Gene AqueK144 (A.queenslandica)

AqueK144

Species: A.queenslandica
Alias: AqueK144
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-C

Sequence

Name Sequence Type Origin Length Description Download
AqueK144.AA Protein None 627 None Fasta, JSON
AqueK144.kin_dom Protein Kinase Domain None 85 None Fasta, JSON

Protein domain

Protein domains of AqueK144.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kelch_1 AqueK144.AA Kelch_1 30-77 25 0.000362 18.71 Pfam 1-45 (45) Show / Hide 
Range on Protein: 30-77
Range on HMM: 1-45/45
Sequence Identity: 25% (12 aa)

AVNSYRCTAINDQLYYFGGYCGHDFCYHNSITQLDTVSLQWRELEPTD
.  .. ....|...| .||..|    | ||.  .|... ||... |  
PRCGHGVCVHNGKIYVIGGCDG---QYLNSVECYDPETNQWTRCPPMP
Kelch_2 AqueK144.AA Kelch_2 30-77 17 0.003058 16.44 Pfam 1-51 (51) Show / Hide 
Range on Protein: 30-77
Range on HMM: 1-51/51
Sequence Identity: 17% (9 aa)

AVNSYRCTAINDQLYYFGGY---CGHDFCYHNSITQLDTVSLQWRELEPTD
   .  .. .....| ||||    ... |....|  .|. . .|... . .
PRYCHASCVPGGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_1 AqueK144.AA Kelch_1 234-264 12 0.311148 8.19 Pfam 14-41 (45) Show / Hide 
Range on Protein: 234-264
Range on HMM: 14-41/45
Sequence Identity: 12% (4 aa)

LVISGGRNKKNEDALDDCWIFNITQHSWIKL
. . ||..     .|....... . ..| ..
IYVIGGCDG---QYLNSVECYDPETNQWTRC
Kelch_2 AqueK144.AA Kelch_2 234-268 18 0.592305 7.75 Pfam 14-51 (51) Show / Hide 
Range on Protein: 234-268
Range on HMM: 14-51/51
Sequence Identity: 18% (7 aa)

LVISGGR---NKKNEDALDDCWIFNITQHSWIKLDVSH
....||.   .  | ... | |...   |.| .. . .
IYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kinase AqueK144.AA TKL 496-584 24 5.5e-16 54.06 In-house 90-202 (364) Show / Hide 
Range on Protein: 496-584
Range on HMM: 90-202/364
Sequence Identity: 24% (29 aa)

FIGATKVDN--------------PLILTELM-STS-LNQEIRRNRLTNEQILSIAQDVALGLNYLHLFKP-----QPIIHRDVSSPNVLLKPCTG-----
|.|. .  .              . | .|..   | |.. .       .|....|.|.|.|.||||  .|      ||||||  |.|.|..         
FMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNY

----AACYEAKVADYGTAK
    .| . .|..|.|...
MYNPNADWCCKICDFGLSR
Kinase AqueK144.AA MLK 528-600 30 1.7e-14 46.78 In-house 124-198 (291) Show / Hide 
Range on Protein: 528-600
Range on HMM: 124-198/291
Sequence Identity: 30% (23 aa)

EQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKP-CTGAACYEAKVADYGTAKLVQVD-STGTVMPGNAA
......| ..| |..|||  .|.||||||  |.|.|.   |   .   .|..| ||.. ..   .. . ..|..|
DHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYA
Kinase AqueK144.AA TKL-Unique 508-594 28 2.9e-14 46.86 In-house 87-175 (290) Show / Hide 
Range on Protein: 508-594
Range on HMM: 87-175/290
Sequence Identity: 28% (26 aa)

LTELMSTSLNQE---IRRNRLTNEQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAACYEAKVADYGTAKLVQVDSTGTV
| .. ....|     .. . |...|....|.|.|.|..|||  .|  |||||  |.|.|.      | . .|..| |..|.   ....|.
LYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTN
Kinase AqueK144.AA CZAK 531-564 57 6.6e-13 43.35 In-house 108-142 (279) Show / Hide 
Range on Protein: 531-564
Range on HMM: 108-142/279
Sequence Identity: 57% (20 aa)

LSIAQDVALGLNYLHL-FKPQPIIHRDVSSPNVLL
...| |.| | ||||  .|| ||.||| || |.||
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILL
Kinase AqueK144.AA TK 496-595 13 1.6e-11 34.11 In-house 108-318 (486) Show / Hide 
Range on Protein: 496-595
Range on HMM: 108-318/486
Sequence Identity: 13% (29 aa)

FIG-ATKVDN------------PLILTELMS-TS----LNQEIRRNR-----------------------------------------------------
..|  |....            ..|..|.|.  .    | .  |..|                                                     
LYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKD

------------------------LTNEQILSIAQDVALGLNYLHLFKP---QPIIHRDVSSPNVLLKPCTGAA------CYEAKVADYG--------TA
                        || .| | .....| |. |||  .    | ..|||.   |.|.      .      .. .|.||.|         |
HPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLA

KLVQVDSTGTVM
. .. |.  ...
RDIYSDDDYYRK
Kinase AqueK144.AA HH498 530-564 51 1.3e-10 29.46 In-house 123-157 (284) Show / Hide 
Range on Protein: 530-564
Range on HMM: 123-157/284
Sequence Identity: 51% (18 aa)

ILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLL
.. |. ||| | ||||   ..||||||  | |.|.
KMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILI
Kinase AqueK144.AA LRRK 533-592 40 1.6e-10 33.39 In-house 169-234 (351) Show / Hide 
Range on Protein: 533-592
Range on HMM: 169-234/351
Sequence Identity: 40% (27 aa)

IAQDVALGLNYLHLFKPQPIIHRDVSSPNVLL-KPCTGA------ACYEAKVADYGTAKLVQVDSTG
|| ..| |..||| ..| ||||||  |||.|| .  ..       | . ||.||.|.  . |.. .|
IALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMG
Kinase AqueK144.AA STE 507-584 27 1.3e-09 30.19 In-house 114-195 (359) Show / Hide 
Range on Protein: 507-584
Range on HMM: 114-195/359
Sequence Identity: 27% (26 aa)

ILTELMS-TSLNQEIRRN---------------RLTNEQILSIAQDVALG-LNYLHLFKPQPIIHRDVSSPNVLLKPCTGAACYEAKVADYGTAK
|  |.|.  || . |...               |.  .||  |....  | |.|||  .   |||||. . |.||          .| .| |...
ICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL----------VKLCDFGVCG
Kinase AqueK144.AA LZK 522-591 32 3.9e-09 26.88 In-house 81-143 (241) Show / Hide 
Range on Protein: 522-591
Range on HMM: 81-143/241
Sequence Identity: 32% (23 aa)

RNRLTNEQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAACYEAKVADYGTAKLVQVD-ST
|. .| . . .  ...| |..|||. |   |||||  |||.|      ..    |..|.|| .  .   ||
RRTITPQLMVDWSKQIAQGMHYLHQHK---IIHRDLKSPNILI-----SHNDVVKICDFGTSHMWNEMDST
Kinase AqueK144.AA IRAK 531-564 45 1.4e-08 26.68 In-house 112-146 (317) Show / Hide 
Range on Protein: 531-564
Range on HMM: 112-146/317
Sequence Identity: 45% (16 aa)

LSIAQDVALGLNYLHLFKPQ-PIIHRDVSSPNVLL
.||..  |.|...|| . |  ||||.|..| |.||
CSICWGTACGIQFLHQNHPCTPIIHGDIKSANILL
Kinase AqueK144.AA Pkinase_Tyr 504-565 26 2.2e-05 18.83 Pfam 81-145 (270) Show / Hide 
Range on Protein: 504-565
Range on HMM: 81-145/270
Sequence Identity: 26% (18 aa)

NPLILTELMST-SLNQEIRRN-----RLTNEQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLK
...| .|.|   .|    |..     .|| ...|......| |..||.  .   .||||.   |.|..
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVT
S_TKc AqueK144.AA S_TKc 355-627 10 8.2e-05 -106.32 SMART 1-220 (231) Show / Hide 
Range on Protein: 355-627
Range on HMM: 1-220/231
Sequence Identity: 10% (35 aa)

LEEYQKPRKGDTADIEQTIQAL------MKSLEEKEREAQVYHQQLEQKEREEAEKEQEIRRYCHQLQEKDREHQVVLQEKDLLIQQKDEEHQKVIEEKD
 |  .|  ||  .   . .         .| .                                                                    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

RELQEKEETLQQKDMQHQVLLQENQEELRQKDRELQE--NQATLRQKDIFIGATKVDNPLILTELMST---SLNQEIRRNR-------LTNEQILSIAQD
                          |  .. ... .       . .|.|      |.  . .|....   .| . |....       ..  .. .... 
--------------------------EHIRREIQILKKHHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQ

VALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAACYEAKVADYGTAKLVQVDSTGT-------VMPGNAA--------------MLHQKLLFLINTVQ-
....|.|.|  .   |||||.   |.||         . |..| | |...     ||       |. |                 ||  . .|  .  . 
ICCALEYCHSHG---IIHRDLKPENILLDE-------HIKICDFGLARQL-TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMM

-------------QWMCTV------TLFSLWK
             . ....      |   . .
FKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQ
Kinase AqueK144.AA Pkinase 503-557 20 9.7e-05 17.84 Pfam 73-134 (293) Show / Hide 
Range on Protein: 503-557
Range on HMM: 73-134/293
Sequence Identity: 20% (13 aa)

DNPLILTELMST-----SLNQEIR---RNRL--TNEQILSIAQDVALGLNYLHLFKPQPIIHRDV
|.. . .|..       .|   |.   ....  . ... ...  .. ||.|.|      |||||.
DHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDL