Gene AqueK300 (A.queenslandica)

AqueK300

Species: A.queenslandica
Alias: AqueK300
External Links:
Annotation:

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
AqueK300.AA Protein None 587 None Fasta, JSON
AqueK300.kin_dom Protein Kinase Domain None 162 None Fasta, JSON

Protein domain

Protein domains of AqueK300.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase_Tyr AqueK300.AA Pkinase_Tyr 404-548 44 2.8e-79 269.12 Pfam 124-270 (270) Show / Hide 
Range on Protein: 404-548
Range on HMM: 124-270/270
Sequence Identity: 44% (66 aa)

MEHLSRKKFVHRDLAARNILVSDKGTGICKIADFGMSRDLQNESYYISQAKK---IPIKWTAPEALHYKKYSSASDVWSYGAVMYEIWSLGHKP-FELYT
||.|..|...||||||||.||..  ....||.|||..||..|..|| .....   .||||.|||...|.|....|||||.| .|.|| ..| .| ..  .
MEYLESKNCIHRDLAARNCLVTE--NNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMS

NQECIRLV-DSGYRLPPPPGCPKPMYKLMMQCWNPDTYNRPSFSDISSSL
|.| .... ..|||.|.|..||...|.||.|||..|  .||.||.| . |
NEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK300.AA TK 404-548 29 2.7e-71 238.06 In-house 247-486 (486) Show / Hide 
Range on Protein: 404-548
Range on HMM: 247-486/486
Sequence Identity: 29% (70 aa)

MEHLSRK------KFVHRDLAARNILVSDKGT---------GICKIADFGMS--------RDLQN-ESYYISQ------------------------AKK
||.|..|      .||||||||||.||.....          .|||||||.|        ||... . || ..                          |
MEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGK

IPIKWTAPEALH---------YKKYSSASDVWSYGAVMYEIWSLG-HKPFELYTN---------QECIRLVDSG--------------YRLPPPPGCP--
.||.|.|||.|          |.|....|||||.| .|.||...|   . .  .|         || .... .|              .|.|.||.||  
LPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDW

------------KPMYKLMMQCWNPDTYNRPSFSDISSSL
            . .| ||.|||..|   ||.||.. . |
MRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK300.AA Eph 404-548 49 1.3e-69 233.02 In-house 118-264 (264) Show / Hide 
Range on Protein: 404-548
Range on HMM: 118-264/264
Sequence Identity: 49% (74 aa)

MEHLSRKKFVHRDLAARNILVSDKGTGICKIADFGMSRDLQNES----YYISQAKKIPIKWTAPEALHYKKYSSASDVWSYGAVMYEIWSLGHKPFELYT
|  ||   .||||||||||||. .   .||..|||.|| |....     | ..  ||||.||||||. |.|..||||||||| || |. | | .|.   .
MKYLSDMNYVHRDLAARNILVNSN--LVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMS

NQECIRLVDSGYRLPPPPGCPKPMYKLMMQCWNPDTYNRPSFSDISSSL
||. |  .. |||||||..||.....||..||  |  .|| |..| | |
NQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase AqueK300.AA UTK 404-548 41 1e-66 227.22 In-house 131-296 (296) Show / Hide 
Range on Protein: 404-548
Range on HMM: 131-296/296
Sequence Identity: 41% (69 aa)

MEHLSRKKFVHRDLAARNILVSDKG-----TGICKIADFG---MSRDLQN--------ES-YYISQ-AKKIPIKWTAPEALHYK-KYSSASDVWSYGAVM
|..|....||||||||||.|| . .       .|||||||   |||....        || || .| ....||.|.||||| .  .....|||||.| |.
MQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVC

YEIWSLGHKPFELYTNQECIRLVDSG--YRLPPPPGCPKPMYKLMMQCWNPDTYNRPSFSDISSSL
.|||. | .|.. ..|.. .  |  |  ||.|.|..|| |.|.||..||..|  .||.| |. . .
WEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase AqueK300.AA Src 404-548 41 2e-63 214.33 In-house 110-255 (255) Show / Hide 
Range on Protein: 404-548
Range on HMM: 110-255/255
Sequence Identity: 41% (62 aa)

MEHLSRKKFVHRDLAARNILVSDKGTGICKIADFGMSRDLQ--NESYYISQAKKIPIKWTAPEALHYKKYSSASDVWSYGAVMYEIWSLGHKPFELYTNQ
|. |......||||||||.||...   .||.||||  | ..   . |  ..  |.|||||||||..| ...  |||||.|  ..|| . |  | .  ||.
MAYLESMNYIHRDLAARNVLVGENN--VCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNH

ECIRLVDSGYRLPPPPGCPKPMYK-LMMQCWNPDTYNRPSFSDISSSL
| .. |. |||.| |..||. .|. .|.|||. |   || |  . . |
EVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK300.AA SFK-Src 404-541 47 6.9e-62 181.94 In-house 109-248 (259) Show / Hide 
Range on Protein: 404-541
Range on HMM: 109-248/259
Sequence Identity: 47% (68 aa)

MEHLSRKKFVHRDLAARNILVSDKGTGICKIADFGMSRDLQNESY-YIS-QAKKIPIKWTAPEALHYKKYSSASDVWSYGAVMYEIWSLGHKPFELYTNQ
|  |  . ||||||||||.|| |    .||..|||||| | ...  |   .  | |||||||||  . ..|  |||||.|  |.||  .| .|..  ||.
MAYLEAQNFVHRDLAARNVLVGD--NNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPYPGMTNM

ECIRLVDS--GYRLPPPPGCPKPMYKLMMQCWNPDTYNRPSF
| .. ||   |||.| ||.||  .||.|..||     .|| |
EVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTF
Kinase AqueK300.AA Fer 404-549 36 8.8e-59 198.82 In-house 124-283 (283) Show / Hide 
Range on Protein: 404-549
Range on HMM: 124-283/283
Sequence Identity: 36% (58 aa)

MEHLSRKKFVHRDLAARNILVSDKGTGI-CKIADFGMSRDLQ--NESYYIS-QAKKIPIKWTAPEALHYKKYSSASDVWSYGAVMYEIWSLGHKPFEL--
||.|  |. .|||.||||.|...... . |||.||||||..    ..|.    |.|.||.|.|||.. .. ||...||||.| ...|| . | .|..   
MEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQP

----YTNQ--ECIRL-VDSGYRLPPPPGCPKPMYKLMM-QCWNPDTYNRPSFSDISSSLS
     ||.  ....  ...||..|.|...|......|| |||. |. .||....|   | 
HGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase AqueK300.AA TK-Unique 404-548 41 3.1e-57 195.88 In-house 144-294 (294) Show / Hide 
Range on Protein: 404-548
Range on HMM: 144-294/294
Sequence Identity: 41% (63 aa)

MEHLSR--KKFVHRDLAARNILVSDKGTGICKIADFGMSRDLQNESYYISQAK--KIPIKWTAPEALH--YKKY-SSASDVWSYGAVMYEIWSLGHKPFE
||.|..  ||.|||||.|||.|...   ..|||.||||.||....  |... .  .|||.| |||.|   .. | .. |||||.| .|.|| .||  |. 
MEYLASQRKKIVHRDLCARNVLLTE--DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYP

LYTNQECIRLVDSGYRLPPPPGC-PKPMYKLMMQCWNPDTYNRPSFSDISSSL
 . . . ....  |||.| |..| .. ||.|| .||. .   ||||..| . |
GMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK300.AA SRM 404-549 43 3.2e-57 189.9 In-house 110-253 (253) Show / Hide 
Range on Protein: 404-549
Range on HMM: 110-253/253
Sequence Identity: 43% (64 aa)

MEHLSRKKFVHRDLAARNILVSDKGTGICKIADFGMSRDLQNESYYISQAKKIPIKWTAPEALHYKKYSSASDVWSYGAVMYEIWSLGHKPFELYTNQEC
|  |  ....||||||||.|| |  .  ||..|||. | . .  |  |   .||.|||||||. |  ||  |||||.|  ..|. . |  |..  || | 
MCYLEEQNYIHRDLAARNVLVGDNNL--CKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYPGMTNHET

IRLVDSGYRLPPPPGCPKPMYKLMMQCWNPDTYNRPSFSDISSSLS
.  .| |||.| |  ||   .|||..||  |   ||.| |    |.
FQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase AqueK300.AA Syk 404-542 44 1.6e-53 182.61 In-house 119-257 (257) Show / Hide 
Range on Protein: 404-542
Range on HMM: 119-257/257
Sequence Identity: 44% (63 aa)

MEHLSRKKFVHRDLAARNILVSDKGTGICKIADFGMSRDL-QNESYYISQAK-KIPIKWTAPEALHYKKYSSASDVWSYGAVMYEIWSLGHKPFELYTNQ
|  |  |.||||||||||.|  ..  .  || |||||. |  ...|| ..   | |.|| |||   | | |..|||||.|  | |  |.| ||    ..|
MCYLEEKHFVHRDLAARNVLLVNR--HYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMWEMFSYGQKPYGEMKGQ

ECIRLVDSGYRLPPPPGCPKPMYKLMMQCWNPDTYNRPSFS
| . ....| |.. |.|||. || || .||  .  .|| |.
EVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase AqueK300.AA Tec 404-550 40 4.6e-53 182.62 In-house 110-254 (254) Show / Hide 
Range on Protein: 404-550
Range on HMM: 110-254/254
Sequence Identity: 40% (60 aa)

MEHLSRKKFVHRDLAARNILVSDKGTGICKIADFGMSRDLQNESYYISQAKKIPIKWTAPEALHYKKYSSASDVWSYGAVMYEIWSLGHKPFELYTNQEC
|. | |..|.|||||||| ||.|.  .. |..||||.|      |  |   | |.|| .|| .|| .||| ||||..|  | |..|.|  |.| ..| | 
MAYLERHCFIHRDLAARNCLVGDQ--CVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYENMSNSEV

IRLVDSGYRLPPPPGCPKPMYKLMMQCWNPDTYNRPSFSDISSSLSS
.  |  |.||  |  |.. .|. | .||      ||.|..  ...  
VEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
TyrKc AqueK300.AA TyrKc 278-548 25 1e-44 155.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 278-548
Range on HMM: 1-280/280
Sequence Identity: 25% (86 aa)

YNFTSDI------EVQYGDILVINVTTNSNPMYYQQYNGPLNYELNSSNGLIPLEHNDYPLISVMMKPIPSVTETSSSTVTEDIDT-VATMAML------
  .   .      ||  |                                           | |  | . . .        ||.      | .|      
ITLGKKLGEGAFGEVYKGTWK----------------------------------------IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPN

-------SSST-------TTTDIVMTP------NSILTSTEVIYYSTSLHYTTTLSLLR-----MEHLSRKKFVHRDLAARNILVSDKGTGICKIADFGM
        ..            |||        .. | ...       |   . ||        ||.|..|...||||||||.||....  ..||.|||.
IVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGL

SRDLQNE-------SYYISQ---AKK--IPIKWTAPEALHYKKYSSASDVWSYGAVMYEIWSLGHKPFEL-----YTNQECIRLVDSGYRLPPPPG----
|||. ..       .|| ..    .|  .||.|.|||.. |.|....|||||.| .|.|| ..| .| .       .||| |..|..|||.|.||     
SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPM

----CPKPMYKLMMQCWNPDTYNRPSFSDISSSL
    ||. ||..| |||. |  .||.||.| . .
SFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Pkinase AqueK300.AA Pkinase 401-548 20 1.1e-13 49.51 Pfam 118-293 (293) Show / Hide 
Range on Protein: 401-548
Range on HMM: 118-293/293
Sequence Identity: 20% (37 aa)

LLRMEHLSRKKFVHRDLAARNILVSDKGTGIC----KIADFGMSRDLQNESYYISQAKKIP---IKWTAPEALH-YKKYSSASDVWSYGAVMYEIWSLGH
|  .|.. .....||||   |||..   .| .    ||.||| .. ..   |  ..  . .   . . ||| .  ...|....|.||.| ..||  . |.
LRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GR

KPFELY------TNQECIRLVDS-GYRLPPPPGCP-------------------KPMYKLMMQCWNPDTYNRPSFSDISSS--L
 ||         . ...|... .  .. . |  |.                   ... ...  |...| . ||.. .|  .  .
PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
S_TKc AqueK300.AA S_TKc 263-549 14 3.7e-10 -28.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 263-549
Range on HMM: 1-231/231
Sequence Identity: 14% (45 aa)

LTVDASVATSSNGNVYNFTSDIEVQYGDILVINVTTNSNPMYYQQYNGPLNYELNSSNGLIPLEHNDYPLISVMMKPIPSVTETSSSTVTEDIDTVATMA
 ..   .   . | ||  .       | |  | .                               . .  |....|  | .     . ..   .    | 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK----------------------------EHIRREIQILKKHHPNIVKLYDVFQD--DHLYMVME

MLSSSTTTTDIVMTPNSI------LTSTEVIYYSTSLHYTTTLSLLRMEHLSRKKFVHRDLAARNILVSDKGTGICKIADFGMSRDLQNESYYISQAKKI
... .. .   ..  .        ..  .. .|   .       .. .|.. .....||||   |||...      ||.|||..| |             
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQI-------CCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------TTFCG

PIKWTAPEALHYKKYSS-ASDVWSYGAVMYEIWSLGHKPFELYTNQECIRLVDSGYRLPPPPGCPKPMYKLMMQCWNPDTYNRPSFSDISS--------S
   . ||| |   .|.  ..|.|| | ..||  . |  ||.  . |. ....            ....  ....|.. |  .||.  ..           
TPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

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