Gene AqueK390 (A.queenslandica)

AqueK390

Species: A.queenslandica
Alias: AqueK390
External Links:
Annotation:

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
AqueK390.AA Protein None 1309 None Fasta, JSON
AqueK390.kin_dom Protein Kinase Domain None 288 None Fasta, JSON

Protein domain

Protein domains of AqueK390.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SR AqueK390.AA SR 29-130 42 8.3e-47 162.74 SMART 1-118 (118) Show / Hide 
Range on Protein: 29-130
Range on HMM: 1-118/118
Sequence Identity: 42% (50 aa)

LRLVNGYTAADGRVEICINN----TWGTVCDDYWTDTHAKVVCRQLGYSTTDAVHYK----MGYFGEGSGEIFLDNVKCGGFESSLLLCGHAPIGINN--
.|||.| ..  ||||. .|.    .|||||||.|. . | |||||||...  ... .     ..||.||| | .||| | | |.||  | | ..| .|  
VRLVGGNNPCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSGPIWMDNVRCTGTETSLWDCPHWGWGQHNNC

CDH------YEDVGVACL
|.|      .||.|| |.
CSHNHHRNRQEDAGVVCS
SRCR AqueK390.AA SRCR 32-130 43 9.8e-42 142.01 Pfam 1-112 (112) Show / Hide 
Range on Protein: 32-130
Range on HMM: 1-112/112
Sequence Identity: 43% (49 aa)

VNGYTAADGRVEICI-NNTWGTVCDD-Y-WTDTHAKVVCRQLGY-STTDAVHYKMGY--FG--EGSGEIFLDNVKCGGFESSLLLCGHAPIGI--NN--C
|.| .   ||||..  |..|||||||   |... | |||||||. ..   .    .|  ||  .|.| | .||| | | |.||  | | | |   .|  |
VGGSSPCEGRVEVRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPGTGPIWMDNVRCHGNETSLWQCPHSPWGWHRHNPMC

DHY-EDVGVACL
.|  ||.|| | 
SHSREDAGVICS
SR AqueK390.AA SR 139-239 26 3.4e-22 80.97 SMART 1-118 (118) Show / Hide 
Range on Protein: 139-239
Range on HMM: 1-118/118
Sequence Identity: 26% (32 aa)

LRLVGGDSFNEGDIELCIDY----TWELICADNWTHNNTEVVCRELGYSTLGAVYYN----STDLSSANRLEPFINDVKCDGSENALIDCSY--NFSAD-
.|||||.. .||  |  ..     .|  .| |||. .. .||||.||...  ... .    .   .....      .| | |.|..| ||.     . . 
VRLVGGNNPCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSG-PIWMDNVRCTGTETSLWDCPHWGWGQHNN

-CSM------QPHVSVKCS
 ||       |  ..| ||
CCSHNHHRNRQEDAGVVCS
SRCR AqueK390.AA SRCR 142-239 25 6.4e-22 75.45 Pfam 1-112 (112) Show / Hide 
Range on Protein: 142-239
Range on HMM: 1-112/112
Sequence Identity: 25% (29 aa)

VGGDSFNEGDIELCI-DYTWELICAD-N-WTHNNTEVVCRELGY-STLGAVYYNSTD--LS--SANRLEPFINDVKCDGSENALIDC--SYNFS--AD--
|||.| .|| .|..  . .|  .|.| . |. .. .||||.||. ..   .. ...       .  .    ...| | |.| .| .|  |  .    .  
VGGSSPCEGRVEVRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPG-TGPIWMDNVRCHGNETSLWQCPHSPWGWHRHNPM

CSMQ-PHVSVKCS
|| .  ...| ||
CSHSREDAGVICS
SR AqueK390.AA SR 248-349 43 1.1e-48 168.98 SMART 1-118 (118) Show / Hide 
Range on Protein: 248-349
Range on HMM: 1-118/118
Sequence Identity: 43% (51 aa)

LRLIDGNTPNEGRLEICVNN----TWGTVCDDYWTNTNADVACRQLGYTTIGNFYRN----RAYFGMGKGTIWLDNVRCLGFEKSLLHCGHHIIGTGN--
.|| .||.|.|||.|.  |.    .|||||||.|. ..|.|.|||||. .    ...    .|.|| | | ||.||||| | | ||  | |. .|  |  
VRLVGGNNPCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSGPIWMDNVRCTGTETSLWDCPHWGWGQHNNC

CEH------KEDVSVLCY
| |      .||..| |.
CSHNHHRNRQEDAGVVCS
SRCR AqueK390.AA SRCR 251-349 43 6.7e-44 149.29 Pfam 1-112 (112) Show / Hide 
Range on Protein: 251-349
Range on HMM: 1-112/112
Sequence Identity: 43% (49 aa)

IDGNTPNEGRLEICV-NNTWGTVCDD-Y-WTNTNADVACRQLGY-TTIGNFYRNRAY--FG--MGKGTIWLDNVRCLGFEKSLLHCGHHIIGT--GN--C
..|..|.|||.|..  |..|||||||   |....|.|.|||||.  .  . . ..||  ||   |.| ||.||||| | | ||  | |   |   .|  |
VGGSSPCEGRVEVRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPGTGPIWMDNVRCHGNETSLWQCPHSPWGWHRHNPMC

EHK-EDVSVLCY
 |. ||..| |.
SHSREDAGVICS
SR AqueK390.AA SR 528-629 45 8e-53 182.73 SMART 1-118 (118) Show / Hide 
Range on Protein: 528-629
Range on HMM: 1-118/118
Sequence Identity: 45% (54 aa)

LRLVNGNTPKEGRVEICIDI----SWGTVCDDYWSNINADVVCKQLGYSTVGSVYRN----RAFFGAGNGRIWLDDVRCIGSETSLLDCQHKAIGENN--
.|||.||.| |||||. ..     .|||||||.|.  .|.|||.|||...  |....    .|.||.|.|.||.|.||| |.|||| ||.|  .|..|  
VRLVGGNNPCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSGPIWMDNVRCTGTETSLWDCPHWGWGQHNNC

CEH------KEDVSVMCI
| |      .||..| | 
CSHNHHRNRQEDAGVVCS
SRCR AqueK390.AA SRCR 531-629 43 8.6e-45 152.28 Pfam 1-112 (112) Show / Hide 
Range on Protein: 531-629
Range on HMM: 1-112/112
Sequence Identity: 43% (49 aa)

VNGNTPKEGRVEICI-DISWGTVCDD-Y-WSNINADVVCKQLGY-STVGSVYRNRAF--FG--AGNGRIWLDDVRCIGSETSLLDCQHKAIGE--NN--C
|.|..| |||||..  . .|||||||   |.. .|.|||.|||. ... ... ..|.  ||  .|.|.||.|.||| |.|||| .| | . |.  .|  |
VGGSSPCEGRVEVRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPGTGPIWMDNVRCHGNETSLWQCPHSPWGWHRHNPMC

EHK-EDVSVMCI
 |. ||..| | 
SHSREDAGVICS
SR AqueK390.AA SR 638-738 35 6.2e-44 153.2 SMART 1-118 (118) Show / Hide 
Range on Protein: 638-738
Range on HMM: 1-118/118
Sequence Identity: 35% (42 aa)

IRLVNGTSGNEGRLEICLNR----SWGTICDDGWTNNDAEVVCRQLGYSTTGAVYR----DKSYFGGGNGSIHLTDIDCNGNENLFLQCSH-TRKTTN--
.|||.|.. .|||.|. .|     .|||.|||.|. .||.|||||||...  ....    . ..||.|.| |.. ...|.|.|. . .|.| .   .|  
VRLVGGNNPCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSGPIWMDNVRCTGTETSLWDCPHWGWGQHNNC

CNH------NEDIGIICF
|.|      .|| |..| 
CSHNHHRNRQEDAGVVCS
SRCR AqueK390.AA SRCR 641-738 41 8.3e-40 135.53 Pfam 1-112 (112) Show / Hide 
Range on Protein: 641-738
Range on HMM: 1-112/112
Sequence Identity: 41% (46 aa)

VNGTSGNEGRLEICL-NRSWGTICDD-G-WTNNDAEVVCRQLGY-STTGAVYRDKSY--FG--GGNGSIHLTDIDCNGNENLFLQC--SHTRK-TTN--C
|.|.| .|||.|... | .|||.||| | |...||.|||||||. ..   ..   .|  ||  .|.| |.. ...|.|||  . ||  |.... ..|  |
VGGSSPCEGRVEVRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPGTGPIWMDNVRCHGNETSLWQCPHSPWGWHRHNPMC

NHN-EDIGIICF
.|. || |.|| 
SHSREDAGVICS
TyrKc AqueK390.AA TyrKc 1013-1292 36 3.6e-115 389.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 1013-1292
Range on HMM: 1-280/280
Sequence Identity: 36% (111 aa)

LVLEETVGQGEFGIVYRGIMTNDKCVPQAVAVKTLKGLYSKSDIEDIVSECIKMSNF--DDLNVLSLIGVCLDLG------PAPYIVMPFMSRGSLLSYL
..|... | |.||.||.|...      . ||||.||       .||. .|   |...  .  |.. |.|||.. |      . ..||| .|. |.|..||
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKERPNLTVSDTSEEDVILNVRKQLLSICLQVANGMSYLASHNFIHRDLAARNCMIDDEGIIKVADFGLSEEVHGQ-------DYFRQSSKEESGSAPAK
.| ||.            |.. |.|||.|.|.|.||.||.|.|.||||||||||........|..||||| ...         || |....   ... . 
RKHRPK------------LCM-KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEH---KGGKTM

LPIKWMALESLHDGVFSVKTDVWSYGVLCWEVFSLGKTPYPG-----LDPVGVVELLDTGGRLHRPYNGA------CSEEIYALMLSCWCESINDRPTFS
|||.|||.|.. .|.|. |.||||.||..||.|..|..||||     ...  |.|....|.|. .| |.       |..|.| .|..|| |  .||||||
LPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFS

DLATSI
..   .
EIHECF
Pkinase_Tyr AqueK390.AA Pkinase_Tyr 1013-1292 39 8e-114 386.11 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1013-1292
Range on HMM: 1-270/270
Sequence Identity: 39% (114 aa)

LVLEETVGQGEFGIVYRGIMT-NDKCVPQAVAVKTLKGLYSKSD--IEDIVSECIKMSNF-DDLNVLSLIGVCLDLGPA--PYIVMPFMSRGSLLSYLKK
... .. |.|.|| ||.|...  ..   . ||||.||  .....  .||  .|   |... .  |...|.|||.| |    .||||..|  |.||.||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

ERPNLTVSDTSEEDVILNVRKQLLSICLQVANGMSYLASHNFIHRDLAARNCMIDDEGIIKVADFGLSEEVHGQDYF-RQSSKEESGSAPAKLPIKWMAL
 |         |..  |..   ||..|.|.|.||.||.|.|.||||||||||........|..||||.  ..  ||  |....       .||||||||.
HR---------EDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGG-------GKLPIKWMAP

ESLHDGVFSVKTDVWSYGVLCWEVFSLGKTP-YPGLDPVGVVELL-DTGGRLHRPYNGACSEEIYALMLSCWCESINDRPTFSDLATSI
|....|.|..|.||||.|||.||.|..|..| |||...  |.|.. . |.|. .| |  |..||| ||..|| .  .||||||..   .
ECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPEN--CPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK390.AA TK 1013-1292 23 3.4e-101 340.04 In-house 1-486 (486) Show / Hide 
Range on Protein: 1013-1292
Range on HMM: 1-486/486
Sequence Identity: 23% (116 aa)

LVLEETVGQGEFG---IVYRGIMTNDK----------------------CVPQAVAVKTLKGLYSKSDIEDIV-------------SECIKMSNFD----
..|... |.|.||    ||.|.. ...                       ... ||||.||   . |. | .              .|.  |. ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-DLNVLSLIGVCLDLG-----------PAPYIVMPFMSRGS----LLSYLKKERP-----------------------------NLTVSDTSEEDVILNV
   |...|.|||.. .           . ..||| .|. |.    |..||.| ||                             ..  .. .... . . 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY-SHESNSPC-PEEQ

---------------RKQLLS-------------------ICLQVANGMSYLASH------NFIHRDLAARNCMIDDEGI-----------IKVADFG--
                |.||.                   .|.|.|.||.||.|.      ||.|||||||||.......           .|.||||  
DYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LSEEV-HGQDYFRQSSKEESGSAPA-----------------KLPIKWMALESLHDGV---------FSVKTDVWSYGVLCWEVFSLGKTPYPG
      |. .. ...|| |.||.  .. .                   ||||.||| |.| |.|         |. |.||||.|||.||.|..|..||.|
RQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYG

LDPV----------GVVELLDTGGRL-----------HRPY--NGACS-------------EEIYALMLSCWCESINDRPTFSDLATSI
  .            |.|.| .||||           .|.    ....             ||.| ||..|| .  .||||||.|   .
GMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK390.AA Met 1014-1286 36 7.5e-93 304.76 In-house 1-271 (271) Show / Hide 
Range on Protein: 1014-1286
Range on HMM: 1-271/271
Sequence Identity: 36% (106 aa)

VLEETVGQGEFGIVYRGIMTNDKCVPQAVAVKTLK--GLYSKSDIEDIVSECIKMSNFDDLNVLSLIGVCLDLGP-APYIVMPFMSRGSLLSYLKKERPN
.... .||| || ||.| ..  .     .|.|.|.         |.    | | |. ||  |||||||.|||     |..| |.|  | |... . .  |
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQNN

LTVSDTSEEDVILNVRKQLLSICLQVANGMSYLASHNFIHRDLAARNCMIDDEGIIKVADFGLSEEV-HGQDYFRQSSKEESGSAPAKLPIKWMALESLH
..|             ..|.. |.||| ||.|.||  |.|||||.||||.| . ..|||||||.  .     |  | ..      ||.||.||||.|.| 
PCV-------------RDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTH----PARLPVKWMAPECLQ

--------DGV-FSVKTDVWSYGVLCWEVFSLGKTPYPGLDP-VGVVELLDTG--GRLHRPYNGACSEEIY-ALMLSCWCESINDRPTFS
        .   |. |.|||| ||. || .  | .|||  |. . .   | .|   || .|    | . .|  .||.||  .  |||.||
QGVCLGCPTYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEY--CPDHLYTDVMLCCWHANPEDRPQFS
Kinase AqueK390.AA TK-Unique 1013-1292 31 8.4e-90 304.65 In-house 1-294 (294) Show / Hide 
Range on Protein: 1013-1292
Range on HMM: 1-294/294
Sequence Identity: 31% (96 aa)

LVLEETVGQGEFGIVYRGIMTNDK---CVPQAVAVKTLKGLYSKSDIEDIVSECIKMSNFDDL-NVLSLIGVCLDLGPAPYIVMPFMSRGSLLSYLKKER
|......|.|.|| |.|| .....   . .. ||||.||   .. |  |  .|   |.. .|  |.....|.| . .  ..|.|.....|.|..||.. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PNLTVS----------DTSEEDVILN-VR-KQLLSICLQVANGMSYLAS--HNFIHRDLAARNCMIDDEGIIKVADFGLSEEVH-GQDYFRQSSKEESGS
|.   .          .. .... .. .  |.|.... |.|.||.||||  ....||||.|||... . ...|..|||....|. ...| .. |.     
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQ-----

APAKLPIKWMALESLH--DGVF-SVKTDVWSYGVLCWEVFSLGKTPYPGLDPVGVVELLDTGGRLHRPYNGACSEEIYALMLSCWCESINDRPTFSDLAT
   ..||.|||.|||   .|.. . |.||||.||| ||.|.||..||||...  ..|..  | |. .| .. ||.|.| || |||...  .||.|.... 
--GRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQP-EHCCSHEMYNLMKSCWQWEPEERPSFRQIKH

SI
 .
RL
Kinase AqueK390.AA UTK 1013-1292 32 2.6e-89 303.0 In-house 1-296 (296) Show / Hide 
Range on Protein: 1013-1292
Range on HMM: 1-296/296
Sequence Identity: 32% (101 aa)

LVLEETVGQGEFGIVYRGIMTNDK--CVPQAVAVKTLK-GLYSKSDIE---DIVSECI---KMSNFD-DLNVLSLIGVCLDLGPAPYIVMPFMSRGSLLS
. | .. |||.||.|...  |...     ..||||... .  .  . |   |.  |.     |..|.   ||| |.|||.. .| ..||. .|..|.|.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRS

YLKKERPNLTVSDTSEEDVILNVRKQLLSICLQVANGMSYLASHNFIHRDLAARNCMIDDEG-------IIKVADFG---LSEEVH---------GQDYF
|| . ||..      .....|. . |.|. ....|.||.||.|..|.||||||||| ... .       ..|.||||   .| .|.         ...|.
YLRRHRPTPP-----ACPHWLTLH-QRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYY

RQSSKEESGSAPAKLPIKWMALESLHDG-VFSVKTDVWSYGVLCWEVFSLGKTPYPGLDPVGVVELLDTGGRLHRPYNGACSEEIYALMLSCWCESINDR
.... .       ..||.||| |.| ..  |. |.||||.||.|||... |..||||.  . |.. .  |||...| . .|....| ||..||  .. .|
MAQHQD-------RWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQER

PTFSDLATSI
|.| ||   .
PDFEDLVQQM
Kinase AqueK390.AA Axl 1013-1290 39 9.6e-79 267.92 In-house 1-267 (267) Show / Hide 
Range on Protein: 1013-1290
Range on HMM: 1-267/267
Sequence Identity: 39% (113 aa)

LVLEETVGQGEFGIVYRGIMTNDKCVPQAVAVKTLK-GLYSKSDIEDIVSECIKMSNFDDLNVLSLIGVCLDLG-----PAPYIVMPFMSRGSLLSYLKK
.||  ..|.|||| |  | .  .    . ||||..|    ..|.||. .|| . | .||  ||. |||||. .      |.| ...|||  | | ..|  
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLY

ERPNLTVSDTSEEDVILNVRKQLLSICLQVANGMSYLASHNFIHRDLAARNCMIDDEGIIKVADFGLSEEVHGQDYFRQSSKEESGSAPAKLPIKWMALE
 |         .. . | . . |.   . .| || ||...|||||||||||||. ..  . |||||||  .   ||.||      | . ||.|.||.|.|
SR-------LGDQPFYLPL-QMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQ------GCI-AKMPVKWIAIE

SLHDGVFSVKTDVWSYGVLCWEVFSLGKTPYPGLDPVGVVELLDTGGRLHRPYNGACSEEIYALMLSCWCESINDRPTFSDLAT
|| | |. .| |||..||  ||.   |.|||||..   . . |  | ||  | .  | .|.|.|| .||     |||.|| |  
SLADRVYTSKSDVWAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPED--CMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase AqueK390.AA ALK 1013-1294 38 7.9e-74 251.59 In-house 1-273 (273) Show / Hide 
Range on Protein: 1013-1294
Range on HMM: 1-273/273
Sequence Identity: 38% (111 aa)

LVLEETVGQGEFGIVYRGIMTN--DKCVPQAVAVKTLKGLYSKSDIEDIVSECIKMSNFDDLNVLSLIGVCLDLGPAPYIVMPFMSRGSLLSYLKKERPN
. |    |.| || || |  .      || .||.|||. . |. | ||   |   |..|.. || ..||.|..  |  .||  .|. | ..|.|.  ||.
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPY-MIVLEYMEGGDMKSFLRECRPH

LTVSDTSEE--DVILNVRKQLLSICLQVANGMSYLASHNFIHRDLAARNCMIDDEG---IIKVADFGLSEEV-HGQDYFRQSSKEESGSAPAKLPIKWMA
       .|     . . | || .|. || |  || .  ||||| |||||    .|   . |.|||| . ..  . ||.|   .       | .|.||| 
-------PESLQPSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGR-------AMMPVKWMP

LESLHDGVFSVKTDVWSYGVLCWEVFSLGKTPYPGLDPVGVVELLDTGGRLHRPYNGACSEEIYALMLSCWCESINDRPTFSDLATSINE
 | . ||.|  ||||||.||||||.||||  ||||     | |.. .|||.  |.|  |   .| .|  ||     |||.| ..  .| .
PEAFMDGIFTSKTDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRN--CPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase AqueK390.AA FGFR 1013-1292 37 4.4e-72 244.99 In-house 1-293 (293) Show / Hide 
Range on Protein: 1013-1292
Range on HMM: 1-293/293
Sequence Identity: 37% (113 aa)

LVLEETVGQGEFGIVYRGIMTNDKCV----PQAVAVKTLKGLYSKSDIEDIVSE--CIKMSNFDDLNVLSLIGVCLDLGPAPYIVMPFMSRGSLLSYLKK
|.| .. | | || | ..     .|       .|||| ||   .  |. | |||    ||      |.. |.|.|   || .|..  . ..| |  .|..
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIG-KHKNIINLLGCCTQEGP-LYVIVEYCHHGNLRDFLRA

ERPNL--TVSDTS----------EED----VILN-VRKQLLSICLQVANGMSYLASHNFIHRDLAARNCMIDDEGIIKVADFGLSEEVHGQDYFRQSSKE
 ||      .|..          |.     .| |   |.| |.  ||| || ||||   |||||||||  . |. ..|..||||.  .|  ||.|   | 
RRPPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYR---KT

ESGSAPAKLPIKWMALESLHDGVFSVKTDVWSYGVLCWEVFSLGKTPYPGLD-PVGVVELLDTGGRLHRPYNGACSEEIYALMLSCWCESINDRPTFSDL
  |     |||||||.|.| | |. .. |||||||| ||.. .| .|||.        ..| .| |. .| |  ||.||| .| .|| ..  .||||  |
TNG----RLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHN--CSQEIYHMMCQCWHFKPCQRPTFKQL

ATSI
  ..
VEYL
Kinase AqueK390.AA Src 1013-1292 37 9.6e-71 239.56 In-house 1-255 (255) Show / Hide 
Range on Protein: 1013-1292
Range on HMM: 1-255/255
Sequence Identity: 37% (105 aa)

LVLEETVGQGEFGIVYRGIMTNDKCVPQAVAVKTLKGLYSKSDIEDIVSECIKMSNFDDLNVLSLIGVCLDLGPAPYIVMPFMSRGSLLSYLKKERPNLT
. |..  ||| || |. |.  .       |||||||      . |.   |   | ...  ....|  || .  |  |||  .||.|||| ||||      
IKLCRKLGQGQFGEVWMGYWNGN----TKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPI-YIVTEYMSHGSLLDYLKK------

VSDTSEEDVILNVRKQLLSICLQVANGMSYLASHNFIHRDLAARNCMIDDEGIIKVADFGLSEEVH--GQDYFRQSSKEESGSAPAKLPIKWMALESLHD
    ..|   |... ||...  |||.||.|| | |.|||||||||  .... . |||||||   .      |  ..         ||.||||.| | .. 
----DGEGRHLHLP-QLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH--------GAKFPIKWTAPEAINY

GVFSVKTDVWSYGVLCWEVFSLGKTPYPGLDPVGVVELLDTGGRLHRPYNGACSEEIYA-LMLSCWCESINDRPTFSDLATSI
|.|..|.||||.|.| .|... |..|||| .   |.. .. | |. .| |  | .|.|  .|| ||...  .||||  |    
GRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHN--CPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK390.AA InsR 1013-1294 34 1e-70 236.72 In-house 1-278 (278) Show / Hide 
Range on Protein: 1013-1294
Range on HMM: 1-278/278
Sequence Identity: 34% (101 aa)

LVLEETVGQGEFGIVYRG----IMTNDKCVPQAVAVKTLKGLYSKSDIEDIVSECIKMSNFDDLNVLSLIGVCLDLGPAPYIVMPFMSRGSLLSYLKKER
.||    ||| || || |    |. . .    ..|.||..   |  .  .  .|   | .|.  .|  | |||    |. |.|| .| .| | |||   |
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPM-YVVMEMMTYGDLKSYLRSRR

PNLTVSDTSEEDVI----LNVRKQLLSICLQVANGMSYLASHNFIHRDLAARNCMIDDEGIIKVADFGLSEEVHGQDYFRQSSKEESGSAPAKLPIKWMA
|        . ...       . |...   ... ||.|||. .|.|||||.||||..... .|..|||.   .   || | . |        .||. |||
PEEEF---NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGK-------GMLPVRWMA

LESLHDGVFSVKTDVWSYGVLCWEVFSLGKTPYPGLDPVGVVELL-DTGGRLHRPYNGACSEEIYALMLSCWCESINDRPTFSDLATSINE
 ||| ||||. . ||||.||. ||. .||  || ||    | .     |. | .| |  |.|  ..||  ||  .  .|||| |.  .. .
PESLKDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPEN--CPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase AqueK390.AA Tec 1013-1294 37 4.3e-69 235.84 In-house 1-254 (254) Show / Hide 
Range on Protein: 1013-1294
Range on HMM: 1-254/254
Sequence Identity: 37% (106 aa)

LVLEETVGQGEFGIVYRGIMTNDKCVPQAVAVKTLK-GLYSKSDIEDIVSECIKMSNFDDLNVLSLIGVCLDLGPAPYIVMPFMSRGSLLSYLKKERPNL
| . . .|.| ||.| .|  ..       ||.|..| |  |    || . |   | .    .   | |||.   |  |||  .|..|.||.||....  .
LTFMKELGSGQFGVVHLGKWRHQ----YDVAIKMIKEGSMSE---EDFIEEAKVMMKLSHPKLVQLYGVCSQQRPI-YIVTEYMEHGCLLNYLREHKHHF

TVSDTSEEDVILNVRKQ--LLSICLQVANGMSYLASHNFIHRDLAARNCMIDDEGIIKVADFGLSEEVHGQDYFRQSSKEESGSAPAKLPIKWMALESLH
              ...  ||..|..|  || || .|.||||||||||| ..|....||.|||..  |   .|          |  .| |.|| . | .|
Q-------------KNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYT--------SSVGTKFPVKWCPPEVFH

DGVFSVKTDVWSYGVLCWEVFSLGKTPYPGLDPVGVVELLDTGGRLHRPYNGACSEEIYALMLSCWCESINDRPTFSDLATSINE
   .| | |||..||| |||||.|| ||. .. . |||   .| ||.||    ||..||  | .|| |.  .||||..|  .| |
YSRYSSKSDVWAFGVLMWEVFSCGKMPYENMSNSEVVEHVSQGHRLYRPH--LCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase AqueK390.AA S_TKc 1013-1296 20 4.8e-36 127.0 SMART 1-231 (231) Show / Hide 
Range on Protein: 1013-1296
Range on HMM: 1-231/231
Sequence Identity: 20% (62 aa)

LVLEETVGQGEFGIVYRGIMTNDKCVPQAVAVKTLKGLYSKSDIEDIVSECIKMSNFDDLNVLSLIGVCLDLGPAPYIVMPFMSR--GSLLSYLKKERPN
  . ...|.| || ||... ..     . ||.| .|        |.| .|   ... .  |.  |..|. |     |.|| ...   |.|..|.|| ...
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LTVSDTSEEDVILNVRKQLLSICLQVANGMSYLASHNFIHRDLAARNCMIDDEGIIKVADFGLSEEVHGQDYFRQSSKEESGSAPAKLPIKWMAL
     ..  ..              ... |..... |. ||..|||||   | ..|.   ||..||||. ..                        .|| 
GLRFPFPE-HAR-------------FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCGTPWYMAP

ESLHDGVFSV-KTDVWSYGVLCWEVFSLGKTPYPGLDPVGVVELLDTGGRLHRPYNGACSEEIYALMLSCWCESINDRPTFSDLATSI-----NELI
| |    ..  | |.|| |.. .| .. |..|.|      . ....  |          |.|   ..  |..   ..|||  .. ..       . .
EVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK390.AA Pkinase 1013-1182 23 8.2e-22 78.2 Pfam 1-168 (293) Show / Hide 
Range on Protein: 1013-1182
Range on HMM: 1-168/293
Sequence Identity: 23% (44 aa)

LVLEETVGQGEFGIVYRGIMTNDKCVPQAVAVKTLKGLYSKSDIEDIV---SECIKMSNFDDLNVLSLIGVCLDLGPAPYIVMPFMSRG----SLLSYLK
.......|.| || ||...  .. .    ||||..|    ||. . .    ||.  | ...  |.. |.... | .. .|.||...  |    .| .|..
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIS

KERPNLTVSDTSEEDVIL--NVRKQLLSICLQVANGMSYLASHNFIHRDLAARNCMIDDEGII----KVADFGLSE---EVHGQDY
            ...  .     ... ....|.. |. |. |...|||||   |..||..| |    |..||||..   . ... .
T-----------WRHGCFYFS-EWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-M
Kinase AqueK390.AA Pkinase 1214-1292 19 9.6e-08 28.47 Pfam 190-293 (293) Show / Hide 
Range on Protein: 1214-1292
Range on HMM: 190-293/293
Sequence Identity: 19% (21 aa)

SVKTDVWSYGVLCWEVFSLGKTPYPGL----DPVGVVELLDTGGR--LHRPYNGACS-------------------EEIYALMLSCWCESINDRPTFSDL
. | |.||.|....|... |..|.||     . .   ....  ..  ||...   ||                   ||   .. .|.|   ..|||. ..
GPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI

ATS--I
  .  .
LQHPWF