Gene AqueK314 (A.queenslandica)

AqueK314

Species: A.queenslandica
Alias: AqueK314
External Links:
Annotation:

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
AqueK314.AA Protein None 219 None Fasta, JSON
AqueK314.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of AqueK314.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK314.AA Pkinase_Tyr 3-218 40 9.90000000001e-106 358.71 Pfam 29-253 (270) Show / Hide 
Range on Protein: 3-218
Range on HMM: 29-253/270
Sequence Identity: 40% (92 aa)

IEVAVKVLSDEADEND--KIRFLQEAALMGQF-THTNVLTLHGVVSSEDTT--IMIVIELMKGGDLRHWLMKR-KREKSYQANILLNFCRQICLGMCYLS
|.||||.| . |.. .  .  |..||..| |.  | |.. |.||.....    |.|| |.|..|||.. | |.   ...     ||..|.||. || ||.
IPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE

SRKFVHRDLAARNILVTHDNICKISDFGMSRDLTETDYY-TASEGGLIPVKWTAPEALKFRKYSSASDVWSYGCLMYEIWSLGHKP-FDTIKNNEYMKKI
|....||||||||.|||..|..||.|||..||....||| ....|| .|.||.|||.....|....|||||.| ||.|| ..| .| .  ..|.| ...|
SKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI

-SSGYRLQPVPGCPKMMYEIMMKCW
  .|||. . ..||. .|..|..||
YEDGYRMPCPENCPDEIYDLMKQCW
Kinase AqueK314.AA TK 1-218 22 1.5e-92 310.58 In-house 51-469 (486) Show / Hide 
Range on Protein: 1-218
Range on HMM: 51-469/486
Sequence Identity: 22% (93 aa)

ESIEVAVKVLS--DEADENDKIR-----------FLQEAALMGQFT-----HTNVLTLHGVVSSEDTT-----------IMIVIELMKGGD----LRHWL
. ..||||.|   |........            ||.||. | ..      | |.. |.||.. ...            .||| |.|..||    ||..|
GKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYL

MKRKREKSYQAN-------------------------------------------------------------------------ILLNFCRQICLGMCY
 |...... ...                                                                          || .|.||. || |
RKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEY

LSSR------KFVHRDLAARNILVTHDNI-----------CKISDFGMS--------RDLTETDYYTASE------------------------GGLIPV
|.|.      .||||||||||.||...|.           |||.|||.|        ||. . |.|....                        || .|.
LHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPI

KWTAPEALK---------FRKYSSASDVWSYGCLMYEIWSLG-HKPFDTIKN---------NEYMKKISSG--------------YRLQPVPGCP-----
.|.|||.|.         ..|....|||||.|.||.||...|   .   . |          | |... .|              .|. . |.||     
RWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRY

---------KMMYEIMMKCW
         ...|..|..||
RMHPPHCPPEEYYDLMQQCW
Kinase AqueK314.AA Eph 5-218 44 1e-82 277.68 In-house 34-247 (264) Show / Hide 
Range on Protein: 5-218
Range on HMM: 34-247/264
Sequence Identity: 44% (98 aa)

VAVKVLSDEADENDKIRFLQEAALMGQFTHTNVLTLHGVVSSEDTTIMIVIELMKGGDLRHWLMKRKREKSYQANILLNFCRQICLGMCYLSSRKFVHRD
||.| | . . | ... || ||..|||| | |.. | |||..   ..|||.| |  | |  .|  |...   ..  |.   | |  || |||.  .||||
VAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKS-RPVMIVTEYMENGSLDSFL--RQHDGQFTVIQLVGMLRGIASGMKYLSDMNYVHRD

LAARNILVTHDNICKISDFGMSRDLTETD----YYTASEGGLIPVKWTAPEALKFRKYSSASDVWSYGCLMYEIWSLGHKPFDTIKNNEYMKKISSGYRL
||||||||  . .||.||||.|| | . .     || . || ||..||||||. .||..||||||||| .| |. | | .|.    | . .| |  ||||
LAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTR-GGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEQGYRL

QPVPGCPKMMYEIMMKCW
 | ..||. ....|..||
PPPMDCPEALHQLMLDCW
Kinase AqueK314.AA Src 2-218 39 3.4e-81 275.61 In-house 23-238 (255) Show / Hide 
Range on Protein: 2-218
Range on HMM: 23-238/255
Sequence Identity: 39% (86 aa)

SIEVAVKVLSDEADENDKIRFLQEAALMGQFTHTNVLTLHGVVSSEDTTIMIVIELMKGGDLRHWLMKRKREKSYQANILLNFCRQICLGMCYLSSRKFV
...||||.|.      .   ||||| .| .. | ... |. |.| |.  | || |.|. | |  .| |...... . ..|. .  |.  ||.||.|....
NTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEE-PIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLIDMAAQVAEGMAYLESMNYI

HRDLAARNILVTHDNICKISDFGMSRDLTE--TDYYTASEGGLIPVKWTAPEALKFRKYSSASDVWSYGCLMYEIWSLGHKPFDTIKNNEYMKKISSGYR
||||||||.|| ..|.||. |||  | |..   | |.|..|  .|.|||||||. .....  |||||.| |..|| . |  |    .| | ..... |||
HRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYR

LQPVPGCPKMMYE-IMMKCW
.   ..||. .|| ||..||
MPCPHNCPDELYEQIMLQCW
Kinase AqueK314.AA TyrKc 1-219 32 2.5e-80 274.09 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-219
Range on HMM: 1-280/280
Sequence Identity: 32% (93 aa)

ES-------------------IEVAVKVLSDEADENDKIRFLQEAALMGQF--THTNVLTLHGVVSSE------DTTIMIVIELMKGGDLRHWLMKRKRE
 .                   |.||||.| ..|    .  |..|| .| ..   | |.. |.||....      .  .||| |.|..|||.. | |....
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

KSYQANILLNFCRQICLGMCYLSSRKFVHRDLAARNILVTHDNICKISDFGMSRDLTET-------DYYTASE--GGL--IPVKWTAPEALKFRKYSSAS
   .   ||.|| ||. || ||.|....||||||||.||......||||||.|||...        |||...|  ||   .|..|.|||.....|....|
--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVWSYGCLMYEIWSLGHKPFDT-----IKNNEYMKKISSGYRLQPVPG--------CPKMMYEIMMKCW----------------X
||||.| .|.|| ..| .|        ..| | .... .|||. . |         ||. ||.|| .||                 
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK314.AA UTK 5-218 36 6.3e-79 268.52 In-house 32-279 (296) Show / Hide 
Range on Protein: 5-218
Range on HMM: 32-279/296
Sequence Identity: 36% (91 aa)

VAVKVLSDEADENDKIR----FLQEAA---LMGQFT-HTNVLTLHGVVSSEDTTIMIVIELMKGGDLRHWLMKRKR----EKSYQANI-LLNFCRQICLG
|||||.. .|| ... .    |. ||.   .|.||  | ||| | ||...|   .|||.|.|..||||. |.. ..    .  .. .  .| ....|  |
VAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARG

MCYLSSRKFVHRDLAARNILVTHD-------NICKISDFG---MSRDLT---------ETDYYTASEGGLIPVKWTAPEALKFR-KYSSASDVWSYGCLM
| ||.|..||||||||||.||...       ..|||.|||   |||..          |..||.|.. . .|..|.|||||  . .....|||||.| ..
MQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVC

YEIWSLGHKPFDTIKNNEYMKKISSG--YRLQPVPGCPKMMYEIMMKCW
.|||. | .|.  . | .  . .. |  ||. . ..||  .|..|..||
WEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCW
Kinase AqueK314.AA Fer 1-218 32 6.6e-71 240.69 In-house 33-265 (283) Show / Hide 
Range on Protein: 1-218
Range on HMM: 33-265/283
Sequence Identity: 32% (77 aa)

ESIEVAVKVL-SDEADENDKIRFLQEAALMGQ-FTHTNVLTLHGVVSSEDTTIMIVIELMKGGDLRHWLMKRKREKSYQANILLNFCRQICLGMCYLSSR
....|.|| . .. |..  ...|..|| .| . . | ||  ..| |.. .  ||||.|...||.|.  | | | . .   | ....| |.. || || |.
NKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYG-VCVDEQPIMIVMEFCNGGSLDSYLKKNKNK-TVSDNEKIRMCYQAACGMEYLHSK

KFVHRDLAARNILVTH-DNICK--ISDFGMSRDLT--ETDYYTASEGGLIPVKWTAPEALKFRKYSSASDVWSYGCLMYEIWSLGHKPFDT----IKNNE
. .|||.||||.|... .. .|  ||||||||...  ..||. . .   .|..|.|||..... ||...||||.|....|| . | .|. .    .|...
NCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTN

Y-----MKKISSGYRLQPVPGCPKMMYEIMM-KCW
      ...| .||.... ...|. ...||| .||
VKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCW
Kinase AqueK314.AA InsR 1-218 37 2.7e-68 228.47 In-house 28-259 (278) Show / Hide 
Range on Protein: 1-218
Range on HMM: 28-259/278
Sequence Identity: 37% (88 aa)

ESI--EVAVKVLSDEADENDKIRFLQEAALMGQFTHTNVLTLHGVVSSEDTTIMIVIELMKGGDLRHWLMKRKREKS-----YQ-------ANILLNFCR
|..  ..|.| . ..|   ..| ||.||  | .|.. .|  | ||.|    . ..| |.|. |||. .|  |  |       ..          ...   
EWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPM-YVVMEMMTYGDLKSYLRSRRPEEEFNNPGCNRNQHVPCLDQMHQMAA

QICLGMCYLSSRKFVHRDLAARNILVTHDNICKISDFGMSRDLTETDYYTASEGGLIPVKWTAPEALKFRKYSSASDVWSYGCLMYEIWSLGHKPFDTIK
.|| || || ..||||||||.|| .| ||  .|| |||| ||. |.|||  . .|. || | ||| ||  .....|||||.| ...|. .||  |     
EICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLS

NNEYMKKI-SSGYRLQPVPGCPKMMYEIMMKCW
| .  | |   |  |.|  .||....|.|| ||
NEQVLKYIGMDGNVLRPPENCPEYWQELMMMCW
Kinase AqueK314.AA Syk 3-218 40 5.1e-68 232.28 In-house 32-246 (257) Show / Hide 
Range on Protein: 3-218
Range on HMM: 32-246/257
Sequence Identity: 40% (89 aa)

IEVAVKVLSDEADE-NDKIRFLQEAALMGQFTHTNVLTLHGVVSSEDTTIMIVIELMKGGDLRHWLMKRKREKSYQANILLNFCRQICLGMCYLSSRKFV
|.||.|.|.... . .||  |. || .| |  |  .  . |.   |    | | |.  .| .  .| . . | . .. . |    |.  ||||| ...||
IKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAE--MMMMVMEMAELGPMHKYLQQHRHEITANNVLELWHT-QVAMGMCYLEEKHFV

HRDLAARNILVTHDNICKISDFGMSRDL-TETDYYTASEGGLIPVKWTAPEALKFRKYSSASDVWSYGCLMYEIWSLGHKPFDTIKNNEYMKKISSGYRL
||||||||.| .     ||||||||. |    .||.|  .|  |||| |||   ..| |..|||||.| .| |  |.| ||   .|. | || | .| |.
HRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMWEMFSYGQKPYGEMKGQEVMKFIENGHRM

QPVPGCPKMMYEIMMKCW
   .|||. ||..| |||
NCPNGCPQEMYQLMNKCW
Kinase AqueK314.AA TK-Unique 5-218 36 1.8e-66 227.12 In-house 33-277 (294) Show / Hide 
Range on Protein: 5-218
Range on HMM: 33-277/294
Sequence Identity: 36% (89 aa)

VAVKVLSDEADENDKIRFLQEAALMGQFT-HTNVLTLHGVVSSEDTTIMIVIELMKGGDLRHWLMKRKREKSYQ---ANIL--------------LN---
|||| | |.|.. ||  ||.|...| . . | |.... |.  . |   ||..| . .|.|.| | ....... .   .|.               ..   
VAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKD

---FCRQICLGMCYLSS--RKFVHRDLAARNILVTHDNICKISDFGMSRDLT-ETDYYTASEGGLIPVKWTAPEALK--FRKY-SSASDVWSYGCLMYEI
   |. ||. || ||.|  .|.|||||.|||.|.|.|..|||.||||.||.  ...| .  . | ||..| |||.||   . | .. |||||.|.||.||
LYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEI

WSLGHKPFDTIKNNEYMKKISSGYRLQPVPGC-PKMMYEIMMKCW
 .||  |.  ... . |..|  |||..  ..| .. ||..|  ||
FTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCW
Kinase AqueK314.AA FAK 1-218 42 2.8e-66 221.04 In-house 50-263 (285) Show / Hide 
Range on Protein: 1-218
Range on HMM: 50-263/285
Sequence Identity: 42% (92 aa)

ESIEVAVKVLSDEADENDKIRFLQEAALMGQFTHTNVLTLHGVVSSEDTTIMIVIELMKGGDLRHWLMKRKREKSYQANILLNFCRQICLGMCYLSSRKF
. |.||.|    . |.. | .|.|||  | || |  .  | |... .   | |..||.| |.|||.|  .| . .     |. .| |.|  | || |.||
DKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICEEM--PIWIIMELCKYGELRHYLQRNKNSLKHAT--LILYCYQLCMAMAYLESKKF

VHRDLAARNILVTHDNICKISDFGMSRDLTETDYYTASEGGLIPVKWTAPEALKFRKYSSASDVWSYGCLMYEIWSLGHKPFDTIKNNEYMKKISSGYRL
|||| ||||.||   .  |  |||.|| .   .|| ||  |  |.|| .||   || . .||||| .|  | || ..| |||  .|||.   .|  | ||
VHRDIAARNVLVSSPDCVKLGDFGLSRWMHDHSYYKASPKGKLPIKWMSPESINFRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERL

QPVPGCPKMMYEIMMKCW
   | ||  .| .| .||
PMPPNCPPTLYSLMTRCW
Kinase AqueK314.AA Tec 22-218 41 4.9e-65 222.38 In-house 41-235 (254) Show / Hide 
Range on Protein: 22-218
Range on HMM: 41-235/254
Sequence Identity: 41% (83 aa)

FLQEAALMGQFTHTNVLTLHGVVSSEDTTIMIVIELMKGGDLRHWLMKRKREKSYQANI--LLNFCRQICLGMCYLSSRKFVHRDLAARNILVTHDNICK
|..||  |   .| .   | ||  |.   | || | |. | |  .|  |....  |.|   ||  | ..| || || . .|.|||||||| ||  ... |
FIEEAKVMMKLSHPKLVQLYGVC-SQQRPIYIVTEYMEHGCLLNYL--REHKHHFQKNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVK

ISDFGMSRDLTETDYYTASEGGLIPVKWTAPEALKFRKYSSASDVWSYGCLMYEIWSLGHKPFDTIKNNEYMKKISSGYRLQPVPGCPKMMYEIMMKCW
.|||||.|     | || | |   |||| .|| ... .||| ||||..| || |..|.|  |..  .| |  ...| |.||     |.. .|.|| .||
VSDFGMTRYVLD-DQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCW
Kinase AqueK314.AA Pkinase 1-173 24 2.8e-30 108.12 Pfam 23-204 (293) Show / Hide 
Range on Protein: 1-173
Range on HMM: 23-204/293
Sequence Identity: 24% (46 aa)

ESIEVAVKVLSDEADEN--DKIRFL-QEAALMGQFTHTNVLTLHGVVSSEDTTIMIVIELMKGG----DLRHWLMKRKREKSY--QANILLNFCRQICLG
....||||... . ..   |..... .|...|  . | |...|.... . .. | .| |.. ||    || ....  .|....  . . . ....||. |
TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST-WRHGCFYFSEWECKFYMYQILRG

MCYLSSRKFVHRDLAARNILVTHDNIC----KISDFGMSRDLTETDYYTASEGGLIPVKWTAPEALK-FRKYSSASDVWSYGCLMYE
. |. |....||||   |||. ... .    ||.||| .. .  .  ..   .      . ||| ..  ..|....|.||.||..||
LEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYE
Kinase AqueK314.AA S_TKc 1-219 22 1.4e-18 68.94 SMART 19-231 (231) Show / Hide 
Range on Protein: 1-219
Range on HMM: 19-231/231
Sequence Identity: 22% (57 aa)

ESIE----VAVKVLSDEADENDKIRFLQEAALMGQFTHTNVLTLHGVVSSEDTTIMIVIELMKG--GDLRHWLMKRKREKS---YQANILLNFCRQICLG
  ..    ||.|...        .....| ... .  | |. .|..|  .  . . .| |.. |  |||.. . ||.|..    .       ...|||..
RHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCA

MCYLSSRKFVHRDLAARNILVTHDNICKISDFGMSRDLTETDYYTASEGGLIPVKWTAPEALKFRKYSS-ASDVWSYGCLMYEIWSLGHKPFDTIKNNEY
. |. |....||||   |||...    ||.|||..| |                 . ||| |   .|.  ..|.|| ||..||  . |  ||.    .. 
LEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMM

MKKISSGYRLQPVPGC----------PK---MMYEIMM-------KCWX
.|||       . ...          |.      |..          | 
FKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF