Gene AqueK142 (A.queenslandica)

AqueK142

Species: A.queenslandica
Alias: AqueK142
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-C

Sequence

Name Sequence Type Origin Length Description Download
AqueK142.AA Protein None 693 None Fasta, JSON
AqueK142.kin_dom Protein Kinase Domain None 121 None Fasta, JSON

Protein domain

Protein domains of AqueK142.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kelch_1 AqueK142.AA Kelch_1 13-69 19 0.009215 13.67 Pfam 1-45 (45) Show / Hide 
Range on Protein: 13-69
Range on HMM: 1-45/45
Sequence Identity: 19% (11 aa)

ERAGHCTVSVGDSLYVWGGAQAGLPKVHDSEEKIRFTSNIQHFTPSTGQWITRATTG
 |.||. ..... .|| ||               ......  . |.|.||   .. .
PRCGHGVCVHNGKIYVIGGCDG------------QYLNSVECYDPETNQWTRCPPMP
Kelch_2 AqueK142.AA Kelch_2 13-69 19 0.05407 11.7 Pfam 1-51 (51) Show / Hide 
Range on Protein: 13-69
Range on HMM: 1-51/51
Sequence Identity: 19% (11 aa)

ERAGHCTVSVGDSLYVWGGAQAGLPKVHDSEEKIRFTSNIQHFTPSTGQWITRATTG
 |..| ....|. .||.||.        .. ..  ... |. . |.| .|   .  .
PRYCHASCVPGGKIYVFGGYC------RHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_1 AqueK142.AA Kelch_1 74-121 25 0.000102 20.68 Pfam 1-45 (45) Show / Hide 
Range on Protein: 74-121
Range on HMM: 1-45/45
Sequence Identity: 25% (12 aa)

GVIQYCCTAINDLLYYFGGWCGHDSCYHNSITQLDTVSLQWRELEPTR
    ......|...| .||..|    | ||.  .|... ||... | .
PRCGHGVCVHNGKIYVIGGCDG---QYLNSVECYDPETNQWTRCPPMP
Kelch_2 AqueK142.AA Kelch_2 74-121 15 0.009555 14.56 Pfam 1-51 (51) Show / Hide 
Range on Protein: 74-121
Range on HMM: 1-51/51
Sequence Identity: 15% (8 aa)

GVIQYCCTAINDLLYYFGGW---CGHDSCYHNSITQLDTVSLQWRELEPTR
.  .  .. ... .| |||.    ....|....|  .|. . .|... .  
PRYCHASCVPGGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_1 AqueK142.AA Kelch_1 275-304 16 0.394607 7.82 Pfam 14-41 (45) Show / Hide 
Range on Protein: 275-304
Range on HMM: 14-41/45
Sequence Identity: 16% (5 aa)

LVISGGKDDDDDTLDDCWIFNLTQHSWIKL
. . || |.    |......... ..| ..
IYVIGGCDG--QYLNSVECYDPETNQWTRC
Kelch_2 AqueK142.AA Kelch_2 275-308 18 2.445552 5.41 Pfam 14-51 (51) Show / Hide 
Range on Protein: 275-308
Range on HMM: 14-51/51
Sequence Identity: 18% (7 aa)

LVISGGK----DDDDDTLDDCWIFNLTQHSWIKLDVPR
....||     ...|. . | |....  |.| .. .. 
IYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_2 AqueK142.AA Kelch_2 312-363 17 26.925495 1.45 Pfam 1-51 (51) Show / Hide 
Range on Protein: 312-363
Range on HMM: 1-51/51
Sequence Identity: 17% (10 aa)

KRYGHSLSVFIMSPHCVWIITVGGA----TNDSIAMLTELVLDSNEGCLVCDTYDS
 ||.|. .|      . .|. .||.     |.. . .. ...| .. .  | . . 
PRYCHASCVP-----GGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kinase AqueK142.AA TKL 514-628 25 2.2e-25 88.37 In-house 1-165 (364) Show / Hide 
Range on Protein: 514-628
Range on HMM: 1-165/364
Sequence Identity: 25% (43 aa)

LGRGSYAVVTIGIFRG----------LRVAVKSLHTIIISDYNL-------------------------GMFSREMSIASRVRHPNLVQFIGATK-----
.|.|....|  |..||            |||| ...   .  ..                           . .|. . || ||||.|||.|. .     
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------VGNPLILTELM-STSLNHELQRNRLSNQQILSISQDVALGLNYLHLFKP-----RPIIHRD
          |.. | .|..   || | |.      .|......|.|.|.||||  .|     .||||||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRD
Kinase AqueK142.AA Dicty4 510-628 32 1.3e-21 69.05 In-house 3-139 (277) Show / Hide 
Range on Protein: 510-628
Range on HMM: 3-139/277
Sequence Identity: 32% (45 aa)

TKEELGRGSYAVVTIGIFRGLRVAVKSL--HTIIISDYNLGMFSREMSIASRVRHPNLVQFIGA-T----KVGNPLILTELM-STSLNHELQRN------
. ...|.||.. |  |. ||  |||| |  | .  . . |  | .| .| .  ||||...| || |    . | ..| ||.| ...| ..| ..      
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNL-YSLLHDKPSEQQ

-RLSNQ--QILS---ISQDVALGLNYLHLFKPRPIIHRD
 . . .   |..   .  |.|.|.|.||   |. |||||
QSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRD
Kinase AqueK142.AA MLK 508-628 25 2.5e-19 63.83 In-house 1-152 (291) Show / Hide 
Range on Protein: 508-628
Range on HMM: 1-152/291
Sequence Identity: 25% (39 aa)

TLTKEELGRGSYAVVTIGIFRGLR-----VAVKSLHTIIISDYNL-----GMFSREMSIASRVRHPN----LVQFIGA-TKVGN-PLILTELMST-SLNH
 ...| .| ||. .|  | .|. .     ||||  .. |. |          | .|  ......|||     .|| |. .. ..  .|..| ..  ||..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ELQRNR---------------LSNQQILSISQDVALGLNYLHLFKPRPIIHRD
 |  .|                . ....... ..| |..|||  .| ||||||
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRD
Kinase AqueK142.AA TKL-Unique 510-628 29 1.3e-18 62.44 In-house 1-137 (290) Show / Hide 
Range on Protein: 510-628
Range on HMM: 1-137/290
Sequence Identity: 29% (41 aa)

TKEELGRGSYAVVTIGIFRGLRVAVKSLHTIIISDYNLG---MFSREMSIASRVR-HPNLVQFIGATK---VGNP--LILTELMST-SLNHELQ------
  . .|.|.|..|  |..||  ||.|..|    .| ..     |..| .. .. . |||.|...|...   | .|   | .| ..  ||.  |.      
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

-----RNRLSNQQILSISQDVALGLNYLHLFKPRPIIHRD
      . |..||.... .|.|.|..|||  .|  |||||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRD
Kinase AqueK142.AA TK 508-628 13 7.6e-18 55.69 In-house 1-265 (486) Show / Hide 
Range on Protein: 508-628
Range on HMM: 1-265/486
Sequence Identity: 13% (36 aa)

TLTKEELGRGSYA---VVTIGIFRGL---------------------------RVAVKSLH---TIIISDYNLGMFS---------REMSIASRVR----
    ..||.| .    .|  |. ||.                           .|||| |.   .    .  . ..          .|.....  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLVQFIG-ATKVGN------------PLILTELMS-TS----LNHELQRNR----------------------------------------------
 |||.|...|  |....            ..|..|.|.  .    | . |...|                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSNQQILSISQDVALGLNYLHLFKPRPI----IHRD
                               |. .| | .....| |. |||  . .      .|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRD
Pkinase_Tyr AqueK142.AA Pkinase_Tyr 507-628 26 1.8e-17 59.77 Pfam 1-136 (270) Show / Hide 
Range on Protein: 507-628
Range on HMM: 1-136/270
Sequence Identity: 26% (37 aa)

VTLTKEELGRGSYAVVTIGIFR------GLRVAVKSLHTIIISDYN--LGMFSREMSIASRV-RHPNLVQFIGATK-VGNP---LILTELMST-SLNHEL
.|.  ..||.|.. .|  |. .      .. ||||.|     .. .  . .| ||..| .   .|||.|...|.    | |   .| .|.|   .| . |
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

QRN-----RLSNQQILSISQDVALGLNYLHLFKPRPIIHRD
...     .|. ...|......| |..||.  .   .||||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRD
Kinase AqueK142.AA CZAK 509-628 33 1.5e-15 53.12 In-house 1-134 (279) Show / Hide 
Range on Protein: 509-628
Range on HMM: 1-134/279
Sequence Identity: 33% (45 aa)

LTKE-ELGRGSYAVVTIGIFRGLRVAVKSLHTIIISDYNL----GMFSREMSIASRVRHPNLVQFIGATKVGN---PLILTELMS-TSLNHEL-QRNRLS
|. . . |.| .  |  .  ||  ||.| .| .   .        || .| || |  .||| |||.||   ..     | .| |   ||   |  .  . 
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYH

NQ---QILSISQDVALGLNYLHL-FKPRPIIHRD
 |     ...  |.| | ||||  .|| ||.|||
KQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRD
Kinase AqueK142.AA STE 509-628 18 3e-15 50.39 In-house 1-177 (359) Show / Hide 
Range on Protein: 509-628
Range on HMM: 1-177/359
Sequence Identity: 18% (33 aa)

LTK-EELGRGSYAVVTIGIFR-----------------GLRVAVKSLH---------------TIIISDYNLGMFSREMSIASRVR--HPNLVQFIGATK
... |..|.|.. .|  .. .                 | ..|.| ..               . .. . ..  . .|..| .. .  ||| |...|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG--------NPLILTELMS-TSLNHELQRN---------------RLSNQQILSISQDVALG-LNYLHLFKPRPIIHRD
..        .  |  |.|.  ||   ....               |.. .||  | ...  | |.|||  .   |||||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRD
Kinase AqueK142.AA DRK 515-628 37 1.2e-14 46.02 In-house 8-125 (258) Show / Hide 
Range on Protein: 515-628
Range on HMM: 8-125/258
Sequence Identity: 37% (45 aa)

GRGSYAVVTIGIFRGLRVAVKSLHTIIISDYN-LGMFSREMSIASRVRHPNLVQFIGA-TKVGNPLILTELMST-SLNHELQRNRLSNQ--QILSISQDV
|||.|. |  |  ||  |||| |    | | | |  | ||  . .. |||| .||.|. .    ..| .| |.  ||   |    .. .   ....  |.
GRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDC

ALGLNYLHLFKPRPIIHRD
| |..|||   |  |||||
AKGMIYLHCCNPI-IIHRD
Kinase AqueK142.AA HH498 510-628 31 1.7e-13 38.75 In-house 3-149 (284) Show / Hide 
Range on Protein: 510-628
Range on HMM: 3-149/284
Sequence Identity: 31% (47 aa)

TKEELGRGSYAVVTIGIFRGLRVAVKSLHTIIISDYNL------GMFSREMSIASRVRHPNLVQFIGATKVGNP---LILTELMST-SLNHEL-------
..|  | ||.  |  | .|.  ||||      ..           || || || .|  ||. |||..|. .  |   .| |.  .  ||   |       
FHEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYAC-CDDPSQFAIVTQYCDNGSLFSILNTIPIGG

-------QRNR-----LSNQQILSISQDVALGLNYLHLFKPRPIIHRD
         ..     .. | .. || ||| | ||||   ..||||||
AGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRD
Kinase AqueK142.AA Shk 509-628 34 5e-13 43.28 In-house 1-128 (269) Show / Hide 
Range on Protein: 509-628
Range on HMM: 1-128/269
Sequence Identity: 34% (45 aa)

LTKEE-LGRGSYAVVTIGIFRGLRVAVKSLHTIIISDYNLGMFSREMSIASRVRHPNLVQFIGA-T-KVGNPLILTELM-STSLNHELQRNRLSNQQ---
 ..|. || ||.  |  |. ||  |||| .|    . . .  |  | .| |...|||.. | || | . |   | ||||  ..| . | ..         
INREDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNL-EKLLHDQMVKKPFIL

---ILSISQDVALGLNYLHLFKPRPIIHRD
    . .  | ||| | ||   .. |||||
YKRAMRMCRDAALGMNWLHGSNCN-IIHRD
Kinase AqueK142.AA Pkinase 508-628 21 4.7e-12 43.72 Pfam 1-133 (293) Show / Hide 
Range on Protein: 508-628
Range on HMM: 1-133/293
Sequence Identity: 21% (29 aa)

TLTKEELGRGSYAVVTIGIFRGLR--VAVKSLHTIIISDYNLGMFSR--EMSIASRVRHPNLVQFIGATK-VGNPLILTELMST-----SLNHELQ---R
  ... .|.||...| ... .| .  |||| .    ...  .    |  | .|  |..||| |.....    ... . .|..       .| . ..   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NRL--SNQQILSISQDVALGLNYLHLFKPRPIIHRD
...  | ... ..   .. ||.|.|      |||||
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRD
Kinase AqueK142.AA S_TKc 508-690 13 1.9e-09 -38.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 508-690
Range on HMM: 1-231/231
Sequence Identity: 13% (34 aa)

TLTKEELGRGSYAVVTIGIFRG--LRVAVKSLHTIIISDYNLGMFSREMSIASRVRHPNLVQFIGATKVGNPLILTELMST---SLNHELQRNR------
    ...|.|....|  .. ..   .||.| ..          .. ||..| .. .|||.|.....   ..  . .|....   .| . .....      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LSNQQILSISQDVALGLNYLHLFKPRPIIHRD------------------------------FWQCIKKPEAIDQWPVGR-------------CLHAGA
 ..  .. .. . ....|.|.|  .   |||||                              ..     || .   . |.              . .| 
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMA---PEVL---GYGKCKCDWWSCGCILYEMLCGY

IIITGSDCPMLVISGGLDKNNDILDDCWIFNIT--------Q-------HSWI
      .  |. . |  .   |... |. .. .        |       | |.
PPFP-QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase AqueK142.AA TyrKc 508-690 16 8.6e-09 -80.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 508-690
Range on HMM: 1-280/280
Sequence Identity: 16% (48 aa)

TLTKEELGRGSYAVVTIGIFRGLRVAVKSLHTIIISDYNLGMFSREMSIASRV--RHPNLVQFIGATKV--------GNPLILTELMST-SLNHELQRNR
   ...||.| . .|  |. . . ||||.|.        . .| ||..| ...  .|||.|...|.           . ..|..|.|.  .|.. |...|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LSNQQILSISQDVALGLNYLHLFKPRPIIHRD-----------------------FWQCI---------KKPEA--IDQ--WPV--------------
  |.... ||.. ..| | .|||     ..||||                       ..            ...         .|.              
PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

------------------GRCLHAGAII--ITGSDCPMLVISG-GLDKNND---------------ILDDCWIF---------NITQHSWI
                  |   . | |   .. ..   .| .|  ...  .               |  .|| .         .|  |. .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase AqueK142.AA Kelch_1 663-692 16 0.275406 8.38 Pfam 14-41 (45) Show / Hide 
Range on Protein: 663-692
Range on HMM: 14-41/45
Sequence Identity: 16% (5 aa)

LVISGGLDKNNDILDDCWIFNITQHSWIKL
. . || |    .|....... . ..| ..
IYVIGGCDG--QYLNSVECYDPETNQWTRC
Kinase AqueK142.AA Kelch_2 663-692 20 29.843705 1.28 Pfam 14-47 (51) Show / Hide 
Range on Protein: 663-692
Range on HMM: 14-47/51
Sequence Identity: 20% (7 aa)

LVISGGL----DKNNDILDDCWIFNITQHSWIKL
....||.    . |.. . | |...   |.| ..
IYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCV