Gene AqueK248 (A.queenslandica)

AqueK248

Species: A.queenslandica
Alias: AqueK248
External Links:
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: MEK7

Sequence

Name Sequence Type Origin Length Description Download
AqueK248.AA Protein None 294 None Fasta, JSON
AqueK248.kin_dom Protein Kinase Domain None 261 None Fasta, JSON

Protein domain

Protein domains of AqueK248.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK248.AA MEK7 10-270 50 8.9e-135 454.05 In-house 1-269 (269) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-269/269
Sequence Identity: 50% (138 aa)

MLDVKRVGSGISGEVYRMVHNPSSIAIAAKKMLWQHDTWEEQRRVLMDLEVMNSQH-SPFIVEYYGSAIVKNEVWVFMELMATCLDRLLKRLKGP----I
.  .   |.| .|.| .| |  |   .|.| |    .  || .|.|||| ||   | .|.||  .|  .   .||. ||.|.||.|.||||.|.|    |
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMR-RTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECMSTCCDKLLKRIKHPKLDFI

PERIIGKMCVSIVKALDYLKRAHKVIHRDVKPSNILIDVNGNVKLCDFGISGRLVDSKAFTRGAGAAAYMAPERINM-SHDSKGYDVRADVWSLGISLVE
||.||||| |.|..||.|||  | ..||||||||||.|  ||.||||||||||.||||| || || .||||||||         ||.|||||||||.|||
PEQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVE

MATGSAPYKFNEFSSEFDLLTHIVQA--PPPLLDEDK---FSPNFYDFVAQCLCKDVDERPQYDKLLLHPLI
.|||  ||. ..   ||. .| | .   .||.|.| .   ||| | .|| .|| ||. .||.|..|. || |
LATGQYPYPGCDM--EFEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase AqueK248.AA STE7 10-270 44 1.1e-126 427.22 In-house 1-288 (288) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-288/288
Sequence Identity: 44% (131 aa)

MLDVKRVGSGISGEVYRMVHNPSSIAIAAKKMLWQHDTWEEQRRVLMDLEVMNSQH-SPFIVEYYGSAIVKNE--VWVFMELMA-TCLDRLLKRLK----
. .....|.| .| || |.| ||.. .| |..  . .  ||| . ||.|.|... . .|.|| .||  . ...  .| .||.|. .||| ..||.|    
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

----GPIPERIIGKMCVSIVKALDYLKRAHKVIHRDVKPSNILIDVNGNVKLCDFGISGRLVDSK-AFTRGAGAAAYMAPERINMSHDSKGYDVRADVWS
    |.|||.|.||. |...|.|.||.. ||.|||||||||||.. .|.||||||||.|.||||. | |. .| ..|||||||.   ....||||.||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDG--NKQHYDVRSDVWS

LGISL-VEMATGSAPY-KFNE-----------FS---SEFDLLTHIVQA-PPPLLDEDKFSPNFYDFVAQCLCKDVDERPQYDKLLL-HPLI
|||.. .|||||  || ..|            |.   ..|..|| ||.  ||| |.  |||| | |||..|| || .||| |..|.  || |
LGITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP--KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase AqueK248.AA MEK4 10-270 43 6e-103 336.88 In-house 1-275 (275) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-275/275
Sequence Identity: 43% (120 aa)

MLDVKRVGSGISGEVYRMVHNPSSIAIAAKKML-WQHD----TWEEQRRVLMDLEV-MNSQHSPFIVEYYGSAIVKNEVWVFMELMATCLDRLLKR----
  |   .| |  | |. |.|..|   .| |.      |       ||.| ||...| | |.  | || .||        |. |||| . .| . |.    
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMDISMDKFYKYVYMV

LKGPIPERIIGKMCVSIVKALDYLKRAHKVIHRDVKPSNILIDVNGNVKLCDFGISGRLVDSKAFTRGAGAAAYMAPERINMSHDSKGYDVRADVWSLGI
 |  ||| |.|.  | .|.||.|||. ||.|||||||||||.|  |.||||||||.| |||| | |. ||   |||||||  .. . |||.| |||||||
QKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLGI

SLVEMATGSAPYKFNEFS--SEFDLLTHIVQAPPPLLDEDKF----SPNFYDFVAQCLCKDVDERPQYDKLLLHPLI
 ..| |||  ||.  ...  | || .. .|.  || |..|..    |. . .|.. || || ..|| ||.|. .| .
TMYEVATGKFPYR--KWNDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase AqueK248.AA MEK3 10-270 46 5.3e-96 325.24 In-house 1-264 (264) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-264/264
Sequence Identity: 46% (123 aa)

MLDVKRVGSGISGEVYRMVHNPSSIAIAAKKMLWQHDTWEEQRRVLMDLEV-MNSQHSPFIVEYYGSAIVKNEVWVFMELMATCLDRLLKRLKG----PI
|  .   | |  | |  | | .| . .| |..  .  .  ||.| |||. . | |   |. |..||       ||. ||.| |||| . ..        |
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNS-QEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMDTCLDKFYRHVYKPHGMHI

PERIIGKMCVSIVKALDYLKRAHKVIHRDVKPSNILIDVNGNVKLCDFGISGRLVDSKAFTRGAGAAAYMAPERINMSHDSKGYDVRADVWSLGISLVEM
|| |.||. .|||.|| |..   |||||||||||.||  .| ||.||||||| |||| | |  ||   |||||||.    .|||||..||||||| ..||
PEDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEM

ATGSAPYKFNEFSSEFDLLTHIVQAPPPLLDEDK-FSPNFYDFVAQCLCKDVDERPQYDKLLLHPLI
|.|  ||        |. |. .|  ||| | ..| ||| . ||..||| |.  |||.| .|. || .
AIGRYPY--DNWHTPFQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase AqueK248.AA STE 10-270 27 1.2e-89 304.09 In-house 1-359 (359) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-359/359
Sequence Identity: 27% (102 aa)

MLDVKRVGSGISGEVYRMVHN------PSSIA---------IAAKKMLWQHDTW---------------EEQRRVLMDLEVMNSQH--SPFIVEYYGSAI
  .....|.| .|.||. ...      ..            .| |.|  ....                ||. ..|.....|.  .  .|.||.|||. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VK-------NEVWVFMELMA-TCLDRLLKRLK-------------GPIPERIIGKMCVSIVKALDYLKRAHKVIHRDVKPSNILIDVNGNVKLCDFGISG
..       .|.|..||.|.  .|| ..|. .             ...|| .|...|..|.|.| |..  |..||||.||.|||.     |||||||..|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

RLVDSKA----------------FT-RGAGAAAYMAPERINM-SHD-SKGYDVRADVWSLGISLVEMATGSAPY---KFN----EFSSE------FDLLT
.|.|| |                 .   .|   .||||.|.  ... .||||...|.||||. ..|||||  |.   .      ..  .      |..| 
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-

HIVQAPPPLLDED------------------KFSPNFYDFVAQCLCKDVDERPQYDKLLL--HPLI
 ||. ||| | ..                  |.||.| ||...|| || ..|| ...||   || |
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase AqueK248.AA STE7-Unclassified 10-270 32 8.8e-84 284.65 In-house 1-301 (301) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-301/301
Sequence Identity: 32% (97 aa)

MLDVKRVGSGISGEVYRMVHNP------SSIAIAAKKMLWQHDTWEEQRRVLMDLEVMNSQH-SPFIVEYYGSAIVKNE---VWVFMELMAT-CLD---R
   .|..|.| .| |.  .| .      .....| |.   . .. | ..  |. |.. ..   .|.|| |||  . .     .  .||.|.   ||    
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

LLKRL-------KGPIPERIIGKMCVSIVKALDYLKRAHKVIHRDVKPSNILIDVNGNVKLCDFGISGRLVDSK--AFTRGAGAAAYMAPERINMS-HDS
..|..       .|.|||...||.  .. ..|.||.. |..||||.||.|||.. .|.||.||||..|.|...   | |  .|   ||.||||.    ..
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTW-VGCQMYMSPERIQGQMPHR

KGYDVRADVWSLGISLVEMATGSAPY--------KFNEFS----SEFDLLTHIVQAPPPLLDEDK----FSPNFYDFVAQCLCKDVDERPQYDKLLL-HP
 .| |. |.||||... |.|||  ||        . . |.    |...||. ||. | | |..|.    .|..| ||...|. |.  ||| .  ||  ||
PSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHP

LI
.|
WI
Kinase AqueK248.AA S_TKc 10-270 25 1.2e-69 238.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-231/231
Sequence Identity: 25% (70 aa)

MLDVKRVGSGISGEVYRMVHNPSSIAIAAKKMLWQHDTWEEQRRVLMDLEVMNSQHSPFIVEYYGSAIVKNEVWVFMELMAT---CLDRLLKRLKGP---
   .. .|.|  |.||. .|. .    | |..          ....  .... . | |.|| .|..    ......||.. .    | ...|. ...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--IPERIIGKMCVSIVKALDYLKRAHKVIHRDVKPSNILIDVNGNVKLCDFGISGRLVDSKAFTRGAGAAAYMAPERINMSHDSKGYDV-RADVWSLGIS
  .||  . ...  |..||.|. .  ..||||.||.|||.|   ..|.||||.. .|      |   |   ||||| .       ||.  ..|.||.|. 
FPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCI

LVEMATGSAPYKFNEFSSEFDLLTHIVQAPPPLLDEDKFSPNFYDFVAQCLCKDVDERPQYDKLLL-------HPLI
| ||..|  |.       . ... ...            || . ||. .||.|| ..||   ..|        || .
LYEMLCGYPPFP------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK248.AA MEK5 10-270 40 3.7e-64 219.48 In-house 1-254 (254) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-254/254
Sequence Identity: 40% (106 aa)

MLDVKRVGSGISGEVYRMVHNPSSIAIAAKKMLWQHDTWEEQRRVLMDLEVMNSQHSPFIVEYYGSAIVKNEVWVFMELMATCLDRLLKRLKGPIPERII
.     .| |  | ||.  | ||   .| | .| .  | | |.... .||..    ||.|. .||   | | . .  | |      . ..    ||| |.
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDI-TLELQKQIMSELEILYKCDSPYIIGFYGAFFVENRISICTEFMDGGSLDMYRC----IPEHIL

GKMCVSIVKALDYLKRAHKVIHRDVKPSNILIDVNGNVKLCDFGISGRLVDSKAFTRGAGAAAYMAPERINMSHDSKGYDVRADVWSLGISLVEMATGSA
|.| |.||| | ||    |..||||||||.|.  .|..||||||.|  ||.| . |   |  ||||||||   .    | . .|||||||...|||||  
GRMTVAIVKGLNYL-WNLKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTY-IGTNAYMAPERISGDQ----YGIHSDVWSLGIFFMEMATGRF

PYKFNEFSS----EFDLLTHIVQAPPPLLDEDKFSPNFYDFVAQCLCKDVDERPQYDKLLLHPLI
||   .          ||  ||.  || |  ||||  | .|. ||. |   .||. . |. || |
PYPQIQRDQGELMPIQLLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase AqueK248.AA STE20 12-270 34 4e-59 202.75 In-house 3-288 (288) Show / Hide 
Range on Protein: 12-270
Range on HMM: 3-288/288
Sequence Identity: 34% (100 aa)

DVKRVGSGISGEVYRMVHNPSSIA----IAAKKMLWQHD---TWEEQRRVLMDLEVMNSQHSPFIVEYYGSAIVK----NEVWVFMELMAT-CLDRLLK-
.....|.| .|.||.  |.|.       .| |||   ..     .|.. ..    .|.  ..| ||.|||| ...    .| |. ||...  .|  ..| 
LLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKH

--RLKG-----PIPERIIGKMCVSIVKALDYLKRAHKVIHRDVKPSNILIDVNGNVKLCDFGISGRLVD----SKAFTRG--AGAAAYMAPERINMSHD-
  ....     |. |  |  .|  ....||||  ....||||.|  |||.. .|.|||.||| .. | .    ...|.|    |   .|||| |.  .. 
CMKCGKNHKGHPMNEEQIAYICREVLQGLDYL-HSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

SKGYDVRADVWSLGISLVEMATGSAPYKFNEFS-SEFDLLTHIV--QAPPPLLDED---KFSPNFYDFVAQCLCKDVDERPQYDKLLLHPLI
 |||| ..|.||||| . |||.|  ||    |  . .  . .|   | ||| | .|   |.||.| |||..||.||...||  ..|| || |
DKGYDYKCDIWSLGITAIEMAEGEPPY----FDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase AqueK248.AA Pkinase 10-270 25 2.1e-57 201.84 Pfam 1-293 (293) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-293/293
Sequence Identity: 25% (75 aa)

MLDVKRVGSGISGEVYRMVHNPSSIAIAAKKMLWQHDTWEEQRRVLM--DLEVMNSQHSPFIVEYYGSAIVKNEVWVFMELMAT-----CLDRLLK-RLK
   ....||| .|.||. .|  ...  | |..  .|. ...... .    ...|.. ..|.||..|..   |..... ||..        | .... . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GPI--PERIIGKMCVSIVKALDYLKRAHKVIHRDVKPSNILIDVNGNV----KLCDFGISGR--LVDSKAFTRGAGAAAYMAPERINMSHDSKGYDVRAD
|..  .|. . ...  |...|.|. . ...||||.||.||||| ||..    |.||||..    .  .  .|  .|   ||||| |.   ....|. ..|
GCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPKVD

VWSLGISLVEMATGSAPYKFN----EFSSEFDLLTHIVQAPPPLLDEDKFS-------------------PNFYDFVAQCLCKDVDERPQYDKLLLHPLI
.||.|. | ||..|  |..      .  ..  ..  | ..|..   . . |                   ... ||.  |||||  .||  . .| || .
MWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK248.AA MEK1 10-210 40 1.1e-54 185.16 In-house 1-195 (297) Show / Hide 
Range on Protein: 10-210
Range on HMM: 1-195/297
Sequence Identity: 40% (81 aa)

MLDVKRVGSGISGEVYRMVHNPSSIAIAAKKMLWQHDTWEEQRRVLMDLEVMNSQHSPFIVEYYGSAIVKNEVWVFMELM-ATCLDRLLKRLKGPIPERI
.  .. .|.|  | | ...| .. . | |.|..        .. .. .|.|.    ||.|| .||  .  .|. . || |    || .||.  | |||.|
FEKIGELGHGNGGVVMKCRHRHTGM-IMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA-GRIPEKI

IGKMCVSIVKALDYLKRAHKVIHRDVKPSNILIDVNGNVKLCDFGISGRLVDSKAFTRGAGAAAYMAPERINMSHDSKGYDVRADVWSLGISLVEMATGS
.||. | ... | ||.  ||..||||||||||.  .| .||||||.||.|.|| |     |  .||.|||.  .|    | |..|.||.|.|||||| | 
LGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERLQGTH----YTVQSDIWSMGLSLVEMAIGR

AP
 |
YP
Kinase AqueK248.AA PAKA 13-211 32 7.1e-28 94.95 In-house 4-203 (260) Show / Hide 
Range on Protein: 13-211
Range on HMM: 4-203/260
Sequence Identity: 32% (68 aa)

VKRVGSGISGEVYRMVHNPSSIA--IAAKKMLWQHDTWEEQRRVLMDLEVMNSQHSPFIVEYYGSAIVKNEVWVFMELMAT-CLDRLLKRLKG----PIP
.. .| | |||||.           .| |.|  . .   |   ... . ||.. . . || |. | .|. | || || |.  ||  ...        ...
MEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKE--LIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYMD

ERIIGKMCVSIVKALDYLKRAHKVIHRDVKPSNILIDVNGNVKLCDFGISGRLVD--SKAFTRGAGAAAYMAPERINMSHDSKGYDVRADVWSLGISLVE
|..|.  |  . ..|... . | .||||.|  |||.. .|.||. |||   .| .  .|  |   |  ..|||| |.     | ||   |.||||| . |
EGQIAYVCRECLQGLEFIHSKH-RIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTM-VGTPYWMAPEVIRR----KQYDEKVDIWSLGIMAIE

MATGSAPY
|. |  ||
MIEGEPPY
Kinase AqueK248.AA PAKA 231-270 47 4.9e-15 49.31 In-house 221-260 (260) Show / Hide 
Range on Protein: 231-270
Range on HMM: 221-260/260
Sequence Identity: 47% (19 aa)

PPLLDEDKFSPNFYDFVAQCLCKDVDERPQYDKLLLHPLI
|...| ||.|..| ||...|||.|||.|.  ..|| || .
PDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase AqueK248.AA TyrKc 10-270 21 1.1e-13 -1.12 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

MLDVKRVGSGISGEVYRMVHNPSSIAIAAKKMLWQHDTWEEQRRVLMDLEVMNSQ--HSPFIVEYYGSAIVK-------NEVWVFMELMAT-CLDRLLKR
    |  |.|  ||||. . .   |  | |..   .     ..  .  ...| .   | | ||  || .. .         ... ||.|.  .|.  |..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

LKGPIPERIIGKMCVSIVKALDYLKRAHKVIHRDVKPSNILIDVNGNVKLCDFGISGRLVDS-------KAFT-----RGA--GAAAYMAPERINMSHDS
 .. .. .   ..|. | .  .|| .  ..||||    |.|.. |. || .||| |  . |        .  .      |        |||| |    . 
HRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NY

KGYDVRADVWSLGISLVEMATGSAPYKFNE---FSSEFDLLTHIVQA---PPPLLDEDK-----FSPNFYDFVAQCLCKDVDERPQYDKLLLHPLI
. .    |||| |. . |. |  ..   ..   . | .... .. |    |.|  |.        ..  |.   ||   | ..||    .  | ..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase AqueK248.AA MEK1 220-270 45 6.8e-13 39.89 In-house 247-297 (297) Show / Hide 
Range on Protein: 220-270
Range on HMM: 247-297/297
Sequence Identity: 45% (23 aa)

FDLLTHIVQAPPPLLDEDKFSPNFYDFVAQCLCKDVDERPQYDKLLLHPLI
|..|  ||. ||| |..  || .| ||| .|| |  ||| .  .|. |. |
FEMLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase AqueK248.AA Pkinase_Tyr 67-212 30 7e-07 23.93 Pfam 64-217 (270) Show / Hide 
Range on Protein: 67-212
Range on HMM: 64-217/270
Sequence Identity: 30% (49 aa)

PFIVEYYGSAI-VKNE--VWVFMELMAT-CLDRLLKRL---KGPIPERIIGKMCVSIVKALDYLKRAHKVIHRDVKPSNILIDVNGNVKLCDFGISGRLV
| || .||  .  .    ... ||.|.  .|.  |..    |.|..   . .||. | |...|| . .  ||||.   |.|.. |. || |||| . |..
PNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN-CIHRDLAARNCLVTENNVVKICDFGLA-RDI

----DS-KAFTRGAGAAAYMAPERINMSHDSKGYDVRADVWSLGISLVEMAT-GSAP-YK
       .. . |      |||| || .     . .  |||| |. . |. | |  | |.
YNDDYYYRKRGGGKLPIKWMAPECINYGK----FTTKSDVWSFGVLMWEIFTYGEQPTYP