Gene AqueK375 (A.queenslandica)

AqueK375

Species: A.queenslandica
Alias: AqueK375
External Links:
Annotation:

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
AqueK375.AA Protein None 577 None Fasta, JSON
AqueK375.kin_dom Protein Kinase Domain None 275 None Fasta, JSON

Protein domain

Protein domains of AqueK375.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IGc2 AqueK375.AA IGc2 52-138 13 0.000405 14.38 SMART 1-56 (56) Show / Hide 
Range on Protein: 52-138
Range on HMM: 1-56/56
Sequence Identity: 13% (12 aa)

LDYKTVYVNCSVYGESPFEVSWLYSTDEISNRSSDYTIISGSKVSNIVYNPNSDDEGYTWWNSSLLLNPINNSTVGYYYCRVNTSFG
.   .|  .| . |    ...|..   ...                              ||..| . ..  .  ||| |..  . |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG AqueK375.AA IG 46-150 11 0.013776 13.41 SMART 1-58 (58) Show / Hide 
Range on Protein: 46-150
Range on HMM: 1-58/58
Sequence Identity: 11% (13 aa)

DPFLYYLDYKTVYVNCSVYGESPFEVSWLYSTDEISNRSSDYTIISGSKVSNIVYNPNSDDEGYTWWNSSLLLNPINNSTV---GYYYCRVNTSFGLNYS
 | ..     ||  .| |      ...|.                                         | . ..  .     | |||...   |  .|
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWS

-KPVYVRKP
 ......  
IQGTTLTVQ
IG AqueK375.AA IG 158-255 14 4.8e-08 33.97 SMART 1-58 (58) Show / Hide 
Range on Protein: 158-255
Range on HMM: 1-58/58
Sequence Identity: 14% (15 aa)

PQNITAFENENITIIVKIIRAHPPVLPDHISWTYTTSNRSARTINQSIEEEYDSRVNISEDGRSLYISDLTSADE---GYYQVLIWHPAGYKNK--ITHL
|. .|. | |..|.   .          .|.|.                               | | ... .|.   | |.   .  .| . .   |.|
PP-VTVKEGETVTLTC-VS---------QIWWY-------------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTL

KIE
...
TVQ
V-set AqueK375.AA V-set 154-254 16 1.4e-07 27.97 Pfam 1-128 (128) Show / Hide 
Range on Protein: 154-254
Range on HMM: 1-128/128
Sequence Identity: 16% (21 aa)

EIELPQ--------NITAFENENITIIVKII-RAHPPVLPDHISWTY-TTS------------NRSARTINQSIEEEYDSRVNISEDGR----SLYISDL
 ... |         .|. | ...|.  .     ...  . .|.| .  ..            . .... ..  ....  || .| ...    || ||.|
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

TSADEGYYQVLIWHP-AGYKNKITHLKI
...|.| |   .|..  .|  . |.| .
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
TyrKc AqueK375.AA TyrKc 284-562 36 6.30000000001e-110 372.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 284-562
Range on HMM: 1-280/280
Sequence Identity: 36% (111 aa)

LKLLDCIGQGEFAKVYKGHYYINGECTLVAVKALKGIMDRYNSNDIKDLIEESLVMKDL--QHPNVMGLIGICLDAG------PSPLIVLPYMEGGSLFK
..|.. .| |.| .||||...     . |||| ||          ..|...|  .|. |  .|||.  |.|.|.. |      . ..||. ||..|.| .
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLVRNRNILMTSASTDDDEVINQVRSQLLSICLQIGKGMQYIAEKNLIHRDLAARNCMIDAVGNVKVADFGLSKDVSGN-------IYFRQQMSSGVK--
|| ..|.             ..   ..|||.|.|| .||.|...||.||||||||||.... . ||..|||||.|.           | |.. ..| |  
YLRKHRPK------------LCM--KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTM

LPIKWMAIESIEDGIFTEKTDIWSFGITVWEVFNGGKTPYGG-----FSPTCVKTMISDGYRLEAPSNSA------CNDDIYQKTMLKCWERDPNERPTF
|||.|||.|.| .|.||.|.|.||||.. ||.|  |..|| |      |.. |   . .|||.. | |        | |..||  |..||..||..||||
LPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTF

AQVVTDI
.... ..
SEIHECF
Pkinase_Tyr AqueK375.AA Pkinase_Tyr 284-562 38 4.5e-109 370.03 Pfam 1-270 (270) Show / Hide 
Range on Protein: 284-562
Range on HMM: 1-270/270
Sequence Identity: 38% (111 aa)

LKLLDCIGQGEFAKVYKGHYY--INGECTLVAVKALKGIMDRYNSND--IKDLIEESLVMKDL-QHPNVMGLIGICL-DAGP-SPLIVLPYMEGGSLFKY
....  .|.|.| .||||...    .... |||| ||   . . . .  ..|...|  .|| | .|||.  |.|.|. . .| ...||..||..|.| .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK---EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LVRNRNILMTSASTDDDEVINQVRSQLLSICLQIGKGMQYIAEKNLIHRDLAARNCMIDAVGNVKVADFGLSKDV-SGNIYFRQQMSSGVKLPIKWMAIE
| ..|           ..  .   ..||..|.|| |||.| ..||.||||||||||...  . ||..||||..|. .   |  .. ..|  ||||||| |
LRKHR-----------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGK-LPIKWMAPE

SIEDGIFTEKTDIWSFGITVWEVFNGGKTP-YGGFSPTCVKTMI-SDGYRLEAPSNSACNDDIYQKTMLKCWERDPNERPTFAQVVTDI
.| .|.||.|.|.||||.. ||.|  |..| | | |.. |. .|  ||||...| |  | |.||.  |..||. ||..||||.... ..
CINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPEN--CPDEIYDL-MKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK375.AA TK 284-562 22 1.4e-96 324.26 In-house 1-486 (486) Show / Hide 
Range on Protein: 284-562
Range on HMM: 1-486/486
Sequence Identity: 22% (112 aa)

LKLLDCIGQGEFA---KVYKGHYYI-----------------------NGECTLVAVKALKGIMDRYNSNDIK-------------DLIEESLVMKD--L
..|.. .|.|.|    .|||| ..                        .|..| |||| ||   .      .               . ||  .|.   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHPNVMGLIGICLDAGPS-----------PLIVLPYMEGGS----LFKYLVRNRNILMTSASTDDDEVINQVRS--------------------------
.|||.  |.|.|.. .|.           ..||. ||..|.    | .|| ..|.  ...... |..   ...|                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------------------------------QLLSICLQIGKGMQYIAEK------NLIHRDLAARNCMIDAVGN-----------VKVADFG---
                                   ||| .|.|| .||.|...|      |..|||||||||...  ..           .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSKDV-SGNIYFRQQ---------------------MSSGVKLPIKWMAIESIEDGI---------FTEKTDIWSFGITVWEVFNGG-KTPYGGF
     |..|. |.  | |..                     ..|| ||||.||| |...|..         ||.|.|.||||...||.|  | ...||| 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SP---------TCVKTMISD------------GYRLEAPSNSACND-------------DIYQKTMLKCWERDPNERPTFAQVVTDI
|          . |  .. .            |||.. |    | |             ..|.  |..||..||..||||.|..  .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK375.AA Met 285-556 36 4.1e-84 275.65 In-house 1-271 (271) Show / Hide 
Range on Protein: 285-556
Range on HMM: 1-271/271
Sequence Identity: 36% (107 aa)

KLLDCIGQGEFAKVYKGHYYI-NGECTLVAVKALK--GIMDRYNSNDIKDLIEESLVMKDLQHPNVMGLIGICLDAGP-SPLIVLPYMEGGSLFKYLVRN
 ..| |||| |  ||.| |    |. . .|.| |.   | |    . |    .| ..||...||||  |||||||    .|..|||||..| | .. .||
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITD---IQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTF-IRN

RNILMTSASTDDDEVINQVRSQLLSICLQIGKGMQYIAEKNLIHRDLAARNCMIDAVGNVKVADFGLSKDV-SGNIYFRQQMSSG-VKLPIKWMAIESIE
 .  ..            || .|.. |.|. |||.| |..  .|||||.||||.|.   ||||||||. |.     |  |.   .  .||.|||| |. .
PQNNPC------------VR-DLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQ

--------DGI-FTEKTDIWSFGITVWEVFNGGKTPYGGFSP-TCVKTMISDG--YRLEAPSNSACNDDIYQKTMLKCWERDPNERPTFA
        . . || |.|.||||.  || .  | .||.  .. . . .    |   ||  |    | | .|   ||.||. .| .||.| 
QGVCLGCPTYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEY--CPDHLYTDVMLCCWHANPEDRPQFS
Kinase AqueK375.AA UTK 284-562 31 1.3e-83 284.06 In-house 1-296 (296) Show / Hide 
Range on Protein: 284-562
Range on HMM: 1-296/296
Sequence Identity: 31% (97 aa)

LKLLDCIGQGEFAKVYKGHY-YIN--GECTLVAVKALKGIMDRYNSNDIK---DLIEESL---VMKDLQ-HPNVMGLIGICLDAGPSPLIVLPYMEGGSL
..|....|||.|  |.|...  ..  ..  .||||...   .     .     |..||.    .|| .. ||||..|.|.|.. .| ..||. |||.|.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ--HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDL

FKYLVRNRNILMTSASTDDDEVINQVRSQLLSICLQIGKGMQYIAEKNLIHRDLAARNCMIDAVG-------NVKVADFG---LSKDVS---------GN
 .|| |.|  ..      .....   . |.|. ...|  ||||.......||||||||| ... .        .|.||||   .|..|.         . 
RSYLRRHRPTPP------ACPHWLTLH-QRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWES

IYFRQQMSSGVKLPIKWMAIESIEDG-IFTEKTDIWSFGITVWEVFNGGKTPYGGFSPTCVKTMISDGYRLEAPSNSACNDDIYQKTMLKCWERDPNERP
 |...|  .  ..||.||| |.. ..  ||.|.|.||||...||.. .|..||.| |   | . ...|.|.  |.. .| ...|.  |..||. || |||
YYYMAQ--HQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYR-LMHRCWHYDPQERP

TFAQVVTDI
.| ..|  .
DFEDLVQQM
Kinase AqueK375.AA TK-Unique 284-562 31 3.7e-77 262.66 In-house 1-294 (294) Show / Hide 
Range on Protein: 284-562
Range on HMM: 1-294/294
Sequence Identity: 31% (96 aa)

LKLLDCIGQGEFAKVYKGHYY-IN---GECTLVAVKALKGIMDRYNSNDIKDLIEESLVMKDLQ-HPNVMGLIGICLDAGPSPLIVLPYMEGGSLFKYLV
|...| ||.|.|  |..| .  |.   .. . ||||.||   |. .  | .|.  |  .|| |  |||.  ..|.| . . ...|...|...|.| .|| 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLK---DNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLR

RNR-------------NILMTSASTDDDEVINQVRSQLLSICLQIGKGMQYIAE--KNLIHRDLAARNCMIDAVGNVKVADFGLSKDVSGNIYFRQQMSS
..|             .....  ... .| |.    .|.... || .||.|.|.  |. .||||.|||...   ...|..|||...||.     ......
TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISP--KDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT---NGVYSMM

G--VKLPIKWMAIESIE--DGIF-TEKTDIWSFGITVWEVFNGGKTPYGGFSPTCVKTMISDGYRLEAPSNSACNDDIYQKTMLKCWERDPNERPTFAQV
.   ..||.||| ||.   .|.. |.|.|.||||.. ||.|  |..||.| ... . ..| ||||.. |... |....|.  |  || ..| |||.|.|.
CSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHC-CSHEMYN-LMKSCWQWEPEERPSFRQI

VTDI
.  .
KHRL
Kinase AqueK375.AA Src 284-562 36 3.1e-73 248.16 In-house 1-255 (255) Show / Hide 
Range on Protein: 284-562
Range on HMM: 1-255/255
Sequence Identity: 36% (102 aa)

LKLLDCIGQGEFAKVYKGHYYINGECTLVAVKALKGIMDRYNSNDIKDLIEESLVMKDLQHPNVMGLIGICLDAGPSPLIVLPYMEGGSLFKYLVRNRNI
.||.. .||| |  |..| .  |   | |||| ||         . ... .|  .|| |.|...  |  .| .  |  .||  ||. ||| .|| .    
IKLCRKLGQGQFGEVWMGYWNGN---TKVAVKTLKPGT-----MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPI-YIVTEYMSHGSLLDYLKK----

LMTSASTDDDEVINQVRSQLLSICLQIGKGMQYIAEKNLIHRDLAARNCMIDAVGNVKVADFGLSKDVS--GNIYFRQQMSSGVKLPIKWMAIESIEDGI
        |.|  .    ||...  |. .||.|. ..|.|||||||||  ..    .||||||| . .    ..|  ..   | |.||||.| | |  | 
--------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH---GAKFPIKWTAPEAINYGR

FTEKTDIWSFGITVWEVFNGGKTPYGGFSPTCVKTMISDGYRLEAPSNSACNDDIYQKTMLKCWERDPNERPTFAQVVTDI
|| |.| |||||  .|..  |..|| | .   | .... |||.  |.|  | | .|.. ||.||..|| .||||.      
FTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHN--CPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK375.AA Axl 284-560 36 3.9e-69 235.99 In-house 1-267 (267) Show / Hide 
Range on Protein: 284-560
Range on HMM: 1-267/267
Sequence Identity: 36% (104 aa)

LKLLDCIGQGEFAKVYKGHYYING-ECTLVAVKALKGIMDRYNSNDIKDLIEESLVMKDLQHPNVMGLIGICLDAG-----PSPLIVLPYMEGGSLFKYL
. |   .|.|||  |  |.   .      |||| .|  .|   . .| . . |   ||. .||||| |||.|. .      | |...||.|  | |  .|
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMK--IDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFL

VRNRNILMTSASTDDDEVINQVRSQLLSICLQIGKGMQYIAEKNLIHRDLAARNCMIDAVGNVKVADFGLSKDVSGNIYFRQQMSSGVKLPIKWMAIESI
.         .|  .|. ..     |.   . |  || |....| |||||||||||.     | |||||||| .    |.||   .  |.|.||.||||.
L---------YSRLGDQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQGCIA--KMPVKWIAIESL

EDGIFTEKTDIWSFGITVWEVFNGGKTPYGGFSPTCVKTMISDGYRLEAPSNSACNDDIYQKTMLKCWERDPNERPTFAQVVT
 | ..| | |.|.||.|.||.   |.||| |     .   . .| ||  | .  | |..|.  | .||| || .||.|...  
ADRVYTSKSDVWAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPED--CMDELYD-LMYQCWEADPKDRPSFSVLRE
Kinase AqueK375.AA EGFR 284-563 32 3.9e-69 228.63 In-house 1-258 (258) Show / Hide 
Range on Protein: 284-563
Range on HMM: 1-258/258
Sequence Identity: 32% (92 aa)

LKLLDCIGQGEFAKVYKGHYYINGECTLVAVKALKGIMDRYNSNDIKDLIEESLVMKDLQHPNVMGLIGICLDAGPSPLIVLPYMEGGSLFKYLVRNRNI
||..   | | | .|||| .. .||   . | | | . .  . .  .....| .||  ..||... |.|.|.       .|  ||  |.|  |.  ... 
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPV-AIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ--MQLVTQYMPYGCLLDYVRQHKDN

LMTSASTDDDEVINQVRSQLLSICLQIGKGMQYIAEKNLIHRDLAARNCMIDAVGNVKVADFGLSKDVSGNIYFRQQMSSGVKLPIKWMAIESIEDGIFT
.   .              ||  |.|| |||||  |. ..|||||||| ..     ||..||||.|  . .    .   .| |.||||||.|.|. ...|
IGSQH--------------LLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDE--KEYHAQGGKMPIKWMALECIHHRCYT

EKTDIWSFGITVWEVFNGGKTPYGGFSPTCVKTMISDGYRLEAPSNSACNDDIYQKTMLKCWERDPNERPTFAQVVTDID
 . |.||.|.|.||.   |. || | .   .  .. .| ||. | .  |  |.|. .|.|||  |.. |||| . ..  .
HQSDVWSYGVTCWELMTFGQKPYDGIPAREIPDLLEKGERLPQPPI--CTIDVYM-VMVKCWMIDEDMRPTFKELYEEFK
Kinase AqueK375.AA Fer 284-563 32 1.7e-68 232.34 In-house 1-283 (283) Show / Hide 
Range on Protein: 284-563
Range on HMM: 1-283/283
Sequence Identity: 32% (98 aa)

LKLLDCIGQGEFAKVYKG----HYYINGECTL--VAVKALKGIMDRYNSNDIKDLIEESLVMKD-LQHPNVMGLIGICLDAGPSPLIVLPYMEGGSLFKY
 .| . .| | | .||||    . .  . ..   ||||  | ...  .   ||..  |  .|.  ..||||  ..|.| |  |  .||. .. |||| .|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPI-MIVMEFCNGGSLDSY

LVRNRNILMTSASTDDDEVINQVRSQLLSICLQIGKGMQYIAEKNLIHRDLAARNCMIDA-VGNVK--VADFGLSKDVSGNIYFRQQMS-SGVKLPIKWM
|  | |.             .    ... .|.|. .||.|. .|| ||||.||||| ... . ..|  ..|||.|.. |...| . .|     |.||.|.
LKKNKNK-------------TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGY-DYKMKEKACKVPIRWL

AIESIEDGIFTEKTDIWSFGITVWEVFNGGKTPYGG----FSPTCV-----KTMISDGYRLEAPSNSACNDDIYQKTMLKCWERDPNERPTFAQVVTDID
| |....||...|||.||||.. ||.|. |..||.|    . .|.|     |  | .||..  |..  . ..|.|  | .||..||..|||.....  . 
APETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNH--MPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase AqueK375.AA HMTK 403-561 41 5.5e-59 202.27 In-house 130-291 (291) Show / Hide 
Range on Protein: 403-561
Range on HMM: 130-291/291
Sequence Identity: 41% (68 aa)

LLSICLQIGKGMQYIAEKNLIHRDLAARNCMIDAVGNVKVADFGLSKDVS-GNIYFRQQMSSGVKLPIKWMAIESIE--DGIFTEKTDIWSFGITVWEVF
.|..| |. .||.|||.. ..|.|||||||..     ||.|||||.  .  |  |.... .. |||||||||.|     ..|| ||.|.|.||.|.||..
QLYFCVQCASGMAYIASQRMVHMDLAARNCLVGHNNQVKIADFGLTRRLDPGQDYWHLRKHM-VKLPIKWMAPEAMDGKRKIFSEKSDVWAFGVTMWEIW

NGGKTPYG--GFSPTCVKTMISDGYRLEAPSNSACNDDIYQKTMLKCWERDPNERPTFAQVVTD
  | .||.  ..    |  .. .|.||. |   .|.||...  | .||..||..||||||    
MYGEQPYESQQIKNKEVQRHVREGRRLTQPPPDDCPDDFWD-LMCTCWHKDPHQRPTFAQLQKM
Kinase AqueK375.AA TKL 290-562 21 6.4e-58 198.73 In-house 1-364 (364) Show / Hide 
Range on Protein: 290-562
Range on HMM: 1-364/364
Sequence Identity: 21% (81 aa)

IGQGEFAKVYKGHYYING------ECTLVAVKALKGIM-----------------------DRYNSNDIKDLIEESLVMKDLQHPNVMGLIGICLDAGP-
||.| |..||||..  .|       .. |||| .|                          |. .|   . ..|| ..|. |.|||.  ..|.|.. .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------SPLIVLPYMEGGSLFKYLVRNRNILMTSASTDDDEVINQVRSQLLSICLQIGKGMQYIAE--------KNLIHRDLAARNCMIDAVGN-
            . ||  |..||||. ||                       .|.....|.| .||.|           ...|||||  .|...|  .. 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTN

-------------VKVADFGLSKDVSGNIY---------------FRQQMSSGVKLPIKWMAIESIEDG----------------IFTEKTDIWSFGITV
             .|..|||||...|..                  . .... .   . ||| | ...                  ..||.|..||||  
VSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL

WEVFNGGKTPYGGFSPTCV---------KTMISDGYRLEAPSNSAC------NDDI---YQKTMLKCWERDPNERPTFAQVVTDI
||.. . .  |.  ... .         .  ...|.|.. |.   .      ..|.   . | | .||. ||..||.| ...  .
WEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK375.AA S_TKc 284-566 21 2.7e-41 144.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 284-566
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

LKLLDCIGQGEFAKVYKGHYYINGECTLVAVKALKGIMDRYNSNDIKDLIEESLVMKDLQHPNVMGLIGICLDAGPSPLIVLPYMEG--GSLFKYLVRNR
 ..|. ||.| |.||||..        .||.| .|           .... |  ..|  .|||.  |.... |   .  .|. |..|  |.||.|.....
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRG

N----ILMTSASTDDDEVINQVRSQLLSICLQIGKGMQYIAEKNLIHRDLAARNCMIDAVGNVKVADFGLSKDVSGNIYFRQQMSSGVKLPIKWMAIESI
       ..               .  ... || ....|. ... |||||   | ..|   ..|..||||.. .           . .     .|| | .
RHGLRFPFP-------------E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL

EDGIFTE-KTDIWSFGITVWEVFNGGKTPYGGFSPTCVKTMISDGYRLEAPSNSACNDDIYQKTMLKCWERDPNERPTFAQVVTDI-----DRLL
    ..  | |.||.|....| .  |..|.    .  .  .|               ..  .  . ||...||..|||  .. .|      .  .
---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK375.AA Pkinase 284-562 23 1.3e-37 134.11 Pfam 1-293 (293) Show / Hide 
Range on Protein: 284-562
Range on HMM: 1-293/293
Sequence Identity: 23% (75 aa)

LKLLDCIGQGEFAKVYKGHYYINGECTLVAVKALKGIMDRYNSNDIKDLI-EESLVMKDLQHPNVMGLIGICLDAGPSPLIVLPYMEGG----SLFKYLV
.... .||.| |..|||.|   .|.  .|||| .|   ..  . |. ..   |  .|| |.|||.  |.... | .... .|..|.|||    .|| |. 
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIS

RNRNILMTSASTDDDEVINQVRSQLLSICLQIGKGMQYIAEKNLIHRDLAARNCMIDAVGNV----KVADFGLSKDVSGNIYFRQQMSSGVKLPIKWMAI
.           ..  ..     .. ....|| .|..|. ... |||||   |..||  |..    |..||||.| ..   | ...  ...   . .|| 
T----------WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAP

ESIE-DGIFTEKTDIWSFGITVWEVFNGGKTPYGGF----SPTCVKTMISDGYRLEAPSNSACNDDIY--------------------QKTMLKCWERDP
| |  .   . | |.||.|....|... |..|. |     .  . . ||    . . ....   ..|.                    .. . .|...||
EVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP

NERPTFAQVVTD--I
..|||..|.. .  .
KKRPTAEQILQHPWF
Kinase AqueK375.AA HMTK 326-369 38 0.0035 7.06 In-house 65-107 (291) Show / Hide 
Range on Protein: 326-369
Range on HMM: 65-107/291
Sequence Identity: 38% (17 aa)

SNDIKDLIEESLVMKDLQHPNVMGLIGICLDAGPSPLIVLPYME
..|. .   |. ||  |.|||.  |.| |.   |  |.|| ||.
HEDREEFLREAEVMCQLRHPNLVQLVGVCMQQRPW-LCVLEYMQ