Gene AqueK263 (A.queenslandica)

AqueK263

Species: A.queenslandica
Alias: AqueK263
External Links:
Annotation:

Classification

Group: TK
Family: EGFR

Sequence

Name Sequence Type Origin Length Description Download
AqueK263.AA Protein None 1193 None Fasta, JSON
AqueK263.kin_dom Protein Kinase Domain None 136 None Fasta, JSON

Protein domain

Protein domains of AqueK263.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain AqueK263.AA Recep_L_domain 35-150 27 6.3e-14 48.53 Pfam 3-121 (121) Show / Hide 
Range on Protein: 35-150
Range on HMM: 3-121/121
Sequence Identity: 27% (35 aa)

EYIEDNIVIRTGSGLVDISQPLVEANFSFLYYVKEISGYLELNNI-PSIERLSLPRLRLIRGRNLRSG-RYSLLVS--GR--IETLHMPSLTEISR--GD
. |. |..|   ..  .      | ..||.  ..||.|||....  .      .|.|| ||||.|  . .|.| .       .. | |..|..|.|  |.
TVIYGNLEITWRDEHNE-----LEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNITRKNGG

VMLGSSSLNS--YLCNTRS-INWTDIA
|     . |    ||.|.. |.| .| 
VYI---HNNPHPKLCYTHTEIMWWMIY
Furin-like AqueK263.AA Furin-like 217-310 31 1.1e-16 55.38 Pfam 83-182 (182) Show / Hide 
Range on Protein: 217-310
Range on HMM: 83-182/182
Sequence Identity: 31% (31 aa)

MACKNVLDDGVCRERCPEQYIIDPFARTVIPNPLFKLEA-KPLCV--YSCP---DPFRNNFLHEHGTQCVKDCPSNYMPVPSNRTMRCVLCNDTCPKECT
.||... ..|.| ..||   | .|    ..|||  . .     ||   .||   .. ..|..  |...|. .|||.|. .  | || |. |. .|||.|.
VACRHFYHNGTCVDQCPPMMIYNPTTFQMEPNPDGTYQFEGWRCVTFKECPKLSHNPDCNYYVIHNGECMRECPSGYTENEENNTMMCEPCEGPCPKVCY
Recep_L_domain AqueK263.AA Recep_L_domain 324-459 19 1.2e-07 27.45 Pfam 1-121 (121) Show / Hide 
Range on Protein: 324-459
Range on HMM: 1-121/121
Sequence Identity: 19% (28 aa)

GCTVITTELRISSVPPNVKLVLHIAKILWQKLSSPSILNDLNDIREICGSLDISGF-NKETFPYLSSLKTVGNDSTQVLSQSCNGSSDSTKFSVIIA-NT
.||||   |.|...  . .              ... |. .  |||| |.| | .  |   .  ...|...  .. .            .... .|  | 
NCTVIYGNLEITWRDEHNE--------------LEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHD----------DNYALYIYDNP

D--LVSIDLSSLETVIN--GGIQLENNP--SLCYLGN-LSYYLAN
.  | .... .|.....  ||.  .|||   |||.   .  .. .
NMGLQELWMWNLKNITRKNGGVYIHNNPHPKLCYTHTEIMWWMIY
FU AqueK263.AA FU 474-527 26 2.1e-05 25.18 SMART 1-48 (48) Show / Hide 
Range on Protein: 474-527
Range on HMM: 1-48/48
Sequence Identity: 26% (15 aa)

INECVKMKMTCHPQCSSASGWCWGPNDTQCVTCTNFIFN---KQCVPDCHDFDTHRV
 ..|    . |||.|..    ||||...||..| .. .     .||..|   . .  
DGVC----KPCHPECAT---GCWGPGPDQCTSCPHGYYLHHNGTCVSQCP--PGYYP
Furin-like AqueK263.AA Furin-like 484-519 51 0.190223 5.36 Pfam 65-98 (182) Show / Hide 
Range on Protein: 484-519
Range on HMM: 65-98/182
Sequence Identity: 51% (19 aa)

CHPQCSSASGWCWGPN-DTQCVTCTNFIFNKQCVPDC
||.||  . | | ||| || || | .| .| .||. |
CHEQC--LGG-CTGPNNDTDCVACRHFYHNGTCVDQC
Kinase AqueK263.AA EGFR 934-1070 48 1.4e-64 213.24 In-house 122-258 (258) Show / Hide 
Range on Protein: 934-1070
Range on HMM: 122-258/258
Sequence Identity: 48% (66 aa)

LVHRDLAARNALVQSHLKVLITDFGLTRFIEPDESHYEASGSKLPVRWLPPESIRQRIFTHKTDIWSFGVTVWEILTFGESPFKGKSVFELLKLLEKGDR
.||||||||| ||.|  .| |||||| .. |.||  |.|.| |.|..|.  |.|..|..||. |.||.|||.||..|||..|..| .  |   |||||.|
MVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTFGQKPYDGIPAREIPDLLEKGER

LKQPKTCTLVFYKSLQNCWELEPEKRPSFEDLVYQFN
|.||. ||.  |  .  || . .. || |. |. .|.
LPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Pkinase_Tyr AqueK263.AA Pkinase_Tyr 934-1069 43 1.2e-63 216.22 Pfam 132-270 (270) Show / Hide 
Range on Protein: 934-1069
Range on HMM: 132-270/270
Sequence Identity: 43% (60 aa)

LVHRDLAARNALVQSHLKVLITDFGLTRFIEPDESH-YEASGSKLPVRWLPPESIRQRIFTHKTDIWSFGVTVWEILTFGESP-FKGKSVFELLKLL-EK
..|||||||| || . ..| |.||||.| |..|.   . ..|.|||..|..||.|. ..||.|.|.|||||. |||.|.||.| ..| | .|..... |.
CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED

GDRLKQPKTCTLVFYKSLQNCWELEPEKRPSFEDLVYQF
| |...|. |.   |. .. ||. .||.||.|.... |.
GYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK263.AA TK 934-1069 29 4e-57 189.68 In-house 261-486 (486) Show / Hide 
Range on Protein: 934-1069
Range on HMM: 261-486/486
Sequence Identity: 29% (66 aa)

LVHRDLAARNALVQSHLK-----------VLITDFG--------LTRFIEPDESHYEAS------------------------GSKLPVRWLPPESIRQR
.||||||||| || ....           . |.|||        |.| |..|.  | .|                        | |||.||..||... |
FVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDR

I---------FTHKTDIWSFGVTVWEILTFG-ESPFKGKSV---------FELLKLLEKGDRL--------------KQPKTCT--------------LV
.         ||.|.|.|||||..|||.|.| | .  | |           |....|..| ||              .||. |.               .
VFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEE

FYKSLQNCWELEPEKRPSFEDLVYQF
.|  .| ||...||.||.|..|. |.
YYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK263.AA Ack 934-1069 38 3.9e-51 170.74 In-house 126-266 (266) Show / Hide 
Range on Protein: 934-1069
Range on HMM: 126-266/266
Sequence Identity: 38% (54 aa)

LVHRDLAARNALVQSH-LKVLITDFGLTRFIEPDESHYEASGSK---LPVRWLPPESIRQRIFTHKTDIWSFGVTVWEILTFGESPFKGKSVFELLKLLE
..|||||||| |. |   || | |||| |     | .|  .. .   .|  | .||..|.| |.|. |.|.|||| ||  ..|| |..| .  . |....
CIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGVTLWEMFSYGEEPWAGCNGYQILQKID

-KGDRLKQPKTCTLVFYKSLQNCWELEPEKRPSFEDLVYQF
 .| || .|. |    |. . .||. .|..||.| ... |.
KEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase AqueK263.AA RTKB 935-1069 41 3.8e-50 167.26 In-house 131-264 (264) Show / Hide 
Range on Protein: 935-1069
Range on HMM: 131-264/264
Sequence Identity: 41% (56 aa)

VHRDLAARNALVQSHLKVLITDFGLTRFIEPDESHYEASGSKLPVRWLPPESIRQRIFTHKT-DIWSFGVTVWEILTFGESPFKGKSVFELLKLLEKGDR
.||||.||| || . |.  | |||. | |. ..  ||    .||..|. |||. .||.| |  |.|||||| ||| ..|  |..  ........||.| |
IHRDLCARNVLVDQQLHCKICDFGMAREIDHEC--YETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHR

LKQPKTCTLVFYKSLQNCWELEPEKRPSFEDLVYQF
| .|.     ..  .| || .|...||.|. ||  |
LPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase AqueK263.AA TK-Unique 935-1069 36 4.8e-50 170.77 In-house 155-294 (294) Show / Hide 
Range on Protein: 935-1069
Range on HMM: 155-294/294
Sequence Identity: 36% (52 aa)

VHRDLAARNALVQSHLKVLITDFGLTRFIEPDESHYEASGS--KLPVRWLPPESIR--QRIF-THKTDIWSFGVTVWEILTFGESPFKGKSVFELLKLLE
|||||.||| |....... |.|||..| ..  .  |. ..|  ..|.||..|||..  .... | |.|.|||||. |||.|.|. |. | .  .......
VHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIR

KGDRLKQPKTC-TLVFYKSLQNCWELEPEKRPSFEDLVYQF
.|.|..||. | .  .|. ...|| .|||.||||.... ..
DGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK263.AA KIN6 934-1069 36 8.5e-50 162.64 In-house 165-305 (305) Show / Hide 
Range on Protein: 934-1069
Range on HMM: 165-305/305
Sequence Identity: 36% (52 aa)

LVHRDLAARNALVQSHL---KVLITDFGLTRFIEPDESHYEASGSK-LPVRWLPPESIRQRIFTHKTDIWSFGVTVWEILTFGESPFKGKS-VFELLKLL
..|||||||| || . .      | |||| | ...|.. | . | . ||..|. ||...   |  |.|.|||||  .|. . |..|. .     |..  .
CIHRDLAARNVLVTEGCRMKTCKISDFGLCRYPYMDQFQYTSKGGRYLPIKWMAPECLKHYEFSYKSDVWSFGVLMFEMFSLGDVPYPEMQRPTEMIEHH

EKGDRLKQPKTCTLVFYKSLQNCWELEPEKRPSFEDLVYQF
..| |.|.|| |.  .|.  | ||   |. || | ..  ||
RSGRRPKHPKWCPEEIYDIMQSCWQEKPDDRPEFNEMRMQF
Kinase AqueK263.AA UTK 934-1069 37 1.5e-49 167.68 In-house 139-296 (296) Show / Hide 
Range on Protein: 934-1069
Range on HMM: 139-296/296
Sequence Identity: 37% (59 aa)

LVHRDLAARNALVQSH-------LKVLITDFG---LTRFIE-------PDES-HYEASG-SKLPVRWLPPESIRQR-IFTHKTDIWSFGVTVWEILTFGE
.||||||||| || .|       ... | |||   ..| .         .||  | |..  ..|.||  ||.. ..  ||.|.|.|||||..|||.|.| 
FVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGR

SPFKGKSVFELLKLLEKGD--RLKQPKTCTLVFYKSLQNCWELEPEKRPSFEDLVYQF
 |..| |  .... ...|.  |...|. | .  |. .. ||. .|..||.||||| |.
LPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase AqueK263.AA FAK 935-1074 43 1e-47 157.88 In-house 146-285 (285) Show / Hide 
Range on Protein: 935-1074
Range on HMM: 146-285/285
Sequence Identity: 43% (61 aa)

VHRDLAARNALVQSHLKVLITDFGLTRFIEPDESHYEAS-GSKLPVRWLPPESIRQRIFTHKTDIWSFGVTVWEILTFGESPFKGKSVFELLKLLEKGDR
|||| |||| || |   |   |||| |... |.| | ||   |||..|. ||||  | ||   |.| ||| .|||| .|  || .    .    .|.|.|
VHRDIAARNVLVSSPDCVKLGDFGLSRWMH-DHSYYKASPKGKLPIKWMSPESINFRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGER

LKQPKTCTLVFYKSLQNCWELEPEKRPSFEDLVYQFNTMMM
|  |. |  . |  .  ||. .| ||| | .|. |   . .
LPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
Kinase AqueK263.AA Src 934-1069 41 5.3e-47 157.7 In-house 118-255 (255) Show / Hide 
Range on Protein: 934-1069
Range on HMM: 118-255/255
Sequence Identity: 41% (57 aa)

LVHRDLAARNALVQSHLKVLITDFGLTRFIEPDESHYEAS-GSKLPVRWLPPESIRQRIFTHKTDIWSFGVTVWEILTFGESPFKGKSVFELLKLLEKGD
..|||||||| ||  .. . . |||| | |. |.  |.|. |.|.|..|  || |. . || |.| ||||.  .|| |.|  | .| .  | |. .|.| 
YIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGY

RLKQPKTCTLVFYK-SLQNCWELEPEKRPSFEDLVYQF
|. .|..|   .|.  .. ||. .||.|| || |   .
RMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK263.AA Frk 935-1073 39 3.5e-44 150.89 In-house 120-260 (260) Show / Hide 
Range on Protein: 935-1073
Range on HMM: 120-260/260
Sequence Identity: 39% (56 aa)

VHRDLAARNALVQSHLKVLITDFGLTR-FIEPDESHYEA-SGSKLPVRWLPPESIRQRIFTHKTDIWSFGVTVWEILTFGESPFKGKSVFELLKLLEKGD
.|||||||| ||  |. . | |||| | ..  .|  ||.  | ..|..|  || ..   || | |.||||. . ||.|.|  |. |    | |. ...| 
IHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGY

RLKQPKTCTLVFYKSLQNCWELEPEKRPSFEDLVYQFNTMM
|. ||  |   .|. ...||. .|.||| || | ....  .
RMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase AqueK263.AA TyrKc 934-1069 21 1.1e-16 47.31 SMART 1-280 (280) Show / Hide 
Range on Protein: 934-1069
Range on HMM: 1-280/280
Sequence Identity: 21% (61 aa)

L---------------------------------------------------------------------------------------------------
.                                                                                                   
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

---------------------VHRDLAARNALVQSHLKVLITDFGLTRFIEPD------ESHYEAS---GSK--LPVRWLPPESIRQRIFTHKTDIWSFG
                     .|||||||| || . . | |.||||.|.|. |      .. | ..   |.|  ||.||..||.|. ..||.|.|.||||
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFG

VTVWEILTFGESPFKG-----KSVFELLKLLEKGDRLKQPKT--------CTLVFYKSLQNCWELEPEKRPSFEDLVYQF
|. |||.|.|..|  |     .| .|.......|.|..||.         |.   |.  . ||. .||.||.|.... .|
VCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK263.AA Pkinase 935-1069 21 2.5e-12 44.68 Pfam 130-293 (293) Show / Hide 
Range on Protein: 935-1069
Range on HMM: 130-293/293
Sequence Identity: 21% (36 aa)

VHRDLAARNALVQSHLKV----LITDFGLTRF--IEPDESHYEASGSKLPVRWLPPESIR-QRIFTHKTDIWSFGVTVWEILTFGESPFKGK------SV
.||||   | |. ..  .     |.|||| ..  . ...  .   |.    ....|| || ..  ..| |.||.|....| |. |. ||.|.      . 
IHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP---WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQ

FELLKLLEKGDRLKQ-PKTCT-------------------LVFYKSLQNCWELEPEKRPSFEDLVYQ--F
 .....  ...   . |..|.                     . . . .|... |.|||..|...    |
MQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK263.AA S_TKc 934-1073 11 0.000251 -113.46 SMART 1-231 (231) Show / Hide 
Range on Protein: 934-1073
Range on HMM: 1-231/231
Sequence Identity: 11% (31 aa)

L---------------------------------------------------------------------------------------------------
                                                                                                    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYM

---------------VHRDLAARNALVQSHLKVLITDFGLTRFIEPDESHYEASGSKLPVRWLPPESIRQRIFTH-KTDIWSFGVTVWEILTFGESPFKG
               .||||   | |. .   . |.|||| |..         .       ...|| .    ... | |.||.|....| |. |. ||  
YQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP-

KSVFELLKLLEKGDRLKQPKTCTLVFYKSLQNCWELEPEKRPSFEDLVYQF-----NTMM
  .....|..            .  .   ...|.. .|||||.  ..            .
-QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF