHCDLRAINILLGDHNTVKIANFHLAQHLNGNKY--WTVEKGTKLAIRWTAPEGYTLNQLSIKSDVWSFGILLWELAT
..|||.. ||  || || .| ||| || | |.|.|.|| .||| | ||  |  ..   .    | .. |.|||||    |. .|||||||||||| |. |
QQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIIT

KGKEPYPDISKLNEIVQILKQYRFPE
 |. ||| .   . . .. . ||.|.
YGRMPYPGMTNAEVLQMVDHGYRMPQ
Kinase AqueK414.AA Abl 784-900 45 5e-38 124.12 In-house 99-213 (252) Show / Hide 
Range on Protein: 784-900
Range on HMM: 99-213/252
Sequence Identity: 45% (53 aa)

LVDITIQVINGMIYLGEQDYIHCDLRAINILLGDHNTVKIANFHLAQHLNGNKYWTVEKGTKLAIRWTAPEGYTLNQLSIKSDVWSFGILLWELATKGKE
|. .  |.  || || ....|| || | | |.|.|. ||.| | ||  .... | | . | |  |.|||||.   |. |.||||| ||.||||.|| |  
LLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTY-TAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMS

PYPDISKLNEIVQILKQ
||| |  |... . | .
PYPGI-DLSHVYHKLEK
Kinase AqueK414.AA TK 780-904 25 2.7e-37 122.04 In-house 233-438 (486) Show / Hide 
Range on Protein: 780-904
Range on HMM: 233-438/486
Sequence Identity: 25% (52 aa)

TPTELVDITIQVINGMIYLGEQ------DYIHCDLRAINILLGDHNT-----------VKIANFH--------LAQHL-NGNKYWTVE------------
|. .|. .  |. .|| || ..       ..| || | |.|.|..|.           .||| |         ||  . ..  |....            
TMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFE

-----------KGTKLAIRWTAPEGYT---------LNQLSIKSDVWSFGILLWELATKGKEPYPD-ISK--------LNEIVQILKQ------------
           .|.|| |||.|||  .          .  ..||||||||.|.||. | |.|||.  .|         . |... |..            
DDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEV

---YRFP
   .| |
GYRMRMP
Kinase AqueK414.AA SrcB 784-904 45 3.2e-35 116.55 In-house 97-216 (251) Show / Hide 
Range on Protein: 784-904
Range on HMM: 97-216/251
Sequence Identity: 45% (55 aa)

LVDITIQVINGMIYLGEQDYIHCDLRAINILLGDHNTVKIANFHLAQHLNGNKYWTVEKGTKLAIRWTAPEGYTLNQLSIKSDVWSFGILLWELATKGKE
|.|.. |.  || |. .. ||| |||| |||  .    ||| | ||  .. | | |   | |  |.|||||        |||||||||||| |. | |. 
LIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEY-TAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRI

PYPDISKLNEIVQILKQYRFP
|||  .  . | .. . || |
PYPGMTNPEVIRNLERGYRMP
Kinase AqueK414.AA UTK 780-904 30 3.3e-35 117.88 In-house 116-262 (296) Show / Hide 
Range on Protein: 780-904
Range on HMM: 116-262/296
Sequence Identity: 30% (45 aa)

TPTELVDITIQVINGMIYLGEQDYIHCDLRAINILLGDH-------NTVKIANFH---LAQHLN---------GNKYWTVEKGTKLAIRWTAPEGYTLN-
| .....   .. .|| || .. ..|.|| | |.|...|       ...|||.|    ..  .|         .  | .    ....|||.||| .| . 
TLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHT

QLSIKSDVWSFGILLWELATKGKEPYPDISKLNEIVQILKQ--YRFP
. ..||||||||...||. | |. |||..|  . ..|....  || |
RFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMP
Kinase AqueK414.AA Pkinase_Tyr 780-896 40 3.8e-35 119.66 Pfam 109-226 (270) Show / Hide 
Range on Protein: 780-896
Range on HMM: 109-226/270
Sequence Identity: 40% (48 aa)

TPTELVDITIQVINGMIYLGEQDYIHCDLRAINILLGDHNTVKIANFHLAQHL-NGNKYWTVEKGTKLAIRWTAPEGYTLNQLSIKSDVWSFGILLWELA
|. .|... .|. .|| || .. .|| ||.| |.|... |.|||. | ||  . |   | .. .|.|| |.|.|||    .  ..||||||||.|.||. 
TMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIF

TKGKEP-YPDISKLNEIVQ
| |..| ||.. . .|...
TYGEQPTYPGM-SNEEVYE
Kinase AqueK414.AA Src-Echino1 782-904 43 1.1e-34 117.53 In-house 96-217 (252) Show / Hide 
Range on Protein: 782-904
Range on HMM: 96-217/252
Sequence Identity: 43% (53 aa)

TELVDITIQVINGMIYLGEQDYIHCDLRAINILLGDHNTVKIANFHLAQHLNGNKYWTVEKGTKLAIRWTAPEGYTLNQLSIKSDVWSFGILLWELATKG
|.|.|.  ..  || |||.....| || | |.|.|. | .|||.| ||. .. . | . . | || |.|||||     .  |||||||||||. |. | |
TTLIDMGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQ-GAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFG

KEPYPDISKLNEIVQILKQYRFP
. |||.. . . . |. . || |
RYPYPGMMNREVLDQVDRGYRMP
Kinase AqueK414.AA Src-Unclassified 785-886 45 3.7e-34 114.5 In-house 122-229 (284) Show / Hide 
Range on Protein: 785-886
Range on HMM: 122-229/284
Sequence Identity: 45% (49 aa)

VDITIQVINGMIYLGEQDYIHCDLRAINILLGDHN-----TVKIANFHLA-QHLNGNKYWTVEKGTKLAIRWTAPEGYTLNQLSIKSDVWSFGILLWELA
|||  || .|| || .  |.| || | |.| |. |      ||.. | ||   | .       .| .. . |.|||  .    ||||||||.||||||..
VDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFIYGNFSIKSDVWSYGILLWEIM

TKGKEPYP
|||. |||
TKGQTPYP
SH2 AqueK414.AA SH2 688-761 44 2.2e-25 76.35 Pfam 1-81 (81) Show / Hide 
Range on Protein: 688-761
Range on HMM: 1-81/81
Sequence Identity: 44% (36 aa)

YYH-TVSRDEAEERLSQGDTQEGTFIIRESI--PGTNTLSVKGEV---TIRHYRISIENNK-YYIYPHVKFDSLNDLVRHY
.||  .|| |||..| ..  ..|||..|||   ||  ||||. .     ..||||  ..|. |||.  .||.||..|| ||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 AqueK414.AA SH2 686-767 37 9.2e-24 86.18 SMART 1-87 (87) Show / Hide 
Range on Protein: 686-767
Range on HMM: 1-87/87
Sequence Identity: 37% (33 aa)

YIYYH-TVSRDEAEERLSQGDTQEGTFIIRESI--PGTNTLSVKGEVTIRHYRISIEN-NKYYIYP--HVKFDSLNDLVRHYMMKADE
. .||  .||.|||. | ..  ..|.|..|.|   ||  .|||. .  ..||||  .. .||||     .||.|| .||.||.  .. 
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
TyrKc AqueK414.AA TyrKc 695-941 21 5.2e-13 -12.31 SMART 1-280 (280) Show / Hide 
Range on Protein: 695-941
Range on HMM: 1-280/280
Sequence Identity: 21% (66 aa)

DEAEERLSQG---DTQEGTFI-------IRESIPGTNTLSVKGEVTI-RHY--R---------ISIE--------NNKYYIYPHVKFDSLNDLVRHYMMK
 . .. |  |      .|| .       ..|.           |  | ...  .         . ..           . .  ...  .|.|  | .  |
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

ADEPINGNLKDYYCATPTELVDITIQVINGMIYLGEQDYIHCDLRAINILLGDHNTVKIANFHLAQHLNGN-------KYWTV--EKGTK--LAIRWTAP
               .. .|... .|. .|| || .. .|| || | |.|.|. .||||. | |.  .          .| ..  .||.|  | |||.||
--------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EGYTLNQLSIKSDVWSFGILLWELATKGKEPYPDI----SKLNEIVQILKQYRFPEAKWFEFGLN---------LGLLYPTLE---AIEANHRGNTSRCL
|    .  ..||||||||...||. | |..|||..     .  |... .|| . ..        |            .|   .   . ... | . | . 
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQP-----PNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-

MECL
 ||.
HECF
S_TKc AqueK414.AA S_TKc 695-999 14 2.6e-10 -25.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 695-999
Range on HMM: 1-231/231
Sequence Identity: 14% (48 aa)

DEAEERLSQG---------DTQ-EGTFIIRESIPGTNTLSVKGEVTIRHYRISIENNKYYIYPHVK--FDSLNDLVRHYMMKADEPIN--GNLKDYYCA-
 |  . . .|         ..     . | .            | ..|  .|  .       |..   .|.  |   |. |  .   .  |.|.|| .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-----HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKR

---------TPTELVDITIQVINGMIYLGEQDYIHCDLRAINILLGDHNTVKIANFHLAQHLNGNKYWTVEKGTKLAIRWTAPEGYTLNQLSI-KSDVWS
         .. .   .. |..... |. ..  ||.||   |||| .  ..||. | || .|         .       . |||     . .  |.|.||
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWS

FGILLWELATKGKEPYPDISKLNEIVQILKQYRFPEAKWFEFGLNLGLLYPTLEAIEANHRGNTSRCLMECLSKWLSKADENVYPPTWQTLASALRKIKE
.|..|.|... |. |.|    .... ....                                                                      
CGCILYEMLC-GYPPFP---QMQMMFKKIG----------------------------------------------------------------------

NAVAEKIMVSQLLQ-HYSSRISGATLSE--------ESV
     | .....||   . |..   . .        . .
-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK414.AA Pkinase 780-908 25 1.4e-07 27.9 Pfam 106-242 (293) Show / Hide 
Range on Protein: 780-908
Range on HMM: 106-242/293
Sequence Identity: 25% (37 aa)

TPTELVDITIQVINGMIYLGEQDYIHCDLRAINILLGDHNTV----KIANFHLAQH--LNGNKYWTVEKGTKLAIRWTAPEGYT-LNQLSIKSDVWSFGI
.. |. ..  |.. |. |. ..  ||.||   |||. .....    ||. | || .  .  |   |.  ||   ... |||     .  . |.|.||.|.
SEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGT---PWYMAPEVIRGGQYYGPKVDMWSCGC

LLWELATKGKEPYPDI------SKLNEIVQILK-QYRFPEAKW
.|.|... |. |.|.       ...  |..|.. ...|.. .|
ILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWW
Kinase AqueK414.AA Death 904-980 24 0.001355 14.33 Pfam 13-87 (87) Show / Hide 
Range on Protein: 904-980
Range on HMM: 13-87/87
Sequence Identity: 24% (19 aa)

PEAKWFEFGLNLGLLYPTLEAIEA-NHRGNTSRCLMECLSKWLSKADENVYPPTWQTLASALRKIKENAVAEKIMVSQ
| ..| ...  ||. .  .. ||  .......   .. | ||  .   .    | ..|..||||.. . .||||  . 
PGKDWRRLARKLGMSDNEIDQIEHDQNPHDLRSQTYQMLWKWEQR---HGKNATVDHLIEALRKMGRRDCAEKIQSWL