Gene AqueK293 (A.queenslandica)

AqueK293

Species: A.queenslandica
Alias: AqueK293
External Links:
Annotation:

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
AqueK293.AA Protein None 733 None Fasta, JSON
AqueK293.kin_dom Protein Kinase Domain None 117 None Fasta, JSON

Protein domain

Protein domains of AqueK293.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase_Tyr AqueK293.AA Pkinase_Tyr 321-452 36 2.2e-46 157.7 Pfam 1-125 (270) Show / Hide 
Range on Protein: 321-452
Range on HMM: 1-125/270
Sequence Identity: 36% (53 aa)

IQIIKELGSGQFGTVYEGMWL------SKPVAIKTLKNSSVEQD--KVKFLQEAAIMGQF-HHPNIVKLHGMVT-VGEP--MMIVLELIPHGDMRQYLHT
|...|.||.|.||.||.| |         |||.|.||... ...  . .|..||.|| |. ||||||.|.| .|  |||  ..||.|. ||||.. ||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

LQPQYVLSVDYVINIVYYRPGELVASTVPGLLVSFCRQIASGME
                     |   .  .  |...|.|||.|||
HR-------------------EDKQPLTMKDLLQMCWQIAKGME
Kinase AqueK293.AA TK 321-452 23 9e-37 120.25 In-house 1-248 (486) Show / Hide 
Range on Protein: 321-452
Range on HMM: 1-248/486
Sequence Identity: 23% (58 aa)

IQIIKELGSGQFG---TVYEGMWLSK---------------------------PVAIKTLK---NSSVEQDKV----------KFLQEAAIMGQFH----
|...|.||.||||   .||.|.| ..                           |||.|.||   ..| |. .           .||.||..| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIVKLHGMVTVG------------EPMMIVLELIPHGD----MRQYLHTLQPQYVLSVDYVI-------------------------NIVYYRPGEL
 |||||.|.| .| |            ||.|||.|. ||||     |.||..  |    . |                            | .   ... 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

VAS-----------------------------TVPGLLVSFCRQIASGME
. .                               .  |. .|.|||.|||
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGME
Kinase AqueK293.AA Eph 321-406 44 1.3e-31 103.33 In-house 1-95 (264) Show / Hide 
Range on Protein: 321-406
Range on HMM: 1-95/264
Sequence Identity: 44% (42 aa)

IQIIKELGSGQFGTVYEGMWLSK---------PVAIKTLKNSSVEQDKVKFLQEAAIMGQFHHPNIVKLHGMVTVGEPMMIVLELIPHGDMRQYL
|.| | .|.|.|| |..|.   .         |||||||| .. |.... || ||.||||| ||||..| | || ..|.||| |   .|   ..|
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFL
Kinase AqueK293.AA SFK-Src 321-407 44 5.5e-31 88.59 In-house 1-86 (259) Show / Hide 
Range on Protein: 321-407
Range on HMM: 1-86/259
Sequence Identity: 44% (39 aa)

IQIIKELGSGQFGTVYEGMWLSK-PVAIKTLKNSSVEQDKVKFLQEAAIMGQFHHPNIVKLHGMVTVGEPMMIVLELIPHGDMRQYLH
|.  | ||||||| |. | |  .  ||.||||  .. ..   |||||..| .  ||| ..|.   | |||. |. ||.  | .  |||
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLH
Kinase AqueK293.AA UTK 321-452 27 3e-30 100.7 In-house 1-132 (296) Show / Hide 
Range on Protein: 321-452
Range on HMM: 1-132/296
Sequence Identity: 27% (40 aa)

IQIIKELGSGQFGTVYEGMW-------LSKPVAIKTLKNSSVEQDKV----KFLQEAA---IMGQFH-HPNIVKLHGMVTVGEPMMIVLELIPHGDMRQY
.|. ..||.|.||.|.....       .   ||.|....... |..     .|. ||.   .|.||| |||...| | .| .||.|||.|. . ||.|.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LHTLQPQYVLSVDYVINIVYYRPGELVASTVPGLLVSFCRQIASGME
| .  |.                 .  ..     .......||.||.
LRRHRPTPP---------------ACPHWLTLHQRLCMAWDIARGMQ
Kinase AqueK293.AA InsR 321-406 35 1.1e-29 96.78 In-house 1-95 (278) Show / Hide 
Range on Protein: 321-406
Range on HMM: 1-95/278
Sequence Identity: 35% (34 aa)

IQIIKELGSGQFGTVYEG---------MWLSKPVAIKTLKNSSVEQDKVKFLQEAAIMGQFHHPNIVKLHGMVTVGEPMMIVLELIPHGDMRQYL
| .|.|.| | ||.||||          | . ..||||.. .    ... ||.|| .| .| . ..|.| | .. |.||..| |.  .|| . ||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYL
Kinase AqueK293.AA Src 321-407 39 3.9e-29 96.09 In-house 1-86 (255) Show / Hide 
Range on Protein: 321-407
Range on HMM: 1-86/255
Sequence Identity: 39% (35 aa)

IQIIKELGSGQFGTVYEGMWLS-KPVAIKTLKNSSVEQDKVKFLQEAAIMGQFHHPNIVKLHGMVTVGEPMMIVLELIPHGDMRQYLH
|. ...||.|||| |..|.|    .||.||||  .   .   ||||| || .. |...|.|.  .. .||  || |.  ||   .||.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLK
Kinase AqueK293.AA Fer 321-406 32 3.9e-26 86.07 In-house 1-100 (283) Show / Hide 
Range on Protein: 321-406
Range on HMM: 1-100/283
Sequence Identity: 32% (32 aa)

IQIIKELGSGQFGTVYEG---------MWLSK---PVAIKTLKNSSVEQD-KVKFLQEAAIMGQ-FHHPNIVKLHGMVTVGEPMMIVLELIPHGDMRQYL
. ..| ||.| ||.|| |         .|. .   .|. |..| ...  . . .|..|| || . . |||.||..|. .  .| |||.|....|. . ||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL
Kinase AqueK293.AA ALK 321-406 39 6.3e-25 82.99 In-house 1-93 (273) Show / Hide 
Range on Protein: 321-406
Range on HMM: 1-93/273
Sequence Identity: 39% (37 aa)

IQIIKELGSGQFGTVYEGMWLS-------KPVAIKTLKNSSVEQDKVKFLQEAAIMGQFHHPNIVKLHGMVTVGEPMMIVLELIPHGDMRQYL
|. .. || | || ||.|            .||.|||. .  .||   |. ||.|||.| |.|.|.. |      | |||||..  |||...|
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFL
Kinase AqueK293.AA Frk 321-410 46 1.4e-24 81.82 In-house 1-89 (260) Show / Hide 
Range on Protein: 321-410
Range on HMM: 1-89/260
Sequence Identity: 46% (42 aa)

IQIIKELGSGQFGTVYEGMW-LSKPVAIKTLKNSSVEQDKVKFLQEAAIMGQFHHPNIVKLHGMVTVGEPMMIVLELIPHGDMRQYLHTLQ
||.|..||||||| |.||.|  . |||.||||  ..  |   ||.|| || .  || ...|. . || ||..|. ||. || . .|| ...
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTM--DPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAIN
Kinase AqueK293.AA TKL 327-452 19 4.4e-23 79.98 In-house 1-146 (364) Show / Hide 
Range on Protein: 327-452
Range on HMM: 1-146/364
Sequence Identity: 19% (34 aa)

LGSGQFGTVYEGMWLS----------KPVAIKTLKNSSV--------------------------EQDKVKFLQEAAIMGQFHHPNIVKLHGMVTVGEP-
.||| ||.|| | |            |.||.|..|  ..                          .. . .. .|. .| ...|||||.. | .. ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------MMIVLELIPHGDMRQYLHTLQPQYVLSVDYVINIVYYRPGELVASTVPGLLVSFCRQIASGME
            ..|| |..|.|. . |||                             . ........||.||.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------------------------WHQRCRWALDIARGMN
Kinase AqueK293.AA Pkinase 321-407 28 2e-19 69.76 Pfam 1-96 (293) Show / Hide 
Range on Protein: 321-407
Range on HMM: 1-96/293
Sequence Identity: 28% (27 aa)

IQIIKELGSGQFGTVYEGMWLSKP--VAIKTLKNSSVEQDKV--KFL-QEAAIMGQFHHPNIVKLHGMVTVGEPMMIVLELIPHG----DMRQYLH
..|.. .||| ||.||.... . .  ||.|..| .. . .|   ... .|..||  ..|||||.|..... .  . .|.|. ..|    |   |..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS
Kinase AqueK293.AA TyrKc 321-516 20 1.2e-13 -2.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 321-516
Range on HMM: 1-280/280
Sequence Identity: 20% (64 aa)

IQIIKELGSGQFGTVYEGMWLSKPVAIKTLKNSSVEQDKVKFLQEAAIMGQF--HHPNIVKLHGMVTVG-------EPMMIVLELIPHGDMRQYLHTLQP
|. .|.||.|.||.||.|.|   .||.|.||...    .  |..|| || ..  ||||||.|.| .| .       ||.|||.|. |||| ..||.  .|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

QYVLSVDYVINIVYYRPGELVASTVPGLLVSFCRQIASGME-------------------PSSN-------------DPG-------KYDLVTG--SER-
.                        .  |.||| |||.|||                    . .             . .       .|  ...  ... 
K----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

----------TI----------------------------YYS-----TSNVSTSGVFEYS-LNPPIPV--------MSGEVVAVVQPLEEE--------
          .|                            |.       ||       .     |. |         .. |.  . .   .|        
MLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF

SVIRVYY
| |. . 
SEIHECF
Kinase AqueK293.AA S_TKc 321-576 10 5.5e-08 -59.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 321-576
Range on HMM: 1-231/231
Sequence Identity: 10% (34 aa)

IQIIKELGSGQFGTVYEGMWLS--KPVAIKTLKNSSVEQDKVKFLQEAAIMGQFHHPNIVKLHGMVTVGEPMMIVLELIPH--GDMRQYLHTLQPQ---Y
 .|....|.| ||.|| . . .  . |||| .|         ....| .|. . ||||||||...    . . .|.|....  ||...|..  ...   .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

VLSVDYVINIV-------------------------------------------------YYRPGELVASTVPG-----------LLVSFCRQIASGMEP
...   .  ..                                                 .|.. |..     .           |   .|..       
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP---

SSNDPGKYDLVTGSERTIYYSTSNVSTSGVFEYSLNPPIPVMSGEVVAVVQPLEEESVIRVYYIEDVSGISFSSSQEISINSDPIDLDGYCVNNTNSITP
  ..   ....                                                                                     |   
--QMQMMFKKIG------------------------------------------------------------------------------------SPEA

SVIKNNFLTIQ-----SSGDIDQ------RRQYL
  . .. |.       .  .. |        ...
KDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF