Gene AqueK349 (A.queenslandica)

AqueK349

Species: A.queenslandica
Alias: AqueK349
External Links:
Annotation:

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
AqueK349.AA Protein None 129 None Fasta, JSON
AqueK349.kin_dom Protein Kinase Domain None 129 None Fasta, JSON

Protein domain

Protein domains of AqueK349.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK349.AA Met 1-129 37 1.2e-42 137.41 In-house 2-136 (271) Show / Hide 
Range on Protein: 1-129
Range on HMM: 2-136/271
Sequence Identity: 37% (53 aa)

VLSIIKIGEFGIVYRALLAT----GKDVAVKTLK------GIIVASIVEESLIMSNFDHPNVLSLIGVSLDLGP-APCIIMPFMSRGSLLSYLKNDRLNI
.. .|  | || ||.. .         .|.|.|.         .    .| ..|. |||||||||||..||     | .. |.|  | |... .|   |.
FDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQNNP

TITDGKDEEILSICLQVANGMCYLASQYFVHRDLAARNCM
.. |      .. |.||| || |.||| |||||||.||||
CVRD-----LIEFCHQVAKGMMYMASQKFVHRDLACRNCM
Kinase AqueK349.AA Pkinase_Tyr 8-129 35 1.3e-41 141.55 Pfam 10-143 (270) Show / Hide 
Range on Protein: 8-129
Range on HMM: 10-143/270
Sequence Identity: 35% (50 aa)

GEFGIVYRALLA-----TGKDVAVKTLKGIIVAS------IVEESLIMSNF-DHPNVLSLIGVSLDLGPA--PCIIMPFMSRGSLLSYLKND---RLNIT
|.|| ||.. .      |. .||||.||     .        .|  ||... .|||...|.|| .| |    ..|.|..|  |.||.||..    . ..|
GAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLT

ITDGKDEEILSICLQVANGMCYLASQYFVHRDLAARNCM
.     ...|..|.|.|.|| ||.|. ..|||||||||.
M-----KDLLQMCWQIAKGMEYLESKNCIHRDLAARNCL
Kinase AqueK349.AA TK 8-129 18 7.9e-37 120.46 In-house 10-272 (486) Show / Hide 
Range on Protein: 8-129
Range on HMM: 10-272/486
Sequence Identity: 18% (48 aa)

GEFG---IVYRALLATGK--------------------------DVAVKTLKGIIVASIVEESL-----------------IMSNFD-----HPNVLSLI
|.||    ||.... ...                          .||||.||    .|  |. .                 .|. ..     |||...|.
GQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLY

GVSLDLG-----------PAPCIIMPFMSRGS----LLSYLKNDRLNITITDGKDE--------------------------------------------
||... .           . ..|.| .|. |.    |..||.. | . .    . .                                            
GVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHP

--------------------------EILSICLQVANGMCYLASQ------YFVHRDLAARNCM
                          . | .|.|.|.|| ||.|.       |||||||||||.
PPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCL
Kinase AqueK349.AA UTK 8-128 34 6.5e-32 106.47 In-house 10-149 (296) Show / Hide 
Range on Protein: 8-128
Range on HMM: 10-149/296
Sequence Identity: 34% (50 aa)

GEFGIVYRALLATGK------DVAVKTLKGIIVAS----------IVEESL---IMSNFD-HPNVLSLIGVSLDLGPAPCIIMPFMSRGSLLSYLKNDRL
|.||.|..| . . .      |||||...    |.          . ||.    .|..|. ||||| |.|| .. .| ..|.. .|..|.|.||| . | 
GAFGEVHKARFTQCSEHMYEMDVAVKVCQ--HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRSYLRRHRP

--NITITDGKDEEILSICLQVANGMCYLASQYFVHRDLAARNC
  ..  .  .... |. ....|.|| ||.|. |||||||||||
TPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNC
Kinase AqueK349.AA TKL 5-123 23 4e-28 98.37 In-house 1-166 (364) Show / Hide 
Range on Protein: 5-123
Range on HMM: 1-166/364
Sequence Identity: 23% (42 aa)

IKIGEFGIVYRALLAT---------GKDVAVKTLKGI------------------------------IVASIVEESLIMSNFDHPNVLSLIGVSLDLGPA
|  | ||.||.. .           |||||||..|                                .   ..|| ..||...|||.....|.... .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PCIIMPFMSRGSLLSYLKNDRLNITITDGKDEEILSICLQVANGMCYLASQY--------FVHRDL
            .||.| ....||||.||              . .....|..| ||.|| |.          .||||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDL
Kinase AqueK349.AA Axl 1-129 35 1.2e-24 84.14 In-house 3-145 (267) Show / Hide 
Range on Protein: 1-129
Range on HMM: 3-145/267
Sequence Identity: 35% (51 aa)

VLSIIKIGEFGIVYRALLATGK----DVAVKTLKGIIVAS-----IVEESLIMSNFDHPNVLSLIGVSLDLG-----PAPCIIMPFMSRGSLLSYLKNDR
.  ..  |||| |  . |         ||||..|  |...      . |   | .||||||. ||||.. .      |.| .|.|||  | | ..|   |
LGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLYSR

LNITITDGKDEEILSICLQVANGMCYLASQYFVHRDLAARNCM
|.      .   ..   . .| || ||... |.||||||||||
LGDQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCM
Kinase AqueK349.AA TK-Unique 1-129 28 1.7e-24 81.43 In-house 3-165 (294) Show / Hide 
Range on Protein: 1-129
Range on HMM: 3-165/294
Sequence Identity: 28% (47 aa)

VLSIIKIGEFGIVYRALLAT-----GKD--VAVKTLK-GIIVAS---IVEESLIMSNFD-HPNVLSLIGVSLDLGPAPCIIMPFMSRGSLLSYLKNDRLN
|...|  |.|| |.|. . .     .|.  ||||.|| .    .      |  .|.. . |||.....|.. . .  ..|||.....|.|..||.. | .
VGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPA

--------------ITITDGKDEEILS------ICLQVANGMCYLAS--QYFVHRDLAARNCM
               . .|.. .| .|      .. |.|.|| ||||  . .|||||.|||..
MRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVL
Kinase AqueK349.AA Csk 1-127 37 8.1e-23 74.72 In-house 3-127 (251) Show / Hide 
Range on Protein: 1-127
Range on HMM: 3-127/251
Sequence Identity: 37% (49 aa)

VLSIIKIGEFGIVYRALLATGKDVAVKTLKGI---IVASIVEESLIMSNFDHPNVLSLIGVSLDLGPAPCIIMPFMSRGSLLSYLKNDRLNITITDGKDE
... |  |||| |    .  .. |||| .|.     . ... |  .|    |||   |||| |. .    |.| .||.|.|. ||   |    ||    .
LGECIGHGEFGDVMQGEYQ-NRKVAVKCIKCDGNGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRS-RGRHVIT---RR

EILSICLQVANGMCYLASQYFVHRDLAARN
. |   . |..||||| .  ||||||||||
QLLKFAMDVCEGMCYLEQKKFVHRDLAARN
Kinase AqueK349.AA Tec 2-128 32 1.1e-22 76.18 In-house 1-128 (254) Show / Hide 
Range on Protein: 2-128
Range on HMM: 1-128/254
Sequence Identity: 32% (44 aa)

LSIIK---IGEFGIVYRALLATGKDVAVKTLK--GIIVASIVEESLIMSNFDHPNVLSLIGVSLDLGPAPCIIMPFMSRGSLLSYLKNDRLNITITDGKD
| ..|    | ||.| .. .    |||.|..|         .||  .| .  ||.   | || .   |  .|.  .|..|.||.||.  .        . 
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPI-YIVTEYMEHGCLLNYLREHKHHF-----QK

EE--ILSICLQVANGMCYLASQYFVHRDLAARNC
.    |..|..|  || || .. |.|||||||||
NMAILLEMCQDVCEGMAYLERHCFIHRDLAARNC
Kinase AqueK349.AA Src 8-127 36 1.4e-21 70.09 In-house 10-127 (255) Show / Hide 
Range on Protein: 8-127
Range on HMM: 10-127/255
Sequence Identity: 36% (45 aa)

GEFGIVYRALLATGKDVAVKTLKG--IIVASIVEESLIMSNFDHPNVLSLIGVSLDLGPAPCIIMPFMSRGSLLSYLKNDRLNITITDGK---DEEILSI
| || |. ..     .|||||||     ..   .|  || ...|.....|  |  .  |   |.  .||.|||| |||.       ..|.    .. ...
GQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPI-YIVTEYMSHGSLLDYLKK------DGEGRHLHLPQLIDM

CLQVANGMCYLASQYFVHRDLAARN
  |||.||.|| |. ..||||||||
AAQVAEGMAYLESMNYIHRDLAARN
Kinase AqueK349.AA Syk 22-127 34 5.9e-20 65.36 In-house 32-136 (257) Show / Hide 
Range on Protein: 22-127
Range on HMM: 32-136/257
Sequence Identity: 34% (39 aa)

KDVAVKTLK--GIIVA---SIVEESLIMSNFDHPNVLSLIGVSLDLGPAPCIIMPFMSRGSLLSYLKNDRLNITITDGKDEEILSICL-QVANGMCYLAS
..||.|.||  . . |    .. |  .|   ||| .  .||.   ....   .|   . |... ||...|  ||     .  .| .   ||| ||||| .
IKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGIC--HAEMMMMVMEMAELGPMHKYLQQHRHEIT-----ANNVLELWHTQVAMGMCYLEE

QYFVHRDLAARN
. ||||||||||
KHFVHRDLAARN
Kinase AqueK349.AA Pkinase 8-123 25 1.1e-15 56.5 Pfam 10-134 (293) Show / Hide 
Range on Protein: 8-123
Range on HMM: 10-134/293
Sequence Identity: 25% (32 aa)

GEFGIVYRALLATGKD-VAVKTLKGIIVASIVE-------ESLIMSNFDHPNVLSLIGVSLDLGPAPCIIMPFMSRG----SLLSYLKNDRLNITITDGK
| || ||..      . ||||..|     | ..       |  || ...|||.. |...  | .. ....|...  |    .| .|..  . . ... . 
GSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST-WRHGCFY-FS

DEEILSICLQVANGMCYLASQYFVHRDL
..|. ....|.. |. |. |. ..||||
EWECKFYMYQILRGLEYCHSMGIIHRDL
Kinase AqueK349.AA TyrKc 2-129 17 2.4e-10 -55.43 SMART 1-280 (280) Show / Hide 
Range on Protein: 2-129
Range on HMM: 1-280/280
Sequence Identity: 17% (49 aa)

LSIIKI---GEFGIVYRALLATGKDVAVKTLKGIIVASIVEESLIMSNF--DHPNVLSLIGVSLDLG------PAPCIIMPFMSRGSLLSYLKNDRLNIT
.. .|.   |.||.||.. .    .||||.||   .. . .|  ||...  .|||.. |.|| .. |      . ..|.| .|. |.|..||.. | .  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

ITDGKDEEILSICLQVANGMCYLASQYFVHRDLAARNC--------------------------------------------------------------
    . .. ||.|.|.|.|| ||.|. ..|||||||||                                                              
---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

--------------------------------------------------------------------------------------M
                                                                                      .
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK349.AA S_TKc 1-129 13 2.3e-05 -98.31 SMART 3-231 (231) Show / Hide 
Range on Protein: 1-129
Range on HMM: 3-231/231
Sequence Identity: 13% (33 aa)

VLSIIKIGEFGIVYRALLAT-GKDVAVKTLKGIIVASIVEESLIMSNFDHPNVLSLIGVSLDLGPAPCIIMPFMSR--GSLLSYLKNDRLNITITDGKDE
.| .|  | || ||..     |. ||.| .|     .|  |  |... .|||.  |..|  |     ...| ...   |.|..|.|. . . .       
ILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

EILSICLQVANGMCYLASQYFVHRDL----------------------------------------A---------------------------------
.. ... |..... |. |. ..||||                                                                          
HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG

-------------------------A-------RNCM
                         .          .
SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF