Gene AqueK178 (A.queenslandica)

AqueK178

Species: A.queenslandica
Alias: AqueK178
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK11

Sequence

Name Sequence Type Origin Length Description Download
AqueK178.AA Protein None 540 None Fasta, JSON
AqueK178.kin_dom Protein Kinase Domain None 256 None Fasta, JSON

Protein domain

Protein domains of AqueK178.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK178.AA NEK 32-287 42 1e-129 437.21 In-house 1-286 (286) Show / Hide 
Range on Protein: 32-287
Range on HMM: 1-286/286
Sequence Identity: 42% (121 aa)

YGLGCRLGSGNFGTAYVVQDHKTGEK-----KVLKRINIGEVQPNETVEAV-KEATLLAQLDHPAIVKYHDSFMD--VEHFCIITEYCE-GGDLDYM---
| .   .|.|.||..| |.. ..| .      |.|.||.|. .. |. .|. .|. .|.||.|| ||||.|||..   ...||. |||| ||||. .   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

LKKLKSTNKILDESLIMDWFIQLTNAVHYIHDR-----KVLHRDLKTRNIFLKDK-----KIKLGDFGISRILVATSDFATT-FTGTPYYMSPEVLKHEG
.|| |  .| ..|. |.|||||.  |..|.|||     |.||||.|. |||| ..      .|.||||||..|  |.|.|.| ..||||||||||.....
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNSKSDIWSLGAVLYELCTC--EHAYQGQ--NIMAIMYKIVEG-HPPRLPNH--FTPSMRYLHSRMMDKSPARRPSAIEILQDPCV
||.|||||||| ||||.||.  .|. ...  |... ..||..| ..|..| |  . . .. | |.|  |.|  |||. .||..|..
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase AqueK178.AA NEK11 32-287 54 7.4e-119 401.16 In-house 1-259 (259) Show / Hide 
Range on Protein: 32-287
Range on HMM: 1-259/259
Sequence Identity: 54% (141 aa)

YGLGCRLGSGNFGTAYVVQDHKT---GEKKVLKRINIGEVQPNETVEAVKEATLLAQLDHPAIVKYHDSFMDVEHFCIITEYCEGGDLDYMLKKLKSTNK
| |  .|||| ||| |.| | |     | |||| | .||. ||||| |  || ||..|.|||||..| |||. . |||||||||| |||| ..  |   |
YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNFCIITEYCEGRDLDYRIQEYKQAGK

ILDESLIMDWFIQLTNAVHYIHDRKVLHRDLKTRNIFLKDKKIKLGDFGISRILVATSDFATTFTGTPYYMSPEVLKHEGYNSKSDIWSLGAVLYELCTC
|  |  |..|||||   | |.|.|..|||||| .|||||   .|.||||.||.|.   | ||| |||| ||||| ||| || .|||||||  .|||.|  
IFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCM

EHAYQGQNIMAIMYKIVEGHPPRLPNHFTPSMRYLHSRMMDKSPARRPSAIEILQDPCV
.||. | | ..|. .||||. | ||. .   .  .  ||. |.|. |||||.||. | .
DHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM
Kinase AqueK178.AA NEK1 32-287 40 2.7e-97 329.52 In-house 1-276 (276) Show / Hide 
Range on Protein: 32-287
Range on HMM: 1-276/276
Sequence Identity: 40% (112 aa)

YGLGCRLGSGNFGTAYVVQDHKTGEKKVLKRINIGEVQPNETVEAVKEATLLAQLDHPAIVKYHDSFMDVEH--FCIITEYCEGGDLDYMLKKLKSTNKI
|     .|.|.|| |. |..   |   |.| ||. . |. |. |...|. .|| ..|| |||| .||    .    |. |||.||||    .. |  .| 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

LDESLIMDWFIQLTNAVHYIHDRKVLHRDLKTRNIFLK----DK--------------KIKLGDFGISRILVATSDFATTFTGTPYYMSPEVLKHEGYNS
  |  ||.||.|.  |. .|||||.||||.|. ||||     .               ..|||||||.|.|  | ..| |  ||||| |||     .|| 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDIWSLGAVLYELCTCEHAYQGQNIMAIMYKIVEGHPPRLPNHFTPSMRYLHSRMMDKSPARRPSAIEILQDPCV
|||||||| |||||||  |. ...|  .   ||..|. | .|.|.    . | | |  ..|  |||.  ||. | .
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase AqueK178.AA NEK4 32-287 40 3.3e-87 296.04 In-house 1-257 (257) Show / Hide 
Range on Protein: 32-287
Range on HMM: 1-257/257
Sequence Identity: 40% (104 aa)

YGLGCRLGSGNFGTAYVVQDHKTGEKKVLKRINIGEVQPNETVEAVKEATLLAQLDHPAIVKYHDSFMDVEH--FCIITEYCEGGDLDYMLKKLKSTNKI
|      | | .|  . |.  . . . |.|...  .    |. .| .|| || || || ||.| .|.   .    .|.  .||||||   ||. |  |..
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQK--NQF

LDESLIMDWFIQLTNAVHYIHDRKVLHRDLKTRNIFL-KDKKIKLGDFGISRILVATSDFATTFTGTPYYMSPEVLKHEGYNSKSDIWSLGAVLYELCTC
|.|. ...||.|   |  |.|....||||||| |||| |   ||.|||||||.|   .|.| |  |||||||||.     |. ||||||||  .||. | 
LEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITL

EHAYQGQNIMAIMYKIVEGHPPRLPNHFTPSMRYLHSRMMDKSPARRPSAIEILQDPCV
 ||..  ..  ..|.|..|.|| .|  . . .  |   |..| | .|||  .|.| | .
KHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase AqueK178.AA S_TKc 32-287 31 4.5e-84 286.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 32-287
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

YGLGCRLGSGNFGTAYVVQDHKTGEKKVLKRINIGEVQPNETVEAVKEATLLAQLDHPAIVKYHDSFMDVEHFCIITEYCEG--GDLDYMLKKLKS--TN
| ..  .|.| ||. | ....|||..  .|.|.           . .|  .| . .|| |||..|.| | .|.....|||.|  |||  ..|| ..  ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

KILDESLIMDWFIQLTNAVHYIHDRKVLHRDLKTRNIFLKDKKIKLGDFGISRILVATSDFATTFTGTPYYMSPEVLKHEGYNS-KSDIWSLGAVLYELC
. ..|  .  .. |. .|. |.|.....|||||  ||.| .  ||..|||..|.|       ||| |||.||.||||   ||.  |.|.||.| .|||..
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

TCEHAYQGQNIMAIMYKIVEGHPPRLPNHFTPSMRYLHSRMMDKSPARRPSAIEILQ-------DPCV
. .  ..  ...... ||.           .|... . .....| |..||.| |.||       .| .
CGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK178.AA NEK8 59-287 35 2.8e-78 223.04 In-house 30-278 (278) Show / Hide 
Range on Protein: 59-287
Range on HMM: 30-278/278
Sequence Identity: 35% (88 aa)

VLKRINIGEVQPNETVEAVKEATLLAQLDHPAIVKYHDSFMDVEHFCIITEYCEGGDLDYMLKKLKSTNKILDES----------------LIMDWFIQL
..| ||  .  ..|   |  |  .|. |.|| |. | |.||.     |  ||..|| |  |. . . . . ..|                 .| . |.| 
IWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNK-LFEEERQLKQVNHCFNIYFNEQMILWYFFQM

TNAVHYIHDRKVLHRDLKTRNIFLKDKK---IKLGDFGISRILVATSDFAT--TFTGTPYYMSPEVLKHEGYNSKSDIWSLGAVLYELCTCEHAYQGQNI
  |||..|.  .||||||| |||. ..    .|.|||||| |.   .  .|  |  |||||||||  .   || |||.|.|| ||||.|. . |  . | 
CSAVHHMHQHNILHRDLKTQNIFM-TRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNL

MAIMYKIVEG-HPPRLPNHFTPSMRYLHSRMMDKSPARRPSAIEILQDPCV
 |.  ||. .     .. | .. || | .   .. |..|||| .|. .| .
PALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase AqueK178.AA NEK-Unclassified 82-287 42 3.8e-74 244.82 In-house 46-258 (258) Show / Hide 
Range on Protein: 82-287
Range on HMM: 46-258/258
Sequence Identity: 42% (92 aa)

LLAQLDHPAIVKYHDSFMDVEHFCIITEYCEGGDLDYMLKKLKSTNKILDESLIMDWFIQLTNAVHYIHDRKVLHRDLKTRNIFL-KDKKIKLGDFGISR
.|.|| || || ||||| .        .||.||.||  ..|    |  .||  || |.||.  || ||| ||..|||||. |||| .|  . .|||||||
ILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFDEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISR

ILVATSDFATTFTGTPYYMSPEVLKHEGYNSKSDIWSLGAVLYELCTCEHAYQGQNIMAIMYKIVEGHPPRLPNHFTP-SMRY------LHSRMMDKSPA
|.  | | | |  ||. .|||||..   || .||.|||| ..||.|||| .   .|.  ...||. . . ||     | |  |      .   |. . . 
IMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFDTHNMGEVYMKIKQD-DNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQ

RRPSAIEILQDPCV
.||||.||.  . .
QRPSATEIVEQDYI
Kinase AqueK178.AA Pkinase 32-287 27 5.8e-73 253.5 Pfam 1-293 (293) Show / Hide 
Range on Protein: 32-287
Range on HMM: 1-293/293
Sequence Identity: 27% (81 aa)

YGLGCRLGSGNFGTAYVVQDHKTGEKKVLKRINIGEVQPNETVEAVK--EATLLAQLDHPAIVKYHDSFMDVEHFCIITEYCEGG----DLDYMLKKLKS
| .| ..|||.||. |  ....||.. ..|.|.  .  ... .....  |. ... |.|| ||...|.|.|  | ....||||||    ||  ...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

TNKIL--DESLIMDWFIQLTNAVHYIHDRKVLHRDLKTRNIFLK-DKKI----KLGDFGISRIL-VATSDFATTFTGTPYYMSPEVLK-HEGYNSKSDIW
 .. .  .|  . ... |.  .. |.|.....|||||  ||... .  |    |..|||... .    .  .|||.|||.||.|||.. ...| .|.|.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SLGAVLYELCTCEHAYQGQ----NIMAIMYKIVEGHPPRLPNHFT-----------------------PSMRYLHSRMMDKSPARRPSAIEILQDPCV
|.| .|||... .  ..|.    | .  |..|..  .|.|. ..                        .... . ... .| |..||.| .|||.| .
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK178.AA STE 32-287 24 1.6e-66 227.29 In-house 1-359 (359) Show / Hide 
Range on Protein: 32-287
Range on HMM: 1-359/359
Sequence Identity: 24% (89 aa)

YGLGCRLGSGNFGTAYVVQDHK---------------TGEKKVLKRINIGEVQP---------------NETVEAVKEATLLAQLD--HPAIVKYHDSFM
. .  ..|.|.||| |   .||               |||    |..|. . ..               .|  .  ||  .. ...  || ||||.....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DV-------EHFCIITEYCEGGDLDYMLKKLKSTNKILD----------ESLIMDWFIQLTNA-VHYIHDRKVLHRDLKTRNIFLKDKKIKLGDFGISRI
.        .. .|. ||..|| || ..|. ....| |.          ||.|     |.  .  .|.|. .. |||.|  ||.|    .|| |||.. .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

LVA---------------TSD-FATTFTGTPYYMSPEVLKH------EGYNSKSDIWSLGAVLYELCTCEHAYQGQNIM----AIMYK-----------I
|.                |..   .||.||| .|.|||..        ||. |.|||||| .. |..| .. .   . |    .|. .           |
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

VEGHPPRLPN-------------------HFTPSMRYLHSRMMDKSPARRPSAIEILQ--DPCV
|.|.||.||.                   ...|...   ..  .| |  ||.| . |.   | .
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase AqueK178.AA CAMK 37-287 19 1e-62 200.59 In-house 1-425 (425) Show / Hide 
Range on Protein: 37-287
Range on HMM: 1-425/425
Sequence Identity: 19% (82 aa)

RLGSGNFGTAYVVQDHKTG------------EKKVLKRINIGEVQ--------------------------PNETVEAVKEATLLAQ-------LDHPAI
 ||.|.||. . ... .|.            .|   | |.   ..                          |.   .  .|  .. .       |||| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKYHDSFMD-------------------VEHFCIIT---EYCEGG----D-LDYMLKK-----------LKSTNKILDESLIMDWFIQLTNAVHYIHDRK
.| .. . |                    .|.....   |||.||    | .||  ..           .   .. ..|.    .| |.  ||||.|...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN

VLHRDLKTRNIFLKDK------------------KIKLGDFGISRILVA-----------------------TSDFATTFTGTPYYMS-PEVLKH-----
. |||||  || | |.                  .||. ||| ....                         . .  .|| |||.||. ||||.      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------EGYNSKSDIWSLGAVLYELCTCEHAYQGQNIMAIMY-------------KIVEGHPPRLPNHFTP-----------------------SMR
         ..|. |.|.||.| .|| . . .  ..| . . |.              || .|     | .|.|                       . .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

YLHSRMMDKSPARRPSAIEILQDPCV
 | ..|. . | .|... ..|..| .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase AqueK178.AA NEK2 32-287 32 4.5e-62 207.77 In-house 1-319 (319) Show / Hide 
Range on Protein: 32-287
Range on HMM: 1-319/319
Sequence Identity: 32% (103 aa)

YGLGCRLGSGNFGTAYVVQDHKTGEKKVLKRINIGEVQPNETVEAVKEATLLAQLDHPAIVKYHDSFMDVEHFC--IITEYCEGGDLDYMLKKLKSTNKI
|     .|.| ||. . | .  .|.  | | |. |. |  |    | |  .| || || ||.| |   | .     |. ||||||||  | || ..  . 
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

LDESLIMDWFIQLTNAVHYIHD---------------------RKVLHRDLKTRNIFL-KDKK-------------------------------------
..|. |   . ||. |   .|                      . .||||.|  ||||  |.                                      
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--IKLGDFGISRILVATSDFATTFTGTPYYMSPEVLKHEGYNSKSDIWSLGAVLYELCTCEHAYQGQNIMAIMYKIVEGHPPRLPNHFTPSMRYLHSRMM
  .||||||  |.|   . ||.|| |||||||||...   || ||||||.| ..||.|.     |. |  .   || .||  |.|         . ..|.
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

DKSPARRPSAIEILQDPCV
.  .  |||  ||||.| .
NVDHYHRPSIEEILQHPQI
Kinase AqueK178.AA Ciliate-E2 32-287 21 1.7e-59 202.85 In-house 1-365 (365) Show / Hide 
Range on Protein: 32-287
Range on HMM: 1-365/365
Sequence Identity: 21% (80 aa)

YGLGCRLGSGNFGTAYVVQDHKTGE------------------KKVLKRINIGEVQPNETVEAVKEATLL----------------AQLDHPAIVKYHDS
| .   .|.||||. | ... |...                  |   | ...  ...|.  .  .|  ..                 ||.|| |.|....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FM--DVEHFCIITEYCEGGDLDYMLK--KLKSTNKIL-----DESLIMDWFIQLTN---------------AVHYIHDRK-VLHRDLKTRNIFLKDKKIK
|   | ... ...|||.|||| . .|  |.|....|      .|  | . . |...               |..|.| .. ..|||.|  ||..    ||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

LGDFGISR-----------------ILVATSDFATTFT---------------GTPYYMSPEVLK---------HEGYNSKSDIWSLGAVLYELCTCEHA
. |||.|.                 ..   .|  .|..               |||.||.||.|.         ..||. |.|||||| .|||... .. 
IIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

YQGQNIMAIMYKIVEGHPPRLP------------------NHFTPSMRYLHSR----MMDKSPARRPS-AIEILQDPCV
.         ... .  . ..|                  .. ....  | ..    |..| |  |.. . .||. |  
F---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase AqueK178.AA Pkinase_Tyr 78-227 26 2.9e-27 92.96 Pfam 52-209 (270) Show / Hide 
Range on Protein: 78-227
Range on HMM: 52-209/270
Sequence Identity: 26% (44 aa)

KEATLLAQL-DHPAIVKYHDSFM-DVEH--FCIITEYCEGGDLDYMLKKLKSTNKILDESLIMDWFIQLTNAVHYIHDRKVLHRDLKTRNIFLK-DKKIK
.|| .. || .|| ||...   . . |.   .|..||...|||.  |.| .. .. |. . . .. .|  ..  | ....  |||| .||. .. ....|
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVK

LGDFGISRILVATSDFATTFTGTPYY-------------MSPEVLKHEGYNSKSDIWSLGAVLYELCT
 .||| .| .          . . ||             |.||....  ...|||.|| | ...|..|
ICDFGLARDI----------YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFT
Kinase AqueK178.AA TyrKc 32-285 21 1e-18 69.44 SMART 1-280 (280) Show / Hide 
Range on Protein: 32-285
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

YGLGCRLGSGNFGT---AYVVQDHKTGEK---KVLKRINIGEVQPNETVEAVKEATLLAQL--DHPAIVKYHDSFMDV-------EHFCIITEYCEGGDL
  ||  ||.|.||.   .         ..   |.||             .  .|| .. .|  .|| ||. .   ..        |  .|..||...|||
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

DYMLKKLKSTNKILDESLIMDWFIQLTNAVHYIHDRKVLHRDLKTRNIFLKDKK-IKLGDFGISRILVAT-------SDFATTF-TGTP-----YYMSPE
.  |.| . .   |  .   .. .|  .   |.|.... |||| .||. ..... .| .||| || .          .   ..   |.        |.||
KDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

VLKHEGYNSKSDIWSLGAVLYELCT-CEHAYQG-----QNIMAIMYKIVEGHPPRLPNH--------FTPSMRYLHSRMMDKSPARRPSAIEILQDP
....  ...|||.|| | ...|..| ..  | |      .   .. .. .|. .. | .         .. |  . ..  .  |. ||.  || .. 
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF