Gene AqueK338 (A.queenslandica)
AqueK338
Species: A.queenslandica
Alias: AqueK338
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| AqueK338.AA | Protein | None | 924 | None | Fasta, JSON |
| AqueK338.kin_dom | Protein Kinase Domain | None | 86 | None | Fasta, JSON |
Protein domains of AqueK338.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| IG | AqueK338.AA | IG | 47-111 | 17 | 0.286569 | 1.98 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 47-111 Range on HMM: 1-58/58 Sequence Identity: 17% (13 aa) SSDYTIISGSKVS-NIVYNPNSDDEGYVWWNSSLLLNPINNSTV---GYYYCRANTSFGLMYSK----PVYVR .. .| |. |. . .. ..|| | . .. . | |||.|. . .|.. ..|. PP-VTVKEGETVTLTC-VS-------QIWWY--LTI-NVQPEDSQQHGTYYCQAT---HGQYWSIQGTTLTVQ |
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| IG | AqueK338.AA | IG | 231-327 | 14 | 4.5e-08 | 34.05 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 231-327 Range on HMM: 1-58/58 Sequence Identity: 14% (15 aa) PENIAAYENENIIITVKVIRAHPPVLPDHISWTHTTSYGSASLNQSIEEGYDSRVNISENGRSLYISDLTSDDE---GYYQVLIWHPAGYKNK--TTYLK |. . . | |.. .| | .|.|. | | ... .|. | |. . .| . . .|.|. PP-VTVKEGETVTLTC-VS---------QIWWY------------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLT IN . VQ |
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| V-set | AqueK338.AA | V-set | 225-326 | 16 | 1e-06 | 24.51 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 225-326 Range on HMM: 1-128/128 Sequence Identity: 16% (21 aa) APEIEL--PE----NIAAYENENIIITVKVI-RAHPPVLPDHISWTH-TTS-------------YGSASLNQSIEEGYDSRVNISENGR----SLYISDL . ... |. . . | ... .. .. ... . .|.| .. | . . .. .. . || .| |.. || ||.| QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL TSDDEGYYQVLIWHP-AGYKNKTTYLKI ...|.| | .|.. .| . | | . QPSDSGTYYCAVWNCNEDYFGHGTRLTV |
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| Pkinase_Tyr | AqueK338.AA | Pkinase_Tyr | 430-515 | 33 | 1.2e-24 | 84.08 | Pfam | 1-90 (270) | Show / Hide |
Range on Protein: 430-515 Range on HMM: 1-90/270 Sequence Identity: 33% (31 aa) LKILDCVGQGEFAKVYKGHYY--IDSQCITVAVKALKGTLDRYSSES--MKELIEESLVMKDL-QHPNVMGLIGICL-DAGP-SPLIVLPYME .... |.|.| .||||... |...|.|||| || . ...| ......| .|| | .|||. |.|.|. . .| ...||..||. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK---EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMP |
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| Kinase | AqueK338.AA | Met | 431-515 | 37 | 1.9e-23 | 73.51 | In-house | 1-86 (271) | Show / Hide |
Range on Protein: 431-515 Range on HMM: 1-86/271 Sequence Identity: 37% (34 aa) KILDCVGQGEFAKVYKGHYYI-DSQCITVAVKALK----GTLDRYSSESMKELIEESLVMKDLQHPNVMGLIGICLDAGP-SPLIVLPYME .| .||| | ||.| | |.. . .|.| |. ... | . .| ..||...|||| ||||||| .|..|||||. HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHIS-----QFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMK |
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| Kinase | AqueK338.AA | TK | 430-515 | 21 | 4e-20 | 63.46 | In-house | 1-138 (486) | Show / Hide |
Range on Protein: 430-515 Range on HMM: 1-138/486 Sequence Identity: 21% (29 aa) LKILDCVGQGEFA---KVYKGHYYIDS-----------------------QCITVAVKALKGTLDRYSSESMK-------------ELIEESLVMKD--L ..... |.|.| .|||| .. .. ....|||| || . . . | . |. || .|. . ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG QHPNVMGLIGICLDAGPS-----------PLIVLPYME .|||. |.|.|.. .|. ..||. ||. HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMP |
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| Kinase | AqueK338.AA | UTK | 430-515 | 29 | 4.4e-20 | 65.41 | In-house | 1-93 (296) | Show / Hide |
Range on Protein: 430-515 Range on HMM: 1-93/296 Sequence Identity: 29% (28 aa) LKILDCVGQGEFAKVYKGHYYIDS---QCITVAVKALKGTLDRYSSESMK---ELIEESL---VMKDLQ-HPNVMGLIGICLDAGPSPLIVLPYME ...... |||.| |.|... .| . ||||... . . .. ...||. .|| .. ||||..|.|.|.. .| ..||. ||| VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ--HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYME |
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| Kinase | AqueK338.AA | TKL | 436-515 | 21 | 2e-16 | 55.68 | In-house | 1-121 (364) | Show / Hide |
Range on Protein: 436-515
Range on HMM: 1-121/364
Sequence Identity: 21% (26 aa)
VGQGEFAKVYKGHYYIDS------QCITVAVKALKGTL-----------------------DRYSSESMKELIEESLVMKDLQHPNVMGLIGICLDAGP-
.|.| |..||||.. . . .|||| .| . |. .| .....|| ..|. |.|||. ..|.|.. ..
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
-----------SPLIVLPYME
. || |..
CVCMHPVGPWGQLCIVMEYCP
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| Kinase | AqueK338.AA | Axl | 430-514 | 32 | 1.1e-14 | 48.3 | In-house | 1-89 (267) | Show / Hide |
Range on Protein: 430-514 Range on HMM: 1-89/267 Sequence Identity: 32% (30 aa) LKILDCVGQGEFAKVYKGHYYIDS-QCITVAVKALKGTLDRYSSESMKELIEESLVMKDLQHPNVMGLIGICLDAG-----PSPLIVLPYM . . .|.||| | |. . . |||| .| .| .. . | . | ||. .||||| |||.|. . | |...||.| FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMK--IDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFM |
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| Kinase | AqueK338.AA | TKL-Unique | 432-515 | 30 | 5.7e-13 | 42.23 | In-house | 1-83 (290) | Show / Hide |
Range on Protein: 432-515 Range on HMM: 1-83/290 Sequence Identity: 30% (27 aa) ILDCVGQGEFAKVYKGHYYIDSQCITVAVKALKGTLDRYSSESMKELIEESLVMKDLQ-HPNVMGLIGICLDAGPSPL---IVLPYME .. .|.|....|||| . .. ||.| .. . |.|.|.|...| .|| |. |||. ..|.| | ..| ||. |.. FWNKIGEGGYGQVYKGKWRGYP----VAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCP |
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| Kinase | AqueK338.AA | EGFR | 430-501 | 29 | 7.2e-13 | 38.89 | In-house | 1-71 (258) | Show / Hide |
Range on Protein: 430-501 Range on HMM: 1-71/258 Sequence Identity: 29% (21 aa) LKILDCVGQGEFAKVYKGHYYIDSQCITVAVKALKGTLDRYSSESMKELIEESLVMKDLQHPNVMGLIGICL || . | | | .|||| .. . . . . | | | . . .. .|...| .|| ..||... |.|.|. LKKVKVLGSGAFGTVYKGIWIPEGENVKIPV-AIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCM |
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| Kinase | AqueK338.AA | Pkinase | 430-515 | 28 | 1.5e-12 | 45.49 | Pfam | 1-83 (293) | Show / Hide |
Range on Protein: 430-515 Range on HMM: 1-83/293 Sequence Identity: 28% (26 aa) LKILDCVGQGEFAKVYKGHYYIDSQCITVAVKALKGTLDRYSSESMKELIE-----ESLVMKDLQHPNVMGLIGICLDAGPSPLIVLPYME ..|. ..|.| |..|||.| ... .|||| .| ...|....... | .|| |.|||. |.... | .... .|..|.| YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIK-----KRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCE |
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| Kinase | AqueK338.AA | Ror | 430-501 | 30 | 1.6e-12 | 46.29 | In-house | 1-72 (308) | Show / Hide |
Range on Protein: 430-501 Range on HMM: 1-72/308 Sequence Identity: 30% (23 aa) LKILDCVGQGEFAKVYKGHYYIDS---QCITVAVKALKGTLDRYSSESMKELIEESLVMKDLQHPNVMGLIGICL .. . | . | ||||||.. .|..||.|..| . | ... | .| .|.|||. |.|.|. VRFMEELGECQFGKVYKGHLMGPNFMYHCMAVAIKTCK---HDASPAQWQDFRQEIMLMATLHHPNIVCLLGVCT |
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| Kinase | AqueK338.AA | ALK | 430-515 | 34 | 8.8e-12 | 36.95 | In-house | 1-85 (273) | Show / Hide |
Range on Protein: 430-515 Range on HMM: 1-85/273 Sequence Identity: 34% (31 aa) LKILDCVGQGEFAKVYKGHYYI---DSQCITVAVKALKGTLDRYSSESMKELIEESLVMKDLQHPNVMGLIGICLDAGPSPLIVLPYME .. . |.| | || | | || . ||.| |. | .. | |.| .|.|| .||||... | .||| ||| ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLP---EDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPY-MIVLEYME |
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| Kinase | AqueK338.AA | STE | 430-515 | 18 | 6e-11 | 35.01 | In-house | 1-120 (359) | Show / Hide |
Range on Protein: 430-515 Range on HMM: 1-120/359 Sequence Identity: 18% (22 aa) LKILDCVGQGEFAKVYKGHYYI-----DSQCI--------TVAVKALKGTLDRYSS---------------ESMKELIEESLVMKDLQ--HPNVMGLIGI .......|.| | .|||. . ... . .|.| .. |.. .. | |.....| .||... |||. .| WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMN--LENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC CLDAGP------SPLIVLPYME ... |. . |.. ||. YFKEGHNHKNDDELWICMEYMD |
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| Kinase | AqueK338.AA | TyrKc | 430-658 | 14 | 2.5e-07 | -104.18 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 430-658 Range on HMM: 1-280/280 Sequence Identity: 14% (50 aa) LKILDCVGQGEFAKVYKGHYYIDSQCITVAVKALKGTLDRYSSESMKELIEESLVMKDL--QHPNVMGLIGICLDAG------PSPLIVLPYMEVPVILQ .. .. | |.| .||||... |.|||| || ......| .|. | .|||. |.|.|.. | . ..||. ||. |. ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLK NPFLYYLDYKTVYVNCSVYGESPFEVSW--------------------------------LYSTDE------------ISNR-----SSDYTIIS---GS . .| . | ... |.. . | . |.|| . |. D-YLRKHRPK---------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG K------------VSNIVYSPNSD---------------DEGYVW-----WNSSLLLNPINNSTAGYYYCRVNT----SFGLNYSKPVYVRSTYLPRLNS | .... || .. | . . . |.. .||. . | KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEV---IEYVKQGYRMPQPPNDYPMS--------------------- TRFVKSGQAYVNFLAL----------SFTERKVTF || .. . .|.| . | --FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | AqueK338.AA | IGc2 | 528-614 | 13 | 0.000113 | 19.68 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 528-614 Range on HMM: 1-56/56 Sequence Identity: 13% (12 aa) LDYKTVYVNCSVYGESPFEVSWLYSTDEISNRSSDYTIISGSKVSNIVYSPNSDDEGYVWWNSSLLLNPINNSTAGYYYCRVNTSFG . .| .| . | ...|.. ... ||..| . .. . .||| |.. . | HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------------------------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| Kinase | AqueK338.AA | S_TKc | 430-622 | 11 | 0.000608 | -119.1 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 430-622
Range on HMM: 1-231/231
Sequence Identity: 11% (33 aa)
LKILDCVGQGEFAKVYKGHYYIDSQCITVAVKALKGTLDRYSSESMKELIEESLVMKDLQHPNVMGLIGICLDAGPSPLIVLPYMEV------PVILQNP
.||. .|.| |.||||.. ||.| .| . .. | ..| .|||. |.... | . .|. |.. .| ...
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRG
F---------------------LYYLDYKTV------------------------------------------YVNC--------------SVYGESPFE
| |. . . .. ..|. ||.
RHGLRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP
VSWLYSTDEISNRSSDYTIISGSKVSNIVYSPNSDDEGYVWWNSSLLLNPINNSTAGYYYCRVNTSFGLNYS-----KPVY
... .. |. ... |.. | |.. |
-----QMQMMFKKIG----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | AqueK338.AA | IG | 522-626 | 11 | 0.001677 | 18.88 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 522-626 Range on HMM: 1-58/58 Sequence Identity: 11% (13 aa) NPFLYYLDYKTVYVNCSVYGESPFEVSWLYSTDEISNRSSDYTIISGSKVSNIVYSPNSDDEGYVWWNSSLLLNPINNSTA---GYYYCRVNTSFGLNYS | .. || .| | ...|. | . .. . . | |||... | .| PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWS -KPVYVRST ...... . IQGTTLTVQ |
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| IGc2 | AqueK338.AA | IGc2 | 799-885 | 16 | 0.000283 | 15.87 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 799-885 Range on HMM: 1-56/56 Sequence Identity: 16% (14 aa) LDYKTVHVNCSVYGESPFEVSWLYSTDEISNRSSDYTIISGSKVSNIVYSPNSDDEGYVWWNSSLLLNPINNLTVGYYYCRANNSFG . .| .| . | ...|.. ... ||..| . .. ||| |.| |. | HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------------------------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| IG | AqueK338.AA | IG | 744-897 | 10 | 0.027845 | 10.76 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 744-897
Range on HMM: 1-58/58
Sequence Identity: 10% (16 aa)
PEASTYVPGETLTQKCSARSLYPMTVTWQESEFLFPIKDKIDSRPVIFQDPFLYYLDYKTVHVNCSVYGESPFEVSWLYSTDEISNRSSDYTIISGSKVS
|. | ..|||.| .| . ...|
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------------------------------------------------------
NIVYSPNSDDEGYVWWNSSLLLNPINNLTV---GYYYCRANNSFGLMYS-KPVYIRKT
| . .. | |||.|. | .| ...... .
-------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
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