Gene AqueK376 (A.queenslandica)

AqueK376

Species: A.queenslandica
Alias: AqueK376
External Links:
Annotation:

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
AqueK376.AA Protein None 958 None Fasta, JSON
AqueK376.kin_dom Protein Kinase Domain None 275 None Fasta, JSON

Protein domain

Protein domains of AqueK376.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SR AqueK376.AA SR 1-96 20 1e-05 -0.78 SMART 4-118 (118) Show / Hide 
Range on Protein: 1-96
Range on HMM: 4-118/118
Sequence Identity: 20% (24 aa)

MGFNTPDKGILFVCKNN----KKHSLCSTEHDNNNAQAACRQLGFIEGRVVESK----RIKSGKTFS---PLIFFCTGTEDRMANGGCRN--ATLNN--C
.| |.|  | . |  |.    . .. |..  | ..|. .|||||. ... . ..    .   |          . |||||.. ..  |..     .|  |
VGGNNPCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSGPIWMDNVRCTGTETSLWD--CPHWGWGQHNNCC

ES------NRNFIIQCY
 .      ..   . |.
SHNHHRNRQEDAGVVCS
SRCR AqueK376.AA SRCR 13-41 31 0.008307 11.24 Pfam 13-44 (112) Show / Hide 
Range on Protein: 13-41
Range on HMM: 13-44/112
Sequence Identity: 31% (10 aa)

VCK-NNKKHSLCST-E-HDNNNAQAACRQLGF
|.  |.. .. |.     |...|. .|||||.
VRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGC
SRCR AqueK376.AA SRCR 435-468 26 0.001625 13.62 Pfam 72-112 (112) Show / Hide 
Range on Protein: 435-468
Range on HMM: 72-112/112
Sequence Identity: 26% (11 aa)

DNLNCNGFEKTIAQCPFQELQP------RLSR-EAAALKCP
||..|.| | ...|||.  ..         .. |.|.. | 
DNVRCHGNETSLWQCPHSPWGWHRHNPMCSHSREDAGVICS
TyrKc AqueK376.AA TyrKc 657-931 35 2.2e-119 403.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 657-931
Range on HMM: 1-280/280
Sequence Identity: 35% (108 aa)

LRLLDSIGQGEFGLVYKAHLFDDQGAPIDVAVKTLKGTYDQNDINNLLLESLKMKEL--SHQNVMSIIGVCLDAG------TAPFIILPYMSGGSLHSYL
..|.. .| |.|| |||...       |.||||.||       .  .. |   |..|  .|.|.  ..|||.. |        ..|.. ||..|.|..||
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QRNRNSIILTDDAIDPEQKVGI-QLTSICLQIAKGMQYISSKGIIHRDLAARNCMLDHNGIIKVADFGLSKSLYEK-------LYYKQEKDETVK--LPV
...|.              .   .| |.|.|||.||.|..||..||||||||||....|...|..|||||. .|..        ||.. . .  |  ||.
RKHRPK-------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

KWMAIESINDGIFSEKSDVWSFGVTCWEVYSGGKVPYGG-----LSPMSIPKLLEEGHRMNKPNNNA------CCDNMYNEMMLQCWNASPEERPSFLNL
.|||.|.||.|.|..|||||||||..||... |. || |     .|.  . .....|.|| .| |.       | | ||. .|.|||.. ||.||.| ..
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI

LQKI
 ...
HECF
Pkinase_Tyr AqueK376.AA Pkinase_Tyr 657-931 38 5.4e-117 396.85 Pfam 1-270 (270) Show / Hide 
Range on Protein: 657-931
Range on HMM: 1-270/270
Sequence Identity: 38% (110 aa)

LRLLDSIGQGEFGLVYKAHLF-DDQGAPIDVAVKTLKGTYDQND--INNLLLESLKMKEL-SHQNVMSIIGVCL-DAGT-APFIILPYMSGGSLHSYLQR
....  .|.|.|| |||.... |...  |.||||.|| .... .  .  .. |   ||.| .|.|. . .|||. . .   ..|...|| .|.|..||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

NRNSIILTDDAIDPEQKVGIQLTSICLQIAKGMQYISSKGIIHRDLAARNCMLDHNGIIKVADFGLSKSLYEKLYYKQEKDETVKLPVKWMAIESINDGI
.|          |...    .| ..|.||||||.| .||..||||||||||....|...|..||||.. .|.. ||   | .  |||.|||| |.||.|.
HR---------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGK

FSEKSDVWSFGVTCWEVYSGGKVP-YGGLSPMSIPKLL-EEGHRMNKPNNNACCDNMYNEMMLQCWNASPEERPSFLNLLQKI
|..|||||||||..||... |. | | |.|.  . ... |.|.|| .| |  |.| .|.  |.|||.. ||.||.|  .....
FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPEN--CPDEIYDL-MKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK376.AA TK 657-931 21 1e-105 355.5 In-house 1-486 (486) Show / Hide 
Range on Protein: 657-931
Range on HMM: 1-486/486
Sequence Identity: 21% (105 aa)

LRLLDSIGQGEFG---LVYKAHLFDDQ----------------------GAPIDVAVKTLKG--TYDQNDINN--------------LLLESLKMKE--L
..|.. .|.|.||    |||. ....                       |....||||.||   . .|..                 ...|  .|..  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

SHQNVMSIIGVCLDAGTA-----------PFIILPYMSGGS----LHSYLQRNRNS--------------------------------------------
 |.|. ...|||.. ..            . |.. ||..|.    |..||...|.                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----IILTDDAIDPEQKVG---------------IQLTSICLQIAKGMQYISSK------GIIHRDLAARNCMLDHNGI-----------IKVADFG---
    | .  ....  . .                 ||  .|.|||.||.|..||      ...|||||||||....|..           .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSKSLYEKLYYKQEKDETV----------------------KLPVKWMAIESINDGI---------FSEKSDVWSFGVTCWEVYSGG-KVPYGGL
     |.. .|.. .|   .....                      |||..||| |..||..         |..|||||||||..||... | . .|||.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SP---------MSIPKLLEE------------GHRMNKPNNNACCD-------------NMYNEMMLQCWNASPEERPSFLNLLQKI
|            . ..|..            |.|| .|    |.|              .| ..|.|||.. ||.||.|  |....
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK376.AA Met 658-925 39 2.1e-96 316.62 In-house 1-271 (271) Show / Hide 
Range on Protein: 658-925
Range on HMM: 1-271/271
Sequence Identity: 39% (112 aa)

RLLDSIGQGEFGLVYKAHLFDDQGAPIDVAVKTLK--GTYDQNDINNLLLESLKMKELSHQNVMSIIGVCLDAGT-APFIILPYMSGGSLHSYLQRNRNS
 ..| |||| || ||.. . |  |  . .|.|.|.     | . | . | | . ||...| || | ||.|||  .  | ..|||| .| | ..     | 
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQNN

IILTDDAIDPEQKVGIQLTSICLQIAKGMQYISSKGIIHRDLAARNCMLDHNGIIKVADFGLSKSL-YEKLYYKQEKDETV--KLPVKWMAIESIN----
.   |            | . |.|.||||.|  |.  .|||||.||||||   ..|||||||.  . |.| || |. ..|   .||||||| |.      
PCVRD------------LIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQM-HHTHPARLPVKWMAPECLQQGVC

----DGI-FSEKSDVWSFGVTCWEVYSGGKVPYGGLSP-MSIPKLLEEG--HRMNKPNNNACCDNMYNEMMLQCWNASPEERPSFL
    . . |. |||||||||  ||    | .||.  ..   |   |..|   |  .|    | |  | . ||.|| |.||.||.| 
LGCPTYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEY--CPDHLYTDVMLCCWHANPEDRPQFS
Kinase AqueK376.AA UTK 657-931 32 2e-92 313.38 In-house 1-296 (296) Show / Hide 
Range on Protein: 657-931
Range on HMM: 1-296/296
Sequence Identity: 32% (100 aa)

LRLLDSIGQGEFGLVYKAHLFD--DQGAPIDVAVKTLK-GTYDQNDIN---NLLLESL---KMKELS-HQNVMSIIGVCLDAGTAPFIILPYMSGGSLHS
..|.. .|||.|| |.||.. .  ...   |||||... .  .| .      ...|.     || .. |.||.  .|||.. .  . |.. ||..|.| |
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRS

YLQRNRNSIILTDDAIDPEQKVGIQLTSICLQIAKGMQYISSKGIIHRDLAARNCMLDHNG-------IIKVADFG---LSKSLY-------EKLYYKQE
||.|.| .       ..|..    |... ...|| ||||..|.|..||||||||| .....       ..|.||||   .|. ..       .. .|   
YLRRHRPTPP-----ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYM

KDETVKLPVKWMAIESINDG-IFSEKSDVWSFGVTCWEVYSGGKVPYGGLSPMSIPKLLEEG--HRMNKPNNNACCDNMYNEMMLQCWNASPEERPSFLN
...  ..|..||| |.....  |..|||||||||.|||....|..||.|.| | . . ...|  .||..|   .| ...|. .|..||...|.|||.|  
AQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCP--WDCPHPVYR-LMHRCWHYDPQERPDFED

LLQKI
|.|..
LVQQM
Kinase AqueK376.AA TK-Unique 657-931 32 4.5e-88 298.9 In-house 1-294 (294) Show / Hide 
Range on Protein: 657-931
Range on HMM: 1-294/294
Sequence Identity: 32% (96 aa)

LRLLDSIGQGEFGLVYKAHLFD---DQGAPIDVAVKTLKGTYDQNDINNLLLESLKMKELS-HQNVMSIIGVCLDAGTAPFIILPYMSGGSLHSYLQRNR
|...|.||.|.|| |... ..    ...... ||||.||   .. |  ..| |   ||||  |.|. ...|.| . .  ..||..|...|.| .||...|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-N-----------SIILTDDAIDPEQKVG-IQLTSICLQIAKGMQYISS--KGIIHRDLAARNCMLDHNGIIKVADFGLSKSLY-EKLYYKQEKDETVKL
 .            .  .. .....  .   .| ... |||.||.|..|  |.|.||||.|||..| .....|..|||... .| .. |  . ...  ..
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVY--SMMCSQGRI

PVKWMAIESIN--DGIF-SEKSDVWSFGVTCWEVYSGGKVPYGGLSPMSIPKLLEEGHRMNKPNNNACCDNMYNEMMLQCWNASPEERPSFLNLLQKI
|..||| ||.   .|.. ..|||||||||. ||. . |. ||.|... .| .....|.||..|..  || .   . | .||. .|||||||  .....
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEH--CCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK376.AA Axl 657-929 41 1.2e-80 274.23 In-house 1-267 (267) Show / Hide 
Range on Protein: 657-929
Range on HMM: 1-267/267
Sequence Identity: 41% (116 aa)

LRLLDSIGQGEFGLVYKAHLFDDQGAPIDVAVKTLK-GTYDQNDINNLLLESLKMKELSHQNVMSIIGVCLDAGT-----APFIILPYMSGGSLHSYLQR
. |   .|.|||| |  ..|  . |. . ||||..|     | .| . | |   ||| .| ||| .||||. .       .| .|||.|  | ||..|  
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLY

NRNSIILTDDAIDPEQKVGIQLTSICLQIAKGMQYISSKGIIHRDLAARNCMLDHNGIIKVADFGLSKSLYEKLYYKQEKDETVKLPVKWMAIESINDGI
 |   . ..    | |     |    . || || |.|..  ||||||||||||  .  . |||||||| .|.  ||.| .    |.||||.||||. | .
SR---LGDQPFYLPLQ----MLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQGC--IAKMPVKWIAIESLADRV

FSEKSDVWSFGVTCWEVYSGGKVPYGGLSPMSIPKLLEEGHRMNKPNNNACCDNMYNEMMLQCWNASPEERPSFLNLLQ
.  |||||.|||| ||.   |. || |.    .   | .|||. .|..  | |..| ..| |||.| |..||||  | .
YTSKSDVWAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPED--CMDELY-DLMYQCWEADPKDRPSFSVLRE
Kinase AqueK376.AA Src 657-931 36 1.4e-71 242.48 In-house 1-255 (255) Show / Hide 
Range on Protein: 657-931
Range on HMM: 1-255/255
Sequence Identity: 36% (101 aa)

LRLLDSIGQGEFGLVYKAHLFDDQGAPIDVAVKTLKGTYDQNDINNLLLESLKMKELSHQNVMSIIGVCLDAGTAPFIILPYMSGGSLHSYLQRNRNSII
..|.. .||| || |... .....   ..|||||||      . . .| |   ||.|.|... ..  || . .   .|.  ||| |||  ||..      
IKLCRKLGQGQFGEVWMG-YWNGN---TKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVC-SQEEPIYIVTEYMSHGSLLDYLKK------

LTDDAIDPEQKVGI-QLTSICLQIAKGMQYISSKGIIHRDLAARNCMLDHNGIIKVADFGLSKSLY--EKLYYKQEKDETVKLPVKWMAIESINDGIFSE
      . .... . || ..  |.|.||.|..|. .|||||||||   ..| . ||||||| . .   .  |  ..     |.|.||.| | || | |. 
-----DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH---GAKFPIKWTAPEAINYGRFTI

KSDVWSFGVTCWEVYSGGKVPYGGLSPMSIPKLLEEGHRMNKPNNNACCDNMYNEMMLQCWNASPEERPSFLNLLQKI
||||||||.  .|. . |.||| | . .   . .| | || .| |  | |..|.. |||||...||.|| |  | .. 
KSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHN--CPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK376.AA Fer 657-932 31 2.9e-70 238.45 In-house 1-283 (283) Show / Hide 
Range on Protein: 657-932
Range on HMM: 1-283/283
Sequence Identity: 31% (94 aa)

LRLLDSIGQGEFGLVYKA----HLFD---DQGAPIDVAVKTLKGTYDQND-INNLLLESLKMKE-LSHQNVMSIIGVCLDAGTAPFIILPYMSGGSLHSY
  | . .| | || |||.    .. .    .. ...|.||..|.. .. . |. .. |   |.  ..| ||  ..||| |   .  |.. ...|||| ||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDE-QPIMIVMEFCNGGSLDSY

LQRNRN-SIILTDDAIDPEQKVGIQLTSICLQIAKGMQYISSKGIIHRDLAARNCMLDHNGIIK---VADFGLSKSLYEKLYYKQEKDETVKLPVKWMAI
|. | | .. .             ..  .|.|.|.||.|. ||..||||.||||| ...... |   ..|||.|. . .  | ...|..  |.|..|.| 
LKKNKNKTVSD------------NEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAP

ESINDGIFSEKSDVWSFGVTCWEVYSGGKVPYGG----LSPMSI-----PKLLEEGHRMNKPNNNACCDNMYNEMMLQCWNASPEERPSFLNLLQKIE
|....||.|.|.|||||||.|||... |. ||.|    . .. .      .  ..|..|  ||.  . . ... || |||.. ||.||..  . ||..
ETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNH--MPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase AqueK376.AA ALK 657-933 37 1.2e-65 224.44 In-house 1-273 (273) Show / Hide 
Range on Protein: 657-933
Range on HMM: 1-273/273
Sequence Identity: 37% (106 aa)

LRLLDSIGQGEFGLVYKAHLFD--DQGAPIDVAVKTLKGTYDQNDINNLLLESLKMKELSHQNVMSIIGVCLDAGTAPFIILPYMSGGSLHSYLQRNRNS
. |.   |.| || || .          |. ||.|||.    | |    . | | |   .|||| . ||.|... .  .|.| ||.|| . |.|  .|. 
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQK-QPYMIVLEYMEGGDMKSFLRECRP-

IILTDDAIDPEQKVGIQLTSICLQIAKGMQYISSKGIIHRDLAARNCMLDHNG---IIKVADFGLSKSL-YEKLYYKQEKDETVKLPVKWMAIESINDGI
   .  .. | | .   |  .|. .|.| .|. ... |||| ||||| |   |   . |.|||| ..   |   ||   |     .|||||  |   |||
---HPESLQPSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYR--KGGRAMMPVKWMPPEAFMDGI

FSEKSDVWSFGVTCWEVYSGGKVPYGGLSPMSIPKLLEEGHRMNKPNNNACCDNMYNEMMLQCWNASPEERPSFLNLLQKIER
|  |.||||||| |||..| | .|| | .   . ... || ||. | |  |    |. .| |||.  || ||.|  .| .|. 
FTSKTDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRN--CPQPVYR-IMTQCWQHQPEDRPKFVTILEHIQY
Kinase AqueK376.AA HMTK 774-930 41 6.1e-65 222.05 In-house 132-291 (291) Show / Hide 
Range on Protein: 774-930
Range on HMM: 132-291/291
Sequence Identity: 41% (68 aa)

SICLQIAKGMQYISSKGIIHRDLAARNCMLDHNGIIKVADFGLSKSLY-EKLYYKQEKDETVKLPVKWMAIESIN--DGIFSEKSDVWSFGVTCWEVYSG
..| |.|.||.||.|.. .|.|||||||.. || ..|.|||||.  |  .. |....|   ||||.||||.|     ..|||||||||.||||.||. . 
YFCVQCASGMAYIASQRMVHMDLAARNCLVGHNNQVKIADFGLTRRLDPGQDYWHLRKHM-VKLPIKWMAPEAMDGKRKIFSEKSDVWAFGVTMWEIWMY

GKVPYG--GLSPMSIPKLLEEGHRMNKPNNNACCDNMYNEMMLQCWNASPEERPSFLNLLQK
| .||.  ..    . . . || |  .|. ..| | .. ..| .||.. |..||.| .| ..
GEQPYESQQIKNKEVQRHVREGRRLTQPPPDDCPDDFW-DLMCTCWHKDPHQRPTFAQLQKM
Kinase AqueK376.AA EGFR 776-932 41 3.2e-55 181.7 In-house 107-258 (258) Show / Hide 
Range on Protein: 776-932
Range on HMM: 107-258/258
Sequence Identity: 41% (65 aa)

CLQIAKGMQYISSKGIIHRDLAARNCMLDHNGIIKVADFGLSKSLYEKLYYKQEKDETVKLPVKWMAIESINDGIFSEKSDVWSFGVTCWEVYSGGKVPY
|.||||||||   . ..|||||||| ..     .|..||||.| |  .   |. . .  |.|.||||.|.|  ...  .|||||.||||||.   |. ||
CVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLL--EHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTFGQKPY

GGLSPMSIPKLLEEGHRMNKPNNNACCDNMYNEMMLQCWNASPEERPSFLNLLQKIE
 |..  .|| |||.| |.  | .  |   .|  .|..|| . .. || |  | .. .
DGIPAREIPDLLEKGERLPQPPI--CTIDVY-MVMVKCWMIDEDMRPTFKELYEEFK
Kinase AqueK376.AA Pkinase 657-931 22 1.9e-36 129.98 Pfam 1-293 (293) Show / Hide 
Range on Protein: 657-931
Range on HMM: 1-293/293
Sequence Identity: 22% (71 aa)

LRLLDSIGQGEFGLVYKAHLFDDQGAPIDVAVKTLKGTYDQNDINNLLL---ESLKMKELSHQNVMSIIGVCLDAGTAPFIILPYMSGG----SLHSYLQ
....  ||.| || |||.|  ...     ||||..|   .  . .  ..   |   ||.|.| |.  ..... | .. . ....|. ||    .|..|..
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIS

RNRNSIILTDDAIDPEQKVGI-----QLTSICLQIAKGMQYISSKGIIHRDLAARNCMLDHNGII----KVADFGLSKSLYEKLYYKQEKDETVKLPVKW
.              ... ..     .. ....||..|..|. |.|||||||   |...|.|| |    |..||||.| ..   | ...   |.     .
T--------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWY

MAIESIN-DGIFSEKSDVWSFGVTCWEVYSGGKVPYGGL----SPMSIPKLLEEGHRMNKPNNNA--CCD------------------NMYNEMMLQCWN
|| | |. .   . |.|.||.|....|... |. |. |     . ..  .....  .   . .    |.                       . .  |..
MAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

ASPEERPSFLNLLQK--I
  |..||..  .||   .
KDPKKRPTAEQILQHPWF
Kinase AqueK376.AA S_TKc 657-935 22 3.9e-36 127.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 657-935
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

LRLLDSIGQGEFGLVYKAHLFDDQGAPIDVAVKTLKGTYDQNDINNLLLESLKMKELSHQNVMSIIGVCLDAGTAPFIILPYMSG--GSLHSYLQRNRNS
 ..|. ||.| || |||..  .       ||.| .|        .... |   .|.  | |.  ...|. |  .  .... |..|  |.|..|.....  
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH

---IILTDDAIDPEQKVGIQLTSICLQIAKGMQYISSKGIIHRDLAARNCMLDHNGIIKVADFGLSKSLYEKLYYKQEKDETVKLPVKWMAIESINDGIF
     ..   .           ... ||.....|. |.|||||||   | .||.   ||..||||.. |            |.     .|| | .    .
GLRFPFPE-HA----------RFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GY

SE-KSDVWSFGVTCWEVYSGGKVPYGGLSPMSIPKLLEEGHRMNKPNNNACCDNMYNEMMLQCWNASPEERPSFLNLLQ-----KIERIL
.  |.|.||.|.. .| .. |. |.       . ....              . . . .. .|..  ||.||.   .||     |.   .
GKCKCDWWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK376.AA EGFR 657-755 26 3.3e-11 33.29 In-house 1-98 (258) Show / Hide 
Range on Protein: 657-755
Range on HMM: 1-98/258
Sequence Identity: 26% (26 aa)

LRLLDSIGQGEFGLVYK-AHLFDDQGAPIDVAVKTLKGTYDQNDINNLLLESLKMKELSHQNVMSIIGVCLDAGTAPFIILPYMSGGSLHSYLQRNRNSI
|...   | | || |||     . .   | ||.| |. . ...  . .| | . |  . |.... ..|||.       ..  ||  |.|  |.. ... |
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ--MQLVTQYMPYGCLLDYVRQHKDNI
Kinase AqueK376.AA HMTK 657-726 26 1.2e-08 26.4 In-house 1-94 (291) Show / Hide 
Range on Protein: 657-726
Range on HMM: 1-94/291
Sequence Identity: 26% (25 aa)

LRLLDSIGQGEFG-----------------LVYKAHLF------DDQGAPID-VAVKTLKGTYDQNDINNLLLESLKMKELSHQNVMSIIGVCL
|  .  ||.| ||                  || | .        |.. ..  .|||.|.|    .|. . | |.  | .|.| |. ...|||.
LKAIKVIGAGQFGMVQCLRLAPPDEGCTSLKVYLAEWSVKDGDGKDDSNQPHHRAVKMLRGDASHEDREEFLREAEVMCQLRHPNLVQLVGVCM