Gene AqueK146 (A.queenslandica)

AqueK146

Species: A.queenslandica
Alias: AqueK146
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a2

Sequence

Name Sequence Type Origin Length Description Download
AqueK146.AA Protein None 178 None Fasta, JSON
AqueK146.kin_dom Protein Kinase Domain None 153 None Fasta, JSON

Protein domain

Protein domains of AqueK146.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK146.AA TKL 22-174 19 9.1e-25 86.11 In-house 132-364 (364) Show / Hide 
Range on Protein: 22-174
Range on HMM: 132-364/364
Sequence Identity: 19% (45 aa)

PVILSIMHDVAVGLDYLHC--L----PDPIIHRDVSSANVLLEPKGP----------GKWKTKISDFGSANLVQD----------------------AVT
........|.| |..|||        . ||||||  |.|.|.  ..             |. ||.||| .  ..                       .  
HQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTM

KAPGAVLYSAPEA---HQTVATAY--------KKQTTKMDSFSYGVLFCEVLA--CNFPSIETFPDL------LEQVKAS--------------------
.  |   . |||.   ..    ..        .. ..|.| .|.|....|.|.    .  .  .| .      .......                    
TQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCP

---SPQSLLDVIVSCIEEDPDKRPSMQQILQVL
    |.|. . .  | ..||.||||.|.||. |
CPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK146.AA TK 13-174 16 1.6e-18 57.96 In-house 206-486 (486) Show / Hide 
Range on Protein: 13-174
Range on HMM: 206-486/486
Sequence Identity: 16% (47 aa)

ELTPDPSCRPVILS-------------------IMHDVAVGLDYLHCLPD----PIIHRDVSSANVLLEPKGPGKWK-------TKISDFGSAN-----L
.. |.| .    |.                   .....| |. ||| ..      ..|||.   |.|.  ... ||.        ||.||| .      |
KDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVL

VQDAVT--------------------------------KAPGAVLYSAPEAHQ--TVATA--YKKQTTKMDSFSYGVLFCEVLA---CNFPSIETF----
  |                                   ..   . . |||. .  .  .|  |.| ||| | .|.|||  |..      ..   .     
ARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVW

-----PDLLEQVKA----------------------SSPQ-------------SLL-DVIVSCIEEDPDKRPSMQQILQVL
      ...|....                        |               .. |.. .| ..||..||...|... |
KDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK146.AA MLK 23-129 29 3.1e-15 49.39 In-house 125-235 (291) Show / Hide 
Range on Protein: 23-129
Range on HMM: 125-235/291
Sequence Identity: 29% (34 aa)

VILSIMHDVAVGLDYLHC-LPDPIIHRDVSSANVLLEP--KGPGKWKTKISDFGSANLVQDA---VTKAPGAVLYSAPEA-HQTVATAYKKQTTKMDSFS
.........| |..|||. .|.||||||  | |.|.    .  .. . ||.||| .  ...     ....| . . |||.  |  .. |   . | | .|
HAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKY---SEKCDVWS

YGVLFCEVLACNFP
.||.. |.|..  |
WGVVLWEMLTREVP
Kinase AqueK146.AA HH498 22-129 35 2.1e-14 41.68 In-house 121-225 (284) Show / Hide 
Range on Protein: 22-129
Range on HMM: 121-225/284
Sequence Identity: 35% (40 aa)

PVILSIMHDVAVGLDYLHC-LPDPIIHRDVSSANVLLEPKGPGKWKTKISDFGSANLVQ----DAVTKAPGAVLYSAPEAHQTVATAYKKQTTKMDSFSY
. .. |  ||| | .|||  |. ||||||  | |.|.   |    . .. |||    |.    |  || ||   . |||    | .   | . | | |||
QSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDG----HAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPE----VFSQCQKYSIKVDVFSY

GVLFCEVLACNFP
.    | .    |
AMCIWEMHTREVP
Kinase AqueK146.AA Pkinase 23-174 22 1.2e-12 45.75 Pfam 109-293 (293) Show / Hide 
Range on Protein: 23-174
Range on HMM: 109-293/293
Sequence Identity: 22% (45 aa)

VILSIMHDVAVGLDYLHCLPDPIIHRDVSSANVLLEPKGPGKWKT----KISDFGSA----NLVQDAVTKAPGAVLYSAPEAHQTVATAYKKQTTKMDSF
.. ..|  .. ||.|.|     |||||. ..|.|.  .|     .    ||.|||.|    .  .   |   |   | ||| ..     ... ..| | .
ECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNG----HIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKVDMW

SYGVLFCEVLACNFPSIET------------FPDLLEQVKASSP-----------------------QSLLDVIVSCIEEDPDKRPSMQQILQV--L
|.|... |.|  ..|  .             . ..  ... ..|                       ....|.| .|.. || |||. .||||   .
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK146.AA TKL-Unique 4-73 30 3.5e-09 28.72 In-house 86-162 (290) Show / Hide 
Range on Protein: 4-73
Range on HMM: 86-162/290
Sequence Identity: 30% (24 aa)

SLRKAYE---------NKELTPDPSCRPVILSIMHDVAVGLDYLHCLPDPIIHRDVSSANVLLEPK-GPGKWKTKISDFG
||..            |........   ..... .|.| |..||| .  ||||||  | |.|.  .    .|. ||.|||
SLYDVLHQNNNNNNNNNNNCKLNMQ---QRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFG
Kinase AqueK146.AA TKL-ciliate1 146-174 34 3.9e-09 27.42 In-house 251-279 (279) Show / Hide 
Range on Protein: 146-174
Range on HMM: 251-279/279
Sequence Identity: 34% (10 aa)

PQSLLDVIVSCIEEDPDKRPSMQQILQVL
||.. ...  | ...| |||. ..|.|.|
PQNFHNLMMRCWCQNPNKRPNFNEIIQIL
Kinase AqueK146.AA Dicty4 143-178 33 5.7e-09 26.25 In-house 242-277 (277) Show / Hide 
Range on Protein: 143-178
Range on HMM: 242-277/277
Sequence Identity: 33% (12 aa)

ASSPQSLLDVIVSCIEEDPDKRPSMQQILQVLDLDE
.. | |. . |. | ..|| .|||...|.| . |..
DWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK146.AA TK-Unique 25-80 33 2e-08 25.26 In-house 134-185 (294) Show / Hide 
Range on Protein: 25-80
Range on HMM: 134-185/294
Sequence Identity: 33% (19 aa)

LSIMHDVAVGLDYLHCLPDPIIHRDVSSANVLLEPKGPGKWKTKISDFGSANLVQD
.... ..| |. ||. ... |.|||... ||||      . . ||.||| |  |..
YHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE----DKVCKICDFGMARDVYT
Kinase AqueK146.AA Dicty4-Unclassified 153-174 54 2.2e-08 24.8 In-house 242-263 (263) Show / Hide 
Range on Protein: 153-174
Range on HMM: 242-263/263
Sequence Identity: 54% (12 aa)

IVSCIEEDPDKRPSMQQILQVL
|. |  .|| |||.| || | |
IKWCWHNDPNKRPTMNQIIQYL
Kinase AqueK146.AA DRK 22-73 42 2.8e-08 24.17 In-house 98-145 (258) Show / Hide 
Range on Protein: 22-73
Range on HMM: 98-145/258
Sequence Identity: 42% (22 aa)

PVILSIMHDVAVGLDYLHCLPDPIIHRDVSSANVLLEPKGPGKWKTKISDFG
| ....| |.| |. ||||    |||||  | | |        |. |..|||
PLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVD----EHWQVKVADFG
Kinase AqueK146.AA TKL-ciliate1 24-57 38 3e-08 24.32 In-house 105-138 (279) Show / Hide 
Range on Protein: 24-57
Range on HMM: 105-138/279
Sequence Identity: 38% (13 aa)

ILSIMHDVAVGLDYLHCLPDPIIHRDVSSANVLL
.. .  |.| |. ||| .  |.||||  . | |.
RMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILY
S_TKc AqueK146.AA S_TKc 1-174 17 7.9e-08 -62.09 SMART 19-231 (231) Show / Hide 
Range on Protein: 1-174
Range on HMM: 19-231/231
Sequence Identity: 17% (42 aa)

MDTS------------------------------LRKAYE------------N------KELTPDPS-------CRPVILSIMHDVAVGLDYLHCLPDPI
 ...                              |  ...            .      . .   ..          .. ..|. .. .|.|.| .   |
RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH--GI

IHRDVSSANVLLEPKGPGKWKTKISDFGSANLVQDAVTKAPGAVLYSAPEAHQTVATAYKKQTT-KMDSFSYGVLFCEVLACNFPSIETFPDLLEQVKAS
||||.  .|.||          ||.|||.| ..    |   |   | |||          . .. | |  | |... | |.   |   .   ......  
IHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--

SPQSLLDVIVSCIEEDPDKRPSMQQILQ---------VL
 .....| |  | . ||.|||.  ..||          .
-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK146.AA DRK 153-176 45 9.1e-08 22.42 In-house 235-258 (258) Show / Hide 
Range on Protein: 153-176
Range on HMM: 235-258/258
Sequence Identity: 45% (11 aa)

IVSCIEEDPDKRPSMQQILQVLDL
.  | .|||  |||||..|. |. 
MNDCWNEDPQHRPSMQECLERLEA
TyrKc AqueK146.AA TyrKc 3-174 16 3.6e-07 -106.77 SMART 1-280 (280) Show / Hide 
Range on Protein: 3-174
Range on HMM: 1-280/280
Sequence Identity: 16% (47 aa)

TSLRKAYEN-----------------------------------KEL--------------TPD--------------------------PSCRP-----
 .| |   .                                   ..|              | .                           ..||     
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

VILSIMHDVAVGLDYLHCLPDPIIHRDVSSANVLLEPKGPGKWKTKISDFGSANLVQDA--------VTK------AP--GAVLYSAPEAHQTVATAYKK
  ||.....| | .|||    ..||||    |.|.  ..      |||||| .  . |         . .      .     .   |||.       |.|
DLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----NYGK

QTTKMDSFSYGVL------FCEVLACN-----FPSIETFPDLLEQ----VKAS--------SPQSLLDVIVSCIEEDPDKRPSMQQILQVL
 ||| | .|.||.      ...    .      . .| . .. .       ..         |. . ... .| .|||..||....| . .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK146.AA Dicty4-Unclassified 23-73 35 1e-06 18.93 In-house 110-154 (263) Show / Hide 
Range on Protein: 23-73
Range on HMM: 110-154/263
Sequence Identity: 35% (18 aa)

VILSIMHDVAVGLDYLHCLPDPIIHRDVSSANVLLEPKGPGKWKTKISDFG
.|. .  |.| |. .||     .||||. |.|.|.          || |||
LIIKYAFDIAQGMQHLHTR--NFIHRDIKSSNILMD----KHFNIKIADFG
Kinase AqueK146.AA TKL-Unique 146-174 37 1e-06 19.6 In-house 262-290 (290) Show / Hide 
Range on Protein: 146-174
Range on HMM: 262-290/290
Sequence Identity: 37% (11 aa)

PQSLLDVIVSCIEEDPDKRPSMQQILQVL
|... | |  |   ||..||| ..|.  |
PKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK146.AA MLK 156-174 57 2e-06 18.68 In-house 273-291 (291) Show / Hide 
Range on Protein: 156-174
Range on HMM: 273-291/291
Sequence Identity: 57% (11 aa)

CIEEDPDKRPSMQQILQVL
| ..|| ||||..||.| |
CWNQDPHKRPSFRQIVQHL
Kinase AqueK146.AA Pkinase_Tyr 146-174 31 1.2e-05 19.73 Pfam 242-270 (270) Show / Hide 
Range on Protein: 146-174
Range on HMM: 242-270/270
Sequence Identity: 31% (9 aa)

PQSLLDVIVSCIEEDPDKRPSMQQILQVL
|. . |.. .| ..||..||....|.. |
PDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK146.AA Dicty4 24-73 38 2.1e-05 14.15 In-house 111-159 (277) Show / Hide 
Range on Protein: 24-73
Range on HMM: 111-159/277
Sequence Identity: 38% (21 aa)

ILS---IMHDVAVGLDYLHC-LPDPIIHRDVSSANVLLEPKGPGKWKTKISDFG
|..   .. |.| |. .|||  |. |||||  |.| |        |. |..|||
IKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVD----KNWRVKVCDFG
Kinase AqueK146.AA TK-Unique 155-174 45 2.7e-05 14.36 In-house 275-294 (294) Show / Hide 
Range on Protein: 155-174
Range on HMM: 275-294/294
Sequence Identity: 45% (9 aa)

SCIEEDPDKRPSMQQILQVL
||. ..|..|||  ||...|
SCWQWEPEERPSFRQIKHRL
Kinase AqueK146.AA Pkinase_Tyr 24-73 32 0.000481 14.32 Pfam 113-156 (270) Show / Hide 
Range on Protein: 24-73
Range on HMM: 113-156/270
Sequence Identity: 32% (16 aa)

ILSIMHDVAVGLDYLHCLPDPIIHRDVSSANVLLEPKGPGKWKTKISDFG
.|.. ...| |..||.  .  .||||.   |.|..    .. . ||.|||
LLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE---NN-VVKICDFG
Kinase AqueK146.AA HH498 146-174 31 0.001013 7.23 In-house 256-284 (284) Show / Hide 
Range on Protein: 146-174
Range on HMM: 256-284/284
Sequence Identity: 31% (9 aa)

PQSLLDVIVSCIEEDPDKRPSMQQILQVL
|.. .  |  | .  |. ||.  ||. .|
PHHWSNLIQMCWHPCPENRPDFDQIVTIL