Gene AqueK353 (A.queenslandica)

AqueK353

Species: A.queenslandica
Alias: AqueK353
External Links:
Annotation:

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
AqueK353.AA Protein None 355 None Fasta, JSON
AqueK353.kin_dom Protein Kinase Domain None 148 None Fasta, JSON

Protein domain

Protein domains of AqueK353.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK353.AA Met 209-355 36 1.6e-44 143.72 In-house 1-136 (271) Show / Hide 
Range on Protein: 209-355
Range on HMM: 1-136/271
Sequence Identity: 36% (55 aa)

VVTPVLVTGEFGIVYRAFMTLKSDDMPQVVAIKTLK--GLFSKNDVHSFVEECITMSNFDDPNVLPLFGVCLDLGP-APCIIMPFMSRGSLLSYLKNERS
..  |.  | || ||.. . . .|     .|.|.|.       . .  | .| |.|. || |||| | |.|||     | .. |.|  | |... .|.  
HFDDVIGQGHFGCVYHGMY-HDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQN

NLTMTNVSDKDTVLNVRKQLLCICLQVAKGMSYLASQHFVHRDLAARNCM
|...             ..|.  |.||||||.|.|||.|||||||.||||
NPCV-------------RDLIEFCHQVAKGMMYMASQKFVHRDLACRNCM
Kinase AqueK353.AA Pkinase_Tyr 217-355 36 4.6e-44 149.87 Pfam 10-143 (270) Show / Hide 
Range on Protein: 217-355
Range on HMM: 10-143/270
Sequence Identity: 36% (52 aa)

GEFGIVYRAFMTLKSDDMPQVVAIKTLKGLFSKND--VHSFVEECITMSNF-DDPNVLPLFGVCLDLGPA--PCIIMPFMSRGSLLSYLKNERSNLTMTN
|.|| ||.. .. . |.  . ||.|.||   .. .    .| .|  .|... . ||.. | |||.| |    ..|.|..|  |.||.||.. |       
GAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR-------

VSDKDTVLNVRKQLLCICLQVAKGMSYLASQHFVHRDLAARNCM
  . .  |..   ||..|.|.||||.||.|....|||||||||.
--EDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCL
Kinase AqueK353.AA TK 208-355 19 3.8e-39 128.35 In-house 1-272 (486) Show / Hide 
Range on Protein: 208-355
Range on HMM: 1-272/486
Sequence Identity: 19% (52 aa)

YVVTPVLVTGEFG---IVYRAFMTLKS---------------------DDMPQVVAIKTLKGL--FSKNDVHS-----------FVEECITMSNFD----
 ..  .|  |.||    ||.. .  ..                     .. .. ||.|.||     |... .            | ||.  |. ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-DPNVLPLFGVCLDLG-----------PAPCIIMPFMSRGS----LLSYLKNER---------------------------------SNLTMTNVSDKDT
  ||.. |.|||.. .           . ..|.| .|. |.    |..||.. |                                 .. .. . .....
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

VLNV----------RKQLLC-------------------ICLQVAKGMSYLASQ------HFVHRDLAARNCM
...            |.||.                   .|.|.|.||.||.|.      .|||||||||||.
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCL
Kinase AqueK353.AA UTK 217-354 36 2.5e-34 114.87 In-house 10-149 (296) Show / Hide 
Range on Protein: 217-354
Range on HMM: 10-149/296
Sequence Identity: 36% (54 aa)

GEFGIVYRAFMTLKSDDMPQ-VVAIKTLK-GLFSKNDVH---SFVEECI---TMSNFD-DPNVLPLFGVCLDLGPAPCIIMPFMSRGSLLSYLKNERSNL
|.||.|..|  |  |. |.. .||.|... . ..  .      | ||.     |..|.  |||| | |||.. .| ..|.. .|..|.|.||| . | ..
GAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRSYLRRHRPTP

TMTNVSDKDTVLNVRKQLLCICLQVAKGMSYLASQHFVHRDLAARNC
      . .. |. . |.|| ....| ||.||.|..|||||||||||
P-----ACPHWLTLH-QRLCMAWDIARGMQYLHSCGFVHRDLAARNC
Kinase AqueK353.AA TK-Unique 208-355 30 2e-33 112.65 In-house 1-165 (294) Show / Hide 
Range on Protein: 208-355
Range on HMM: 1-165/294
Sequence Identity: 30% (51 aa)

YVVTPVLVTGEFGIVYRAFMTL--KSDDMPQVVAIKTLKGLFSKNDVHSFVEECITMSNFD-DPNVLPLFGVCLDLGPAPCIIMPFMSRGSLLSYLKNER
 .|  |. .|.|| |.|. ..   |..| ...||.|.||  ... |.  |  |   |.. .  ||.. ..|.| . .  ..|||.....|.|..||.. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

S---------NLTMTNVSDKDTVLN--VR-KQLLCICLQVAKGMSYLAS--QHFVHRDLAARNCM
          || ..  ...|....  .  |.|. .. |.|.||.||||  ...|||||.|||..
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVL
Kinase AqueK353.AA Axl 208-355 35 3.5e-27 93.18 In-house 1-145 (267) Show / Hide 
Range on Protein: 208-355
Range on HMM: 1-145/267
Sequence Identity: 35% (55 aa)

YVVTPVLVTGEFGIVYRAFMTLKSDD-MPQVVAIKTLK-GLFSKNDVHSFVEECITMSNFDDPNVLPLFGVCLDLG-----PAPCIIMPFMSRGSLLSYL
 |.  .|  |||| |  .   || .|   . ||.|..|   ... ..  |. | . | .|| |||. | |||. .      |.| .|.|||  | | ..|
FVLGKMLGEGEFGSVMEG--QLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFL

KNERSNLTMTNVSDKDTVLNVRKQLLCICLQVAKGMSYLASQHFVHRDLAARNCM
   |       . |.   | . . |.   . .| || ||....|.||||||||||
LYSR-------LGDQPFYLPL-QMLVKFMVDIACGMEYLSNRNFIHRDLAARNCM
Kinase AqueK353.AA ALK 210-354 34 1.2e-24 81.96 In-house 3-142 (273) Show / Hide 
Range on Protein: 210-354
Range on HMM: 3-142/273
Sequence Identity: 34% (50 aa)

VTPVLVTGEFGIVYRAFMTL-KSDDMPQVVAIKTLKGLFSKNDVHSFVEECITMSNFDDPNVLPLFGVCLDLGPAPCIIMPFMSRGSLLSYLKNERSNLT
   .|  | || || .  .    |  |  ||.|||. . |. |   |  |   |..|...||  . |.|..  |   |.  .|. | ..|.|.  | .  
LVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPY-MIVLEYMEGGDMKSFLRECRPHPE

MTNVSDKDTVLNVRKQLLCICLQVAKGMSYLASQHFVHRDLAARNC
  . |     . . | || .|. ||.|  || ..||.||| |||||
SLQPS-----QLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNC
Kinase AqueK353.AA Tec 216-354 33 4e-23 77.69 In-house 9-128 (254) Show / Hide 
Range on Protein: 216-354
Range on HMM: 9-128/254
Sequence Identity: 33% (48 aa)

TGEFGIVYRAFMTLKSDDMPQVVAIKTLK-GLFSKNDVHSFVEECITMSNFDDPNVLPLFGVCLDLGPAPCIIMPFMSRGSLLSYLKNERSNLTMTNVSD
.| ||.| ..  . . |     ||||..| |  |  |   |.||  .| .   |.   |.|||.   |  .|.  .|..|.||.||. ..  .       
SGQFGVVHLGKWRHQYD-----VAIKMIKEGSMSEED---FIEEAKVMMKLSHPKLVQLYGVCSQQRPI-YIVTEYMEHGCLLNYLREHKHHFQ------

KDTVLNVRKQ--LLCICLQVAKGMSYLASQHFVHRDLAARNC
       ...  || .|..| .|| || .. |.|||||||||
-------KNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNC
Kinase AqueK353.AA InsR 217-355 31 7e-23 73.61 In-house 10-151 (278) Show / Hide 
Range on Protein: 217-355
Range on HMM: 10-151/278
Sequence Identity: 31% (47 aa)

GEFGIVYRAFMTLKSDDMPQV---VAIKTLKGLFSKNDVHSFVEECITMSNFDDPNVLPLFGVCLDLGPAPCIIMPFMSRGSLLSYLKNERSNLTMTNVS
| || ||        .|..     .||||..   |  .   |  |   | .|.  .|  |.|||    |.  ..| .| .| | |||   |         
GSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPM-YVVMEMMTYGDLKSYLRSRRPEEEF----

DKDTVLN------VRKQLLCICLQVAKGMSYLASQHFVHRDLAARNCM
  ....|       . |..    ... ||.|||.  |||||||.||||
-NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCM
Kinase AqueK353.AA Sev 235-354 40 7e-23 72.91 In-house 30-145 (277) Show / Hide 
Range on Protein: 235-354
Range on HMM: 30-145/277
Sequence Identity: 40% (50 aa)

PQVVAIKTLKGLFSKNDVHSFVEECITMSNFDDPNVLPLFGVCLDLGPAPCIIMPFMSRGSLLSYLKNERSNLTMTNVSDKD-----TVLNVRKQLLCIC
.| ||||||.      .   |  |   ||.|  ||.. . |||||  |   |||  |  | ||.||   |    ||   .       | .     |. .|
EQRVAIKTLRKGSTDQEKQEFLKEAHLMSKFKHPNIVCQMGVCLDNEPQ-YIIMEHMEGGDLLCYLRAAR----MTTFQNPQPTAGLTLMD----LVEMC

LQVAKGMSYLASQHFVHRDLAARNC
. ..|| .||   ||||||||.|||
IDISKGCEYLEDMHFVHRDLACRNC
Kinase AqueK353.AA TKL 214-349 24 2.5e-22 77.22 In-house 1-166 (364) Show / Hide 
Range on Protein: 214-349
Range on HMM: 1-166/364
Sequence Identity: 24% (45 aa)

LVTGEFGIVYRAFMTL-----KSDDMPQVVAIKTLKG----LFSKND---------------------VHSFVEECI-TMSNFDDPNVLPLFGVCLDLGP
.  | ||.||..         .| |. ..||.|..|     .|.||.                        | || |  ||... ||.... |.|.. ..
IGSGGFGEVYKGKWRGWGGKCPS-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

A------------PCIIMPFMSRGSLLSYLKNERSNLTMTNVSDKDTVLNVRKQLLCICLQVAKGMSYLASQH--------FVHRDL
             .||.| ....||||.||                       |.. ..|..|.||.|| |..         .||||
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDL
Kinase AqueK353.AA TyrKc 208-355 16 3.7e-10 -58.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 208-355
Range on HMM: 1-280/280
Sequence Identity: 16% (50 aa)

YVVTPVLVTGEFGIVYRAFMTLKSDDMPQVVAIKTLK-GLFSKNDVHSFVEECITMSNF--DDPNVLPLFGVCLDLG------PAPCIIMPFMSRGSLLS
 .   .|  |.||.||.. ..       . ||.|.|| .      .  | .|   |...  . ||.. |.|||.. |      . ..|.| .|. |.|..
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLKNERSNLTMTNVSDKDTVLNVRKQLLCICLQVAKGMSYLASQHFVHRDLAARNC--------------------------------------------
||.. | .            |.. |.|| .|.|.|.||.||.|....|||||||||                                            
YLRKHRPK------------LCM-KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML

----------------------------------------------------------------------------------------------------
                                                                                                    
PIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE

----M
    .
IHECF
Kinase AqueK353.AA Pkinase 208-349 19 4e-10 36.87 Pfam 1-134 (293) Show / Hide 
Range on Protein: 208-349
Range on HMM: 1-134/293
Sequence Identity: 19% (30 aa)

YVVTPVLVTGEFGIVYRAFMTLKSDDMPQVVAIKTLKGLFSKNDVH--SFV--EECITMSNFDDPNVLPLFGVCLDLGPAPCIIMPFMSRG----SLLSY
|..  ..  | || ||..     ..    .||.|..|    | ...   .   | .| | ... ||.. |.... | .. ....|...  |    .| .|
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQI-MKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDY

LKNERSNLTMTNVSDKDTVL--NVRKQLLCICLQVAKGMSYLASQHFVHRDL
..            ......     ... ....|...|. |. |. ..||||
IST-----------WRHGCFYFS-EWECKFYMYQILRGLEYCHSMGIIHRDL
Kinase AqueK353.AA S_TKc 208-355 11 0.000153 -110.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 208-355
Range on HMM: 1-231/231
Sequence Identity: 11% (29 aa)

YVVTPVLVTGEFGIVYRAFMTLKSDDMPQVVAIKTLKGLFSKNDVHSFVEECITMSNFDDPNVLPLFGVCLDLGPAPCIIMPFMSR--GSLLSYLKNERS
| .  ..  | || ||..  .       ..|||| .|         ..  |   ... . ||.  |..|. |     ...| ...   |.|..|.|. ..
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGR

N-----LTMTNVSDKDTVLNVRKQLLCICLQVAKGMSYLASQHFVHRDL----------------------------------------A----------
.     ..   .              ... |..... |. |....||||                                                   
HGLRFPFPE-HAR-------------FYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGC

------------------------------------------------A-------RNCM
                                                .          .
ILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF